Donna E Davies

Donna E Davies

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Donna E Davies

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Regarding epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux.

Eur Respir J 2019 Oct 10;54(4). Epub 2019 Oct 10.

NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1183/13993003.01805-2019DOI Listing
October 2019

Engineering multi-layered tissue constructs using acoustic levitation.

Sci Rep 2019 Jul 5;9(1):9789. Epub 2019 Jul 5.

Brooke Laboratories, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1038/s41598-019-46201-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611909PMC
July 2019

Regulation of ectodomain shedding of ADAM33 in vitro and in vivo.

J Allergy Clin Immunol 2019 Jun 2;143(6):2281-2284.e3. Epub 2019 Feb 2.

Brooke Laboratories, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre at University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom; Institute for Life Sciences, University of Southampton, Southampton, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2019.01.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550363PMC
June 2019

Epithelial-mesenchymal transition contributes to pulmonary fibrosis via aberrant epithelial/fibroblastic cross-talk.

J Lung Health Dis 2019 Apr;3(2):31-35

Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485666PMC
April 2019

Hydration and nanomechanical changes in collagen fibrils bearing advanced glycation end-products.

Biomed Opt Express 2019 Apr 14;10(4):1841-1855. Epub 2019 Mar 14.

Insitute of Lightweight Design and Structural Biomechanics, TU Wien, Getreidemarkt 9, 1060 Vienna, Austria.

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http://dx.doi.org/10.1364/BOE.10.001841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484996PMC
April 2019

Establishment of a pulmonary epithelial barrier on biodegradable poly-L-lactic-acid membranes.

PLoS One 2019 17;14(1):e0210830. Epub 2019 Jan 17.

The Brooke Laboratory, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210830PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336298PMC
January 2019

IL-1α mediates cellular cross-talk in the airway epithelial mesenchymal trophic unit.

Tissue Barriers 2016 Jul-Sep;4(3):e1206378. Epub 2016 Jun 28.

Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, University Hospital Southampton, Southampton, UK; NIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton, Southampton, UK; Institute for Life Sciences, Highfield Campus, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1080/21688370.2016.1206378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993579PMC
February 2018

Altered Epithelial Gene Expression in Peripheral Airways of Severe Asthma.

PLoS One 2017 3;12(1):e0168680. Epub 2017 Jan 3.

Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168680PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207492PMC
August 2017

Squamous Metaplasia Is Increased in the Bronchial Epithelium of Smokers with Chronic Obstructive Pulmonary Disease.

PLoS One 2016 26;11(5):e0156009. Epub 2016 May 26.

Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0156009PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881906PMC
July 2017

Long Term Culture of the A549 Cancer Cell Line Promotes Multilamellar Body Formation and Differentiation towards an Alveolar Type II Pneumocyte Phenotype.

PLoS One 2016 28;11(10):e0164438. Epub 2016 Oct 28.

Academic Unit of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, University Hospital Southampton, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0164438PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085087PMC
June 2017

Phenotypic and genetic aspects of epithelial barrier function in asthmatic patients.

J Allergy Clin Immunol 2017 Jun;139(6):1736-1751

Clinical and Experimental Sciences and the Southampton NIHR Respiratory Biomedical Research Unit, University of Southampton Faculty of Medicine, Sir Henry Wellcome Laboratories, University Hospital Southampton, Southampton, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457128PMC
June 2017

Cellular crosstalk between airway epithelial and endothelial cells regulates barrier functions during exposure to double-stranded RNA.

Immun Inflamm Dis 2017 03 18;5(1):45-56. Epub 2017 Jan 18.

Academic Unit of Clinical and Experimental SciencesFaculty of MedicineUniversity of SouthamptonSouthamptonUnited Kingdom; Institute for Life SciencesUniversity of SouthamptonSouthamptonUnited Kingdom; National Institute for Health ResearchSouthampton Respiratory Biomedical Research UnitUniversity Hospital SouthamptonSouthamptonUnited Kingdom.

