Dora Dias-Santagata

Dora Dias-Santagata

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Dora Dias-Santagata

Dora Dias-Santagata

Publications by authors named "Dora Dias-Santagata"

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Clinicopathological and molecular features of SF3B1-mutated myeloproliferative neoplasms.

Hum Pathol 2019 04 27;86:1-11. Epub 2018 Dec 27.

Department of Pathology, Massachusetts General Hospital, 02114 Boston, MA, USA; Harvard Medical School, 02114 Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2018.11.022DOI Listing
April 2019

Novel gene fusions in secretory carcinoma of the salivary glands: enlarging the ETV6 family.

Hum Pathol 2019 01 18;83:50-58. Epub 2018 Aug 18.

Department of Pathology, Massachusetts General Hospital, Boston, MA 02114-2696, USA; Department of Pathology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2018.08.011DOI Listing
January 2019

Widespread Chromosomal Losses and Mitochondrial DNA Alterations as Genetic Drivers in Hürthle Cell Carcinoma.

Cancer Cell 2018 08;34(2):242-255.e5

Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Thyroid Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Internal Medicine, Division of Endocrinology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121811PMC
August 2018

Invasive follicular variant of papillary thyroid cancer harboring the NRAS mutation Q61K and presenting with bone metastasis-A case report.

Int J Surg Case Rep 2017 20;38:180-184. Epub 2017 Jul 20.

Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ijscr.2017.06.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547242PMC
July 2017

Clear Cell Change in Thyroid Carcinoma: A Clinicopathologic and Molecular Study with Identification of Variable Genetic Anomalies.

Thyroid 2017 06 12;27(6):819-824. Epub 2017 Apr 12.

2 Pathology Service, Massachusetts General Hospital , Boston, Massachusetts.

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http://dx.doi.org/10.1089/thy.2016.0631DOI Listing
June 2017

Cytological, molecular, and clinical features of noninvasive follicular thyroid neoplasm with papillary-like nuclear features versus invasive forms of follicular variant of papillary thyroid carcinoma.

Cancer Cytopathol 2017 May 13;125(5):323-331. Epub 2017 Feb 13.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cncy.21839DOI Listing
May 2017

Immunohistochemical Detection of ROS1 Fusion.

Am J Clin Pathol 2017 Jan;147(1):77-82

From the Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston.

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http://dx.doi.org/10.1093/ajcp/aqw201DOI Listing
January 2017

Ki-67, p53, and p16 expression, and G691S RET polymorphism in desmoplastic melanoma (DM): A clinicopathologic analysis of predictors of outcome.

J Am Acad Dermatol 2016 Sep;75(3):595-602

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2016.04.059DOI Listing
September 2016

Acquired Resistance to Crizotinib in NSCLC with MET Exon 14 Skipping.

J Thorac Oncol 2016 08 22;11(8):1242-1245. Epub 2016 Jun 22.

Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jtho.2016.06.013DOI Listing
August 2016

Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma.

Neuro Oncol 2016 05 28;18(5):649-55. Epub 2016 Jan 28.

Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (M.A., P.H.M., R.B., M.L.L., S.H.R., R.D.F., K.L.L., A.H.L., S.S.); Department of Pathology, King Fahad Medical City, Riyadh, Saudi Arabia (M.A.); King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia (M.A.); Harvard Medical School, Boston, Massachusetts (M.A., A.A.A., D.D.-S., P.K.B., D.A.R., P.Y.W., O.A.-M., S.H.R., R.D.F., K.L.L., A.H.L., B.M.A., I.F.D., R.B., S.S.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (W.L.B., O.A.-M., I.F.D.); Department of Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts (A.A.A., B.M.A.); Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts (P.K.A.); Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts (D.D.-S.); Center for Cancer Genomic Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts (A.R.T., P.V.H.); Department of Neuro-Oncology, Massachusetts General Hospital, Boston, Massachusetts (P.K.B.); Center of Neuro-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (D.A.R., P.Y.W, R.B.); Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (K.L.L., R.B.); Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA (S.S.).

