Publications by authors named "Dongdong Zhu"

65 Publications

Organoid Models for Salivary Gland Biology and Regenerative Medicine.

Stem Cells Int 2021 27;2021:9922597. Epub 2021 Aug 27.

Department of Otolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.

The salivary gland is composed of an elegant epithelial network that secrets saliva and maintains oral homeostasis. While cell lines and animal models furthered our understanding of salivary gland biology, they cannot replicate key aspects of the human salivary gland tissue, particularly the complex architecture and microenvironmental features that dictate salivary gland function. Organoid cultures provide an alternative system to recapitulate salivary gland tissue in vitro, and salivary gland organoids have been generated from pluripotent stem cells and adult stem/progenitor cells. In this review, we describe salivary gland organoids, the advances and limitations, and the promising potential for regenerative medicine.
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http://dx.doi.org/10.1155/2021/9922597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421180PMC
August 2021

Contribution of Regulatory T Cell Methylation Modifications to the Pathogenesis of Allergic Airway Diseases.

J Immunol Res 2021 19;2021:5590217. Epub 2021 Jun 19.

Department of Otolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.

Regulatory T (Treg) cells are a subtype of CD4 T cells that play a significant role in the protection from autoimmunity and the maintenance of immune tolerance via immune regulation. Epigenetic modifications of Treg cells (i.e., cytosine methylation at the promoter region of the transcription factor, Forkhead Box P3) have been found to be closely associated with allergic diseases, including allergic rhinitis, asthma, and food allergies. In this study, we highlighted the recent evidence on the contribution of epigenetic modifications in Treg cells to the pathogenesis of allergic diseases. Moreover, we also discussed directions for future clinical treatment approaches, with a particular emphasis on Treg cell-targeted therapies for allergic disorders.
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http://dx.doi.org/10.1155/2021/5590217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238596PMC
June 2021

Facile Synthesis of Thermo-Sensitive Composite Hydrogel with Well Dispersed Ag Nanoparticles for Application in Superior Antibacterial Infections.

J Biomed Nanotechnol 2021 Jun;17(6):1148-1159

School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China.

In this study, we have described a facile process for fabrication of multifunctional composite hydrogel, in which sodium alginate was subjected to cross-linking using Ca derived from ZnO/CaCO₃/Ag composite nanospheres. The ZnO/CaCO₃/Ag composite nanospheres were prepared based on our previously reported AA-[Zn(OH)₄] composite nanosphere reaction conducted with silver and calcium salt following hydrothermal method, that led to the disintegration and release of Ca under acidic conditions for application as a cross-linking agentto catalyze reaction with sodium alginate. Ag nanoparticles were well-dispersed in the multifunctional composite hydrogel, exhibiting excellent antibacterial activity. Additionally, polydopamine (PDA) with photothermal effect was also added to obtain a multifunctional composite hydrogel, and this hydrogel showed photothermal conversion performance and facilitated the release of Ag to achieve the rapid antibacterial effect. Simultaneously, PDA NPs could scavenge free radicals and improve cell adhesion. All such features would promote wound healing. The potent antimicrobial activity of the prepared composite hydrogel was demonstrated in the mouse model of infection, and biosafety of the hydrogel was confirmed by conducting histopathological examination in the mouse model. This type of multifunctional hydrogel wound dressing with photosensitive and antibacterial properties presents with broad applications and prospects in antibacterial treatment.
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http://dx.doi.org/10.1166/jbn.2021.3099DOI Listing
June 2021

Thermochromic Polyvinyl Alcohol-Iodine Hydrogels with Safe Threshold Temperature for Infectious Wound Healing.

Adv Healthc Mater 2021 Jun 24:e2100722. Epub 2021 Jun 24.

School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China.

Iodophor (povidone-iodine) has been widely used for antibacterial applications in the clinic. Yet, limited progress in the field of iodine-based bactericides has been achieved since the invention of iodophor. Herein, a blue polyvinyl alcohol-iodine (PAI) complex-based antibacterial hydrogel is explored as a new generation of biocompatible iodine-based bactericides. The obtained PAI hydrogel maintains laser triggered liquefaction, thermochromic, and photothermal features for highly efficient elimination of bacteria. In vitro antibacterial test reveals that the relative bacteria viabilities of Escherichia coli (E.coli) and methicillin-resistant Staphylococcus aureus (MRSA) incubated with PAI hydrogel are only 8% and 3.8%, respectively. Upon single injection of the PAI hydrogel, MRSA-infected open wounds can be efficiently healed in only 5 days, and the healing speed is further accelerated by laser irradiation due to the dynamic interaction between iodine and polyvinyl alcohol, causing up to ∼29% of wound area being closed on day 1. In addition, a safe threshold temperature of skin scald (∼45 °C) emerges for PAI hydrogels because of thermochromic properties, avoiding thermal injuries during irradiation. In addition, no observed toxicity or skin irritation is observed for the PAI hydrogel. This work expands the category of iodine-based bactericides for safe and controllable management of infected wounds.
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http://dx.doi.org/10.1002/adhm.202100722DOI Listing
June 2021

Ten-eleven translocation 2 modulates allergic inflammation by 5-hydroxymethylcytosine remodeling of immunologic pathways.

Hum Mol Genet 2021 Jun 24. Epub 2021 Jun 24.

Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.

Allergic rhinitis (AR) is an allergen specific IgE-mediated inflammatory disease. Both genetic and environmental factors could play a role in the pathophysiology of AR. 5-methylcytosine (5-mC) can be converted to 5-hydroxymethylcytosine (5hmC) by the Ten-Eleven Translocation (TET) family of proteins as part of active DNA de-methylation pathway. 5hmC plays an important role in regulation of gene expression and differentiation in immune cells. Here we show that loss of ten-eleven translocation protein 2 (Tet2) could impact the severity of AR in the ovalbumin-induced mouse model. Genome-wide 5hmC profiling of both wildtype and Tet2 KO mice in response to AR revealed that the loss of Tet2 could lead to 5hmC alteration at specific immune response genes. Both partial loss and complete loss of Tet2 alters the 5hmC dynamic remodeling for the adaptive immune pathway, as well as cytokines. Thus, our results reveal a new role of Tet2 in immunology, and Tet2 may serve as a promising target in regulating the level of immune response.
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http://dx.doi.org/10.1093/hmg/ddab167DOI Listing
June 2021

A calcium fluoride composite reduction graphene oxide functional separator for lithium-sulfur batteries to inhibit polysulfide shuttling and mitigate lithium dendrites.

J Colloid Interface Sci 2021 Nov 18;601:305-316. Epub 2021 May 18.

State Key Laboratory for Mechanical Behavior of Materials, School of Material Science and Engineering, Xi'an Jiaotong University, Xi'an 710049, PR China. Electronic address:

Lithium-sulfur (Li-S) batteries have attracted tremendous attention as promising next-generation energy-storage systems due to their high specific capacity and high specific energy. However, the shuttle of polysulfides and the growth of Li dendrites severely obstruct the practical applications of these batteries. In this work, a functional separator is designed and fabricated in which nano-calcium fluoride (CaF) particles are embedded in reduced graphene oxide (rGO) and bladed on a PP separator. The density functional theory (DFT) calculations of the adsorption energy and bond length reveal that CaF has a satisfying adsorption and catalytic effect on polysulfides (LiS). The factional separator could accelerate homogenous Li flow and retard the growth of Li dendrites. In addition, an initial specific capacity of 1504 mAh g at 0.05C is achieved, and it still retains a discharge capacity of 1050 mAh g over 100 cycles at 0.2C. Moreover, the capacity decay rate is only 0.06% per cycle over 420 cycles at a high current density of 0.5 C. The excellent performance could be attributed to the [email protected] modified separator not only accelerating the transmission of electrons but also effectively inhibiting the shuttling of polysulfides. This work provides a better method for attaining practical applications of high-performance lithium-sulfur batteries.
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http://dx.doi.org/10.1016/j.jcis.2021.05.083DOI Listing
November 2021

Copper single-atom catalysts with photothermal performance and enhanced nanozyme activity for bacteria-infected wound therapy.

Bioact Mater 2021 Dec 30;6(12):4389-4401. Epub 2021 Apr 30.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, 215123, PR China.

Nanozymes have become a new generation of antibiotics with exciting broad-spectrum antibacterial properties and negligible biological toxicity. However, their inherent low catalytic activity limits their antibacterial properties. Herein, Cu single-atom sites/N doped porous carbon (Cu SASs/NPC) is successfully constructed for photothermal-catalytic antibacterial treatment by a pyrolysis-etching-adsorption-pyrolysis (PEAP) strategy. Cu SASs/NPC have stronger peroxidase-like catalytic activity, glutathione (GSH)-depleting function, and photothermal property compared with non-Cu-doped NPC, indicating that Cu doping significantly improves the catalytic performance of nanozymes. Cu SASs/NPC can effectively induce peroxidase-like activity in the presence of HO, thereby generating a large amount of hydroxyl radicals (•OH), which have a certain killing effect on bacteria and make bacteria more susceptible to temperature. The introduction of near-infrared (NIR) light can generate hyperthermia to fight bacteria, and enhance the peroxidase-like catalytic activity, thereby generating additional •OH to destroy bacteria. Interestingly, Cu SASs/NPC can act as GSH peroxidase (GSH-Px)-like nanozymes, which can deplete GSH in bacteria, thereby significantly improving the sterilization effect. PTT-catalytic synergistic antibacterial strategy produces almost 100% antibacterial efficiency against () and methicillin-resistant (). experiments show a better PTT-catalytic synergistic therapeutic performance on MRSA-infected mouse wounds. Overall, our work highlights the wide antibacterial and anti-infective bio-applications of Cu single-atom-containing catalysts.
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http://dx.doi.org/10.1016/j.bioactmat.2021.04.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111038PMC
December 2021

Irg1-itaconate axis protects against acute kidney injury via activation of Nrf2.

Am J Transl Res 2021 15;13(3):1155-1169. Epub 2021 Mar 15.

Department of Urology, The Linyi People's Hospital Linyi, Shandong Province, PR China.

