Douglas A Lauffenburger

Douglas A Lauffenburger

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Douglas A Lauffenburger

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-Associated Antibiotics Alter Human Mucosal Barrier Functions by Microbiome-Independent Mechanisms.

Antimicrob Agents Chemother 2020 Mar 24;64(4). Epub 2020 Mar 24.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

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http://dx.doi.org/10.1128/AAC.01404-19DOI Listing
March 2020

Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data.

Genome Biol 2020 Feb 12;21(1):36. Epub 2020 Feb 12.

Institute for Computational Biomedicine, Bioquant, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s13059-020-1949-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017576PMC
February 2020

Translating preclinical models to humans.

Science 2020 Feb;367(6479):742-743

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/science.aay8086DOI Listing
February 2020

Pharmacometrics and Systems Pharmacology 2030.

Clin Pharmacol Ther 2020 Jan 23;107(1):76-78. Epub 2019 Nov 23.

Bill & Melinda Gates Foundation, Seattle, Washington, USA.

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http://dx.doi.org/10.1002/cpt.1683DOI Listing
January 2020

Substrate-based kinase activity inference identifies MK2 as driver of colitis.

Integr Biol (Camb) 2019 11;11(7):301-314

Cancer Research Institute and Division of Genetics, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA.

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http://dx.doi.org/10.1093/intbio/zyz025DOI Listing
November 2019

Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes.

Cell Metab 2019 Sep 1;30(3):447-461.e5. Epub 2019 Aug 1.

Department of Microbiology, Boston University School of Medicine, Boston, MA 02118 USA; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA; Department of Pathology, Boston University School of Medicine, Boston, MA 02118, USA; Barnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, KY 40536, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.07.004DOI Listing
September 2019

Development and Application of the Metalloprotease Activity Multiplexed Bead-Based Immunoassay (MAMBI).

Biochemistry 2019 Sep 9;58(38):3938-3942. Epub 2019 Sep 9.

Department of Biological Engineering and Center for Gynepathology Research , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.

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http://dx.doi.org/10.1021/acs.biochem.9b00584DOI Listing
September 2019

Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation.

Cell Syst 2019 Sep 11;9(3):258-270.e6. Epub 2019 Sep 11.

Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Harvard Digestive Disease Center, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2019.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816257PMC
September 2019

VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells.

Cell Syst 2019 Jul 10;9(1):74-92.e8. Epub 2019 Jul 10.

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24054712193019
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http://dx.doi.org/10.1016/j.cels.2019.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688637PMC
July 2019

ROS and Oxidative Stress Are Elevated in Mitosis during Asynchronous Cell Cycle Progression and Are Exacerbated by Mitotic Arrest.

Cell Syst 2019 02 20;8(2):163-167.e2. Epub 2019 Feb 20.

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; MIT Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2019.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688173PMC
February 2019

Computational translation of genomic responses from experimental model systems to humans.

PLoS Comput Biol 2019 01 10;15(1):e1006286. Epub 2019 Jan 10.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States of America.

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http://dx.plos.org/10.1371/journal.pcbi.1006286
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http://dx.doi.org/10.1371/journal.pcbi.1006286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343937PMC
January 2019

A new publisher for our new biology.

Integr Biol (Camb) 2019 01;11(1)

Massachusetts Institute of Technology, Editor-in-Chief, Integrative Biology, V2, 9 November 2018.

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http://dx.doi.org/10.1093/intbio/zyy001DOI Listing
January 2019

In vivo systems biology approaches to chronic immune/inflammatory pathophysiology.

Curr Opin Biotechnol 2018 08 27;52:9-16. Epub 2018 Feb 27.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.copbio.2018.02.006DOI Listing
August 2018

Systems Modeling Identifies Divergent Receptor Tyrosine Kinase Reprogramming to MAPK Pathway Inhibition.

Cell Mol Bioeng 2018 26;11(6):451-469. Epub 2018 Jul 26.

1Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 USA.

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http://dx.doi.org/10.1007/s12195-018-0542-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244947PMC
July 2018

Exploiting glycan topography for computational design of Env glycoprotein antigenicity.

PLoS Comput Biol 2018 04 20;14(4):e1006093. Epub 2018 Apr 20.

Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1006093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931682PMC
April 2018

Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition.

Sci Signal 2018 03 6;11(520). Epub 2018 Mar 6.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/scisignal.aal1601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978689PMC
March 2018

The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile.