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http://dx.doi.org/10.1002/iid3.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322162PMC
March 2017

Functional characterization of a novel 3D model of the epithelial-mesenchymal trophic unit.

Exp Lung Res 2017 03 3;43(2):82-92. Epub 2017 Apr 3.

a Academic Unit of Clinical and Experimental Sciences , University of Southampton Faculty of Medicine, University Hospital Southampton , Southampton , United Kingdom.

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http://dx.doi.org/10.1080/01902148.2017.1303098DOI Listing
March 2017

Mechanical Strain Causes Adaptive Change in Bronchial Fibroblasts Enhancing Profibrotic and Inflammatory Responses.

PLoS One 2016 21;11(4):e0153926. Epub 2016 Apr 21.

Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153926PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839664PMC
September 2016

Modulation of Human Airway Barrier Functions during Burkholderia thailandensis and Francisella tularensis Infection Running Title: Airway Barrier Functions during Bacterial Infections.

Pathogens 2016 Aug 3;5(3). Epub 2016 Aug 3.

Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, University Hospital Southampton, Tremona Road, Southampton SO16 6YD, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039433PMC
http://dx.doi.org/10.3390/pathogens5030053DOI Listing
August 2016

Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life.

JCI Insight 2016 Jul;1(11)

The Brooke Laboratory, Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; National Institute for Health Research (NIHR) Southampton Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.; Institute for Life Sciences, Stem Cells and Regeneration, Human Genetics, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

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http://dx.doi.org/10.1172/jci.insight.87632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968941PMC
July 2016

Temporal Monitoring of Differentiated Human Airway Epithelial Cells Using Microfluidics.

PLoS One 2015 5;10(10):e0139872. Epub 2015 Oct 5.

Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; Institute for Life Sciences, University of Southampton, Southampton, United Kingdom; National Institute for Health Research, Respiratory Biomedical Research Unit, University Hospital Southampton, Southampton, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0139872PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593539PMC
June 2016

Three-dimensional characterization of fibroblast foci in idiopathic pulmonary fibrosis.

JCI Insight 2016 Apr;1(5)

Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Respiratory Biomedical Research Unit, University Hospital Southampton, Southampton, United Kingdom; Institute for Life Sciences, University of Southampton, Southampton, United Kingdom.

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http://dx.doi.org/10.1172/jci.insight.86375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889020PMC
April 2016

Cigarette smoke causes caspase-independent apoptosis of bronchial epithelial cells from asthmatic donors.

PLoS One 2015 20;10(3):e0120510. Epub 2015 Mar 20.

Academic Unit of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom; Southampton National Institute for Health Research (NIHR) Respiratory Biomedical Research Unit, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom.

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http://eprints.soton.ac.uk/380775/1/pone.0120510.pdf
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http://dx.plos.org/10.1371/journal.pone.0120510
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120510PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368206PMC
March 2016

Inhibition of Pim1 kinase, new therapeutic approach in virus-induced asthma exacerbations.

Eur Respir J 2016 Mar 11;47(3):783-91. Epub 2016 Feb 11.

Brooke Laboratory, Academic Unit of Clinical and Experimental Sciences, University of Southampton, Faculty of Medicine, University Hospital Southampton, Southampton, UK National Institute for Health Research, Respiratory Biomedical Research Unit, University Hospital Southampton, Southampton, UK.

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http://dx.doi.org/10.1183/13993003.00171-2015DOI Listing
March 2016

A microRNA network dysregulated in asthma controls IL-6 production in bronchial epithelial cells.

PLoS One 2014 31;9(10):e111659. Epub 2014 Oct 31.

Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111659PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216117PMC
December 2015

Low molecular weight components of pollen alter bronchial epithelial barrier functions.

Tissue Barriers 2015 Jul-Sep;3(3):e1062316. Epub 2015 Jul 15.

