Dong-Soon Im

Dong-Soon Im

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Dong-Soon Im

Publications by authors named "Dong-Soon Im"

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Pro-Inflammatory Role of S1P in Macrophages.

Biomol Ther (Seoul) 2019 Jul;27(4):373-380

College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea.

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http://dx.doi.org/10.4062/biomolther.2018.215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609111PMC
July 2019

Suppressive effects of type I angiotensin receptor antagonists, candesartan and irbesartan on allergic asthma.

Eur J Pharmacol 2019 Jun 21;852:25-33. Epub 2019 Feb 21.

College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2019.02.035DOI Listing
June 2019

Lodoxamide Attenuates Hepatic Fibrosis in Mice: Involvement of GPR35

Biomol Ther (Seoul) 2019 06 13:92-97. Epub 2019 Jun 13.

College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea.

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http://dx.doi.org/10.4062/biomolther.2018.227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939691PMC
June 2019

Deficiency of Sphingosine-1-Phosphate Receptor 2 (S1P) Attenuates Bleomycin-Induced Pulmonary Fibrosis.

Biomol Ther (Seoul) 2019 May;27(3):318-326

College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea.

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http://dx.doi.org/10.4062/biomolther.2018.131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513183PMC
May 2019

Blockage of sphingosine-1-phosphate receptor 2 attenuates allergic asthma in mice.

Br J Pharmacol 2019 04 14;176(7):938-949. Epub 2019 Mar 14.

Molecular Inflammation Research Center for Aging Intervention (MRCA) and College of Pharmacy, Pusan National University, Busan, Korea.

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http://dx.doi.org/10.1111/bph.14597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433643PMC
April 2019

Anti-allergic effects of salvianolic acid A and tanshinone IIA from Salvia miltiorrhiza determined using in vivo and in vitro experiments.

Int Immunopharmacol 2019 Feb 8;67:69-77. Epub 2018 Dec 8.

College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15675769183101
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http://dx.doi.org/10.1016/j.intimp.2018.12.010DOI Listing
February 2019

Protective effect of lodoxamide on hepatic steatosis through GPR35.

Cell Signal 2019 01 7;53:190-200. Epub 2018 Oct 7.

College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08986568183025
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http://dx.doi.org/10.1016/j.cellsig.2018.10.001DOI Listing
January 2019

FFA4 (GPR120) as a fatty acid sensor involved in appetite control, insulin sensitivity and inflammation regulation.

Authors:
Dong-Soon Im

Mol Aspects Med 2018 12 12;64:92-108. Epub 2017 Oct 12.

Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2017.09.001DOI Listing
December 2018

Suppressive Effect of 4-Hydroxy-2-(4-Hydroxyphenethyl) Isoindoline-1,3-Dione on Ovalbumin-Induced Allergic Asthma.

Biomol Ther (Seoul) 2018 Nov;26(6):539-545

Molecular Inflammation Research Center for Aging Intervention (MRCA) and College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea.

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http://dx.doi.org/10.4062/biomolther.2018.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254637PMC
November 2018

Bacterial ornithine lipid, a surrogate membrane lipid under phosphate-limiting conditions, plays important roles in bacterial persistence and interaction with host.

Environ Microbiol 2018 11 28;20(11):3992-4008. Epub 2018 Oct 28.

Department of Pharmacy, College of Pharmacy, Pusan National University, Busan, 609-735, South Korea.

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http://dx.doi.org/10.1111/1462-2920.14430DOI Listing
November 2018

A bile acid derivative with PPARγ-mediated anti-inflammatory activity.

Steroids 2018 09 4;137:40-46. Epub 2018 Aug 4.

College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.steroids.2018.07.011DOI Listing
September 2018

Anti-allergic effects of sesquiterpene lactones from Saussurea costus (Falc.) Lipsch. determined using in vivo and in vitro experiments.

J Ethnopharmacol 2018 Mar 20;213:256-261. Epub 2017 Nov 20.

Molecular Inflammation Research Center for Aging Intervention (MRCA) and College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2017.11.018DOI Listing
March 2018

Omega-3 polyunsaturated fatty acids protect human hepatoma cells from developing steatosis through FFA4 (GPR120).

Biochim Biophys Acta Mol Cell Biol Lipids 2018 Feb 7;1863(2):105-116. Epub 2017 Nov 7.