PLoS Biol 2018 03 29;16(3):e2002417. Epub 2018 Mar 29.

Cancer Research Institute, Beth Israel Deaconess Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.2002417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892915PMC
March 2018

Simultaneous Detection of Metalloprotease Activities in Complex Biological Samples Using the PrAMA (Proteolytic Activity Matrix Assay) Method.

Methods Mol Biol 2017 ;1574:243-253

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://link.springer.com/10.1007/978-1-4939-6850-3_18
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http://dx.doi.org/10.1007/978-1-4939-6850-3_18DOI Listing
February 2018

Apoptotic Bodies Elicit Gas6-Mediated Migration of AXL-Expressing Tumor Cells.

Mol Cancer Res 2017 12 18;15(12):1656-1666. Epub 2017 Sep 18.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
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http://dx.doi.org/10.1158/1541-7786.MCR-17-0012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957761PMC
December 2017

Hepatic Dysfunction Caused by Consumption of a High-Fat Diet.

Cell Rep 2017 Dec;21(11):3317-3328

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.11.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734865PMC
December 2017

Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System.

Drug Metab Dispos 2017 07 27;45(7):855-866. Epub 2017 Apr 27.

Departments of Biological Engineering (U.S., K.C.R., C.L.Y., D.R.-B., J.Y., M.C., J.S.W., D.A.L., L.G.G., S.R.T.) and Chemistry (S.R.T.), Massachusetts Institute of Technology, Cambridge, Massachusetts; and CN Bio Innovations Ltd., Welwyn Garden City, Hertfordshire, United Kingdom (E.L., D.J.H.)

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http://dmd.aspetjournals.org/lookup/doi/10.1124/dmd.116.0740
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http://dx.doi.org/10.1124/dmd.116.074005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469400PMC
July 2017

An engineering design approach to systems biology.

Integr Biol (Camb) 2017 07;9(7):574-583

Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1039/c7ib00014fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534349PMC
July 2017

Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility.

Fertil Steril 2017 05 19;107(5):1191-1199.e2. Epub 2017 Apr 19.

Department of Gynecology, Oslo University Hospital, Ullevål Hospital, Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1016/j.fertnstert.2017.03.013DOI Listing
May 2017

Genital-Systemic Chemokine Gradients and the Risk of HIV Acquisition in Women.

J Acquir Immune Defic Syndr 2017 Mar;74(3):318-325

*Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa; †Department of Medical Microbiology, University of KwaZulu-Natal, Durban, South Africa; ‡Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa; §Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA; ‖Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI; ¶Department of Epidemiology, Columbia University, New York City, NY; and #National Health Laboratory Service, Johannesburg, South Africa.

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http://dx.doi.org/10.1097/QAI.0000000000001218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5305292PMC
March 2017

Molecular Pathways: Receptor Ectodomain Shedding in Treatment, Resistance, and Monitoring of Cancer.

Clin Cancer Res 2017 Feb 28;23(3):623-629. Epub 2016 Nov 28.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290119PMC
February 2017

Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors.

Bioorg Med Chem 2017 02 7;25(4):1320-1328. Epub 2016 Dec 7.

Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.11.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484535PMC
February 2017

DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme.

Cancer Res 2017 01 28;77(1):198-206. Epub 2016 Oct 28.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-1151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100738PMC
January 2017

MENA Confers Resistance to Paclitaxel in Triple-Negative Breast Cancer.

Mol Cancer Ther 2017 01 3;16(1):143-155. Epub 2016 Nov 3.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1158/1535-7163.MCT-16-0413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359014PMC
January 2017

Profiling drugs for rheumatoid arthritis that inhibit synovial fibroblast activation.

Nat Chem Biol 2017 Jan 31;13(1):38-45. Epub 2016 Oct 31.

HMS LINCS Center, Laboratory of Systems Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.2211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372219PMC
January 2017

Differential selective pressure alters rate of drug resistance acquisition in heterogeneous tumor populations.

Sci Rep 2016 11 7;6:36198. Epub 2016 Nov 7.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1038/srep36198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098152PMC
November 2016

MenaINV mediates synergistic cross-talk between signaling pathways driving chemotaxis and haptotaxis.

Mol Biol Cell 2016 10 24;27(20):3085-3094. Epub 2016 Aug 24.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142 Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139

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http://dx.doi.org/10.1091/mbc.E16-04-0212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063616PMC
October 2016

Synergistic Communication between CD4+ T Cells and Monocytes Impacts the Cytokine Environment.