Acute kidney injury (AKI) is a common clinical implication with increased tissue damage, uncontrolled immune responses, and risk of mortality, in which ischemia-reperfusion injury (IRI) is one of the leading causes. As critical role for metabolic remodeling in inflammation, Irg1-itaconate axis has received much attention for its immunomodulation in the control of the inflammation. However, its role in the AKI and IRI remains unknown. Here, we found that Irg1 expression was negatively correlated with the expression of inflammatory cytokines during ischemia-reperfusion injury. And Irg1 deficiency promotes renal inflammation and ischemia-reperfusion injury . Itaconate treatment promoted the survival of WT mice from lethal ischemia and protected against renal IRI and systemic inflammation. Mechanistically, dimethyl itaconate protected renal cells from oxidative stress and prevented macrophage activation by enhancing the translocation of Nrf2 into the nuclei. Our study highlighted the importance of the Irg1-itaconate axis in the protecting against ischemia-reperfusion injury and acute kidney injury, providing potential therapeutic targets to control AKI.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8014393PMC
March 2021

Attenuated measles virus overcomes radio‑ and chemoresistance in human breast cancer cells by inhibiting the non‑homologous end joining pathway.

Oncol Rep 2020 Nov 16;44(5):2253-2264. Epub 2020 Sep 16.

Department of Clinical Laboratory, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130028, P.R. China.

Breast cancer is the most commonly diagnosed cancer and is the second leading cause of death in women. However, resistance to radio‑ and chemotherapy remains one of the major difficulties in the treatment of breast cancer. Therefore, the aim of the present study was to identify novel regimens to overcome treatment resistance in patients with breast cancer. The results of the present study demonstrated that the attenuated Edmonston‑B vaccine strain of the measles virus (MV‑Edm) significantly re‑sensitized breast cancer cells to doxorubicin and ionizing radiation. Mechanistically, MV‑Edm reduced DNA double strand repair efficiency by decreasing the mRNA and protein expression levels of p53‑binding protein 1 and disassembling the non‑homologous end joining (NHEJ) complex. NHEJ deficiency, which was achieved using DNA ligase IV knockout via CRISPR/Cas9, resulted in failure to overcome resistance mediated by MV‑Edm infection. As a result of the significant synergy between attenuated MV and radio‑ or chemotherapy, MV‑Edm provides a novel strategy for the treatment of radio‑ and chemoresistant breast cancer.
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http://dx.doi.org/10.3892/or.2020.7768DOI Listing
November 2020

[The study and clinical application of the endotypes of chronic rhinosinusitis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Aug;34(8):765-768

Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disease with an as-yet-undefined etiology. In contrast to the phenotypic classification of chronic rhinosinusitis, endotype classification is based on its underlying pathophysiological mechanisms. Endotypes of CRS can provide information on the risk of disease progression, recurrence and comorbidities, as well as identify appropriate therapeutic targets to further guide the precise treatment of CRS. This article classifies the endotypes of CRS based on cytokines, cell composition, IgE and CysLT, and outlines the clinical application of several targeted therapeutic biologics.
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http://dx.doi.org/10.13201/j.issn.2096-7993.2020.08.021DOI Listing
August 2020

[Preliminary study on life quality assessment of adult allergic rhinitis in immunotherapy, drug guidance and supervised treatment].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Mar;34(3):259-263

Department of Otolaryngology,China-Japan Union Hospital of Jilin University,Changchun,130031,China.

Effects of drugs or immunotherapy on the quality of life of adult patients with allergic rhinitis(AR) were assessed using the rhinoconjunctivitis quality of life questionnaire(RQLQ). A total of 142 patients were included, including 37 patients receiving specific immunotherapy(SIT)(SIT group). The remaining 105 patients received standardized drug treatment, and were divided into 87 cases in the receiving drug application instruction group(A1 group) and 18 cases in the non-receiving drug application instruction group(A2 group) according to whether or not receiving the drug application guidance group. According to whether or not receiving supervision of drug applications, they were divided into 33 cases of receiving drug application supervision group(B1 group) and 72 cases of non-receiving drug application supervision group(B2 group). Using telephone follow-up, RQLQ was used to evaluate the patients 'daily activities, sleep, non-nasal-eye symptoms, nasal symptoms, eye symptoms, practical problems, and emotional 7 major directions, a total of 28 small surveys. Research data was analyzed and processed by SPSS 17.0 software. The higher the education level, the higher the quality of life score of patients with allergic rhinitis(<0.05). There was no statistically significant effect of gender on psychomotor disorder in AR patients(>0.05). Immunotherapy improved nasal and ocular symptoms and possess statistical significance(<0.01). The improvement of nasal symptoms was more pronounced in SIT group and A1 group(<0.05). The quality of life of A1 group and B1 group improved significantly after treatment(<0.01). After treatment, A1 group had a significant improvement in quality of life compared to A2 group(<0.01 or <0.05); The B1 group had a significant improvement in the quality of life compared to the B2 group(<0.05 or <0.01). Life quality of AR patients can be improved to a certain extent, with simple drug therapy or immunotherapy, and SIT is more effective than drug therapy. The quality of life of AR patients can be improved by improving medication guidance and publicity.
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http://dx.doi.org/10.13201/j.issn.2096-7993.2020.03.018DOI Listing
March 2020

Mesenchymal Stem Cell-Based Therapy for Allergic Rhinitis.

Stem Cells Int 2020 10;2020:2367524. Epub 2020 Jun 10.

Department of Otolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.