Brooke Laboratory; Clinical and Experimental Sciences; Faculty of Medicine; University of Southampton; University Hospital Southampton ; Southampton, UK ; Southampton NIHR Respiratory Biomedical Research Unit; University Hospital Southampton ; Southampton, UK.

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http://dx.doi.org/10.1080/15476286.2015.1062316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574901PMC
October 2015

Biocompatibility of poly(2-alkyl-2-oxazoline) brush surfaces for adherent lung cell lines.

Biomaterials 2015 Aug 14;61:26-32. Epub 2015 May 14.

Brooke Laboratories, Clinical and Experimental Sciences and the Southampton NIHR Respiratory Biomedical Research Unit, Faculty of Medicine, University of Southampton, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Institute for Life Sciences, University of Southampton, Southampton, UK. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2015.04.059DOI Listing
August 2015

Inhibition of Pim1 kinase reduces viral replication in primary bronchial epithelial cells.

Eur Respir J 2015 Jun 5;45(6):1745-8. Epub 2015 Mar 5.

Brooke Laboratory, Academic Unit of Clinical and Experimental Sciences, University of Southampton, Faculty of Medicine, University Hospital Southampton, Southampton, UK National Institute for Health Research Respiratory Biomedical Research Unit, University Hospital Southampton, Southampton, UK.

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http://dx.doi.org/10.1183/09031936.00206514DOI Listing
June 2015

The effects on bronchial epithelial mucociliary cultures of coarse, fine, and ultrafine particulate matter from an underground railway station.

Toxicol Sci 2015 May 10;145(1):98-107. Epub 2015 Feb 10.

*Academic Unit of Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton SO16 6YD, United Kingdom, Institute for Life Sciences, Highfield Campus, University of Southampton, Southampton SO17 1BJ, United Kingdom, Ocean and Earth Science, National Oceanography Centre Southampton, University of Southampton, Southampton SO14 3ZH, United Kingdom, NIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton, Southampton SO16 6YD, United Kingdom, Centre for Sustainability, Environment, and Health, National Institute for Public Health and the Environment (RIVM), 3720BA Bilthoven, The Netherlands and Institute for Risk Assessment Sciences (IRAS), Utrecht University, 3508TC Utrecht, The Netherlands *Academic Unit of Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton SO16 6YD, United Kingdom, Institute for Life Sciences, Highfield Campus, University of Southampton, Southampton SO17 1BJ, United Kingdom, Ocean and Earth Science, National Oceanography Centre Southampton, University of Southampton, Southampton SO14 3ZH, United Kingdom, NIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton, Southampton SO16 6YD, United Kingdom, Centre for Sustainability, Environment, and Health, National Institute for Public Health and the Environment (RIVM), 3720BA Bilthoven, The Netherlands and Institute for Risk Assessment Sciences (IRAS), Utrecht University, 3508TC Utrecht, The Netherlands *Academic Unit of Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton SO16 6YD, United Kingdom, Institute for Life Sciences, Highfield Campus, University of Southampton, Southampton SO17 1BJ, United Kingdom, Ocean and Earth Science, National Oceanography Centre Southampton, University of Southampton, Southampton SO14 3ZH, United K

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http://dx.doi.org/10.1093/toxsci/kfv034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408962PMC
May 2015

Rhinovirus-16 induced release of IP-10 and IL-8 is augmented by Th2 cytokines in a pediatric bronchial epithelial cell model.

PLoS One 2014 4;9(4):e94010. Epub 2014 Apr 4.

Academic Unit of Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom; NIHR Respiratory Biomedical Research Unit, University Hospital Southampton, Southampton, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094010PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976391PMC
December 2014

Epithelial barrier function and immunity in asthma.