Molecular Inflammation Research Center for Aging Intervention (MRCA) and College of Pharmacy, Pusan National University, Busan 469241, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2017.11.002DOI Listing
February 2018

GPR35 mediates lodoxamide-induced migration inhibitory response but not CXCL17-induced migration stimulatory response in THP-1 cells; is GPR35 a receptor for CXCL17?

Br J Pharmacol 2018 01 8;175(1):154-161. Epub 2017 Dec 8.

Molecular Inflammation Research Center for Aging Intervention (MRCA) and College of Pharmacy, Pusan National University, Busan, Korea.

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http://dx.doi.org/10.1111/bph.14082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740256PMC
January 2018

Ginsenoside Rg promotes inflammation resolution through M2 macrophage polarization.

J Ginseng Res 2018 Jan 1;42(1):68-74. Epub 2017 Jan 1.

Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan, Republic of Korea.

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https://linkinghub.elsevier.com/retrieve/pii/S12268453163008
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http://dx.doi.org/10.1016/j.jgr.2016.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766702PMC
January 2018

Free Fatty Acid Receptor 4 Mediates the Beneficial Effects of n-3 Fatty Acids on Body Composition in Mice.

Calcif Tissue Int 2017 12 12;101(6):654-662. Epub 2017 Sep 12.

Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.

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http://dx.doi.org/10.1007/s00223-017-0323-yDOI Listing
December 2017

Apelin protects against liver X receptor-mediated steatosis through AMPK and PPARα in human and mouse hepatocytes.

Cell Signal 2017 11 15;39:84-94. Epub 2017 Aug 15.

Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2017.08.003DOI Listing
November 2017

The critical role played by endotoxin-induced liver autophagy in the maintenance of lipid metabolism during sepsis.

Autophagy 2017 Jul 2;13(7):1113-1129. Epub 2017 Jun 2.

a Molecular Inflammation Research Center for Aging Intervention (MRCA) , College of Pharmacy, Pusan National University , Busan , South Korea.

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http://dx.doi.org/10.1080/15548627.2017.1319040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529074PMC
July 2017

ω-3 Polyunsaturated fatty acids accelerate airway repair by activating FFA4 in club cells.

Am J Physiol Lung Cell Mol Physiol 2017 06 17;312(6):L835-L844. Epub 2017 Mar 17.

Molecular Inflammation Research Center for Aging Intervention and College of Pharmacy, Pusan National University, Busan, Republic of Korea;

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http://dx.doi.org/10.1152/ajplung.00350.2016DOI Listing
June 2017

Calcium Signaling of Lysophosphatidylethanolamine through LPA in Human SH-SY5Y Neuroblastoma Cells.

Biomol Ther (Seoul) 2017 Mar;25(2):194-201

Molecular Inflammation Research Center for Aging Intervention (MRCA) and College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea.

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http://dx.doi.org/10.4062/biomolther.2016.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340545PMC
March 2017

Sphingosine 1-Phosphate Receptor Modulators and Drug Discovery.

Biomol Ther (Seoul) 2017 Jan;25(1):80-90

Molecular Inflammation Research Center for Aging Intervention (MRCA) and College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea.

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http://dx.doi.org/10.4062/biomolther.2016.160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207465PMC
January 2017

The In Vitro and In Vivo Anti-Inflammatory Effects of a Phthalimide PPAR-γ Agonist.

Mar Drugs 2017 Jan 4;15(1). Epub 2017 Jan 4.

College of Pharmacy, Pusan National University, Busan 609-735, Korea.

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http://dx.doi.org/10.3390/md15010007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295227PMC
January 2017

β-Hydroxybutyrate suppresses inflammasome formation by ameliorating endoplasmic reticulum stress via AMPK activation.

Oncotarget 2016 Oct;7(41):66444-66454

Molecular Inflammation Research Center for Aging Intervention, College of Pharmacy, Pusan National University, Geumjeong-gu, Busan, Republic of Korea.

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http://dx.doi.org/10.18632/oncotarget.12119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341812PMC
October 2016

Functions of omega-3 fatty acids and FFA4 (GPR120) in macrophages.

Authors:
Dong-Soon Im

Eur J Pharmacol 2016 Aug 15;785:36-43. Epub 2015 May 15.

Molecular Inflammation Research Center for Aging Intervention (MRCA) and College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2015.03.094DOI Listing
August 2016

Free Fatty Acid Receptor 4 (GPR120) Stimulates Bone Formation and Suppresses Bone Resorption in the Presence of Elevated n-3 Fatty Acid Levels.