Allergic rhinitis (AR) is a prevalent disorder that causes a significant and often underestimated health burden for individuals and society. The current drug treatment cannot essentially deal with the regulation of the allergic reaction, while the allergic symptoms could be alleviated. Mesenchymal stem cells (MSCs) bear a variety of properties, such as the ability to differentiate into various cell lineages, to secrete soluble factors crucial for cell survival and proliferation, to migrate to the exact site of injury, and to modulate the immune response. Clinical studies have been extensively conducted in MSCs as the models for varieties of diseases such as neurological diseases. Due to their immunomodulatory properties, the MSCs have gradually been believed to become one of the promising strategies for AR treatments although so far the MSCs-mediated treatment for AR is still at animal experiments stage. Fully understanding the roles and mechanisms of MSCs immunomodulatory effects serves as the prerequisite that will be beneficial to the application of MSCs-based AR clinical treatment methods. In this review article, we highlighted the recent research advances and give a brief perspective in the future study of the MSCs-mediated therapeutic application in AR treatments.
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http://dx.doi.org/10.1155/2020/2367524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303754PMC
June 2020

Phosphate ion functionalized CoP nanowire arrays for efficient alkaline hydrogen evolution.

Chem Commun (Camb) 2020 Jul 28;56(52):7159-7162. Epub 2020 May 28.

School of Chemistry and Materials Science, Nanjing University of Information Science and Technology, Nanjing, 210044, China.

It is revealed that phosphate ion functionalization of transition metal phosphides can achieve outstanding alkaline hydrogen evolution performance. Herein, the obtained phosphate ion functionalized CoP nanowire arrays exhibit high hydrogen evolution reaction (HER) activity (an overpotential of 112 mV to afford 100 mA cm), a low Tafel slope (49 mV dec) and outstanding stability in 1.0 M KOH.
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http://dx.doi.org/10.1039/d0cc02246bDOI Listing
July 2020

Dehydrogenation Performances of Different Al Source Composite Systems of 2LiBH + M (M = Al, LiAlH, LiAlH).

Front Chem 2020 15;8:227. Epub 2020 Apr 15.

Key Laboratory of Advanced Materials and Applications for Batteries of Zhejiang Province, Zhejiang University, Hangzhou, China.

Hydrogen has become a promising energy source due to its efficient and renewable properties. Although promising, hydrogen energy has not been in widespread use due to the lack of high-performance materials for hydrogen storage. Previous studies have shown that the addition of Al-based compounds to LiBH can create composites that have good properties for hydrogen storage. In this work, the dehydrogenation performances of different composite systems of 2LiBH+ M (M = Al, LiAlH, LiAlH) were investigated. The results show that, under a ball to powder ratio of 25:1 and a rotation speed of 300 rpm, the optimum ball milling time is 50 h for synthesizing LiAlH from LiH and LiAlH. The three studied systems destabilized LiBH at relatively low temperatures, and the 2LiBH-LiAlH composite demonstrated excellent behavior. Based on the differential scanning calorimetry results, pure LiBH released hydrogen at 469°C. The dehydrogenation temperature of LiBH is 416°C for 2LiBH-LiAlH versus 435°C for 2LiBH-LiAlH and 445°C for 2LiBH-Al. The 2LiBH-LiAlH, 2LiBH-LiAlH, and 2LiBH-Al samples released 9.1, 8, and 5.7 wt.% of H, respectively. Additionally, the 2LiBH-LiAlH composite released the 9.1 wt.% H within 150 min. An increase in the kinetics was achieved. From the results, it was concluded that 2LiBH-LiAlH exhibits the best dehydrogenation performance. Therefore, the 2LiBH-LiAlH composite is considered a promising hydrogen storage material.
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http://dx.doi.org/10.3389/fchem.2020.00227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174759PMC
April 2020

Electrical transport in amorphous nanofilms embedded with crystalline grains at low temperatures.

Nanotechnology 2020 Aug 29;31(33):335708. Epub 2020 Apr 29.

Research Center of Laser Fusion, China Academy of Engineering Physics, Mianyang 621900, People's Republic of China.

Amorphous and ferromagnetic Al-Ni nanofilms have been grown by the magnetron-sputtering method with some nanosized crystalline grains embedded therein. Resistivity is demonstrated to transit from a positive temperature coefficient to a negative temperature coefficient (NTC) with increasing the fraction of Ni atoms in the Al-Ni nanofilms. The lattice disorder is deduced to induce the Anderson localization of electrons and the formation of polarons so that the NTC of the resistivity is driven in the Al-Ni nanofilms, different from that in the elemental Al and Ni nanofilms. The electron transport in the Al-Ni nanofilms is dominated by polaron hopping while it is also determined by electron-magnon and electron-phonon scatterings. The electron-magnon scatterings are further revealed to have a more important contribution to the electron transport at low temperatures than electron-phonon scatterings in the amorphous Al-Ni nanofilms. A so-called polaron-metal physical model has thus been proposed to well explain the electron transport in disorder lattices with crystalline grains embedded therein. This study may help to optimize the design of nano-engineered devices.
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http://dx.doi.org/10.1088/1361-6528/ab8e73DOI Listing
August 2020

Chinese Society of Allergy and Chinese Society of Otorhinolaryngology-Head and Neck Surgery Guideline for Chronic Rhinosinusitis.

Allergy Asthma Immunol Res 2020 03;12(2):176-237

Department of Otolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.

