Publications by authors named "Dorothee Abramowski"

33Publications

The Discovery of SWI/SNF Chromatin Remodeling Activity as a Novel and Targetable Dependency in Uveal Melanoma.

Authors:
Florencia Rago GiNell Elliott Ailing Li Kathleen Sprouffske Grainne Kerr Aurore Desplat Dorothee Abramowski Julie T Chen Ali Farsidjani Kay X Xiang Geoffrey Bushold Yun Feng Matthew D Shirley Anka Bric Anthony Vattay Henrik Möbitz Katsumasa Nakajima Christopher D Adair Simon Mathieu Rukundo Ntaganda Troy Smith Julien P N Papillon Audrey Kauffmann David A Ruddy Hyo-Eun C Bhang Deborah Castelletti Zainab Jagani

Mol Cancer Ther 2020 10 3;19(10):2186-2195. Epub 2020 Aug 3.

Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.

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October 2020

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening.

Authors:
E Robert McDonald Antoine de Weck Michael R Schlabach Eric Billy Konstantinos J Mavrakis Gregory R Hoffman Dhiren Belur Deborah Castelletti Elizabeth Frias Kalyani Gampa Javad Golji Iris Kao Li Li Philippe Megel Thomas A Perkins Nadire Ramadan David A Ruddy Serena J Silver Sosathya Sovath Mark Stump Odile Weber Roland Widmer Jianjun Yu Kristine Yu Yingzi Yue Dorothee Abramowski Elizabeth Ackley Rosemary Barrett Joel Berger Julie L Bernard Rebecca Billig Saskia M Brachmann Frank Buxton Roger Caothien Justina X Caushi Franklin S Chung Marta Cortés-Cros Rosalie S deBeaumont Clara Delaunay Aurore Desplat William Duong Donald A Dwoske Richard S Eldridge Ali Farsidjani Fei Feng JiaJia Feng Daisy Flemming William Forrester Giorgio G Galli Zhenhai Gao François Gauter Veronica Gibaja Kristy Haas Marc Hattenberger Tami Hood Kristen E Hurov Zainab Jagani Mathias Jenal Jennifer A Johnson Michael D Jones Avnish Kapoor Joshua Korn Jilin Liu Qiumei Liu Shumei Liu Yue Liu Alice T Loo Kaitlin J Macchi Typhaine Martin Gregory McAllister Amandine Meyer Sandra Mollé Raymond A Pagliarini Tanushree Phadke Brian Repko Tanja Schouwey Frances Shanahan Qiong Shen Christelle Stamm Christine Stephan Volker M Stucke Ralph Tiedt Malini Varadarajan Kavitha Venkatesan Alberto C Vitari Marco Wallroth Jan Weiler Jing Zhang Craig Mickanin Vic E Myer Jeffery A Porter Albert Lai Hans Bitter Emma Lees Nicholas Keen Audrey Kauffmann Frank Stegmeier Francesco Hofmann Tobias Schmelzle William R Sellers

Cell 2017 Jul;170(3):577-592.e10

Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002, Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.

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July 2017

CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions.

Authors:
Diana M Munoz Pamela J Cassiani Li Li Eric Billy Joshua M Korn Michael D Jones Javad Golji David A Ruddy Kristine Yu Gregory McAllister Antoine DeWeck Dorothee Abramowski Jessica Wan Matthew D Shirley Sarah Y Neshat Daniel Rakiec Rosalie de Beaumont Odile Weber Audrey Kauffmann E Robert McDonald Nicholas Keen Francesco Hofmann William R Sellers Tobias Schmelzle Frank Stegmeier Michael R Schlabach

Cancer Discov 2016 08 3;6(8):900-13. Epub 2016 Jun 3.

Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.

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August 2016

Amyloid-β in the Cerebrospinal Fluid of APP Transgenic Mice Does not Show Prion-like Properties.

Authors:
Zhiva Skachokova Frederik Sprenger Karin Breu Dorothee Abramowski Florence Clavaguera Jürgen Hench Matthias Staufenbiel Markus Tolnay David T Winkler

Curr Alzheimer Res 2015 ;12(9):886-91

Institute of Pathology, University Hospital Basel, Basel, Switzerland.

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August 2016

Impact of amyloid β aggregate maturation on antibody treatment in APP23 mice.