Endocrinology 2016 07 4;157(7):2621-35. Epub 2016 May 4.

Department of Endocrinology and Metabolism (S.H.A.), Inha University Hospital, Inha University School of Medicine, Incheon 402-751, South Korea; Asan Institute for Life Sciences (S.-Y.P., J.-E.B., S.-Youn.L., W.-.Y.B., S.-Young.L., Y.-S.L.) and Biomedical Research Center (H.J.Y.) and Division of Endocrinology and Metabolism (H.K., S.H.L., B.-J.K., J.-M.K.), Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea; Molecular Inflammation Research Center for Aging Intervention and College of Pharmacy (D.-S.I.), Pusan National University, Busan 609-735, South Korea; and UConn Center on Aging (S.-K.L.), University of Connecticut Health Center, Farmington, Connecticut 06030-1601.

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http://dx.doi.org/10.1210/en.2015-1855DOI Listing
July 2016

Anti-Allergic Effect of Oroxylin A from Oroxylum indicum Using in vivo and in vitro Experiments.

Biomol Ther (Seoul) 2016 May;24(3):283-90

Molecular Inflammation Research Center for Aging Intervention (MRCA) and College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea.

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http://dx.doi.org/10.4062/biomolther.2016.071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859791PMC
May 2016

Petatewalide B, a novel compound from Petasites japonicus with anti-allergic activity.

J Ethnopharmacol 2016 Feb 7;178:17-24. Epub 2015 Dec 7.

Molecular Inflammation Research Center for Aging Intervention (MRCA) and College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2015.12.010DOI Listing
February 2016

Cytochalasin derivatives from a jellyfish-derived fungus Phoma sp.

Bioorg Med Chem Lett 2015 3;25(10):2096-9. Epub 2015 Apr 3.

College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.03.080DOI Listing
January 2016

Anti-allergic effect of α-cubebenoate isolated from Schisandra chinensis using in vivo and in vitro experiments.

J Ethnopharmacol 2015 Sep 4;173:361-9. Epub 2015 Aug 4.

Molecular Inflammation Research Center for Aging Intervention (MRCA) and College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2015.07.049DOI Listing
September 2015

Age-related sensitivity to endotoxin-induced liver inflammation: Implication of inflammasome/IL-1β for steatohepatitis.

Aging Cell 2015 Aug 7;14(4):524-33. Epub 2015 Apr 7.

Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan, Korea.

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http://dx.doi.org/10.1111/acel.12305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531067PMC
August 2015

Upregulation of Collagen Expression via PPARβ/δ Activation in Aged Skin by Magnesium Lithospermate B from Salvia miltiorrhiza.

J Nat Prod 2015 Aug 17;78(8):2110-5. Epub 2015 Aug 17.

Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University , Busan 609-735, Republic of Korea.

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http://dx.doi.org/10.1021/acs.jnatprod.5b00348DOI Listing
August 2015

Omega-3 fatty acids induce Ca(2+) mobilization responses in human colon epithelial cell lines endogenously expressing FFA4.

Acta Pharmacol Sin 2015 Jul 25;36(7):813-20. Epub 2015 May 25.

Molecular Inflammation Research Center for Aging Intervention (MRCA) and College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.

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http://dx.doi.org/10.1038/aps.2015.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648116PMC
July 2015

Lysophosphatidylethanolamine increases intracellular Ca(2+) through LPA(1) in PC-12 neuronal cells.

Biochem Biophys Res Commun 2015 May 16;461(2):378-82. Epub 2015 Apr 16.

Molecular Inflammation Research Center for Aging Intervention (MRCA), and College of Pharmacy, Pusan National University, Busan, 609-735, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.04.042DOI Listing
May 2015

The essential role of FoxO6 phosphorylation in aging and calorie restriction.

Age (Dordr) 2014 10;36(4):9679. Epub 2014 Jul 10.

Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Gumjung-gu, Busan, 609-735, Republic of Korea.

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http://dx.doi.org/10.1007/s11357-014-9679-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150907PMC
March 2015

Therapeutic effects of s-petasin on disease models of asthma and peritonitis.

Biomol Ther (Seoul) 2015 Jan 1;23(1):45-52. Epub 2015 Jan 1.

Molecular Inflammation Research Center for Aging Intervention (MRCA) and College of Pharmacy, Pusan National University, Busan 609-735.