Authors:
Donna E Davies

Ann Am Thorac Soc 2014 Dec;11 Suppl 5:S244-51

Clinical and Experimental Sciences and the Southampton National Institute for Health Research Respiratory Biomedical Research Unit, University of Southampton Faculty of Medicine, Sir Henry Wellcome Laboratories, University Hospital Southampton, Southampton United Kingdom.

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http://dx.doi.org/10.1513/AnnalsATS.201407-304AWDOI Listing
December 2014

Nanomechanical assessment of human and murine collagen fibrils via atomic force microscopy cantilever-based nanoindentation.

J Mech Behav Biomed Mater 2014 Nov 15;39:9-26. Epub 2014 Jul 15.

Bioengineering Science Research Group, Faculty of Engineering and the Environment, University of Southampton, SO17 1BJ Southampton, UK; Institute for Lightweight Design and Structural Biomechanics, Faculty of Engineering and the Environment, Vienna University of Technology, Gusshausstrasse 27-29, Vienna 1040, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jmbbm.2014.06.015DOI Listing
November 2014

Identification of host miRNAs that may limit human rhinovirus replication.

World J Biol Chem 2014 Nov;5(4):437-56

Victor Paky Bondanese, LGL, LabEx LIO, ENS Lyon, Site Monod, 69364 Lyon, France.

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http://dx.doi.org/10.4331/wjbc.v5.i4.437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243148PMC
November 2014

The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial.

Am J Respir Crit Care Med 2014 Jul;190(2):145-54

1 NIHR Southampton Respiratory Biomedical Research Unit, Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton, United Kingdom.

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http://dx.doi.org/10.1164/rccm.201312-2235OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226052PMC
July 2014

EGF-induced bronchial epithelial cells drive neutrophil chemotactic and anti-apoptotic activity in asthma.

PLoS One 2013 11;8(9):e72502. Epub 2013 Sep 11.

Academic Unit of Clinical and Experimental Sciences and the NIHR Southampton Respiratory Biomedical Research Unit, Southampton University Faculty of Medicine, Sir Henry Wellcome Laboratories, Southampton University Hospital, Southampton, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072502PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770689PMC
June 2014

Barrier disrupting effects of alternaria alternata extract on bronchial epithelium from asthmatic donors.

PLoS One 2013 23;8(8):e71278. Epub 2013 Aug 23.

Academic Unit of Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Sir Henry Wellcome Laboratories, South Block, University Hospital Southampton, Southampton, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0071278PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751915PMC
April 2014

Autocrine ligands of the epithelial growth factor receptor mediate inflammatory responses to diesel exhaust particles.

Respir Res 2014 Feb 20;15:22. Epub 2014 Feb 20.

The Brooke Laboratories, Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK.

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http://dx.doi.org/10.1186/1465-9921-15-22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996104PMC
February 2014

Epithelial injury and repair in airways diseases.

Chest 2013 Dec;144(6):1906-1912

Academic Unit of Clinical and Experimental Sciences, University Hospital Southampton, Southampton, England; University of Southampton Faculty of Medicine, and NIHR Respiratory Biomedical Research Unit, University Hospital Southampton, Southampton, England.

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http://dx.doi.org/10.1378/chest.12-1944DOI Listing
December 2013

TNF-α-mediated bronchial barrier disruption and regulation by src-family kinase activation.

J Allergy Clin Immunol 2013 Sep 28;132(3):665-675.e8. Epub 2013 Apr 28.

Academic Unit of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom; Southampton NIHR Respiratory Biomedical Research Unit, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2013.03.005DOI Listing
September 2013

Barrier responses of human bronchial epithelial cells to grass pollen exposure.

Eur Respir J 2013 Jul 8;42(1):87-97. Epub 2012 Nov 8.

Brooke Laboratory, Clinical and Experimental Sciences, Faculty of Medicine, University Hospital Southampton, Southampton, UK.

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http://dx.doi.org/10.1183/09031936.00075612DOI Listing
July 2013

In vitro and ex vivo models of human asthma.