The current document is based on a consensus reached by a panel of experts from the Chinese Society of Allergy and the Chinese Society of Otorhinolaryngology-Head and Neck Surgery, Rhinology Group. Chronic rhinosinusitis (CRS) affects approximately 8% of Chinese adults. The inflammatory and remodeling mechanisms of CRS in the Chinese population differ from those observed in the populations of European descent. Recently, precision medicine has been used to treat inflammation by targeting key biomarkers that are involved in the process. However, there are no CRS guidelines or a consensus available from China that can be shared with the international academia. The guidelines presented in this paper cover the epidemiology, economic burden, genetics and epigenetics, mechanisms, phenotypes and endotypes, diagnosis and differential diagnosis, management, and the current status of CRS in China. These guidelines-with a focus on China-will improve the abilities of clinical and medical staff during the treatment of CRS. Additionally, they will help international agencies in improving the verification of CRS endotypes, mapping of eosinophilic shifts, the identification of suitable biomarkers for endotyping, and predicting responses to therapies. In conclusion, these guidelines will help select therapies, such as pharmacotherapy, surgical approaches and innovative biotherapeutics, which are tailored to each of the individual CRS endotypes.
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http://dx.doi.org/10.4168/aair.2020.12.2.176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997287PMC
March 2020

Formation of persistent free radicals in biochar derived from rice straw based on a detailed analysis of pyrolysis kinetics.

Sci Total Environ 2020 May 18;715:136575. Epub 2020 Jan 18.

Faculty of Environmental Science & Engineering, Kunming University of Science & Technology, Kunming 650500, Yunnan, China; Yunnan Provincial Key Lab of Soil Carbon Sequestration and Pollution Control, Kunming 650500, Yunnan, China. Electronic address:

The presence of persistent free radicals (PFR) in biochars may greatly broaden the application of biochars in pollution control, but may also cause negative impacts to the environment. Understanding the structural basis and the formation mechanisms of PFR is essential for a targeted biochar production and application. This study used rice straw (RS), a ubiquitous agricultural waste, to investigate the generation processes of PFR in relation to RS pyrolysis kinetics. Based on a detailed thermogravimetric (TG) and derivative thermogravimetric (DTG) analysis, the activation energy was calculated by Kissinger-Akahira-Sunose (KAS) and Flynn-Wall-Ozawa (FWO) methods. This work combined pyrolysis kinetics analysis and solid particle characterization. Our results showed that lignin started to pyrolyze at a lower temperature than cellulose and hemicellulose. Lignin was the main factor for PFR generation. Chemical bond breaking contributed only slightly to PFR formation. The reconfiguration of the carbonaceous structures may be a more important contributor to PFR formation, while the cross-linking between different compositions and the interactions between the chemical compositions and inorganic minerals may play a significant role for PFR generation and stabilization in RS. This study provides useful theoretical basis to understand the thermal pyrolysis process of RS and the manipulation of biochar properties.
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http://dx.doi.org/10.1016/j.scitotenv.2020.136575DOI Listing
May 2020

Structure Engineering of MoS via Simultaneous Oxygen and Phosphorus Incorporation for Improved Hydrogen Evolution.

Small 2020 Jan 1;16(4):e1905738. Epub 2020 Jan 1.

School of Chemistry and Materials Science, Nanjing University of Information Science and Technology, Nanjing, 210044, P. R. China.

Oxygen and phosphorus dual-doped MoS nanosheets (O,P-MoS ) with porous structure and continuous conductive network are fabricated using a one-pot NaH PO -assisted hydrothermal approach. By simply changing the precursor solution, the chemical composition and resulting structure can be effectively controlled to obtain desired properties toward the hydrogen evolution reaction (HER). Thanks to the beneficial structure and strong synergistic effects between the incorporated oxygen and phosphorus, the optimal O,P-MoS exhibit superior electrocatalytic performances compared with those of oxygen single-doped MoS nanosheets (O-MoS ). Specifically, a low HER onset overpotential of 150 mV with a small Tafel slope of 53 mV dec , excellent conductivity, and long-term durability are achieved by the structural engineering of MoS via O and P co-doping, making it an efficient HER electrocatalyst for water electrocatalysis. This work provides an alternative strategy to manipulate transition metal dichalcogenides as advanced materials for electrocatalytic and related energy applications.
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http://dx.doi.org/10.1002/smll.201905738DOI Listing
January 2020

A Hybrid Na//K-Containing Electrolyte//O Battery with High Rechargeability and Cycle Stability.

Research (Wash D C) 2019 16;2019:6180615. Epub 2019 Jan 16.

Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), College of Chemistry, Nankai University, Tianjin 300071, China.

Na-O and K-O batteries have attracted extensive attention in recent years. However, the parasitic reactions involving the discharge product of NaO or K anode with electrolytes and the severe Na or K dendrites plague their rechargeability and cycle stability. Herein, we report a hybrid Na//K-containing electrolyte//O battery consisting of a Na anode, 1.0 M of potassium triflate in diglyme, and a porous carbon cathode. Upon discharging, KO is preferentially produced via oxygen reduction in the cathode with Na stripped from the Na anode, and reversely, the KO is electrochemically decomposed with Na plated back onto the anode. The new reaction pathway can circumvent the parasitic reactions involving instable NaO and active K anode, and alternatively, the good stability and conductivity of KO and stable Na stripping/plating in the presence of K enable the hybrid battery to exhibit an average discharge/charge voltage gap of 0.15 V, high Coulombic efficiency of >96%, and superior cycling stability of 120 cycles. This will pave a new pathway to promote metal-air batteries.
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http://dx.doi.org/10.34133/2019/6180615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750056PMC
January 2019

Expression of programmed cell death-ligand 1 in primary testicular diffuse large B cell lymphoma: A retrospective study.