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http://dx.doi.org/10.4062/biomolther.2014.069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286749PMC
January 2015

Age-related inflammation and insulin resistance: a review of their intricate interdependency.

Arch Pharm Res 2014 Dec 20;37(12):1507-14. Epub 2014 Sep 20.

Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan, 609-735, Republic of Korea.

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http://dx.doi.org/10.1007/s12272-014-0474-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246128PMC
December 2014

Sphingosine 1-phosphate induced anti-atherogenic and atheroprotective M2 macrophage polarization through IL-4.

Cell Signal 2014 Oct 14;26(10):2249-58. Epub 2014 Jul 14.

Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea; Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University, 3-39-15 Showa-machi, Maebashi 371-8512, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2014.07.009DOI Listing
October 2014

Inhibition of interleukin-1β production by extracellular acidification through the TDAG8/cAMP pathway in mouse microglia.

J Neurochem 2014 May 10;129(4):683-95. Epub 2014 Feb 10.

Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.

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http://dx.doi.org/10.1111/jnc.12661DOI Listing
May 2014

Identification of a novel anti-inflammatory compound, α-cubebenoate from Schisandra chinensis.

J Ethnopharmacol 2014 Apr 21;153(1):242-9. Epub 2014 Feb 21.

Molecular Inflammation Research Center for Aging Intervention (MRCA) and College of Pharmacy, Pusan National University, 63 Beon-gil 2, Busandaehag-ro, Geumjeong-gu, Busan 609-735, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2014.02.027DOI Listing
April 2014

Lipoprotein-associated lysolipids are differentially involved in high-density lipoprotein- and its oxidized form-induced neurite remodeling in PC12 cells.

Neurochem Int 2014 Mar 28;68:38-47. Epub 2014 Feb 28.

Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi 371-8512, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.neuint.2014.02.005DOI Listing
March 2014

Action and Signaling of Lysophosphatidylethanolamine in MDA-MB-231 Breast Cancer Cells.

Biomol Ther (Seoul) 2014 Feb;22(2):129-35

Molecular Inflammation Research Center for Aging Intervention (MRCA) and College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.

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http://dx.doi.org/10.4062/biomolther.2013.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975480PMC
February 2014

Lysophosphatidylethanolamine utilizes LPA(1) and CD97 in MDA-MB-231 breast cancer cells.

Cell Signal 2013 Nov 6;25(11):2147-54. Epub 2013 Jul 6.

Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.

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http://dx.doi.org/10.1016/j.cellsig.2013.07.001DOI Listing
November 2013

Yin and Yang of ginseng pharmacology: ginsenosides vs gintonin.

Acta Pharmacol Sin 2013 Nov 14;34(11):1367-73. Epub 2013 Oct 14.

Molecular Inflammation Research Center for Aging Intervention (MRCA) and College of Pharmacy, Pusan National University, Busan 609-735, Korea.

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http://www.nature.com/articles/aps2013100
Publisher Site
http://dx.doi.org/10.1038/aps.2013.100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818586PMC
November 2013

Intercellular Lipid Mediators and GPCR Drug Discovery.

Authors:
Dong-Soon Im

Biomol Ther (Seoul) 2013 Nov;21(6):411-22

Molecular Inflammation Research Center for Aging Intervention (MRCA) and College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.

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http://dx.doi.org/10.4062/biomolther.2013.080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879912PMC
November 2013

How to die chemically? Whole body apoptosis.

Authors:
Dong-Soon Im

Arch Pharm Res 2013 Aug 17;36(8):919-21. Epub 2013 Apr 17.

Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, 63 Beon-gil 2, Busandaehag-ro, Geumjeong-gu, Busan 609-735, Republic of Korea.

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http://dx.doi.org/10.1007/s12272-013-0122-6DOI Listing
August 2013

Anti-allergic and anti-inflammatory effects of bakkenolide B isolated from Petasites japonicus leaves.

J Ethnopharmacol 2013 Jul 25;148(3):890-4. Epub 2013 May 25.

Molecular Inflammation Research Center for Aging Intervention and College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.

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http://dx.doi.org/10.1016/j.jep.2013.05.037DOI Listing
July 2013

Red Liriope platyphylla stimulated the insulin secretion through the regulation of calcium concentration in rat insulinoma cells and animal models.

Lab Anim Res 2013 Jun 24;29(2):84-95. Epub 2013 Jun 24.

Department of Biomaterials Science, College of Natural Resources & Life Science, Pusan National University, Miryang, Korea.