Eur J Pharm Biopharm 2013 Jun 9;84(2):394-400. Epub 2013 Jan 9.

Brooke Laboratory, Clinical and Experimental Sciences and the Southampton NIHR, Respiratory Biomedical Research Unit, University of Southampton, University Hospital Southampton, Southampton, United Kingdom.

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http://dx.doi.org/10.1016/j.ejpb.2012.12.014DOI Listing
June 2013

Physicochemical characterization of airborne particulate matter at a mainline underground railway station.

Environ Sci Technol 2013 Apr 2;47(8):3614-22. Epub 2013 Apr 2.

The Brooke Laboratory, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, University Hospital Southampton, Tremona Road, Southampton, SO16 6YD, United Kingdom.

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http://dx.doi.org/10.1021/es304481mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687366PMC
April 2013

Transforming growth factor-beta promotes rhinovirus replication in bronchial epithelial cells by suppressing the innate immune response.

PLoS One 2012 6;7(9):e44580. Epub 2012 Sep 6.

Academic Unit of Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044580PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435262PMC
March 2013

The innate antiviral response upregulates IL-13 receptor α2 in bronchial fibroblasts.

J Allergy Clin Immunol 2013 Mar 12;131(3):849-55. Epub 2012 Oct 12.

Academic Unit of Clinical and Experimental Sciences and the Southampton NIHR Respiratory Biomedical Research Unit, University of Southampton Faculty of Medicine, Sir Henry Wellcome Laboratories, Southampton General Hospital, Southampton, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2012.08.030DOI Listing
March 2013

Resistin-like molecule-β is induced following bronchoconstriction of asthmatic airways.

Respirology 2012 Oct;17(7):1094-100

Academic Unit of Clinical and Experimental Sciences, Southampton University Faculty of Medicine, NIHR Respiratory Biomedical Research Unit and Wellcome Trust Clinical Research Facility, Southampton, UK.

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http://dx.doi.org/10.1111/j.1440-1843.2012.02215.xDOI Listing
October 2012

Spiruchostatin A inhibits proliferation and differentiation of fibroblasts from patients with pulmonary fibrosis.

Am J Respir Cell Mol Biol 2012 May 12;46(5):687-94. Epub 2012 Jan 12.

Sir Henry Wellcome Laboratories, Southampton General Hospital, South Block, Southampton, United Kingdom.

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http://dx.doi.org/10.1165/rcmb.2011-0040OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854311PMC
May 2012

Thin film polycrystalline silicon nanowire biosensors.

Nano Lett 2012 Apr 26;12(4):1868-72. Epub 2012 Mar 26.

School of Electronics & Computer Science, University of Southampton, Southampton, SO17 1BJ, UK.

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http://dx.doi.org/10.1021/nl2042276DOI Listing
April 2012

A disintegrin and metalloprotease (ADAM) 33 protein in patients with pulmonary sarcoidosis.

Respirology 2012 Feb;17(2):342-9

Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Southampton, Hampshire, UK.

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http://dx.doi.org/10.1111/j.1440-1843.2011.02098.xDOI Listing
February 2012

Artificial airways for the study of respiratory disease.

Expert Rev Respir Med 2011 Dec;5(6):757-65

Academic Unit of Clinical and Experimental Sciences and Southampton NIHR Respiratory Biomedical Research Unit, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, SO16 6YD, UK.

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http://www.tandfonline.com/doi/full/10.1586/ers.11.78
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http://dx.doi.org/10.1586/ers.11.78DOI Listing
December 2011

Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation.

Am J Respir Crit Care Med 2011 Aug;184(4):421-9

Perinatal Institute, Divisions of Neonatology, Perinatal, and Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA.

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http://dx.doi.org/10.1164/rccm.201101-0106OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175541PMC
August 2011

Tumor necrosis factor alpha (TNF-α) autoregulates its expression and induces adhesion molecule expression in asthma.