Authors:
Karthikeyan Balakrishnan Ajeet Rijal Upadhaya Julia Steinmetz Julia Reichwald Dorothee Abramowski Marcus Fändrich Sathish Kumar Haruyasu Yamaguchi Jochen Walter Matthias Staufenbiel Dietmar Rudolf Thal

Acta Neuropathol Commun 2015 Jul 4;3:41. Epub 2015 Jul 4.

Institute of Pathology - Laboratory of Neuropathology, Center of Biomedical Research, University of Ulm, Helmholtzstrasse 8/1, D-89081, Ulm, Germany.

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July 2015

Early-onset axonal pathology in a novel P301S-Tau transgenic mouse model of frontotemporal lobar degeneration.

Authors:
Janet van Eersel Claire H Stevens Magdalena Przybyla Amadeus Gladbach Kristie Stefanoska Chesed Kai-Xin Chan Wei-Yi Ong John R Hodges Greg T Sutherland Jillian J Kril Dorothee Abramowski Matthias Staufenbiel Glenda M Halliday Lars M Ittner

Neuropathol Appl Neurobiol 2015 Dec 30;41(7):906-25. Epub 2015 May 30.

Dementia Research Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia.

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December 2015

The type of Aβ-related neuronal degeneration differs between amyloid precursor protein (APP23) and amyloid β-peptide (APP48) transgenic mice.

Authors:
Ajeet Rijal Upadhaya Frederik Scheibe Irina Kosterin Dorothee Abramowski Janina Gerth Sathish Kumar Stefan Liebau Haruyasu Yamaguchi Jochen Walter Matthias Staufenbiel Dietmar Rudolf Thal

Acta Neuropathol Commun 2013 Nov 18;1:77. Epub 2013 Nov 18.

Institute of Pathology - Laboratory of Neuropathology, University of Ulm, Ulm, Germany.

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November 2013

Mutant huntingtin gene-dose impacts on aggregate deposition, DARPP32 expression and neuroinflammation in HdhQ150 mice.

Authors:
Douglas Young Franziska Mayer Nella Vidotto Tatjana Schweizer Ramon Berth Dorothee Abramowski Derya R Shimshek P Herman van der Putten Peter Schmid

PLoS One 2013 23;8(9):e75108. Epub 2013 Sep 23.

Novartis Institutes for BioMedical Research, Neuroscience, Novartis Pharma AG, Basel, Switzerland.

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July 2014

Transgenic expression of β1 antibody in brain neurons impairs age-dependent amyloid deposition in APP23 mice.

Authors:
Paolo Paganetti Julia Reichwald Dorothee Bleckmann Dorothee Abramowski Domenico Ammaturo Carmen Barske Simone Danner Maurizio Molinari Matthias Müller Stéphanie Papin Sabine Rabe Peter Schmid Matthias Staufenbiel

Neurobiol Aging 2013 Dec 17;34(12):2866-78. Epub 2013 Jul 17.

Novartis Institutes for Biomedical Research, Basel, Switzerland. Electronic address:

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December 2013

The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors.

Authors:
Géraldine M Mang Thomas Dürst Hugo Bürki Stefan Imobersteg Dorothee Abramowski Edi Schuepbach Daniel Hoyer Markus Fendt Christine E Gee

Sleep 2012 Dec 1;35(12):1625-35. Epub 2012 Dec 1.

Novartis Institutes for BioMedical Research, Basel, Switzerland.

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December 2012

Fragments of HdhQ150 mutant huntingtin form a soluble oligomer pool that declines with aggregate deposition upon aging.

Authors:
David Marcellin Dorothee Abramowski Douglas Young Jens Richter Andreas Weiss Audrey Marcel Julia Maassen Muriel Kauffmann Miriam Bibel Derya R Shimshek Richard L M Faull Gillian P Bates Rainer R Kuhn P Herman Van der Putten Peter Schmid Gregor P Lotz

PLoS One 2012 12;7(9):e44457. Epub 2012 Sep 12.

Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.

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March 2013

TR-FRET-based duplex immunoassay reveals an inverse correlation of soluble and aggregated mutant huntingtin in huntington's disease.

Authors:
Barbara Baldo Paolo Paganetti Stephan Grueninger David Marcellin Linda S Kaltenbach Donald C Lo Martin Semmelroth Andjelija Zivanovic Dorothée Abramowski Donna Smith Gregor P Lotz Gillian P Bates Andreas Weiss

Chem Biol 2012 Feb;19(2):264-75

Neuroscience Discovery, Novartis Institutes for BioMedical Research, Basel CH-4002, Switzerland.

