Publications by authors named "Dongqing Pang"

8 Publications

  • Page 1 of 1

Abnormal functional connectivity within the prefrontal cortex in interstitial cystitis/bladder pain syndrome (IC/BPS): A pilot study using resting state functional near-infrared spectroscopy (rs-fNIRS).

Neurourol Urodyn 2021 Aug 15;40(6):1634-1642. Epub 2021 Jun 15.

School of Rehabilitation, Capital Medical University, Beijing, China.

Purpose: To investigate the abnormalities of functional connectivity (FC) within the prefrontal cortex (PFC) of patients with interstitial cystitis/bladder pain syndrome (IC/BPS) based on resting state functional near-infrared spectroscopy (rs-fNIRS) data using FC matrix analysis.

Materials And Methods: Ten patients with IC/BPS (females, 9; mean age, 56.9 ± 12.432 years) and 15 age- and gender-matched healthy controls (HC) (females, 12; mean age, 55.067 ± 7.46 years) participated in this rs-fNIRS study. Two rs-fNIRS scans were performed (when the bladder was empty and when the desire to void was strong). The Pearson's correlation coefficient between the time series of the 22 channels was calculated to obtain a 22 × 22 FC matrix for each subject. A two-sample t-test (p < .05) was performed to compare group differences in the FC matrix between patients with IC/BPS and HC.

Results: FC was significantly decreased within the PFC in the IC/BPS group based on a two-sample t-test (p < .05) compared with HC. FC decreased in a wider range of brain regions during the strong desire to void state (4 brain regions and 28 edges) when compared with the empty bladder state (3 brain regions and 18 edges).

Conclusion: FC abnormalities in IC/BPS patients may lead to frontal lobe disorders involved in processing sensory integration, motivation drive, emotional control, and decision-making whether to urinate, leading to urinary control dysfunction manifested as typical clinical IC/BPS symptoms. Our results may provide new insight into the pathogenesis of IC/BPS and new brain biomarkers for diagnosis.
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http://dx.doi.org/10.1002/nau.24729DOI Listing
August 2021

Responses of functional brain networks to bladder control in healthy adults: a study using regional homogeneity combined with independent component analysis methods.

Int Urol Nephrol 2021 May 1;53(5):883-891. Epub 2021 Feb 1.

School of Rehabilitation, Capital Medical University, Department of Urology of Capital Medical University, Beijing, China.

Objective: A functional magnetic resonance imaging (fMRI) study was performed during urodynamic examination in healthy adults to determine the responses of functional brain networks to bladder control during urine storage.

Methods: The brain imaging was performed in empty and full bladder states during urodynamic examination. First, we used independent component analysis (ICA) to obtain several resting state network masks, then the brain regions with significantly different regional homogeneity (ReHo) values between the two states were determined using a paired t test (p < 0.05; Gaussian random field correction [GRF]: voxel p < 0.01 and cluster p < 0.05) and presented in their corresponding resting state network (RSN) masks.

Results: Data sets obtained from the remaining 20 subjects were analyzed after motion correction. Nine RSNs were identified by group-ICA, including the salience network (SN), default mode network (DMN), central executive network (CEN), dorsal attention network (dAN), auditory network (AN), sensorimotor network (SMN), language network (LN), visual network (VN), and cerebellum network (CN). The ReHo values were significantly increased (p < 0.05, GRF corrected) within the SN, DMN, and CEN in the full bladder state compared with the empty bladder state.

Conclusion: Significant changes within the three functional brain networks were demonstrated when the bladder was full, suggesting that SN provides bladder sensation and DMN may provide self-reference, self-reflection, and decision-making about whether to void after assessment of the external environment, while CEN may provide support related to episodic memory, which provides new insight into the processing of bladder control and could serve as a premise to further explore the pathologic process underlying bladder dysfunction.
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http://dx.doi.org/10.1007/s11255-020-02742-1DOI Listing
May 2021

Direct femtosecond laser ablation of large-area TaSe, SnS, and TiS thick films by a back ablation procedure.