Clin Immunol 2011 Jul 13;140(1):18-25. Epub 2011 Mar 13.

The Brooke Laboratories, Division of Infection, Inflammation, and Repair, University of Southampton School of Medicine, Southampton General Hospital, Southampton, SO16 6YD, UK.

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http://dx.doi.org/10.1016/j.clim.2011.03.005DOI Listing
July 2011

Exogenous IFN-β has antiviral and anti-inflammatory properties in primary bronchial epithelial cells from asthmatic subjects exposed to rhinovirus.

J Allergy Clin Immunol 2011 May 16;127(5):1148-54.e9. Epub 2011 Feb 16.

Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine and National Institute for Health Research Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2011.01.023DOI Listing
May 2011

Effect of bronchoconstriction on airway remodeling in asthma.

N Engl J Med 2011 05;364(21):2006-15

Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Southampton, United Kingdom.

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http://dx.doi.org/10.1056/NEJMoa1014350DOI Listing
May 2011

Double-stranded RNA induces disproportionate expression of thymic stromal lymphopoietin versus interferon-beta in bronchial epithelial cells from donors with asthma.

Thorax 2010 Jul;65(7):626-32

The Brooke Laboratories, Sir Henry Wellcome Laboratories, South Block, Southampton General Hospital, Southampton SO16 6YD, UK.

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http://dx.doi.org/10.1136/thx.2009.125930DOI Listing
July 2010

On-chip epithelial barrier function assays using electrical impedance spectroscopy.

Lab Chip 2010 Jun 8;10(12):1611-7. Epub 2010 Apr 8.

Nano Research Group, School of Electronics and Computer Science, University of Southampton, SO17 1BJ, United Kingdom.

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http://dx.doi.org/10.1039/c000699hDOI Listing
June 2010

Identification of lipocalin and apolipoprotein A1 as biomarkers of chronic obstructive pulmonary disease.

Am J Respir Crit Care Med 2010 May 28;181(10):1049-60. Epub 2010 Jan 28.

Inflammatory Cell Biology Group, Division of Infection, Inflammation, and Immunity, Sir Henry Wellcome Laboratories, South Block, Southampton General Hospital, Southampton, UK.

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http://dx.doi.org/10.1164/rccm.200906-0857OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874448PMC
May 2010

The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis.

Proc Am Thorac Soc 2009 Dec;6(8):655-9

Infection, Inflammation and Immunity Division, School of Medicine, Southampton University, Southampton General Hospital, Southampton SO166YD, UK.

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http://dx.doi.org/10.1513/pats.200907-072DPDOI Listing
December 2009

The role of the epithelium in airway remodeling in asthma.

Authors:
Donna E Davies

Proc Am Thorac Soc 2009 Dec;6(8):678-82

The Brooke Laboratories, Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797070PMC
December 2009

A new look at the pathogenesis of asthma.

Clin Sci (Lond) 2009 Dec 23;118(7):439-50. Epub 2009 Dec 23.

University of Southampton, Southampton General Hospital, UK.

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http://dx.doi.org/10.1042/CS20090474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805922PMC
December 2009

Leukocyte analysis and differentiation using high speed microfluidic single cell impedance cytometry.

Lab Chip 2009 Oct 7;9(20):2881-9. Epub 2009 Aug 7.

School of Electronics and Computing Science, University of Southampton, Highfield, Southampton, SO17 1BJ, UK.

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http://dx.doi.org/10.1039/b910053aDOI Listing
October 2009

Induction of a disintegrin and metalloprotease 33 during embryonic lung development and the influence of IL-13 or maternal allergy.

J Allergy Clin Immunol 2009 Sep 8;124(3):590-7, 597.e1-11. Epub 2009 Aug 8.

Division of Infection Inflammation and Immunity, Roger Brooke Laboratory, School of Medicine, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1016/j.jaci.2009.06.026DOI Listing
September 2009

Rethinking the pathogenesis of asthma.

