Doreen A Cantrell

Doreen A Cantrell

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Doreen A Cantrell

Doreen A Cantrell

Publications by authors named "Doreen A Cantrell"

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56Publications

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Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation.

Elife 2020 Feb 5;9. Epub 2020 Feb 5.

Cell Signalling and Immunology Division, School of Life Sciences, University of Dundee, Dundee, United Kingdom.

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http://dx.doi.org/10.7554/eLife.53725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056270PMC
February 2020

Move to metabolism.

Nat Rev Immunol 2019 05;19(5):270

University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1038/s41577-019-0157-0DOI Listing
May 2019

Single cell analysis of kynurenine and System L amino acid transport in T cells.

Nat Commun 2018 05 17;9(1):1981. Epub 2018 May 17.

Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1038/s41467-018-04366-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958064PMC
May 2018

Interleukin-2 shapes the cytotoxic T cell proteome and immune environment-sensing programs.

Sci Signal 2018 04 17;11(526). Epub 2018 Apr 17.

Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1126/scisignal.aap8112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483062PMC
April 2018

Signaling and Function of Interleukin-2 in T Lymphocytes.

Annu Rev Immunol 2018 04;36:411-433

Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom; email:

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http://dx.doi.org/10.1146/annurev-immunol-042617-053352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472684PMC
April 2018

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition.

Nat Commun 2016 11 4;7:13312. Epub 2016 Nov 4.

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.

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http://dx.doi.org/10.1038/ncomms13312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097156PMC
November 2016

Mathematical Models for Immunology: Current State of the Art and Future Research Directions.

Bull Math Biol 2016 10 6;78(10):2091-2134. Epub 2016 Oct 6.

Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1007/s11538-016-0214-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069344PMC
October 2016

Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8(+) T Cells.

Immunity 2016 09 23;45(3):685-700. Epub 2016 Aug 23.

Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040828PMC
http://dx.doi.org/10.1016/j.immuni.2016.07.022DOI Listing
September 2016

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy.

Nat Immunol 2016 06 25;17(6):712-20. Epub 2016 Apr 25.

Division of Cell Signalling and Immunology, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1038/ni.3439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900450PMC
June 2016

The cytotoxic T cell proteome and its shaping by the kinase mTOR.

Nat Immunol 2016 Jan 9;17(1):104-12. Epub 2015 Nov 9.

Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dow Street, Dundee, UK.

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http://dx.doi.org/10.1038/ni.3314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685757PMC
January 2016

Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells.

PLoS One 2014 2;9(9):e106710. Epub 2014 Sep 2.

Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0106710PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152329PMC
November 2015

ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation.

Immunity 2015 Feb;42(2):239-251

Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0377, USA; Molecular Biology Section, Division of Biological Sciences, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0377, USA. Electronic address:

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http://www.cell.com/immunity/pdf/S1074-7613(15)00043-6.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S107476131500043
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http://dx.doi.org/10.1016/j.immuni.2015.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334393PMC
February 2015

Quantitative phosphoproteomics of cytotoxic T cells to reveal protein kinase d 2 regulated networks.

Mol Cell Proteomics 2014 Dec 29;13(12):3544-57. Epub 2014 Sep 29.

From the ‡Division of Cell Signalling and Immunology. College of Life Sciences University of Dundee, Dundee, Scotland, U.K.

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http://dx.doi.org/10.1074/mcp.M113.037242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256504PMC
December 2014

Protein kinase D2 is a digital amplifier of T cell receptor-stimulated diacylglycerol signaling in naïve CD8⁺ T cells.

Sci Signal 2014 Oct 21;7(348):ra99. Epub 2014 Oct 21.

Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1126/scisignal.2005477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768351PMC
October 2014

Serine-threonine kinases in TCR signaling.

Nat Immunol 2014 Sep;15(9):808-14

The College of Life Sciences, Division of Cell Signalling and Immunology, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1038/ni.2941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443032PMC
September 2014

The impact of KLF2 modulation on the transcriptional program and function of CD8 T cells.

PLoS One 2013 14;8(10):e77537. Epub 2013 Oct 14.

Department of Cell Signalling & Immunology, College of Life Sciences, University of Dundee, Dundee, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0077537PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796494PMC
June 2014

AMPKα1: a glucose sensor that controls CD8 T-cell memory.