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http://dx.doi.org/10.5625/lar.2013.29.2.84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696629PMC
June 2013

Omega-3 fatty acids in anti-inflammation (pro-resolution) and GPCRs.

Authors:
Dong-Soon Im

Prog Lipid Res 2012 Jul 20;51(3):232-7. Epub 2012 Apr 20.

Molecular Inflammation Research Center for Aging Intervention-MRCA, College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.

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http://dx.doi.org/10.1016/j.plipres.2012.02.003DOI Listing
July 2012

Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo.

Cancer Sci 2012 Jun 15;103(6):1099-104. Epub 2012 Mar 15.

Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2012.02246.xDOI Listing
June 2012

First-in-class antifibrotic therapy targeting type 1 lysophosphatidic acid receptor.

Authors:
Dong-Soon Im

Arch Pharm Res 2012 Jun;35(6):945-8

College of Pharmacy (BK21 Project) and Longevity Institute of Life Science and Technology, Pusan National University, Busan 609-735, Korea.

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http://dx.doi.org/10.1007/s12272-012-0600-2DOI Listing
June 2012

Effect of Di-(2-ethylhexyl)-phthalate on Sphingolipid Metabolic Enzymes in Rat Liver.

Toxicol Res 2011 Sep;27(3):185-90

Laboratories of Pharmacology, Pusan National University, Busan 609-735, Korea.

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http://dx.doi.org/10.5487/TR.2011.27.3.185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834377PMC
September 2011

A promising anti-inflammatory and anti-thrombotic drug for sepsis treatment.

Authors:
Dong-Soon Im

Arch Pharm Res 2011 Mar;34(3):339-42

College of Pharmacy, Longevity Institute of Life Science and Technology, Pusan National University, Busan, Korea.

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http://dx.doi.org/10.1007/s12272-011-0300-3DOI Listing
March 2011

Sphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis.

Arterioscler Thromb Vasc Biol 2011 Jan 14;31(1):81-5. Epub 2010 Oct 14.

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA.

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http://dx.doi.org/10.1161/ATVBAHA.110.213496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013369PMC
January 2011

Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors.

Authors:
Dong-Soon Im

Acta Pharmacol Sin 2010 Sep 23;31(9):1213-22. Epub 2010 Aug 23.

Longevity Institute of Life Science and Technology, Pusan National University, Busan, Republic of Korea.

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http://dx.doi.org/10.1038/aps.2010.135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002311PMC
September 2010

Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics.

J Exp Med 2010 Jul 28;207(7):1475-83. Epub 2010 Jun 28.

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA.

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http://dx.doi.org/10.1084/jem.20091343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901064PMC
July 2010

Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation.

J Immunol 2010 Feb 30;184(3):1475-83. Epub 2009 Dec 30.

Department of Cell Biology, Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://dx.doi.org/10.4049/jimmunol.0901586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068864PMC
February 2010

Increase in sphingolipid catabolic enzyme activity during aging.

Acta Pharmacol Sin 2009 Oct 14;30(10):1454-61. Epub 2009 Sep 14.

Laboratories of Pharmacology, College of Pharmacy (BK21 Project) and Longevity Institute of Life Science and Technology, Pusan National University, Busan 609-735, Republic of Korea.

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http://dx.doi.org/10.1038/aps.2009.136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007327PMC
October 2009

New intercellular lipid mediators and their GPCRs: an update.

Authors:
Dong-Soon Im

Prostaglandins Other Lipid Mediat 2009 Sep 3;89(3-4):53-6. Epub 2009 Feb 3.

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http://dx.doi.org/10.1016/j.prostaglandins.2009.01.002DOI Listing
September 2009

Cell biology. The ABCs of lipophile transport.

Science 2009 Feb;323(5916):883-4

Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1126/science.1170009DOI Listing
February 2009

Screening and characterization of probiotic lactic acid bacteria isolated from Korean fermented foods.

J Microbiol Biotechnol 2009 Feb;19(2):178-86

Department of Food Science and Technology, Tongmyong University, Busan 608-735, Korea.

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http://dx.doi.org/10.4014/jmb.0804.269DOI Listing
February 2009

Discovery of sphingosine 1-O-methyltransferase in rat kidney and liver homogenates.

Acta Pharmacol Sin 2008 Oct;29(10):1227-32

Laboratory of Pharmacology, College of Pharmacy (BK21 Project) and Longevity Life Science and Technology Institutes, Pusan National University, Busan 609-735, Korea.

