Dong-Er Zhang

Dong-Er Zhang

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The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations.

Mol Cell 2018 02 27;69(3):412-425.e6. Epub 2018 Jan 27.

Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0651, USA; Institute of Genomic Medicine, University of California, San Diego, La Jolla, CA 92093-0651, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.12.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957072PMC
February 2018

Negative regulation of type I IFN signaling.

J Leukoc Biol 2018 Jan 22. Epub 2018 Jan 22.

Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1002/JLB.2MIR0817-342RDOI Listing
January 2018

R-ChIP Using Inactive RNase H Reveals Dynamic Coupling of R-loops with Transcriptional Pausing at Gene Promoters.

Mol Cell 2017 Nov 2;68(4):745-757.e5. Epub 2017 Nov 2.

Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0651, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957070PMC
November 2017

USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA.

Cell Res 2016 Dec 1;26(12):1302-1319. Epub 2016 Nov 1.

State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, China.

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http://dx.doi.org/10.1038/cr.2016.125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143414PMC
December 2016

Sex chromosome loss and the pseudoautosomal region genes in hematological malignancies.

Oncotarget 2016 Nov;7(44):72356-72372

Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.18632/oncotarget.12050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342167PMC
November 2016

Multiple functions of USP18.

Cell Death Dis 2016 11 3;7(11):e2444. Epub 2016 Nov 3.

Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstr. 55, Essen 45147, Germany.

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http://dx.doi.org/10.1038/cddis.2016.326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260889PMC
November 2016

De Novo Mutations in SON Disrupt RNA Splicing of Genes Essential for Brain Development and Metabolism, Causing an Intellectual-Disability Syndrome.

Am J Hum Genet 2016 09 18;99(3):711-719. Epub 2016 Aug 18.

Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA; Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA. Electronic address:

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http://www.cell.com/ajhg/pdf/S0002-9297(16)30267-1.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S000292971630267
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http://dx.doi.org/10.1016/j.ajhg.2016.06.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011044PMC
September 2016

Type I IFN induces protein ISGylation to enhance cytokine expression and augments colonic inflammation.

Proc Natl Acad Sci U S A 2015 Nov 29;112(46):14313-8. Epub 2015 Oct 29.

Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093; Department of Pathology and Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093

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http://www.pnas.org/lookup/doi/10.1073/pnas.1505690112
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http://dx.doi.org/10.1073/pnas.1505690112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655505PMC
November 2015

SRSF2 Is Essential for Hematopoiesis, and Its Myelodysplastic Syndrome-Related Mutations Dysregulate Alternative Pre-mRNA Splicing.

Mol Cell Biol 2015 Sep 29;35(17):3071-82. Epub 2015 Jun 29.

Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California, USA Division of Biological Sciences, University of California, San Diego, La Jolla, California, USA Department of Pathology, University of California, San Diego, La Jolla, California, USA

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http://dx.doi.org/10.1128/MCB.00202-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525309PMC
September 2015

Identification and characterization of a novel ISG15-ubiquitin mixed chain and its role in regulating protein homeostasis.

Sci Rep 2015 Jul 30;5:12704. Epub 2015 Jul 30.

1] Moores UCSD Cancer Center, University of California San Diego, La Jolla CA, 92093, USA [2] Department of Pathology and Division of Biological Sciences, University of California San Diego, La Jolla CA, 92093, USA.

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http://dx.doi.org/10.1038/srep12704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520236PMC
July 2015

Mechanisms for U2AF to define 3' splice sites and regulate alternative splicing in the human genome.

Nat Struct Mol Biol 2014 Nov 19;21(11):997-1005. Epub 2014 Oct 19.

State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China.

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http://dx.doi.org/10.1038/nsmb.2906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429597PMC
November 2014

Plakophilin-2 promotes tumor development by enhancing ligand-dependent and -independent epidermal growth factor receptor dimerization and activation.

Mol Cell Biol 2014 Oct 11;34(20):3843-54. Epub 2014 Aug 11.

Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California, USA Department of Pathology and Division of Biological Sciences, University of California, San Diego, La Jolla, California, USA

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http://dx.doi.org/10.1128/MCB.00758-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187709PMC
October 2014

Hmga2 is a direct target gene of RUNX1 and regulates expansion of myeloid progenitors in mice.