Sci Rep 2016 10 10;6:34942. Epub 2016 Oct 10.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1038/srep34942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056362PMC
October 2016

Pathway-based network modeling finds hidden genes in shRNA screen for regulators of acute lymphoblastic leukemia.

Integr Biol (Camb) 2016 07 17;8(7):761-74. Epub 2016 Jun 17.

Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 16-343, Cambridge MA 02139, USA.

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http://dx.doi.org/10.1039/c6ib00040aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224708PMC
July 2016

Inflammatory cytokine biomarkers to identify women with asymptomatic sexually transmitted infections and bacterial vaginosis who are at high risk of HIV infection.

Sex Transm Infect 2016 May 28;92(3):186-93. Epub 2015 Oct 28.

Institute of Infectious Diseases and Molecular Medicine, University of Cape Town Medical School, Cape Town, South Africa Centre for the AIDS Programme of Research in South Africa, University of KwaZulu Natal, Durban, South Africa National Health Laboratory Services, South Africa.

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http://dx.doi.org/10.1136/sextrans-2015-052072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801014PMC
May 2016

Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation.

Cell 2016 May 14;165(4):910-20. Epub 2016 Apr 14.

The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK; Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.03.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868820PMC
May 2016

Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance.

Cancer Discov 2016 Apr 16;6(4):382-99. Epub 2016 Mar 16.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087317PMC
http://dx.doi.org/10.1158/2159-8290.CD-15-0933DOI Listing
April 2016

Characterization of the expression of the pro-metastatic Mena(INV) isoform during breast tumor progression.

Clin Exp Metastasis 2016 Mar 17;33(3):249-61. Epub 2015 Dec 17.

Koch Institute for Integrative Cancer Research, MIT, 76-317, 77 Massachusetts Ave, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1007/s10585-015-9775-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777680PMC
March 2016

Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution.

Cell 2016 Mar 25;165(1):234-246. Epub 2016 Feb 25.

The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.01.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152932PMC
March 2016

Modeling Tumor Clonal Evolution for Drug Combinations Design.

Trends Cancer 2016 03;2(3):144-158

The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.

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http://dx.doi.org/10.1016/j.trecan.2016.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400294PMC
March 2016

Time series modeling of live-cell shape dynamics for image-based phenotypic profiling.

Integr Biol (Camb) 2016 Jan 11;8(1):73-90. Epub 2015 Dec 11.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058786PMC
http://dx.doi.org/10.1039/c5ib00283dDOI Listing
January 2016

Network-level effects of kinase inhibitors modulate TNF-α-induced apoptosis in the intestinal epithelium.

Sci Signal 2015 Dec 15;8(407):ra129. Epub 2015 Dec 15.

Cancer Research Institute, Beth Israel Deaconess Cancer Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1126/scisignal.aac7235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812576PMC
December 2015

PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena.

Mol Biol Cell 2015 Nov 2;26(21):3867-78. Epub 2015 Sep 2.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139

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http://dx.doi.org/10.1091/mbc.E15-06-0442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626070PMC
November 2015

Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening.

Sci Rep 2015 Nov 13;5:16622. Epub 2015 Nov 13.

Cancer Research Institute, Beth Israel Deaconess Cancer Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1038/srep16622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643219PMC
November 2015

Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain.

Sci Rep 2015 Oct 19;5:15150. Epub 2015 Oct 19.

Massachusetts Institute of Technology, Department of Biological Engineering, 77 Massachusetts Ave., Cambridge, MA 02139.

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http://dx.doi.org/10.1038/srep15150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609913PMC
October 2015

CD4+ T cell-dependent and CD4+ T cell-independent cytokine-chemokine network changes in the immune responses of HIV-infected individuals.

Sci Signal 2015 Oct 20;8(399):ra104. Epub 2015 Oct 20.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/scisignal.aab0808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634873PMC
October 2015

Molecular Signatures of Immune Activation and Epithelial Barrier Remodeling Are Enhanced during the Luteal Phase of the Menstrual Cycle: Implications for HIV Susceptibility.

J Virol 2015 Sep 17;89(17):8793-805. Epub 2015 Jun 17.

National Lab for HIV Immunology, JC Wilt Infectious Disease Research Centre, Public Health Agency of Canada, Winnipeg, Manitoba, Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada Unit of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1128/JVI.00756-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524071PMC
September 2015

Identification of drug-specific pathways based on gene expression data: application to drug induced lung injury.