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http://dx.doi.org/10.1111/j.1745-7254.2008.00857.xDOI Listing
October 2008

Wuweizisu C from Schisandra chinensis decreases membrane potential in C6 glioma cells.

Acta Pharmacol Sin 2008 Sep;29(9):1006-12

Department of Horticultural Bioscience, Pusan National University, Miryang-si 627-706, Republic of Korea.

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http://dx.doi.org/10.1111/j.1745-7254.2008.00838.xDOI Listing
September 2008

Lysophosphatidylglycerol stimulates chemotactic migration in human natural killer cells.

Biochem Biophys Res Commun 2008 Jul 9;372(1):147-51. Epub 2008 May 9.

Department of Biochemistry, College of Medicine, Dong-A University, 3-1 Dongdaesindong Seogu, Busan 602-714, Republic of Korea.

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http://dx.doi.org/10.1016/j.bbrc.2008.05.004DOI Listing
July 2008

N,N-Dimethyl-D-erythro-sphingosine inhibits store-operated Ca2+ entry in U937 monocytes.

J Pharmacol Sci 2008 Jul;107(3):303-7

Laboratory of Pharmacology, College of Pharmacy (BK21 Project) and Longevity Life Science and Technology Institutes, Pusan National University, Busan, Korea.

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http://dx.doi.org/10.1254/jphs.08078fpDOI Listing
July 2008

Characterization of N,N,-dimethyl-D-erythro-sphingosine-induced apoptosis and signaling in U937 cells: independence of sphingosine kinase inhibition.

Prostaglandins Other Lipid Mediat 2008 Jun 12;86(1-4):18-25. Epub 2008 Jan 12.

Laboratory of Pharmacology, College of Pharmacy (BK21 Project) and Research Institute for Drug Development, Pusan National University, San 30, Jang-Jun-dong, Geum-Jung-gu, Busan 609-735, Republic of Korea.

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http://dx.doi.org/10.1016/j.prostaglandins.2008.01.001DOI Listing
June 2008

Differential signaling of sphingosine derivatives in U937 human monocytes depends on the degree of N-methylation.

Prostaglandins Other Lipid Mediat 2008 Jun 7;86(1-4):68-72. Epub 2008 Apr 7.

Laboratory of Pharmacology, College of Pharmacy (BK21 Project) and Longevity Life Science and Technology Institutes, Pusan National University, Busan 609-735, Republic of Korea.

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http://dx.doi.org/10.1016/j.prostaglandins.2008.03.003DOI Listing
June 2008

Effects of mitochondrial inhibitors on cell viability in U937 monocytes under glucose deprivation.

Arch Pharm Res 2008 Jun 19;31(6):749-57. Epub 2008 Jun 19.

Laboratory of Pharmacology, College of Pharmacy (BK21 Project) and Longevity Life Science and Technology Institutes, Pusan National University, Busan, 609-735, Korea.

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http://dx.doi.org/10.1007/s12272-001-1222-5DOI Listing
June 2008

Dioleoyl phosphatidic acid induces morphological changes through an endogenous LPA receptor in C6 glioma cells.

Arch Pharm Res 2008 May 15;31(5):628-33. Epub 2008 May 15.

Laboratory of Pharmacology, Pusan National University, Busan, Republic of Korea.

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http://dx.doi.org/10.1007/s12272-001-1204-7DOI Listing
May 2008

Lysophosphatidylserine induces calcium signaling through Ki16425/VPC32183-sensitive GPCR in bone marrow-derived mast cells and in C6 glioma and colon cancer cells.

Arch Pharm Res 2008 Mar 13;31(3):310-7. Epub 2008 Apr 13.

Laboratory of Pharmacology, College of Pharmacy (BK21 Project), Pusan National University, San 30, Jang-Jun-dong, Geum-Jung-gu, Busan 609-735, Korea.

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http://dx.doi.org/10.1007/s12272-001-1157-xDOI Listing
March 2008

Pharmacokinetics and pharmacodynamics of ketoprofen plasters.

Biopharm Drug Dispos 2008 Jan;29(1):37-44

College of Pharmacy, Pusan National University, Busan 609-735, Korea.

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http://dx.doi.org/10.1002/bdd.587DOI Listing
January 2008

N, N-dimethyl-D-erythro-sphingosine increases intracellular Ca2+ concentration via Na+-Ca2+-exchanger in HCT116 human colon cancer cells.