Oncol Lett 2019 Sep 9;18(3):2670-2676. Epub 2019 Jul 9.

Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Center, Beijing 100034, P.R. China.

The present study evaluated programmed cell death-ligand 1 (PD-L1) expression in tumor cells and in the tumor microenvironment (TME) and its association with clinical data in primary testicular diffuse large B cell lymphoma (DLBCL). PD-L1 was determined by immunohistochemistry in 30 patients with primary testicular DLBCL and assessed for associations with clinical characteristics, progression-free survival (PFS) and overall survival (OS). The mean patient age was 62.2 years. Overall, 10 (33.3%) patients had advanced-stage (stage III/IV) disease and 14 (46.7%) patients had an International Prognostic Index (IPI) of ≥3. The median follow-up time following orchiectomy was 23.5 months. During this time, 10 (33.3%) patients experienced disease progression and 11 (36.7%) patients succumbed. PD-L1 expression in tumor cells and in the TME was detected in 20 (66.7%) and 13 (43.3%) patients, respectively. PD-L1 expression on tumor cells and in the TME was higher in those at an early stage compared with patients with an advanced stage of disease (P=0.045 and 0.017, respectively). In addition, PD-L1 expression in tumor cells was higher in patients with a low IPI compared with those with a high IPI (P=0.019). A Kaplan-Meier analysis identified no association of PD-L1 expression on tumor cells with PFS (P=0.763) or OS (P=0.531), or of PD-L1 expression in the TME with PFS (P=0.572) or OS (P=0.934). The present study demonstrated that PD-L1 expression in tumor cells and in the TME was higher in patients at an early stage of disease compared with those at an advanced stage, and that PD-L1 expression on tumor cells was higher in patients with a low IPI than in those with a high IPI. Furthermore, PD-L1 expression in tumor cells and in the TME was not associated with PFS or OS.
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http://dx.doi.org/10.3892/ol.2019.10595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676532PMC
September 2019

Photoinduced Oxygen Reduction Reaction Boosts the Output Voltage of a Zinc-Air Battery.

Angew Chem Int Ed Engl 2019 Sep 1;58(36):12460-12464. Epub 2019 Aug 1.

Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Renewable Energy Conversion and Storage Center (RECAST), College of Chemistry, Nankai University, Tianjin, 300071, China.

Utilization of solar energy is of great interest for a sustainable society, and its conversion into electricity in a compact battery is challenging. Herein, a zinc-air battery with the polymer semiconductor polytrithiophene (pTTh) as the cathode is reported for direct conversion of photoenergy into electric energy. Upon irradiation, photoelectrons are generated in the conduction band (CB) of pTTh and then injected into the π * orbitals of O for its reduction to HO , which is disproportionated to OH and drives the oxidation of Zn to ZnO at the anode. The discharge voltage was significantly increased to 1.78 V without decay during discharge-charge cycles over 64 h, which corresponds to an energy density increase of 29.0 % as compared to 1.38 V for a zinc-air battery with state-of-the-art Pt/C. The zinc-air battery with an intrinsically different reaction scheme for simultaneous conversion of chemical and photoenergy into electric energy opens a new pathway for utilization of solar energy.
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http://dx.doi.org/10.1002/anie.201905954DOI Listing
September 2019

Hydrogen Desorption Properties of LiBH/LiAlH ( = 0.5, 1, 2) Composites.

Molecules 2019 May 15;24(10). Epub 2019 May 15.

Key Laboratory of Air-driven Equipment Technology of Zhejiang Province, Quzhou University, Quzhou 324000, China.

A detailed analysis of the dehydrogenation mechanism of LiBH/LiAlH ( = 0.5, 1, 2) composites was performed by thermogravimetry (TG), differential scanning calorimetry (DSC), mass spectral analysis (MS), powder X-ray diffraction (XRD) and scanning electronic microscopy (SEM), along with kinetic investigations using a Sievert-type apparatus. The results show that the dehydrogenation pathway of LiBH/LiAlH had a four-step character. The experimental dehydrogenation amount did not reach the theoretical expectations, because the products such as AlB and LiAl formed a passivation layer on the surface of Al and the dehydrogenation reactions associated with Al could not be sufficiently carried out. Kinetic investigations discovered a nonlinear relationship between the activation energy (E) of dehydrogenation reactions associated with Al and the ratio , indicating that the E was determined both by the concentration of Al produced by the decomposition of LiAlH and the amount of free surface of it. Therefore, the amount of effective contact surface of Al is the rate-determining factor for the overall dehydrogenation of the LiBH/LiAlH composites.
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http://dx.doi.org/10.3390/molecules24101861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572031PMC
May 2019

Engineering 2D Metal-Organic Framework/MoS Interface for Enhanced Alkaline Hydrogen Evolution.