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http://dx.doi.org/10.1093/neuonc/nov316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827048PMC
May 2016

Impact of next-generation sequencing on the clinical diagnosis of pancreatic cysts.

Gastrointest Endosc 2016 Jan 5;83(1):140-8. Epub 2015 Aug 5.

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.gie.2015.06.047DOI Listing
January 2016

Immunohistochemical Detection of NRASQ61R Mutation in Diverse Tumor Types.

Am J Clin Pathol 2016 Jan;145(1):29-34

From the Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1093/ajcp/aqv015DOI Listing
January 2016

Identification of insertions in PTEN and TP53 in anaplastic thyroid carcinoma with angiogenic brain metastasis.

Endocr Relat Cancer 2015 Dec;22(6):L23-8

Department of Pathology, WRN219, Harvard Medical School, Massachusetts General Hospital55 Fruit Street, Boston, Massachusetts, 02114USA

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https://erc.bioscientifica.com/view/journals/erc/22/6/L23.xm
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http://dx.doi.org/10.1530/ERC-15-0198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609031PMC
December 2015

Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical model.

Oncotarget 2015 Dec;6(40):42445-67

Laboratory of Human Thyroid Cancers Preclinical and Translational Research, Division of Cancer Biology and Angiogenesis, Cancer Research Institute (CRI), Cancer Center, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.18632/oncotarget.6442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767444PMC
December 2015

Pulmonary adenocarcinoma mutation profile in smokers with smoking-related interstitial fibrosis.

Int J Chron Obstruct Pulmon Dis 2014 24;9:525-31. Epub 2014 May 24.

Pathology Service, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA ; Pulmonary Medicine/Critical Care Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.2147/COPD.S61932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043428PMC
February 2015

Identification of oncogenic mutations and gene fusions in the follicular variant of papillary thyroid carcinoma.

J Clin Endocrinol Metab 2014 Nov 22;99(11):E2457-62. Epub 2014 Aug 22.

Thyroid Unit (D.G.M., S.E.D., G.H.D.), Department of Medicine, Department of Pathology (D.D.-S., P.M.S., K.D.L., Z.Z., L.L., A.J.I.), and Department of Surgery (C.L.), Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114.

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http://dx.doi.org/10.1210/jc.2014-2611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223441PMC
November 2014

The prognostic impact of KRAS, its codon and amino acid specific mutations, on survival in resected stage I lung adenocarcinoma.

J Thorac Oncol 2014 Sep;9(9):1363-9

*Division of Hematology/Oncology, Department of Medicine; †Division of Thoracic Surgery; ‡Biostatistics Center; §Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston,Massachusetts; and ‖Department of Thoracic Surgery, Guangdong General Hospital, Southern Medical University, Guangdong, China.

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https://linkinghub.elsevier.com/retrieve/pii/S15560864153068
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http://dx.doi.org/10.1097/JTO.0000000000000266DOI Listing
September 2014

Standardized decision support in next generation sequencing reports of somatic cancer variants.

Mol Oncol 2014 Jul 4;8(5):859-73. Epub 2014 Apr 4.

Massachusetts General Hospital and Harvard Medical School, Molecular Pathology Lab, USA.

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http://dx.doi.org/10.1016/j.molonc.2014.03.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528527PMC
July 2014

Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery.

Proc Natl Acad Sci U S A 2014 Jul 30;111(30):11121-6. Epub 2014 Jun 30.

Department of Cancer Biology, Harvard Medical School and Dana-Farber Cancer Institute, Boston, MA 02115;Neurosurgery, andRadiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1404724111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121790PMC
July 2014

The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy.

Cell 2014 Jul;158(3):564-78

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674140080
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http://dx.doi.org/10.1016/j.cell.2014.05.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249939PMC
July 2014

Hobnail variant of papillary thyroid carcinoma: an institutional case series and molecular profile.