Immunity 2009 Sep;31(3):362-7

III Division, School of Medicine, University of Southampton, Southampton S016 61D, UK.

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http://dx.doi.org/10.1016/j.immuni.2009.08.013DOI Listing
September 2009

Cytoplasmic tail of IL-13Ralpha2 regulates IL-4 signal transduction.

Biochem Soc Trans 2009 Aug;37(Pt 4):873-6

School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK.

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August 2009

Breakdown in epithelial barrier function in patients with asthma: identification of novel therapeutic approaches.

J Allergy Clin Immunol 2009 Jul;124(1):23-34; quiz 35-6

Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, United Kingdom.

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July 2009

Contribution of bronchial fibroblasts to the antiviral response in asthma.

J Immunol 2009 Mar;182(6):3660-7

Division of Infection, Inflammation, and Repair, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.0802471DOI Listing
March 2009

The soluble form of a disintegrin and metalloprotease 33 promotes angiogenesis: implications for airway remodeling in asthma.

J Allergy Clin Immunol 2008 Jun 14;121(6):1400-6, 1406.e1-4. Epub 2008 Apr 14.

Division of Infection, Inflammation, and Repair, School of Medicine, Southampton General Hospital, University of Southampton, Southampton, United Kingdom.

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June 2008

Epigenetic mechanisms silence a disintegrin and metalloprotease 33 expression in bronchial epithelial cells.

J Allergy Clin Immunol 2008 Jun 21;121(6):1393-9, 1399.e1-14. Epub 2008 Apr 21.

Brooke Laboratories, Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2008.02.031DOI Listing
June 2008

Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium.

Part Fibre Toxicol 2008 May 6;5. Epub 2008 May 6.

Department of Respiratory Medicine and Allergy, University Hospital, Umeå, Sweden.

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http://dx.doi.org/10.1186/1743-8977-5-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2405801PMC
May 2008

IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations.

J Allergy Clin Immunol 2007 Sep 12;120(3):586-93. Epub 2007 Jul 12.

Brooke Laboratories, University of Southampton, Southampton, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2007.04.046DOI Listing
September 2007

Effect of IL-13 receptor alpha2 levels on the biological activity of IL-13 variant R110Q.

J Allergy Clin Immunol 2007 Jul 8;120(1):91-7. Epub 2007 Jun 8.

Infection, Inflammation and Repair Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK.

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http://dx.doi.org/10.1016/j.jaci.2007.04.026DOI Listing
July 2007

Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary disease.

Am J Respir Crit Care Med 2007 Feb 30;175(4):306-11. Epub 2006 Nov 30.

Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, L Floor, Royal Hallamshire Hospital, Sheffield, UK.

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http://dx.doi.org/10.1164/rccm.200606-777PPDOI Listing
February 2007

Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts.

J Allergy Clin Immunol 2007 Jan 7;119(1):132-40. Epub 2006 Nov 7.

Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, Southampton General Hospital, UK.

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January 2007

IL-13 receptor alpha 2: a regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts.

J Allergy Clin Immunol 2006 Oct 8;118(4):858-65. Epub 2006 Sep 8.

Brooke Laboratories, Division of Infection, Inflammation, and Repair, UK.

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October 2006

CD40 ligation protects bronchial epithelium against oxidant-induced caspase-independent cell death.

Am J Respir Cell Mol Biol 2006 Aug 16;35(2):155-64. Epub 2006 Mar 16.

Department of Medicine, Pneumology, Physiology, and Human Nutrition, Universita' di Palermo, Ospedale V, Cervello, Via Trabucco 180, 90146 Palermo, Italy.

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http://dx.doi.org/10.1165/rcmb.2005-0433OCDOI Listing
August 2006

Shotgun proteomic analysis of human-induced sputum.

Proteomics 2006 Aug;6(15):4390-401

Division of Infection, Inflammation and Repair, School of Medicine, Southampton General Hospital, Southampton, UK.