Eur J Immunol 2013 Apr 13;43(4):889-96. Epub 2013 Feb 13.

Division of Cell Signalling and Immunology, University of Dundee, Dundee, Scotland, UK.

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http://dx.doi.org/10.1002/eji.201243008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734624PMC
April 2013

Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells.

Biochem J 2012 Mar;442(3):649-59

The College of Life Sciences, Division of Cell Signalling and Immunology, The University of Dundee, Scotland, UK.

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http://dx.doi.org/10.1042/BJ20111700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462612PMC
March 2012

Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes.

Nat Immunol 2011 Apr 13;12(4):352-61. Epub 2011 Mar 13.

The College of Life Sciences, Division of Immunology and Cell Biology, The University of Dundee, Dundee, Scotland, UK.

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http://www.nature.com/articles/ni.2008
Publisher Site
http://dx.doi.org/10.1038/ni.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110993PMC
April 2011

Metabolism, migration and memory in cytotoxic T cells.

Nat Rev Immunol 2011 02 14;11(2):109-17. Epub 2011 Jan 14.

Division of Cell Biology and Immunology, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1038/nri2888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521506PMC
February 2011

New insights into the regulation and function of serine/threonine kinases in T lymphocytes.

Immunol Rev 2009 Mar;228(1):241-52

Division of Medical Sciences, Centre for Oncology and Molecular Medicine, Ninewell's Hospital and Medical School, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1111/j.1600-065X.2008.00759.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520424PMC
March 2009

Notch-induced T cell development requires phosphoinositide-dependent kinase 1.

EMBO J 2007 Jul 28;26(14):3441-50. Epub 2007 Jun 28.

College of Life Science, Division of Cell Biology & Immunology, MSI/WTB complex, University of Dundee, Dundee, UK.

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http://emboj.embopress.org/cgi/doi/10.1038/sj.emboj.7601761
Publisher Site
http://dx.doi.org/10.1038/sj.emboj.7601761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933393PMC
July 2007

Phosphoinositide-dependent protein kinase-1 (PDK1)-independent activation of the protein kinase C substrate, protein kinase D.

FEBS Lett 2007 Jul 2;581(18):3494-8. Epub 2007 Jul 2.

Division of Cell Biology and Immunology, College of Life Sciences, MSI/WTB/CIR Complex, University of Dundee, Dow Street, Dundee, United Kingdom.

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http://dx.doi.org/10.1016/j.febslet.2007.06.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1942071PMC
July 2007

Protein kinase D enzymes are dispensable for proliferation, survival and antigen receptor-regulated NFkappaB activity in vertebrate B-cells.

FEBS Lett 2007 Apr 2;581(7):1377-82. Epub 2007 Mar 2.

Division of Cell Biology and Immunology, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK.

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http://dx.doi.org/10.1016/j.febslet.2007.02.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1942070PMC
April 2007

Antigen receptor regulation of phosphoinositide-dependent kinase 1 pathways during thymocyte development.

FEBS Lett 2006 Oct 28;580(25):5845-50. Epub 2006 Sep 28.

Division of Cell Biology and Immunology, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.febslet.2006.09.045DOI Listing
October 2006

Differential requirement for RhoA GTPase depending on the cellular localization of protein kinase D.

J Biol Chem 2006 Sep 13;281(35):25089-96. Epub 2006 Jun 13.

Division of Cell Biology and Immunology, Wellcome Trust Biocentre, University of Dundee, Dundee UK DD1 5EH, Scotland, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M603591200DOI Listing
September 2006

Differential regulation of T-cell growth by IL-2 and IL-15.

Blood 2006 Jul 28;108(2):600-8. Epub 2006 Mar 28.

Cancer Research UK, London, England.

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http://dx.doi.org/10.1182/blood-2005-12-4827DOI Listing
July 2006

Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes.

J Exp Med 2006 Jul 3;203(7):1665-70. Epub 2006 Jul 3.

Division of Cell Biology and Immunology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom.

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http://dx.doi.org/10.1084/jem.20052469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118355PMC
July 2006

The role of serine/threonine kinases in T-cell activation.

Curr Opin Immunol 2006 Jun 17;18(3):314-20. Epub 2006 Apr 17.