Thyroid 2014 Jun 6;24(6):958-65. Epub 2014 Mar 6.

1 Endocrine Surgery Unit, Department of Surgery, Massachusetts General Hospital, Harvard Medical School , Boston, Massachusetts.

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https://www.liebertpub.com/doi/10.1089/thy.2013.0573
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http://dx.doi.org/10.1089/thy.2013.0573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046200PMC
June 2014

Targetable signaling pathway mutations are associated with malignant phenotype in IDH-mutant gliomas.

Clin Cancer Res 2014 Jun 8;20(11):2898-909. Epub 2014 Apr 8.

Authors' Affiliations: Department of Neurosurgery; Division of Hematology/Oncology, Department of Neurology, Stephen E. and Catherine Pappas Center for Neuro-Oncology, Translational Research Laboratory; Department of Pathology; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge; Translational Neuro-Oncology Laboratory; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts; Vesalius Research Center, VIB and Department of Oncology, KU Leuven, Leuven, BelgiumAuthors' Affiliations: Department of Neurosurgery; Division of Hematology/Oncology, Department of Neurology, Stephen E. and Catherine Pappas Center for Neuro-Oncology, Translational Research Laboratory; Department of Pathology; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge; Translational Neuro-Oncology Laboratory; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts; Vesalius Research Center, VIB and Department of Oncology, KU Leuven, Leuven, BelgiumAuthors' Affiliations: Department of Neurosurgery; Division of Hematology/Oncology, Department of Neurology, Stephen E. and Catherine Pappas Center for Neuro-Oncology, Translational Research Laboratory; Department of Pathology; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge; Translational Neuro-Oncology Laboratory; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts; Vesalius Research Center, VIB and Department of Oncology, KU Leuven, Leuven, Belgium

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http://dx.doi.org/10.1158/1078-0432.CCR-13-3052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070445PMC
June 2014

VE1 antibody immunoreactivity in normal anterior pituitary and adrenal cortex without detectable BRAF V600E mutations.

Am J Clin Pathol 2014 Jun;141(6):811-5

From the Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1309/AJCP37TLZLTUAOJLDOI Listing
June 2014

Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas.

Nat Genet 2014 Feb 12;46(2):161-5. Epub 2014 Jan 12.

1] Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Pathology, Boston Children's Hospital, Boston, Massachusetts, USA. [3] Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA. [4] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [5].

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http://dx.doi.org/10.1038/ng.2868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982316PMC
February 2014

Inactivation of the tumor suppressor WTX in a subset of pediatric tumors.

Genes Chromosomes Cancer 2014 Jan 5;53(1):67-77. Epub 2013 Nov 5.

Department of Pathology, Massachusetts General Hospital, Boston, MA; Cancer Center, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1002/gcc.22118DOI Listing
January 2014

The impact of EGFR mutation status on outcomes in patients with resected stage I non-small cell lung cancers.

Ann Thorac Surg 2013 Sep 8;96(3):962-8. Epub 2013 Aug 8.

Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1016/j.athoracsur.2013.05.091DOI Listing
September 2013

BRAF V600E mutation identifies a subset of low-grade diffusely infiltrating gliomas in adults.

J Clin Oncol 2013 May 1;31(14):e233-6. Epub 2013 Apr 1.

Stephen E. and Catherine Pappas Center for Neuro-Oncology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA.

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http://dx.doi.org/10.1200/JCO.2012.46.0220DOI Listing
May 2013

Merkel cell carcinoma: 30-year experience from a single institution.

Ann Surg Oncol 2013 Apr 1;20(4):1365-73. Epub 2012 Dec 1.

Department of Surgery, Massachusetts General Hospital, Harvard Medical School, YAW 7B, 55 Fruit Street, Boston, MA 02114, USA.