Appl Opt 2020 Sep;59(25):7606-7612

Direct ablation of large-area graphene-like two-dimensional (2D) materials, i.e., tantalum diselenide (), stannic disulfide (), and titanium disulfide (), by the back ablation method with a femtosecond laser with a repetition rate of 50 MHz and pulse width of 200 fs is studied for the first time to our knowledge. The ablation thresholds of the three kinds of materials are discussed. In addition, the optimization and ablation of narrow grooves on the films are demonstrated. Our work demonstrates the direct femtosecond laser ablation processing of the graphene-like 2D-material films and the potential of 2D-material-film-based devices.
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http://dx.doi.org/10.1364/AO.390667DOI Listing
September 2020

Brain functional network alterations caused by a strong desire to void in healthy adults: a graph theory analysis study.

Neurourol Urodyn 2020 09;39(7):1966-1976

Rehabilitation School of Capital Medical University, Department of Urology of Capital Medical University, Beijing, China.

Purpose: This resting-state functional magnetic resonance imaging (fMRI) study determined the functional connectivity (FC) changes and topologic property alterations of the brain functional network provoked by a strong desire to void in healthy adults using a graph theory analysis (GTA).

Materials And Methods: Thirty-four healthy, right-handed subjects filled their bladders by drinking water. The subjects were scanned under an empty bladder and a strong desire to void states. The Pearson's correlation coefficients were calculated among 90 brain regions in the automated anatomical labeling (AAL) atlas to construct the brain functional network. A paired t test (P < .05, after false discovery rate [FDR] correction) was used to detect significant differences in the FC, topologic properties (small-world parameters [gamma, sigma], C, L, E, E, and E) between the two states in all subjects.

Results: Both the two states showed small-world network properties. The clustering coefficient (C) and local efficiency (E) in the whole brain network decreased, while the FC within the default mode network (DMN) increased during the strong desire to void compared with the empty bladder state. Moreover, an increased nodal efficiency (E) was detected in the basal ganglia (BG), DMN, sensorimotor-related network (SMN), and visual network (VN).

Conclusion: We detected FC changes and topologic property alterations in brain functional networks caused by a strong desire to void in healthy and suggest that the micturition control may be a process dominated by DMN and coordinated by multiple sub-networks (such as, BG, SMN, and VN), which could serve as a baseline for understanding the pathologic process underlying bladder dysfunction and be useful to improve targeted therapy in the future.
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http://dx.doi.org/10.1002/nau.24445DOI Listing
September 2020

Combining Visual Rating Scales for Medial Temporal Lobe Atrophy and Posterior Atrophy to Identify Amnestic Mild Cognitive Impairment from Cognitively Normal Older Adults: Evidence Based on Two Cohorts.

J Alzheimers Dis 2020 ;77(1):323-337

Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.

Background: Visual rating scales for medial temporal lobe atrophy (MTA) and posterior atrophy (PA) have been reported to be useful for Alzheimer's disease diagnosis in routine clinical practice.

Objective: To investigate the efficacy of combined MTA and PA visual rating scales to discriminate amnestic mild cognitive impairment (aMCI) patients from healthy controls.

Methods: This study included T1-weighted MRI images from two different cohorts. In the first cohort, we recruited 73 patients with aMCI and 48 group-matched cognitively normal controls for training and validation. Visual assessments of MTA and PA were carried out for each participant. Global gray matter volume and density were estimated using voxel-based morphometry analysis as the objective reference. We investigated the discriminative power of a single visual rating scale and the combination of the MTA and PA rating scales for identifying aMCI. The second cohort, consisting of 33 aMCI patients and 45 controls, was used to verify the reliability of the visual assessments.