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http://doi.wiley.com/10.1002/pmic.200600011
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August 2006

The genetics of asthma: ADAM33 as an example of a susceptibility gene.

Proc Am Thorac Soc 2006 Jul;3(5):440-3

Infection, Inflammation, and Repair Division, MP810, F Level, South Block, Southampton General Hospital, Southampton SO16 6YD, UK.

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http://dx.doi.org/10.1513/pats.200603-026AWDOI Listing
July 2006

IL-4 receptor alpha is an important modulator of IL-4 and IL-13 receptor binding: implications for the development of therapeutic targets.

J Immunol 2006 Jun;176(12):7456-61

The Brooke Laboratories, Division of Infection, Inflammation, and Repair, Southampton General Hospital, UK.

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http://dx.doi.org/10.4049/jimmunol.176.12.7456DOI Listing
June 2006

ADAM33: a newly identified protease involved in airway remodelling.

Pulm Pharmacol Ther 2006 13;19(1):3-11. Epub 2005 Jun 13.

School of Medicine, University of Southampton, SO17 1BJ Southampton, UK.

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http://dx.doi.org/10.1016/j.pupt.2005.02.008DOI Listing
May 2006

Understanding the pathophysiology of severe asthma to generate new therapeutic opportunities.

J Allergy Clin Immunol 2006 Mar;117(3):496-506; quiz 507

Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton General Hospital, UK.

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http://dx.doi.org/10.1016/j.jaci.2006.01.039DOI Listing
March 2006

ADAM33: a newly identified gene in the pathogenesis of asthma.

Immunol Allergy Clin North Am 2005 Nov;25(4):655-68

Infection, Inflammation, and Repair Division, School of Medicine, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, Hampshire, SO16 6YD, UK.

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http://dx.doi.org/10.1016/j.iac.2005.07.003DOI Listing
November 2005

Epithelial-mesenchymal communication in the pathogenesis of chronic asthma.

Proc Am Thorac Soc 2004 ;1(2):93-8

Respiratory Cell and Molecular Biology, Infection, Inflammation and Repair Division, School of Medicine, University of Southampton, D Level Centre Block, Southampton General Hospital, Southampton SO16 6YD, UK.

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http://dx.doi.org/10.1513/pats.2306034DOI Listing
September 2005

Beta-catenin/T-cell factor-mediated transcription is modulated by cell density in human bronchial epithelial cells.

Int J Biochem Cell Biol 2005 Jun 18;37(6):1281-95. Epub 2005 Jan 18.

The Brooke Laboratories, School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK.

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http://dx.doi.org/10.1016/j.biocel.2004.12.010DOI Listing
June 2005

ADAM33 expression in asthmatic airways and human embryonic lungs.

Am J Respir Crit Care Med 2005 May 11;171(9):958-65. Epub 2005 Feb 11.

Roger Brooke Laboratories, Division of Infection, Inflammation, and Repair, and Human Genetics Division, School of Medicine, University of Southampton, Southampton General Hospital, United Kingdom.

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http://dx.doi.org/10.1164/rccm.200409-1251OCDOI Listing
May 2005

Role of tumor necrosis factor alpha in asthma.

Immunol Allergy Clin North Am 2004 Nov;24(4):583-97, v-vi

Respiratory Cell and Molecular Biology Infection, Inflammation and Repair, Southampton General Hospital, Level D, Centre Block, Mailpoint 810, Southampton SO16 6YD, UK.

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http://dx.doi.org/10.1016/j.iac.2004.06.010DOI Listing
November 2004

The discovery and role of ADAM33, a new candidate gene for asthma.

Expert Rev Mol Med 2004 Aug 3;6(17):1-12. Epub 2004 Aug 3.

Human Genetics Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK.

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http://dx.doi.org/10.1017/S1462399404007963DOI Listing
August 2004