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http://www.researchgate.net/profile/Genevieve_Boland/publica
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http://dx.doi.org/10.1245/s10434-012-2779-3DOI Listing
April 2013

Basal cell carcinoma with osteosarcomatous component.

Am J Dermatopathol 2013 Apr;35(2):261-5

Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1097/DAD.0b013e31826b352bDOI Listing
April 2013

Histologic and cytomorphologic features of ALK-rearranged lung adenocarcinomas.

Mod Pathol 2012 Nov 29;25(11):1462-72. Epub 2012 Jun 29.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1038/modpathol.2012.109DOI Listing
November 2012

Prospective, high-throughput molecular profiling of human gliomas.

J Neurooncol 2012 Oct 22;110(1):89-98. Epub 2012 Jul 22.

Department of Neurology, Stephen E. and Catherine Pappas Center for Neuro-Oncology, Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.

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http://dx.doi.org/10.1007/s11060-012-0938-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583376PMC
October 2012

A potential role for targeted therapy in a subset of metastasizing adnexal carcinomas.

Mod Pathol 2011 Jul 18;24(7):974-82. Epub 2011 Mar 18.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/modpathol.2011.48DOI Listing
July 2011

Tissue-specific signatures of activating PIK3CA and RAS mutations in carcinosarcomas of gynecologic origin.

Gynecol Oncol 2011 Apr 17;121(1):212-7. Epub 2010 Dec 17.

Vincent Center for Reproductive Biology, MGH/Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S009082581000867
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http://dx.doi.org/10.1016/j.ygyno.2010.11.039DOI Listing
April 2011

BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications.

PLoS One 2011 Mar 29;6(3):e17948. Epub 2011 Mar 29.

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017948PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066220PMC
March 2011

A platform for rapid detection of multiple oncogenic mutations with relevance to targeted therapy in non-small-cell lung cancer.

J Mol Diagn 2011 Jan 23;13(1):74-84. Epub 2010 Dec 23.

Vanderbilt-Ingram Cancer Center, the Department of Medicine/Division of Hematology-Oncology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1016/j.jmoldx.2010.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070558PMC
January 2011

Decreased survival in EGFR gene amplified vulvar carcinoma.

Gynecol Oncol 2008 Nov 3;111(2):289-97. Epub 2008 Sep 3.

Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, THR 901A, 55 Fruit Street, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1016/j.ygyno.2008.07.038DOI Listing
November 2008

Unusual tumor response and toxicity from radiation and concurrent erlotinib for non-small-cell lung cancer.

Clin Lung Cancer 2008 Sep;9(5):285-7

Harvard Radiation Oncology Program, Boston Medical Center, Boston, MA 02114, USA.

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http://dx.doi.org/10.3816/CLC.2008.n.044DOI Listing
September 2008

Tau phosphorylation sites work in concert to promote neurotoxicity in vivo.

Mol Biol Cell 2007 Dec 10;18(12):5060-8. Epub 2007 Oct 10.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1091/mbc.e07-04-0327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096612PMC
December 2007

S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila.

J Neurosci Res 2007 May;85(6):1271-8

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1002/jnr.21232DOI Listing
May 2007

Expression of a mutant p193/CUL7 molecule confers resistance to MG132- and etoposide-induced apoptosis independent of p53 or Parc binding.

Biochim Biophys Acta 2007 Mar 15;1773(3):358-66. Epub 2006 Dec 15.

Wells Center for Pediatric Research, Division of Pediatric Cardiology and Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN 46202-5225, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S016748890600447
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http://dx.doi.org/10.1016/j.bbamcr.2006.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1876763PMC
March 2007

Oxidative stress mediates tau-induced neurodegeneration in Drosophila.

J Clin Invest 2007 Jan 14;117(1):236-45. Epub 2006 Dec 14.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://www.jci.org/cgi/doi/10.1172/JCI28769
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http://dx.doi.org/10.1172/JCI28769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1697799PMC
January 2007