Publications by authors named "Doug Speed"

24Publications

Estimating narrow-sense heritability using family data from admixed populations.

Heredity (Edinb) 2020 Jun 9;124(6):751-762. Epub 2020 Apr 9.

Department of Biology, Section for Computational and RNA Biology, University of Copenhagen, 2200, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/s41437-020-0311-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239878PMC
June 2020

Evaluating and improving heritability models using summary statistics.

Nat Genet 2020 04 23;52(4):458-462. Epub 2020 Mar 23.

UCL Genetics Institute, University College London, London, UK.

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http://dx.doi.org/10.1038/s41588-020-0600-yDOI Listing
April 2020

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI.

Sci Adv 2019 09 4;5(9):eaaw3095. Epub 2019 Sep 4.

Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.

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http://dx.doi.org/10.1126/sciadv.aaw3095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904961PMC
September 2019

Summary statistic analyses can mistake confounding bias for heritability.

Genet Epidemiol 2019 12 20;43(8):930-940. Epub 2019 Sep 20.

Melbourne Integrative Genomics, School of Mathematics and Statistics, University of Melbourne, Melbourne, Australia.

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http://dx.doi.org/10.1002/gepi.22259DOI Listing
December 2019

Investigating the association between body fat and depression via Mendelian randomization.

Transl Psychiatry 2019 08 5;9(1):184. Epub 2019 Aug 5.

Department of Affective Disorders, Aarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.1038/s41398-019-0516-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683191PMC
August 2019

SumHer better estimates the SNP heritability of complex traits from summary statistics.

Nat Genet 2019 02 3;51(2):277-284. Epub 2018 Dec 3.

UCL Genetics Institute, University College London, London, UK.

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http://dx.doi.org/10.1038/s41588-018-0279-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485398PMC
February 2019

Reevaluation of SNP heritability in complex human traits.

Nat Genet 2017 Jul 22;49(7):986-992. Epub 2017 May 22.

UCL Genetics Institute, University College London, London, UK.

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http://dx.doi.org/10.1038/ng.3865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493198PMC
July 2017

Genetic Complexity of Crohn's Disease in Two Large Ashkenazi Jewish Families.

Gastroenterology 2016 10 1;151(4):698-709. Epub 2016 Jul 1.

Division of Medicine, University College London (UCL), London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.06.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643259PMC
October 2016

Relatedness in the post-genomic era: is it still useful?

Nat Rev Genet 2015 Jan 18;16(1):33-44. Epub 2014 Nov 18.

1] UCL Genetics Institute, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK. [2] Department of Genetics and Department of Mathematics and Statistics, University of Melbourne, Parkville VIC 3010, Australia.

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http://dx.doi.org/10.1038/nrg3821DOI Listing
January 2015

Describing the genetic architecture of epilepsy through heritability analysis.

Brain 2014 Oct 26;137(Pt 10):2680-9. Epub 2014 Jul 26.

7 Division of Brain Sciences, Imperial College London, London W6 8RF, UK

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http://dx.doi.org/10.1093/brain/awu206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163034PMC
October 2014

MultiBLUP: improved SNP-based prediction for complex traits.

Genome Res 2014 Sep 24;24(9):1550-7. Epub 2014 Jun 24.

UCL Genetics Institute, University College London, London WC1E 6BT, United Kingdom.

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http://dx.doi.org/10.1101/gr.169375.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158754PMC
September 2014

Response to Lee et al.: SNP-based heritability analysis with dense data.

Am J Hum Genet 2013 Dec;93(6):1155-7

UCL Genetics Institute, University College London, London WC1E 6BT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2013.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852920PMC
December 2013

Improved heritability estimation from genome-wide SNPs.

Am J Hum Genet 2012 Dec;91(6):1011-21

University College London Genetics Institute, University College London, London WC1E 6BT, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S00029297120053
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http://dx.doi.org/10.1016/j.ajhg.2012.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516604PMC
December 2012

Understanding complex traits: from farmers to pharmas.

Genome Med 2012 27;4(7):59. Epub 2012 Jul 27.

UCL Genetics Institute, University College London, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1186/gm360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580415PMC
August 2014