Publications by authors named "Douglas Adkins"

96Publications

Duration of radiation therapy is associated with worse survival in head and neck cancer.

Oral Oncol 2020 09 30;108:104819. Epub 2020 May 30.

Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St Louis, MO, United States; Department of Genetics, Washington University School of Medicine, St Louis, MO, United States. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2020.104819DOI Listing
September 2020

Prospective assessment of the clinical benefit of a tailored cancer gene set built on a next-generation sequencing platform in patients with recurrent or metastatic head and neck cancer.

Med Oncol 2019 Dec 21;37(2):12. Epub 2019 Dec 21.

Division of Medical Oncology, Washington University School of Medicine, 660 South Euclid, Campus Box 8056, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s12032-019-1336-3DOI Listing
December 2019

Palbociclib and cetuximab in platinum-resistant and in cetuximab-resistant human papillomavirus-unrelated head and neck cancer: a multicentre, multigroup, phase 2 trial.

Lancet Oncol 2019 09 24;20(9):1295-1305. Epub 2019 Jul 24.

Division of Medical Oncology, Washington University School of Medicine, St Louis, MO, USA; Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, USA.

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http://dx.doi.org/10.1016/S1470-2045(19)30405-XDOI Listing
September 2019

Extranodal extension is a strong prognosticator in HPV-positive oropharyngeal squamous cell carcinoma.

Laryngoscope 2020 04 11;130(4):939-945. Epub 2019 May 11.

Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, U.S.A.

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http://dx.doi.org/10.1002/lary.28059DOI Listing
April 2020

Patterns of care and survival outcomes for laryngeal small cell cancer.

Head Neck 2019 03 10;41(3):722-729. Epub 2018 Dec 10.

Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hed.25430
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http://dx.doi.org/10.1002/hed.25430DOI Listing
March 2019

Outcomes of relapsed human papillomavirus-related oropharyngeal squamous cell carcinoma treated with curative intent.

Head Neck 2019 05 11;41(5):1312-1319. Epub 2018 Dec 11.

Department of Otolaryngology-Head and Neck Surgery, Washington University, Saint Louis, Missouri.

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http://dx.doi.org/10.1002/hed.25557DOI Listing
May 2019

Oral Cavity Squamous Cell Carcinoma Xenografts Retain Complex Genotypes and Intertumor Molecular Heterogeneity.

Cell Rep 2018 08;24(8):2167-2178

McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA; Department of Medicine, Division of Medical Oncology, Washington University School of Medicine, St. Louis, MO 63108, USA; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA; Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63108, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183116
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http://dx.doi.org/10.1016/j.celrep.2018.07.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417872PMC
August 2018

Pretreatment metabolic tumor volume as a prognostic factor in HPV-associated oropharyngeal cancer in the context of AJCC 8th edition staging.

Head Neck 2018 10 26;40(10):2280-2287. Epub 2018 Jul 26.

Washington University School of Medicine, Department of Radiation Oncology, St Louis, MO.

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http://dx.doi.org/10.1002/hed.25337DOI Listing
October 2018

Antitumor Activity of Nivolumab in Recurrent and Metastatic Nasopharyngeal Carcinoma: An International, Multicenter Study of the Mayo Clinic Phase 2 Consortium (NCI-9742).

J Clin Oncol 2018 05 27;36(14):1412-1418. Epub 2018 Mar 27.

Brigette B.Y. Ma, Edwin P. Hui, Kwok-Wai Lo, Ka-Fai To, K.C. Allen Chan, Y.M. Dennis Lo, Ann D. King, and Anthony T.C. Chan, The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region, People's Republic of China; Wan-Teck Lim, National Cancer Centre; Boon-Cher Goh, National University Cancer Institute of Singapore; Alex Y.C. Chang, Johns Hopkins University School of Medicine; Akhil Chopra, OncoCare Cancer Centre, Singapore; Adam Pettinger, Nathan R. Foster, Charles Erlichman, Jun Yin, and Brian A. Costello, Mayo Clinic, Rochester, MN; Jonathan W. Riess, University of California Davis Comprehensive Cancer Center, Sacramento; Barbara J. Gitlitz, University of Southern California Keck School of Medicine, Los Angeles; Dean W. Lim, City of Hope Comprehensive Cancer Center, Duarte, CA; Mark Agulnik, Northwestern University, Evanston, IL; Julie A. Kish and Christine H. Chung, Moffitt Cancer Center, University of South Florida, Tampa, FL; Douglas R. Adkins, Washington University School of Medicine, St Louis, MO; Kevin J. Cullen, University of Maryland, Baltimore, MD.