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February 2012

Dispersible amyloid β-protein oligomers, protofibrils, and fibrils represent diffusible but not soluble aggregates: their role in neurodegeneration in amyloid precursor protein (APP) transgenic mice.

Authors:
Ajeet Rijal Upadhaya Estibaliz Capetillo-Zarate Irina Kosterin Dorothee Abramowski Sathish Kumar Haruyasu Yamaguchi Jochen Walter Marcus Fändrich Matthias Staufenbiel Dietmar Rudolf Thal

Neurobiol Aging 2012 Nov 2;33(11):2641-60. Epub 2012 Feb 2.

Laboratory of Neuropathology, Institute of Pathology, Center for Clinical Research at the University of Ulm, Ulm, Germany.

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November 2012

Transgenic expression of intraneuronal Aβ42 but not Aβ40 leads to cellular Aβ lesions, degeneration, and functional impairment without typical Alzheimer's disease pathology.

Authors:
Dorothee Abramowski Sabine Rabe Ajeet Rijal Upadhaya Julia Reichwald Simone Danner Dieter Staab Estibaliz Capetillo-Zarate Haruyasu Yamaguchi Takaomi C Saido Karl-Heinz Wiederhold Dietmar Rudolf Thal Matthias Staufenbiel

J Neurosci 2012 Jan;32(4):1273-83

Novartis Institutes for Biomedical Research, CH-4056 Basel, Switzerland.

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January 2012

Noninvasive magnetic resonance imaging detection of cerebral amyloid angiopathy-related microvascular alterations using superparamagnetic iron oxide particles in APP transgenic mouse models of Alzheimer's disease: application to passive Abeta immunotherapy.

Authors:
Nicolau Beckmann Christelle Gérard Dorothée Abramowski Catherine Cannet Matthias Staufenbiel

J Neurosci 2011 Jan;31(3):1023-31

Global Imaging Group, Novartis Institutes for BioMedical Research, CH-4056 Basel, Switzerland.

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January 2011

Microtiter plate quantification of mutant and wild-type huntingtin normalized to cell count.

Authors:
Andreas Weiss Stephan Grueninger Dorothée Abramowski Francesco Paolo Di Giorgio Miriam Moscovitch Lopatin H Diana Rosas Steven Hersch Paolo Paganetti

Anal Biochem 2011 Mar 4;410(2):304-6. Epub 2010 Dec 4.

Neuroscience Discovery, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.

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March 2011

Rapid cerebral amyloid binding by Aβ antibodies infused into β-amyloid precursor protein transgenic mice.

Authors:
David T Winkler Dorothee Abramowski Simone Danner Mauro Zurini Paolo Paganetti Markus Tolnay Matthias Staufenbiel

Biol Psychiatry 2010 Nov 31;68(10):971-4. Epub 2010 Mar 31.

Department of Neurology, University Hospital Basel, Basel, Switzerland.

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November 2010

Single-step detection of mutant huntingtin in animal and human tissues: a bioassay for Huntington's disease.

Authors:
Andreas Weiss Dorothée Abramowski Miriam Bibel Ruth Bodner Vanita Chopra Marian DiFiglia Jonathan Fox Kimberly Kegel Corinna Klein Stephan Grueninger Steven Hersch David Housman Etienne Régulier H Diana Rosas Muriel Stefani Scott Zeitlin Graeme Bilbe Paolo Paganetti

Anal Biochem 2009 Dec 6;395(1):8-15. Epub 2009 Aug 6.

Novartis Institutes for BioMedical Research, Basel, Switzerland.

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December 2009

Transmission and spreading of tauopathy in transgenic mouse brain.

Authors:
Florence Clavaguera Tristan Bolmont R Anthony Crowther Dorothee Abramowski Stephan Frank Alphonse Probst Graham Fraser Anna K Stalder Martin Beibel Matthias Staufenbiel Mathias Jucker Michel Goedert Markus Tolnay

Nat Cell Biol 2009 Jul 7;11(7):909-13. Epub 2009 Jun 7.

Department of Neuropathology, Institute of Pathology, University of Basel, Switzerland.

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July 2009

Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease.

Authors:
Marc Aurel Busche Gerhard Eichhoff Helmuth Adelsberger Dorothee Abramowski Karl-Heinz Wiederhold Christian Haass Matthias Staufenbiel Arthur Konnerth Olga Garaschuk

Science 2008 Sep;321(5896):1686-9

Institut für Neurowissenschaften, Technische Universität München (TUM), 80802 München, Germany.

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September 2008