Publications by authors named "Dong Wu"

657 Publications

Simulation of portal/hepatic vein associated remnant liver ischemia/congestion by three-dimensional visualization technology based on preoperative CT scan.

Ann Transl Med 2021 May;9(9):756

Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: Remnant liver hypoperfusion is frequently observed after hepatectomy, and associated with a higher risk of postoperative complications and poorer survival. However, the development of remnant liver hypoperfusion was not fully understood.

Methods: We retrospectively analyzed patients who received hepatectomy and took contrast-enhanced computed tomography (CT) scans before, 1-week (POW1) and 4-week (POW4) after resection in our department from June 2017 to July 2019. We simulated and estimated the occurrence of portal-vein-related remnant liver ischemia (RLI) and hepatic-vein-related remnant liver congestion (RLC) after hepatectomy via three-dimensional visualization technology (3DVT) according to blood vessels ligated in the resection; then we analyzed association between the estimated RLI, RLC, and postoperative clinical outcomes.

Results: A total of 102 eligible patients were analyzed. Remnant liver hypoperfusion was observed in 47 (46%) patients in the POW1 CT scans and shrunk in the POW4 CT scans. RLC had better diagnostic significance than RLI in predicting remnant liver hypoperfusion [area under receiver operating characteristic (ROC) curve: 0.745 0.569, P=0.026]. Multivariate analysis showed that larger RLI [odds ratio (OR), 1.154; 95% confidence interval (CI), 1.075-1.240; P<0.001] was independent risk factor for post-hepatectomy liver failure (PHLF). Besides, larger RLC (OR, 1.114; 95% CI, 1.032-1.204; P=0.006) was independent risk factor for major postoperative complications.

Conclusions: Remnant liver hypoperfusion can be predicted during the preoperative surgical plan by 3DVT. Portal vein related RLI was associated with PHLF, and hepatic vein related RLC was associated with major postoperative complications. Preservation of the hepatic vein and complete removal of the perfusion territory of ligated vessels are essential procedures to reduce RLI/RLC and the risk of PHLF or other surgical complications.
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http://dx.doi.org/10.21037/atm-20-7920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246180PMC
May 2021

Quasi-phase-matching-division multiplexing holography in a three-dimensional nonlinear photonic crystal.

Light Sci Appl 2021 Jul 15;10(1):146. Epub 2021 Jul 15.

National Laboratory of Solid State Microstructures, College of Engineering and Applied Sciences, School of Physics, and Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing, 210093, China.

Nonlinear holography has recently emerged as a novel tool to reconstruct the encoded information at a new wavelength, which has important applications in optical display and optical encryption. However, this scheme still struggles with low conversion efficiency and ineffective multiplexing. In this work, we demonstrate a quasi-phase-matching (QPM) -division multiplexing holography in a three-dimensional (3D) nonlinear photonic crystal (NPC). 3D NPC works as a nonlinear hologram, in which multiple images are distributed into different Ewald spheres in reciprocal space. The reciprocal vectors locating in a given Ewald sphere are capable of fulfilling the complete QPM conditions for the high-efficiency reconstruction of the target image at the second-harmonic (SH) wave. One can easily switch the reconstructed SH images by changing the QPM condition. The multiplexing capacity is scalable with the period number of 3D NPC. Our work provides a promising strategy to achieve highly efficient nonlinear multiplexing holography for high-security and high-density storage of optical information.
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http://dx.doi.org/10.1038/s41377-021-00588-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282809PMC
July 2021

Magnetism-Actuated Superhydrophobic Flexible Microclaw: From Spatial Microdroplet Maneuvering to Cross-Species Control.

ACS Appl Mater Interfaces 2021 Jul 13. Epub 2021 Jul 13.

CAS Key Laboratory of Mechanical Behavior and Design of Materials, Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education Institutes, Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei 230026, China.

The flexible maneuvering of microliter liquid droplets is significant in both fundamental science and practical applications. However, most current strategies are limited to the rigid locomotion on confined geographies platforms, which greatly hinder their practical uses. Here, we propose a magnetism-actuated superhydrophobic flexible microclaw (MSFM) with hierarchical structures for water droplet manipulation. By virtue of precise femtosecond laser patterning on magnetism-responsive poly(dimethylsiloxane) (PDMS) films doped with carbonyl iron powder, this MSFM without chemical contamination exhibits powerful spatial droplet maneuvering advantages with fast response (<100 ms) and lossless water transport (∼50 cycles) in air. We further performed quantitative analysis of diverse experimental parameters including petal number, length, width, and iron element proportion in MSFM impacting the applicable maneuvering volumes. By coupling the advantages of spatial maneuverability and fast response into this versatile platform, typical unique applications are demonstrated such as programmable coalescence of droplets, collecting debris via droplets, tiny solid manipulation in aqueous severe environments, and harmless living creature control. We envision that this versatile MSFM should provide great potential for applications in microfluidics and cross-species robotics.
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http://dx.doi.org/10.1021/acsami.1c09142DOI Listing
July 2021

Enhancing Formaldehyde Selectivity of SnO Gas Sensors with the ZSM-5 Modified Layers.

Sensors (Basel) 2021 Jun 8;21(12). Epub 2021 Jun 8.