Arch Pharm Res 2008 Jan;31(1):54-9

Laboratory of Pharmacology, College of Pharmacy, Pusan National University, Busan 609-735, Korea.

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http://dx.doi.org/10.1007/s12272-008-1120-yDOI Listing
January 2008

Effect of direct albumin binding to sphingosylphosphorylcholine in Jurkat T cells.

Prostaglandins Other Lipid Mediat 2007 Nov 4;84(3-4):174-83. Epub 2007 Sep 4.

Laboratory of Pharmacology, College of Pharmacy (BK21 Project) and Research Institute for Drug Development, Pusan National University, San 30, Jang-Jun-dong, Geum-Jung-gu, Busan 609-735, Republic of Korea.

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http://dx.doi.org/10.1016/j.prostaglandins.2007.08.003DOI Listing
November 2007

Lysophosphatidylserine increases membrane potentials in rat C6 glioma cells.

Arch Pharm Res 2007 Sep;30(9):1096-101

Laboratory of Pharmacology, College of Pharmacy (BK21 project) and Research Institute for Drug Development, Pusan National University, Busan 609-735, Korea.

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http://dx.doi.org/10.1007/bf02980243DOI Listing
September 2007

Sphingosine 1-phosphate (S1P) induces shape change in rat C6 glioma cells through the S1P2 receptor: development of an agonist for S1P receptors.

J Pharm Pharmacol 2007 Jul;59(7):1035-41

Laboratory of Pharmacology, College of Pharmacy (BK21 Project) and Research Institute for Drug Development, Pusan National University, Busan 609-735, Republic of Korea.

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http://dx.doi.org/10.1211/jpp.59.7.0017DOI Listing
July 2007

Dioleoyl phosphatidic acid increases intracellular Ca2+ through endogenous LPA receptors in C6 glioma and L2071 fibroblasts.

Prostaglandins Other Lipid Mediat 2007 Jun 3;83(4):268-76. Epub 2007 Feb 3.

Laboratory of Pharmacology, College of Pharmacy and Research Institute for Drug Development, Pusan National University, San 30, Jang-Jun-dong, Geum-Jung-gu, Busan 609-735, Republic of Korea.

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http://dx.doi.org/10.1016/j.prostaglandins.2007.01.014DOI Listing
June 2007

Effect of lysophosphatidylglycerol on several signaling molecules in OVCAR-3 human ovarian cancer cells: involvement of pertussis toxin-sensitive G-protein coupled receptor.

Biochem Pharmacol 2007 Mar 17;73(5):675-81. Epub 2006 Nov 17.

Medical Research Center for Cancer Molecular Therapy, Dong-A University, Busan, Republic of Korea.

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http://dx.doi.org/10.1016/j.bcp.2006.11.010DOI Listing
March 2007

Albumin inhibits cytotoxic activity of lysophosphatidylcholine by direct binding.

Prostaglandins Other Lipid Mediat 2007 Feb 22;83(1-2):130-8. Epub 2006 Nov 22.

Laboratory of Pharmacology, College of Pharmacy and Research Institute for Drug Development, Pusan National University, San 30, Jang-Jun-dong, Geum-Jung-gu, Busan 609-735, Republic of Korea.

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http://dx.doi.org/10.1016/j.prostaglandins.2006.10.006DOI Listing
February 2007

Multiple actions of dimethylsphingosine in 1321N1 astrocytes.

Mol Cells 2007 Feb;23(1):11-6

Laboratory of Pharmacology, College of Pharmacy and Research Institute of Drug Development, Pusan National University, Busan 609-735, Korea.

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February 2007

Albumin functions as an inhibitor of T cell adhesion in vitro.

Biochem Biophys Res Commun 2006 Dec 3;351(4):953-7. Epub 2006 Nov 3.

Laboratory of Pharmacology, College of Pharmacy and Research Institute for Drug Development, Pusan National University, San 30, Jang-Jun-dong, Geum-Jung-gu, Busan 609-735, Republic of Korea.

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http://dx.doi.org/10.1016/j.bbrc.2006.10.143DOI Listing
December 2006

Characterization of Ca2+ influx induced by dimethylphytosphingosine and lysophosphatidylcholine in U937 monocytes.

Biochem Biophys Res Commun 2006 Sep 4;348(3):1116-22. Epub 2006 Aug 4.

Laboratory of Pharmacology, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 609-735, Republic of Korea.