Results: Compared with the single visual rating scale, the combination of the MTA and PA exhibited the best discriminative power, with an AUC of 0.818±0.041, which was similar to the diagnostic accuracy of the gray matter volumetric measures. The discriminative power of the combined MTA and PA was verified in the second cohort (AUC 0.824±0.058).

Conclusion: The combined MTA and PA rating scales demonstrated practical diagnostic value for distinguishing aMCI patients from controls, suggesting its potential to serve as a convenient and reproducible method to assess the degree of atrophy in clinical settings.
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http://dx.doi.org/10.3233/JAD-200016DOI Listing
January 2020

Chromatic annuli formation and sample oxidation on copper thin films by femtosecond laser.

J Chem Phys 2016 Apr;144(16):164703

Ultrafast Laser Laboratory, Key Laboratory of Opto-Electronic Information Technical Science of Ministry of Education, College of Precision Instruments and Opto-Electronics Engineering, Tianjin University, Tianjin 300072, China.

We report an experimental investigation on the irradiation of copper thin films with high repetition rate femtosecond laser pulses (1040 nm, 50 MHz), in ambient air and liquid water. We observe a novel, striking phenomenon of chromatic copper oxides (CuO and Cu2O) annuli generation. The characteristic features of the chromatic copper oxide annuli are studied by exploiting micro-Raman spectroscopy, optical and scanning electron microscopies. In the case of irradiation in water, the seldom investigated effects of the immersion time, tw, after irradiation with a fixed number of pulses are analyzed, and an intriguing dependence of the color of the chromatic annuli on tw is observed. This remarkable behavior is explained by proposing an interpretation scenario addressing the various processes involved in the process. Our experimental findings show that Cu2O nanoparticles (size of ≈20 nm) and Cu2O nanocubes (nanocube edges of ≈30, ≈60 nm) can be effectively generated by exploiting high repetition rate laser-assisted oxidation.
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http://dx.doi.org/10.1063/1.4947224DOI Listing
April 2016

Spatial chirp and angular dispersion of a laser crystal for a four-mirror cavity Kerr-lens mode-locked laser.

Appl Opt 2004 Apr;43(10):2184-91

School of Precision Instrument and Optoelectronics Engineering, Key Laboratory of Optoelectronic Information Technical Science, Chinese Ministry of Education, Tianjin University, Tianjin 300072, China.

We describe oscillating loops in a laser cavity and optical paths in a laser crystal of different wavelength rays for a four-mirror cavity Kerr-lens mode-locked laser. The relation between different wavelength ray paths and laser resonator parameters is deduced. The analytical expressions of second- and third-order dispersion including angular dispersion of the crystal are presented. The variations of group-delay dispersion (GDD) and third-order dispersion (TOD) with cavity parameters are calculated exactly. The calculation shows that GDD and TOD increase rapidly when the spacing between two folding mirrors approaches the boundary of a cavity stability zone. The rapid dispersion increase influences the mode-locked pulse width and the mode-locked stability.
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http://dx.doi.org/10.1364/ao.43.002184DOI Listing
April 2004

Theoretical analysis of a noncollinear phase-matched optical parametric amplifier seeded by an optical parametric generation.

Appl Opt 2002 Feb;41(6):1108-12

Optoelectronic Information Science and Technology Laboratory, College of Precision Instruments and Optoelectronics Engineering, Tianjin University, China.

We have theoretically analyzed the characteristics of an optical parametric amplifier system seeded by an optical parametric generation. We investigated the influences of the energy, pulse duration, material dispersion, and the third-order nonlinear effect in beta-barium borate. The group-velocity mismatch (GVM) becomes the most important factor for the amplification of bandwidths. Even though tilting the wave front of the pump can decrease the GVM, it seems impossible to generate pulses smaller than 10-fs with 400-nm pumping. However, 10-fs pulses can be achieved with a 30-fs pump duration with pumping at 800 nm.
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http://dx.doi.org/10.1364/ao.41.001108DOI Listing
February 2002
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