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http://dx.doi.org/10.1200/JCO.2017.77.0388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941615PMC
May 2018

Rationale for neoadjuvant immunotherapy in head and neck squamous cell carcinoma.

Oral Oncol 2017 10 17;73:65-69. Epub 2017 Aug 17.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Division of Otolaryngology-Head & Neck Surgery, Brigham & Women's Hospital, 75 Francis Street, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2017.08.008DOI Listing
October 2017

Trials in head and neck oncology: Evolution of perioperative adjuvant therapy.

Oral Oncol 2017 09 15;72:80-89. Epub 2017 Jul 15.

Washington University, Department of Otolaryngology-Head and Neck Surgery, United States.

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http://dx.doi.org/10.1016/j.oraloncology.2017.07.012DOI Listing
September 2017

nab-Paclitaxel-based induction chemotherapy with or without cetuximab for locally advanced head and neck squamous cell carcinoma.

Oral Oncol 2017 09 8;72:26-31. Epub 2017 Jul 8.

Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, United States; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, United States.

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http://dx.doi.org/10.1016/j.oraloncology.2017.07.001DOI Listing
September 2017

Clinical benefit of nanoparticle albumin-bound-paclitaxel in recurrent/metastatic head and neck squamous cell carcinoma resistant to cremophor-based paclitaxel or docetaxel.

Med Oncol 2017 Feb 11;34(2):28. Epub 2017 Jan 11.

Division of Medical Oncology, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid, Campus Box 8056, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s12032-017-0884-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754095PMC
February 2017

Outcomes of surgically treated human papillomavirus-related oropharyngeal squamous cell carcinoma with N3 disease.

Laryngoscope 2017 09 23;127(9):2033-2037. Epub 2016 Dec 23.

Department of Otolaryngology-Head and Neck Surgery, Washington University, St. Louis, Missouri, U.S.A.

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http://dx.doi.org/10.1002/lary.26455DOI Listing
September 2017

Reevaluation of postoperative radiation dose in the management of human papillomavirus-positive oropharyngeal cancer.

Head Neck 2016 11 6;38(11):1643-1649. Epub 2016 May 6.

Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1002/hed.24486DOI Listing
November 2016

nab-Paclitaxel, cisplatin, and 5-fluorouracil followed by concurrent cisplatin and radiation for head and neck squamous cell carcinoma.

Oral Oncol 2016 10 29;61:1-7. Epub 2016 Jul 29.

Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, United States; Department of Otolaryngology, Washington University School of Medicine, St. Louis, MO, United States.

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http://dx.doi.org/10.1016/j.oraloncology.2016.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105832PMC
October 2016

Phase I trial of palbociclib, a selective cyclin dependent kinase 4/6 inhibitor, in combination with cetuximab in patients with recurrent/metastatic head and neck squamous cell carcinoma.

Oral Oncol 2016 07 28;58:41-8. Epub 2016 May 28.

Division of Medical Oncology, Washington University School of Medicine, St. Louis, MO, United States; Alvin J. Siteman Cancer Center, Washington University School of Medicine, United States. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047057PMC
http://dx.doi.org/10.1016/j.oraloncology.2016.05.011DOI Listing
July 2016

High E6 Gene Expression Predicts for Distant Metastasis and Poor Survival in Patients With HPV-Positive Oropharyngeal Squamous Cell Carcinoma.

Int J Radiat Oncol Biol Phys 2016 07 10;95(4):1132-41. Epub 2016 Mar 10.

Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2016.03.001DOI Listing
July 2016

RTOG 0522: huge Investment in patients and resources and no benefit with addition of cetuximab to radiotherapy--why did this occur?

J Clin Oncol 2015 Apr 23;33(10):1223-4. Epub 2015 Feb 23.

Washington University School of Medicine, St Louis, MO.

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http://dx.doi.org/10.1200/JCO.2014.59.6908DOI Listing
April 2015

Pre-radiotherapy feeding tube identifies a poor prognostic subset of postoperative p16 positive oropharyngeal carcinoma patients.

Radiat Oncol 2015 Jan 9;10. Epub 2015 Jan 9.

Department of Radiation Oncology, Washington University School of Medicine, 4921 Parkview Place, Campus Box 8224, St. Louis, 63110-6311, Missouri, USA.

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http://dx.doi.org/10.1186/s13014-014-0314-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333178PMC
January 2015

Looking beyond the CRT paradigm: why induction chemotherapy is worthy of pursuit.

Oral Oncol 2015 Feb 11;51(2):103-4. Epub 2014 Dec 11.

Washington University School of Medicine, St. Louis, MO, United States.

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http://dx.doi.org/10.1016/j.oraloncology.2014.11.018DOI Listing
February 2015

Metastasis occurring eleven years after diagnosis of human papilloma virus-related oropharyngeal squamous cell carcinoma.