Blood 2014 Oct 22;124(14):2203-12. Epub 2014 Aug 22.

Moores UCSD Cancer Center, University of California-San Diego, La Jolla, CA; Departments of Pathology and Division of Biological Sciences, University of California-San Diego, La Jolla, CA.

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http://dx.doi.org/10.1182/blood-2014-02-554543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183983PMC
October 2014

Runx1 exon 6-related alternative splicing isoforms differentially regulate hematopoiesis in mice.

Blood 2014 Jun 25;123(24):3760-9. Epub 2014 Apr 25.

Moores University California San Diego Cancer Center, Biomedical Science Graduate Program, and Division of Biological Sciences, University of California San Diego, La Jolla, CA; Department of Pathology, University of California San Diego, La Jolla, CA.

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http://dx.doi.org/10.1182/blood-2013-08-521252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055923PMC
June 2014

Cooperation between RUNX1-ETO9a and novel transcriptional partner KLF6 in upregulation of Alox5 in acute myeloid leukemia.

PLoS Genet 2013 10;9(10):e1003765. Epub 2013 Oct 10.

Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794898PMC
March 2014

Plakophilin-2 induced EGFR phosphorylation: a focus on the intracellular activators of EGFR.

Receptors Clin Investig 2014;2(1):e485

Moores UCSD Cancer Center ; Department of Pathology and Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.14800/rci.485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435607PMC
January 2014

Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model.

EMBO Mol Med 2013 Dec 4;5(12):1804-20. Epub 2013 Oct 4.

Medical Center of the Johannes Gutenberg-University Mainz, Department of Internal Medicine III, Division of Translational and Experimental Oncology, Mainz, Germany; German Cancer Research Center, Department of Stem Cells and Cancer, Heidelberg, Germany; Medical Center of the Johannes Gutenberg-University Mainz, Institute for Toxicology, Mainz, Germany.

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http://dx.doi.org/10.1002/emmm.201302661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914523PMC
December 2013

Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles.

Nanoscale 2013 Oct 1;5(19):8884-8. Epub 2013 Aug 1.

Department of NanoEngineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1039/c3nr03064dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831007PMC
October 2013

Usp18 driven enforced viral replication in dendritic cells contributes to break of immunological tolerance in autoimmune diabetes.

PLoS Pathog 2013 Oct 24;9(10):e1003650. Epub 2013 Oct 24.

Institute of Immunology, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany ; Department of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.

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http://dx.doi.org/10.1371/journal.ppat.1003650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812017PMC
October 2013

Erythrocyte membrane-cloaked polymeric nanoparticles for controlled drug loading and release.

Nanomedicine (Lond) 2013 Aug 14;8(8):1271-80. Epub 2013 Feb 14.

Department of Nano Engineering, University of California, San Diego, 9500 Gilman Drive, MC-0448, La Jolla, CA 92093-0448, USA.

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http://dx.doi.org/10.2217/nnm.12.153DOI Listing
August 2013

USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex.

J Exp Med 2013 Jul 1;210(8):1575-90. Epub 2013 Jul 1.

Department of Immunology, Center for Inflammation and Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1084/jem.20122327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727316PMC
July 2013

Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential.

Blood 2013 May 20;121(18):3714-7. Epub 2013 Feb 20.

Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1182/blood-2012-11-465641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643768PMC
May 2013

ISG15 regulates IFN-γ immunity in human mycobacterial disease.

Cell Res 2013 Feb 11;23(2):173-5. Epub 2012 Sep 11.

Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1038/cr.2012.133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567825PMC
February 2013

SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 cluster.

J Biol Chem 2013 Feb 14;288(8):5381-8. Epub 2013 Jan 14.

Moores UCSD Cancer Center, the University of California San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1074/jbc.M112.447227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581430PMC
February 2013

The mitochondrial pathway and reactive oxygen species are critical contributors to interferon-α/β-mediated apoptosis in Ubp43-deficient hematopoietic cells.

Biochem Biophys Res Commun 2012 Jun 5;423(2):436-40. Epub 2012 Jun 5.