Small 2019 Apr 3;15(14):e1805511. Epub 2019 Mar 3.

School of Chemical Engineering, The University of Adelaide, Adelaide, SA, 5005, Australia.

2D metal-organic frameworks (MOFs) have been widely investigated for electrocatalysis because of their unique characteristics such as large specific surface area, tunable structures, and enhanced conductivity. However, most of the works are focused on oxygen evolution reaction. There are very limited numbers of reports on MOFs for hydrogen evolution reaction (HER), and generally these reported MOFs suffer from unsatisfactory HER activities. In this contribution, novel 2D Co-BDC/MoS (BDC stands for 1,4-benzenedicarboxylate, C H O ) hybrid nanosheets are synthesized via a facile sonication-assisted solution strategy. The introduction of Co-BDC induces a partial phase transfer from semiconducting 2H-MoS to metallic 1T-MoS . Compared with 2H-MoS , 1T-MoS can activate the inert basal plane to provide more catalytic active sites, which contributes significantly to improving HER activity. The well-designed Co-BDC/MoS interface is vital for alkaline HER, as Co-BDC makes it possible to speed up the sluggish water dissociation (rate-limiting step for alkaline HER), and modified MoS is favorable for the subsequent hydrogen generation step. As expected, the resultant 2D Co-BDC/MoS hybrid nanosheets demonstrate remarkable catalytic activity and good stability toward alkaline HER, outperforming those of bare Co-BDC, MoS , and almost all the previously reported MOF-based electrocatalysts.
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http://dx.doi.org/10.1002/smll.201805511DOI Listing
April 2019

A 2D metal-organic framework/Ni(OH) heterostructure for an enhanced oxygen evolution reaction.

Nanoscale 2019 Feb;11(8):3599-3605

School of Chemical Engineering, The University of Adelaide, Adelaide, SA 5005, Australia.

2D metal-organic frameworks (MOFs) are widely regarded as promising electrocatalysts for the oxygen evolution reaction (OER). This results from their inherent properties such as a large portion of surface coordinatively unsaturated metal atoms, rapid mass transfer and enhanced conductivity. However, 2D MOFs have a strong tendency to aggregate, which severely limits their potential application in the OER. Here, novel 2D Ni-BDC/Ni(OH)2 (BDC stands for 1,4-benzenedicarboxylate, C8H4O4) hybrid nanosheets are synthesized via a facile sonication-assisted solution method. Because of the rational material design, the large surface area of Ni-BDC is maintained. Significantly, after coupling, the electronic structure of Ni atoms in the Ni(OH)2 component is well modified, leading to the generation of Ni cations with higher oxidation states, which are desirable for the OER. As-prepared Ni-BDC/Ni(OH)2 exhibits high activity, favorable kinetics and strong durability towards the OER. Specifically, the OER current density of Ni-BDC/Ni(OH)2 is 82.5 mA cm-2 at 1.6 V versus a reversible hydrogen electrode (RHE), which is significantly greater than those of Ni-BDC (5.5 times), Ni(OH)2 (20.6 times) and Ir/C (3.0 times). Moreover, the sonication-assisted method developed in this work can be readily adapted for the preparation of various 2D MOF-based hybrid functional materials.
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http://dx.doi.org/10.1039/c8nr09680eDOI Listing
February 2019

A Simple Modification for the Usage of Flexible Cystoscope in Modified Laparoscopic Pyeloplasty for Ureteropelvic Junction Obstruction with Renal Calculi: A Flexible Guiding Tube.

Urol Int 2019 10;102(3):262-268. Epub 2019 Jan 10.

Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Center, Beijing, China.

Objective: To present our technique of laparoscopic pyeloplasty (LP) with concomitant pyelolithotomy in ureteropelvic junction obstruction (UPJO) complicated by renal calculi and compare outcome with a group of UPJO patients undergoing modified LP without coexistent calculi.

Materials And Methods: We retrospectively reviewed the charts of 51 UPJO patients undergoing modified LP from January 2013 to November 2016 at our institution. Sixteen patients were diagnosed as UPJO with coexistent ipsilateral renal calculi and underwent pyelolithotomy using our modified technique at the time of modified LP. The outcome data of this group were compared with those of 16 matched patients undergoing modified LP without calculi.

Results: No conversion to open surgery occurred. The mean operative time for modified LP and pyelolithotomy was 151.6 min, while the mean operative time for modified LP was 137.6 min (p = 0.21). Additionally, no differences in estimated blood loss (p = 0.96) or postoperative complications (p = 1.00) were observed between the 2 groups. The stone-free rate was 100%. During a mean follow-up of 27.1 months, there were no recurrent calculi or secondary UPJO.

Conclusions: The combination of our novel flexible guiding tube and modified suture technique provides a practical and economic approach with satisfying outcome in the treating of UPJO with concomitant renal calculi.
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http://dx.doi.org/10.1159/000495569DOI Listing
December 2019

Cumulative Sum Analysis of the Learning Curve for Modified Retroperitoneoscopic Living-Donor Nephrectomy.

Urol Int 2018 24;101(4):425-436. Epub 2018 Oct 24.

Objectives: To introduce our modified retroperitoneoscopic living-donor nephrectomy (RPLDN) techniques and estimate the learning curve.