Ecancermedicalscience 2014 13;8:480. Epub 2014 Nov 13.

Division of Medical Oncology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.3332/ecancer.2014.480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239125PMC
December 2014

Response to: 'Pre-medications for cetuximab induced infusion reactions - commentary'.

Oral Oncol 2014 Dec 2;50(12):e72. Epub 2014 Oct 2.

Washington University School of Medicine, United States.

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http://dx.doi.org/10.1016/j.oraloncology.2014.09.008DOI Listing
December 2014

Loss of Trop2 causes ErbB3 activation through a neuregulin-1-dependent mechanism in the mesenchymal subtype of HNSCC.

Oncotarget 2014 Oct;5(19):9281-94

Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri. The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253434PMC
http://dx.doi.org/10.18632/oncotarget.2423DOI Listing
October 2014

Phase II study of the safety and antitumor activity of the hypoxia-activated prodrug TH-302 in combination with doxorubicin in patients with advanced soft tissue sarcoma.

J Clin Oncol 2014 Oct 2;32(29):3299-306. Epub 2014 Sep 2.

Sant P. Chawla, Sarcoma Oncology Center, Santa Monica; Andrew E. Hendifar, Cedars Sinai Medical Center, Los Angeles; Stew Kroll, Threshold Pharmaceuticals, South San Francisco; Kristen N. Ganjoo, Stanford University Medical Center, Stanford, CA; Lee D. Cranmer, University of Arizona Cancer Center, Tucson, AZ; Brian A. Van Tine and Douglas R. Adkins, Washington University in St Louis, St Louis, MO; Damon R. Reed, Moffitt Cancer Center and Research Institute, Tampa, FL; Scott H. Okuno, Mayo Clinic, Rochester, MN; and James E. Butrynski, Dana-Farber Cancer Institute, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2013.54.3660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588714PMC
October 2014

A prospective trial comparing FDG-PET/CT and CT to assess tumor response to cetuximab in patients with incurable squamous cell carcinoma of the head and neck.

Cancer Med 2014 Dec 1;3(6):1493-501. Epub 2014 Aug 1.

Division of Medical Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri; Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri.

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http://doi.wiley.com/10.1002/cam4.294
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http://dx.doi.org/10.1002/cam4.294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298375PMC
December 2014

Risk factors for and pre-medications to prevent cetuximab-induced infusion reactions in patients with squamous cell carcinoma of the head and neck.

Oral Oncol 2014 Sep 15;50(9):895-900. Epub 2014 Jul 15.

Division of Medical Oncology, Department of Internal Medicine, St. Louis, MO, United States; Alvin J. Siteman Cancer Center, St. Louis, MO, United States. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2014.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130782PMC
September 2014

Risk-stratified patients with resectable soft tissue sarcoma benefit from epirubicin-based adjuvant chemotherapy.

Cancer Med 2014 Jun 27;3(3):603-12. Epub 2014 Feb 27.

Division of Medical Oncology, Washington University in St. Louis, St. Louis, 63110, Missouri; College of Medicine, Des Moines University, Des Moines, 50312, Iowa.

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http://dx.doi.org/10.1002/cam4.209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101751PMC
June 2014

Prognostic value of F-FDG PET metabolic parameters in oropharyngeal squamous cell carcinoma.

J Radiat Oncol 2013 Mar;2(1):27-34

Department of Radiation Oncology; Siteman Cancer Center, Barnes-Jewish Hospital and Washington University, School of Medicine, 4921 Parkview Place, Lower Level, St., Louis, MO 63110, USA.

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http://link.springer.com/10.1007/s13566-012-0065-4
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http://dx.doi.org/10.1007/s13566-012-0065-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929054PMC
March 2013

Antiangiogenic agents for nonmalignant brain tumors.

J Neurol Surg B Skull Base 2013 Jun 13;74(3):136-41. Epub 2013 Mar 13.

Department of Neurosurgery, Washington University School of Medicine, Saint Louis, Missouri, USA.

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http://dx.doi.org/10.1055/s-0033-1338262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709924PMC
June 2013

A randomized phase II study of docetaxel with or without vandetanib in recurrent or metastatic squamous cell carcinoma of head and neck (SCCHN).

Oral Oncol 2013 Aug 30;49(8):835-41. Epub 2013 May 30.

Dana Farber Cancer Institute/Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.oraloncology.2013.04.010DOI Listing
August 2013

Radiotherapeutic management of cervical lymph node metastases from an unknown primary site.

Arch Otolaryngol Head Neck Surg 2012 Jul;138(7):656-61

Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1001/archoto.2012.1110DOI Listing
July 2012

Squamous cell cancer of the head and neck with distant metastasis at presentation.