Integr Biol (Camb) 2015 Aug;7(8):904-20

Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.

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http://xlink.rsc.org/?DOI=C4IB00294F
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http://dx.doi.org/10.1039/c4ib00294fDOI Listing
August 2015

Genital inflammation and the risk of HIV acquisition in women.

Clin Infect Dis 2015 Jul 21;61(2):260-9. Epub 2015 Apr 21.

Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.

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http://dx.doi.org/10.1093/cid/civ298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565995PMC
July 2015

The AXL Receptor is a Sensor of Ligand Spatial Heterogeneity.

Cell Syst 2015 Jul;1(1):25-36

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA 02139 ; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge MA 02139.

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http://dx.doi.org/10.1016/j.cels.2015.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520549PMC
July 2015

Prioritisation and network analysis of Crohn's disease susceptibility genes.

PLoS One 2014 30;9(9):e108624. Epub 2014 Sep 30.

Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108624PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182533PMC
June 2015

High-throughput protease activity cytometry reveals dose-dependent heterogeneity in PMA-mediated ADAM17 activation.

Integr Biol (Camb) 2015 May 2;7(5):513-24. Epub 2015 Apr 2.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1039/c5ib00019jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428935PMC
May 2015

Tandem phosphorylation within an intrinsically disordered region regulates ACTN4 function.

Sci Signal 2015 May 26;8(378):ra51. Epub 2015 May 26.

Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA.

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http://dx.doi.org/10.1126/scisignal.aaa1977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522051PMC
May 2015

ADAM8 as a drug target in pancreatic cancer.

Nat Commun 2015 Jan 28;6:6175. Epub 2015 Jan 28.

1] King's College London, Institute for Pharmaceutical Science and KCLDI, London SE1 9RT, UK [2] Department of Neurosurgery, Marburg University, , Baldingerstrasse, 35033 Marburg, Germany.

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http://dx.doi.org/10.1038/ncomms7175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014123PMC
January 2015

Reply to Azuaje: Predicting effective combined therapies for heterogeneous tumors.

Proc Natl Acad Sci U S A 2014 Oct 24;111(41):E4288. Epub 2014 Sep 24.

The David H. Koch Institute for Integrative Cancer Research, and Departments of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139

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http://dx.doi.org/10.1073/pnas.1415737111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205616PMC
October 2014

A microphysiological system model of therapy for liver micrometastases.

Exp Biol Med (Maywood) 2014 Sep 12;239(9):1170-9. Epub 2014 May 12.

Departments of Pathology, Cell Biology, Pharmaceutical Sciences, and Bioengineering, and the McGowan Institute for Regenerative Medicine, University of Pittsburgh and Pittsburgh VA Health System, Pittsburgh, PA 15213, USA

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http://dx.doi.org/10.1177/1535370214532596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574864PMC
September 2014

Cell-specific labeling enzymes for analysis of cell-cell communication in continuous co-culture.

Mol Cell Proteomics 2014 Jul 12;13(7):1866-76. Epub 2014 May 12.

From the ‡Division of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK;

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http://dx.doi.org/10.1074/mcp.O113.037119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083121PMC
July 2014

Intratumor heterogeneity alters most effective drugs in designed combinations.

Proc Natl Acad Sci U S A 2014 Jul 7;111(29):10773-8. Epub 2014 Jul 7.

The David H. Koch Institute for Integrative Cancer Research, andDepartments of Biology andBiological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139

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http://dx.doi.org/10.1073/pnas.1323934111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115561PMC
July 2014

Approaches to in vitro tissue regeneration with application for human disease modeling and drug development.

Drug Discov Today 2014 Jun 2;19(6):754-62. Epub 2014 May 2.

Department of Biomedical Engineering, Charles Stark Draper Laboratory, Cambridge, MA 02139, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13596446140015
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http://dx.doi.org/10.1016/j.drudis.2014.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104173PMC
June 2014

Microfluidic probe for single-cell analysis in adherent tissue culture.

Nat Commun 2014 Mar 5;5:3421. Epub 2014 Mar 5.

Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1038/ncomms4421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179103PMC
March 2014

Addressing genetic tumor heterogeneity through computationally predictive combination therapy.

Cancer Discov 2014 Feb 6;4(2):166-74. Epub 2013 Dec 6.

1Computational and Systems Biology Program, 2The David H. Koch Institute for Integrative Cancer Research, Departments of 3Biology, and 4Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975231PMC
February 2014