Methods: We retrospectively evaluated 121 consecutive donors who underwent modified RPLDN performed by a single surgeon. While the surgeon controlled the renal vessels, one hand was inserted through an abdominal incision for assistance. The kidney was manually retrieved through the abdominal incision. The learning curve was evaluated using the cumulative sum (CUSUM) method, which was a graphical method showing changes in individual surgical performance.

Results: The mean operating time and warm ischemic time (WIT) were 129.4 min and 154.5 s, respectively. The mean estimated blood loss (EBL) was 44.4 mL. Regarding intraoperative complications, no open conversions or blood transfusions were required. The CUSUM learning curve included the following 3 unique phases: phase 1 (the initial 32 cases), representing the initial learning curve; phase 2 (the middle 38 cases), representing expert competence; and phase 3 (the final 51 cases), representing mastery.

Conclusions: Our modified method has the advantages of a short operating time, an optimized WIT, a low EBL, and acceptable complication rates. The surgeon completed the initial learning phase of RPLDN after 32 cases and could effectively perform RPLDN after 70 cases.
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http://dx.doi.org/10.1159/000493765DOI Listing
March 2019

Head-to-Head Comparison of Modified Laparoscopic Pyeloplasty and Robot-Assisted Pyeloplasty for Ureteropelvic Junction Obstruction in China.

Urol Int 2018 19;101(3):337-344. Epub 2018 Sep 19.

Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Center, Beijing, China.

Objective: To compare the outcomes of modified laparoscopic pyeloplasty (LP) and robot-assisted pyeloplasty (RLP) for ureteropelvic junction obstruction (UPJO) in China patients.

Materials And Methods: We retrospectively reviewed the medical records of patients who underwent modified LP and RLP using a transperitoneal laparoscopic approach at 2 different medical institutions between October 2009 and November 2017.

Results: Seventy-six patients underwent modified LP and 140 patients underwent RLP. No open conversion occurred. The mean operative time of RLP was shorter than that of modified LP (p = 0.042). For UPJO concomitant with renal calculi, there was no difference in operative time between 2 groups (p = 0.656). With RLP, the operative time for UPJO concomitant with horseshoe was shorter (p = 0.011). In terms of complication rate, there was no significant difference between 2 groups (p = 0.596). The postoperative hospital stay for modified LP was shorter than that for RLP (p < 0.05). The mean follow-up time for modified LP and RLP was 31.79 months and 10.85 months respectively (p < 0.05). The success rate was 96.05 and 97.86% for modified LP and RLP, respectively (p = 0.736).

Conclusions: Modified LP and RLP are safe and efficient treatment for UPJO with similar success rates.
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http://dx.doi.org/10.1159/000492337DOI Listing
April 2019

Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis.

Allergy Asthma Immunol Res 2018 Jul;10(4):300-353

Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China.

Allergic rhinitis (AR) is a global health problem that causes major illnesses and disabilities worldwide. Epidemiologic studies have demonstrated that the prevalence of AR has increased progressively over the last few decades in more developed countries and currently affects up to 40% of the population worldwide. Likewise, a rising trend of AR has also been observed over the last 2-3 decades in developing countries including China, with the prevalence of AR varying widely in these countries. A survey of self-reported AR over a 6-year period in the general Chinese adult population reported that the standardized prevalence of adult AR increased from 11.1% in 2005 to 17.6% in 2011. An increasing number of Journal Articles and imporclinical trials on the epidemiology, pathophysiologic mechanisms, diagnosis, management and comorbidities of AR in Chinese subjects have been published in international peer-reviewed journals over the past 2 decades, and substantially added to our understanding of this disease as a global problem. Although guidelines for the diagnosis and treatment of AR in Chinese subjects have also been published, they have not been translated into English and therefore not generally accessible for reference to non-Chinese speaking international medical communities. Moreover, methods for the diagnosis and treatment of AR in China have not been standardized entirely and some patients are still treated according to regional preferences. Thus, the present guidelines have been developed by the Chinese Society of Allergy to be accessible to both national and international medical communities involved in the management of AR patients. These guidelines have been prepared in line with existing international guidelines to provide evidence-based recommendations for the diagnosis and management of AR in China.
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http://dx.doi.org/10.4168/aair.2018.10.4.300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021586PMC
July 2018

Lower posterior mediastinal benign schwannoma successfully resected with retroperitoneoscopy using a transdiaphragmatic approach: A case report.

Thorac Cancer 2018 08 20;9(8):1087-1089. Epub 2018 Jun 20.

Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Center, Beijing, China.

Lower posterior mediastinal tumors are traditionally excised by conventional thoracotomy or thoracoscopic approaches; however, use of the transdiaphragmatic retroperitoneoscopic approach for these tumors has rarely been reported. Herein, we report a case of a left lower posterior mediastinal paravertebral benign schwannoma in an adult male that was successfully treated with transdiaphragmatic retroperitoneoscopic surgery. The patient presented with no symptoms but had noticed a lesion in the left lower posterior mediastinum two months prior. He underwent transdiaphragmatic retroperitoneoscopic surgery with total resection of the mediastinal mass. To the best of our knowledge, this is the most detailed and challenging case of transdiaphragmatic retroperitoneoscopic surgery to treat a schwannoma in the left lower posterior mediastinum reported to date.
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http://dx.doi.org/10.1111/1759-7714.12786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068460PMC
August 2018
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