Head Neck 2011 May 24;33(5):714-8. Epub 2010 Sep 24.

Division of Hematology/Oncology, Department of Medicine, John Cochran Veterans Administration Medical Center, St. Louis, Missouri, USA.

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http://doi.wiley.com/10.1002/hed.21529
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http://dx.doi.org/10.1002/hed.21529DOI Listing
May 2011

Safety profile and clinical outcomes in a phase I, placebo-controlled study of siplizumab in acute graft-versus-host disease.

Transplantation 2009 Jul;88(2):198-202

Division of Medical Oncology, Department of Internal Medicine, Washington University and Siteman Cancer Center, St. Louis, MI, USA.

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http://pdfs.journals.lww.com/transplantjournal/2009/07270/Sa
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/TP.0b013e3181abfbf7DOI Listing
July 2009

Transoral laser microsurgery (TLM) +/- adjuvant therapy for advanced stage oropharyngeal cancer: outcomes and prognostic factors.

Laryngoscope 2009 Sep;119(9):1709-19

Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://doi.wiley.com/10.1002/lary.20552
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http://dx.doi.org/10.1002/lary.20552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877921PMC
September 2009

Total body irradiation before an allogeneic stem cell transplantation: is there a magic dose?

Curr Opin Hematol 2008 Nov;15(6):555-60

Division of Oncology, Siteman Cancer Center, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8007, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1097/MOH.0b013e32831188f5DOI Listing
November 2008

Temporal relationship between antitumor necrosis factor-alpha antibody therapy and recrudescence of head and neck squamous cell carcinoma.

Laryngoscope 2008 Mar;118(3):450-2

Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://doi.wiley.com/10.1097/MLG.0b013e31815abf4c
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http://dx.doi.org/10.1097/MLG.0b013e31815abf4cDOI Listing
March 2008

A randomized double-blind trial of hydroxychloroquine for the prevention of chronic graft-versus-host disease after allogeneic peripheral blood stem cell transplantation.

Biol Blood Marrow Transplant 2007 Oct;13(10):1201-6

Division of Oncology, Section of Leukemia & Bone Marrow Transplantation, Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S108387910700337
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http://dx.doi.org/10.1016/j.bbmt.2007.06.012DOI Listing
October 2007

Unrelated donor marrow transplantation for B-cell chronic lymphocytic leukemia after using myeloablative conditioning: results from the Center for International Blood and Marrow Transplant research.

J Clin Oncol 2005 Aug 25;23(24):5788-94. Epub 2005 Jul 25.

Graft-versus-Host and Autoimmunity Unit, Experimental Transplantation and Immunology Branch, National Cancer Institute, 9000 Rockville Pike, Building 10, Room CRC 3-3330, Bethesda, MD 20892-1907, USA.

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http://dx.doi.org/10.1200/JCO.2005.03.962DOI Listing
August 2005

Chimerism and clinical outcomes of 110 recipients of unrelated donor bone marrow transplants who underwent conditioning with low-dose, single-exposure total body irradiation and cyclophosphamide.

Blood 2005 Apr 4;105(8):3035-41. Epub 2004 May 4.

Department of Internal Medicine, Division of Oncology, Section of Bone Marrow Transplantation and Leukemia, Washington University School of Medicine, St Louis, MO 63110-1093, USA.

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http://dx.doi.org/10.1182/blood-2003-07-2346DOI Listing
April 2005

Long-term outcomes of allogeneic stem cell transplant recipients after calcineurin inhibitor-induced neurotoxicity.

Br J Haematol 2003 Oct;123(1):110-3

Washington University School of Medicine, Department of Medicine, Division of Oncology, Section of Leukaemia & Bone Marrow Transplantation, St Louis, MO 63110-1093, USA.

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http://dx.doi.org/10.1046/j.1365-2141.2003.04550.xDOI Listing
October 2003

Primary amyloidosis patients with significant organ dysfunction tolerate autologous transplantation after conditioning with single-dose total body irradiation alone: a feasibility study.

Biol Blood Marrow Transplant 2003 Jun;9(6):397-404

Division of Oncology, Section of Bone Marrow Transplantation and Leukemia, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110-1093, USA.

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http://dx.doi.org/10.1016/s1083-8791(03)00106-xDOI Listing
June 2003

Recent advances in allogeneic hematopoietic stem-cell transplantation.

J Lab Clin Med 2003 Jan;141(1):7-32

Division of Oncology, Section of Bone Marrow Transplantation and Leukemia, Department of Medicine, Siteman Cancer Center, Washington University School of Medicine,

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http://dx.doi.org/10.1067/mlc.2003.5DOI Listing
January 2003