Department of Biological Sciences, Research Center for Women's Disease, Sookmyung Women's University, Seoul 140-742, South Korea.

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http://dx.doi.org/10.1016/j.bbrc.2012.05.154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389127PMC
June 2012

Usp18 promotes conventional CD11b+ dendritic cell development.

J Immunol 2012 May 9;188(10):4776-81. Epub 2012 Apr 9.

Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.4049/jimmunol.1101609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345079PMC
May 2012

Negative effects of GM-CSF signaling in a murine model of t(8;21)-induced leukemia.

Blood 2012 Mar 5;119(13):3155-63. Epub 2012 Jan 5.

Moores UCSD Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1182/blood-2011-04-350694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321875PMC
March 2012

Two independent mechanisms promote expression of an N-terminal truncated USP18 isoform with higher DeISGylation activity in the nucleus.

J Biol Chem 2012 Feb 14;287(7):4883-93. Epub 2011 Dec 14.

Moores Cancer Center, University of California San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1074/jbc.M111.255570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281662PMC
February 2012

RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.

Front Biosci (Landmark Ed) 2012 Jan 1;17:1120-39. Epub 2012 Jan 1.

Moores Cancer Center, Department of Pathology and Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433167PMC
January 2012

Increased cerebral protein ISGylation after focal ischemia is neuroprotective.

J Cereb Blood Flow Metab 2011 Dec 17;31(12):2375-84. Epub 2011 Aug 17.

Department of Neurological Surgery, Madison, Wisconsin 53792, USA.

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http://dx.doi.org/10.1038/jcbfm.2011.103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323186PMC
December 2011

SERPINB13 is a novel RUNX1 target gene.

Biochem Biophys Res Commun 2011 Jul 23;411(1):115-20. Epub 2011 Jun 23.

The Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, United States.

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http://dx.doi.org/10.1016/j.bbrc.2011.06.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312028PMC
July 2011

Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool.

Blood 2011 May 30;117(20):5350-61. Epub 2011 Mar 30.

Department of Pathology, School of Medicine, and Section of Molecular Biology, Division of Biological Sciences, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1182/blood-2011-01-333476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109710PMC
May 2011

Interferon-stimulated gene 15 and the protein ISGylation system.

J Interferon Cytokine Res 2011 Jan 29;31(1):119-30. Epub 2010 Dec 29.

Sanford-Burnham Medical Research Institute, La Jolla, California, USA.

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http://dx.doi.org/10.1089/jir.2010.0110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021351PMC
January 2011

Hematopoietic cells from Ube1L-deficient mice exhibit an impaired proliferation defect under the stress of bone marrow transplantation.

Blood Cells Mol Dis 2010 Aug 29;45(2):103-11. Epub 2010 Jun 29.

Moores UCSD Cancer Center, University of California San Diego, La Jolla, 92093, USA.

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http://dx.doi.org/10.1016/j.bcmd.2010.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137368PMC
August 2010

Persistent altered fusion transcript splicing identifies RUNX1-RUNX1T1+ AML patients likely to relapse.

Eur J Haematol 2010 Feb 5;84(2):128-32. Epub 2009 Nov 5.

Laboratory of Immunohematology, Department of Hematology, Aarhus University Hospital, Arhus, Denmark.

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http://dx.doi.org/10.1111/j.1600-0609.2009.01371.xDOI Listing
February 2010

Alteration of tumor spectrum by ISGylation in p53-deficient mice.

Cancer Biol Ther 2009 Jun;8(12):1167-72

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.4161/cbt.8.12.8558DOI Listing
June 2009

Deficiency of a potential 3p21.3 tumor suppressor gene UBE1L (UBA7) does not accelerate lung cancer development in K-rasLA2 mice.

Lung Cancer 2009 Feb 24;63(2):194-200. Epub 2008 Jun 24.

Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01695002080024
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http://dx.doi.org/10.1016/j.lungcan.2008.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137380PMC
February 2009

RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesis.

Blood 2009 Jan 25;113(4):883-6. Epub 2008 Nov 25.

Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1182/blood-2008-04-153742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630273PMC
January 2009

The level of hepatitis B virus replication is not affected by protein ISG15 modification but is reduced by inhibition of UBP43 (USP18) expression.