Division of Cell Biology and Immunology, Wellcome Trust Biocentre, University of Dundee, Dundee, DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1016/j.coi.2006.03.006DOI Listing
June 2006

Phosphoinositide-dependent kinase l (PDK1) haplo-insufficiency inhibits production of alpha/beta (alpha/beta) but not gamma delta (gamma/delta) T lymphocytes.

FEBS Lett 2006 Apr 15;580(8):2135-40. Epub 2006 Mar 15.

Division of Cell Biology and Immunology, School of Life Sciences, WTB Complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.febslet.2006.03.022DOI Listing
April 2006

Essential role for protein kinase D family kinases in the regulation of class II histone deacetylases in B lymphocytes.

Mol Cell Biol 2006 Feb;26(4):1569-77

Division of Cell Biology and Immunology, School of Life Sciences, University of Dundee, Scotland, United Kingdom.

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http://dx.doi.org/10.1128/MCB.26.4.1569-1577.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1367196PMC
February 2006

Integrin regulation by RhoA in thymocytes.

J Immunol 2005 Jul;175(1):350-7

Lymphocyte Activation Laboratory, Cancer Research U.K. London Research Institute, Lincoln's Inn Fields Laboratories, London, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.175.1.350DOI Listing
July 2005

Dual phospholipase C/diacylglycerol requirement for protein kinase D1 activation in lymphocytes.

J Biol Chem 2005 Feb 7;280(7):6245-51. Epub 2004 Dec 7.

Division of Cell Biology and Immunology, School of Life Sciences, MSI/WTB Complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1074/jbc.M411564200DOI Listing
February 2005

Protein kinase C and beyond.

Nat Immunol 2004 Aug;5(8):785-90

School of Life Sciences, Division of Cell Biology & Immunology, University of Dundee, MSI/WTB Complex, Dow Street, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1038/ni1097DOI Listing
August 2004

The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development.

Nat Immunol 2004 May 11;5(5):539-45. Epub 2004 Apr 11.

Lymphocyte Activation Laboratory, Cancer Research UK London Research Institute, Lincoln's Inn Fields, London WC2A 3PX, United Kingdom.

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http://dx.doi.org/10.1038/ni1062DOI Listing
May 2004

Sustained IL-12 signaling is required for Th1 development.

J Immunol 2004 Jan;172(1):61-9

Lymphocyte Activation Laboratory and Biochemical Regulatory Mechanisms Laboratory, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, London, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.172.1.61DOI Listing
January 2004

Regulation and function of serine kinase networks in lymphocytes.

Curr Opin Immunol 2003 Jun;15(3):294-8

Division of Cell Biology and Immunology, School of Life Sciences, MSI/WTB Complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1016/s0952-7915(03)00052-9DOI Listing
June 2003

Approaches to define antigen receptor-induced serine kinase signal transduction pathways.

J Biol Chem 2003 Mar 5;278(11):9267-75. Epub 2003 Jan 5.

Lymphocyte Activation Laboratory, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M211252200DOI Listing
March 2003

Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse.

Nat Immunol 2002 Nov 21;3(11):1082-9. Epub 2002 Oct 21.

Lymphocyte Activation Laboratory, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

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http://dx.doi.org/10.1038/ni848DOI Listing
November 2002

T-cell antigen receptor signal transduction.

Immunology 2002 Apr;105(4):369-74

Lymphocyte Activation Laboratory, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782684PMC
http://dx.doi.org/10.1046/j.1365-2567.2002.01391.xDOI Listing
April 2002

A new role for the p85-phosphatidylinositol 3-kinase regulatory subunit linking FRAP to p70 S6 kinase activation.

J Biol Chem 2002 Jan 29;277(2):1500-8. Epub 2001 Oct 29.

Department of Immunology and Oncology, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Carretera de Colmenar Km 15, Cantoblanco, Madrid E-28049, Spain.

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http://dx.doi.org/10.1074/jbc.M103808200DOI Listing
January 2002

Transgenic analysis of thymocyte signal transduction.

Nat Rev Immunol 2002 Jan;2(1):20-7

Lymphocyte Activation Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK.

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http://dx.doi.org/10.1038/nri703DOI Listing
January 2002