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http://dx.doi.org/10.1016/j.bbrc.2006.07.164DOI Listing
September 2006

Structure-activity relationships of dimethylsphingosine (DMS) derivatives and their effects on intracellular pH and Ca2+ in the U937 monocyte cell line.

Arch Pharm Res 2006 Aug;29(8):657-65

Laboratory of Pharmacology, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 609-735, Korea.

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http://dx.doi.org/10.1007/bf02968250DOI Listing
August 2006

Multiple actions of lysophosphatidylcholine in human Jurkat T cells.

Acta Pharmacol Sin 2006 Jun;27(6):700-7

Laboratories of Pharmacology, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 609-735, Korea.

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http://dx.doi.org/10.1111/j.1745-7254.2006.00339.xDOI Listing
June 2006

Dimethylsphingosine regulates intracellular pH and Ca(2+) in human monocytes.

J Pharmacol Sci 2006 Apr 31;100(4):289-96. Epub 2006 Mar 31.

Laboratory of Pharmacology, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Korea.

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http://dx.doi.org/10.1254/jphs.fpj05009xDOI Listing
April 2006

Two ligands for a GPCR, proton vs lysolipid.

Authors:
Dong-Soon Im

Acta Pharmacol Sin 2005 Dec;26(12):1435-41

Laboratory of Pharmacology and Research Institute of Drug Development, College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.

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http://dx.doi.org/10.1111/j.1745-7254.2005.00237.xDOI Listing
December 2005

Sphingosylphosphorylcholine generates reactive oxygen species through calcium-, protein kinase Cdelta- and phospholipase D-dependent pathways.

Cell Signal 2005 Jun 8;17(6):777-87. Epub 2004 Dec 8.

Department of Physiology and the Medical Research Institute, College of Medicine, Pusan National University, 1-Ga, Ami-Dong, Suh-Gu, Busan 602-739, Republic of Korea.

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http://dx.doi.org/10.1016/j.cellsig.2004.11.004DOI Listing
June 2005

Study on action mode of sphingosine 1-phosphate in rat hepatocytes.

J Pharmacol Sci 2005 Mar 12;97(3):443-6. Epub 2005 Mar 12.

Laboratory of Pharmacology, College of Pharmacy, Pusan National University, Busan, Republic of Korea.

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http://dx.doi.org/10.1254/jphs.scj04011xDOI Listing
March 2005

Differential change of Ins-P3-Ca2+ signaling during culture of rat hepatocytes.

Cell Signal 2005 Jan;17(1):83-91

Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo 113, Japan.

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http://dx.doi.org/10.1016/j.cellsig.2004.06.002DOI Listing
January 2005

Structure-activity relationship of lysophosphatidylcholines in HL-60 human leukemia cells.

Acta Pharmacol Sin 2004 Nov;25(11):1521-4

Laboratory of Pharmacology, College of Pharmacy, Pusan National University, Busan, Korea.

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November 2004

Enhancement of sphingosine 1-phosphate-induced phospholipase C activation during G(0)-G(1) transition in rat hepatocytes.

J Pharmacol Sci 2004 Jun;95(2):284-90

Laboratory of Pharmacology, College of Pharmacy, Pusan National University, Pusan, Republic of Korea.

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http://dx.doi.org/10.1254/jphs.fpj04007xDOI Listing
June 2004

Effects of ginsenosides Rg3 and Rh2 on the proliferation of prostate cancer cells.

Arch Pharm Res 2004 Apr;27(4):429-35

College of Pharmacy, Pusan National University, San 30, Chang-Jun-dong, Keum-Jung-gu, Busan 609-735, Korea.

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http://dx.doi.org/10.1007/bf02980085DOI Listing
April 2004

Discovery of new G protein-coupled receptors for lipid mediators.

Authors:
Dong-Soon Im

J Lipid Res 2004 Mar 1;45(3):410-8. Epub 2003 Dec 1.

Laboratory of Pharmacology, College of Pharmacy, Pusan National University, San 30, Chang-Jun-dong, Keum-Jung-gu, Busan 609-735, Republic of Korea.

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http://dx.doi.org/10.1194/jlr.R300006-JLR200DOI Listing
March 2004

The action mode of lysophosphatidylcholine in human monocytes.

J Pharmacol Sci 2004 Jan;94(1):45-50

Laboratory of Pharmacology, College of Pharmacy, Pusan National University, Busan, Republic of Korea.

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http://dx.doi.org/10.1254/jphs.94.45DOI Listing
January 2004