J Immunol 2008 Nov;181(9):6467-72

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.4049/jimmunol.181.9.6467DOI Listing
November 2008

Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis.

Proc Natl Acad Sci U S A 2008 Nov 24;105(44):17103-8. Epub 2008 Oct 24.

Moores UCSD Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.0802696105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579385PMC
November 2008

Nitrosylation of ISG15 prevents the disulfide bond-mediated dimerization of ISG15 and contributes to effective ISGylation.

J Biol Chem 2008 Sep 7;283(36):24484-8. Epub 2008 Jul 7.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M803795200
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http://dx.doi.org/10.1074/jbc.M803795200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528991PMC
September 2008

t(8;21)(q22;q22) Fusion proteins preferentially bind to duplicated AML1/RUNX1 DNA-binding sequences to differentially regulate gene expression.

Blood 2008 Aug 29;112(4):1392-401. Epub 2008 May 29.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1182/blood-2007-11-124735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515118PMC
August 2008

Different roles for two ubiquitin-like domains of ISG15 in protein modification.

J Biol Chem 2008 May 20;283(19):13370-7. Epub 2008 Mar 20.

Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.1074/jbc.M800162200DOI Listing
May 2008

Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival.

Blood 2008 Apr 7;111(8):4338-47. Epub 2008 Feb 7.

Department of Pediatrics, Division of Pediatric Hematology/Oncology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1182/blood-2007-07-103291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2288729PMC
April 2008

ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response.

J Biol Chem 2008 Apr 20;283(14):8783-7. Epub 2008 Feb 20.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.C800030200
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http://dx.doi.org/10.1074/jbc.C800030200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276364PMC
April 2008

Evidence for annexin II-S100A10 complex and plasmin in mobilization of cytokine activity of human TrpRS.

J Biol Chem 2008 Jan 13;283(4):2070-7. Epub 2007 Nov 13.

Department of Molecular Biology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1074/jbc.M706028200DOI Listing
January 2008

Cell type dependent regulation of multidrug resistance-1 gene expression by AML1-ETO.

Blood Cells Mol Dis 2007 Nov-Dec;39(3):297-306. Epub 2007 Jun 21.

Department of Molecular and Experimental Medicine, MEM-L51, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.bcmd.2007.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2048671PMC
December 2007

Inability of RUNX1/AML1 to breach AML1-ETO block of embryonic stem cell definitive hematopoiesis.

Blood Cells Mol Dis 2007 Nov-Dec;39(3):321-8. Epub 2007 Aug 9.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.bcmd.2007.06.012DOI Listing
December 2007

Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts.

Blood 2007 Aug 5;110(3):799-805. Epub 2007 Apr 5.

Department of Molecular and Experimental Medicine, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1182/blood-2006-11-019265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1924771PMC
August 2007

Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling.

Blood 2007 Jul 20;110(1):305-12. Epub 2007 Mar 20.

Division of Oncovirology, Department of Molecular, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1182/blood-2006-07-033209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1896118PMC
July 2007

Expression of AML/Runx and ETO/MTG family members during hematopoietic differentiation of embryonic stem cells.

Exp Hematol 2007 Jun;35(6):978-88

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.exphem.2007.03.002DOI Listing
June 2007

A leukemia fusion protein attenuates the spindle checkpoint and promotes aneuploidy.

Blood 2007 May 29;109(9):3963-71. Epub 2006 Dec 29.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1182/blood-2006-09-045583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874577PMC
May 2007

The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO.

Blood 2007 May 6;109(10):4392-8. Epub 2007 Feb 6.

Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1182/blood-2006-03-012575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885483PMC
May 2007

Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo.

Blood 2007 Apr 29;109(8):3441-50. Epub 2006 Dec 29.

State Key Laboratory of Medical Genomics and Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Road II, Shanghai 200025, China.

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http://dx.doi.org/10.1182/blood-2006-06-032250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852250PMC
April 2007

Microarray analysis reveals that Type I interferon strongly increases the expression of immune-response related genes in Ubp43 (Usp18) deficient macrophages.

Biochem Biophys Res Commun 2007 Apr 28;356(1):193-9. Epub 2007 Feb 28.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.bbrc.2007.02.101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868545PMC
April 2007

Negative regulation of ISG15 E3 ligase EFP through its autoISGylation.

Biochem Biophys Res Commun 2007 Mar 8;354(1):321-7. Epub 2007 Jan 8.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.bbrc.2006.12.210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1858649PMC
March 2007

Ubp43 gene expression is required for normal Isg15 expression and fetal development.

Reprod Biol Endocrinol 2007 Mar 26;5:13. Epub 2007 Mar 26.

Department of Animal Science, University of Wyoming, Laramie, Wyoming, 82071, USA.

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http://dx.doi.org/10.1186/1477-7827-5-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852108PMC
March 2007

ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP.

Genes Dev 2007 Feb;21(3):255-60

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1101/gad.1521607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1785121PMC
February 2007

[Expression of AML1/ETO9a isoform in acute myeloid leukemia-M2 subtype].

Zhonghua Xue Ye Xue Za Zhi 2007 Jan;28(1):27-9

The First Affiliated Hospital Soochow University, Jiangsu Institute of Hematology, Suzhou 215006, China.

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January 2007

Retinoic acid-induced protein ISGylation is dependent on interferon signal transduction.

Blood Cells Mol Dis 2006 May-Jun;36(3):406-13. Epub 2006 May 2.

Department of Molecular and Experimental Medicine, MEM-L51, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.bcmd.2006.02.005DOI Listing
November 2006

AML1/RUNX1 phosphorylation by cyclin-dependent kinases regulates the degradation of AML1/RUNX1 by the anaphase-promoting complex.

Mol Cell Biol 2006 Oct 5;26(20):7420-9. Epub 2006 Aug 5.

Division of Oncovirology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Rd., MEM-L51, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1128/MCB.00597-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636878PMC
October 2006

A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis.

Nat Med 2006 Aug 30;12(8):945-9. Epub 2006 Jul 30.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, MEM-L51, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nm1443DOI Listing
August 2006

UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity.

EMBO J 2006 Jun 18;25(11):2358-67. Epub 2006 May 18.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1038/sj.emboj.7601149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1478183PMC
June 2006

The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase.

J Biol Chem 2006 Feb 13;281(7):3989-94. Epub 2005 Dec 13.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1074/jbc.M510787200DOI Listing
February 2006

Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling.

Mol Cell Biol 2006 Jan;26(2):472-9

Department of Molecular and Experimental Medicine, The Scripps Research Institute, Mailstop L-51, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1128/MCB.26.2.472-479.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1346917PMC
January 2006

UBP43, an ISG15-specific deconjugating enzyme: expression, purification, and enzymatic assays.

Methods Enzymol 2005 ;398:491-9

Department Of Molecular And Experimental Medicine (MEM-L51), The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/S0076-6879(05)98040-3DOI Listing
December 2005

The hematopoietic transcription factor AML1 (RUNX1) is negatively regulated by the cell cycle protein cyclin D3.

Mol Cell Biol 2005 Dec;25(23):10205-19

Dept. of Molecular Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1128/MCB.25.23.10205-10219.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1291252PMC
December 2005

ISG15 modification of ubiquitin E2 Ubc13 disrupts its ability to form thioester bond with ubiquitin.

Biochem Biophys Res Commun 2005 Oct;336(1):61-8

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.bbrc.2005.08.038DOI Listing
October 2005

Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

Biochem Biophys Res Commun 2005 Oct;336(2):496-506

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63130, USA.

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http://dx.doi.org/10.1016/j.bbrc.2005.08.132DOI Listing
October 2005

Enhanced antibacterial potential in UBP43-deficient mice against Salmonella typhimurium infection by up-regulating type I IFN signaling.

J Immunol 2005 Jul;175(2):847-54

Departments of Molecular and Experimental Medicine and Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.4049/jimmunol.175.2.847DOI Listing
July 2005

Phosphorylation of AML1/RUNX1 regulates its degradation and nuclear matrix association.

Mol Cancer Res 2005 Jul;3(7):391-401

Department of Medicine, P.O. Box 250955, Medical University of South Carolina, 6 Jonathan Lucas Street, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-04-0184DOI Listing
July 2005