School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.

High performance formaldehyde gas sensors are widely needed for indoor air quality monitoring. A modified layer of zeolite on the surface of metal oxide semiconductors results in selectivity improvement to formaldehyde as gas sensors. However, there is insufficient knowledge on how the thickness of the zeolite layer affects the gas sensing properties. In this paper, ZSM-5 zeolite films were coated on the surface of the SnO gas sensors by the screen printing method. The thickness of ZSM-5 zeolite films was controlled by adjusting the numbers of screen printing layers. The influence of ZSM-5 film thickness on the performance of ZSM-5/SnO gas sensors was studied. The results showed that the ZSM-5/SnO gas sensors with a thickness of 19.5 μm greatly improved the selectivity to formaldehyde, and reduced the response to ethanol, acetone and benzene at 350 °C. The mechanism of the selectivity improvement to formaldehyde of the sensors was discussed.
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http://dx.doi.org/10.3390/s21123947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227632PMC
June 2021

[Discussion on current state and research strategies of inter-disciplines of acupuncture-moxibustion and artificial intelligence].

Zhen Ci Yan Jiu 2021 Jun;46(6):541-5

Division of Medical Affairs, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100078.

At present, the breakthrough of the key techniques of artificial intelligence (AI), including image recognition, deep learning, neural network, Robot technique, etc., greatly promote the development of discipline crossing and medicine. In the present paper, we make an in-depth discussion about the future application of inter-discipline techniques of acupuncture-moxibustion and AI. We think that some of the current instruments have been part of the new acupuncture-moxibustion devices and may have the potential to intersect with the AI discipline. Relying on these existing devices and those of meridian detection, we can obtain relatively objective data, and further conduct meridian-syndrome differentiation and big data collection to possibly realize remote medical treatment. In addition, we may also develop an AI system for studying the underlying mechanisms of acupuncture and moxibustion therapies. Nevertheless, there still exist a lot of problems and challenges in clinical, teaching and scientific researches. It is recommended that the discipline of acupuncture-moxibustion should be intersected with the AI subject and formulate appropriate development strategies, promoting a faster and better development of acupuncturology.
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http://dx.doi.org/10.13702/j.1000-0607.20210017DOI Listing
June 2021

Effect of dark environment on intestinal flora and expression of genes related to liver metabolism in zebrafish (Danio rerio).

Comp Biochem Physiol C Toxicol Pharmacol 2021 Jun 23:109100. Epub 2021 Jun 23.

Inner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, College of Animal Science and Technology, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia 028000, China. Electronic address:

To explore the effects of dark environment on intestinal flora and expression of genes related to liver metabolism in zebrafish, a total of 60 zebrafish were fed for 21 days (24 h dark treatments or 14/10 h light/dark cycle), and the influence of dark environment on gut microbes and liver gene expression was studied using sequencing analysis of intestinal flora and liver. The results showed that the body weight of fish was significantly increased in the dark group than that in the control group (P < 0.05). Compared with the control group, dark environment treatment changed the composition of dominant flora, increased the abundance of unconventional bacteria and reduced probiotics in the intestine of zebrafish. Of these, the ratio of Bacteroidetes to Firmicutes in the intestine was reduced. The genome expression of the liver showed significant changes, and liver metabolites were also affected. Meanwhile, dark environment decreased gene expression associated with changes in blood glucose, lipid metabolism and immunization. Dark environment also caused liver steatosis as observed by histological study. This study shows that dark environment treatment has an important impact on liver metabolism and intestinal microbes in zebrafish.
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http://dx.doi.org/10.1016/j.cbpc.2021.109100DOI Listing
June 2021

PCGF1 promotes epigenetic activation of stemness markers and colorectal cancer stem cell enrichment.

Cell Death Dis 2021 Jun 19;12(7):633. Epub 2021 Jun 19.

Key Laboratory for Experimental Teratology of Ministry of Education, Shandong Key Laboratory of Mental Disorders, Department of Anatomy and Histoembryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.

Colorectal cancer (CRC) stem cells are resistant to cancer therapy and are therefore responsible for tumour progression after conventional therapy fails. However, the molecular mechanisms underlying the maintenance of stemness are poorly understood. In this study, we identified PCGF1 as a crucial epigenetic regulator that sustains the stem cell-like phenotype of CRC. PCGF1 expression was increased in CRC and was significantly correlated with cancer progression and poor prognosis in CRC patients. PCGF1 knockdown inhibited CRC stem cell proliferation and CRC stem cell enrichment. Importantly, PCGF1 silencing impaired tumour growth in vivo. Mechanistically, PCGF1 bound to the promoters of CRC stem cell markers and activated their transcription by increasing the H3K4 histone trimethylation (H3K4me3) marks and decreasing the H3K27 histone trimethylation (H3K27me3) marks on their promoters by increasing expression of the H3K4me3 methyltransferase KMT2A and the H3K27me3 demethylase KDM6A. Our findings suggest that PCGF1 is a potential therapeutic target for CRC treatment.
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http://dx.doi.org/10.1038/s41419-021-03914-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214626PMC
June 2021

Potential antibacterial ethanol-bridged purine azole hybrids as dual-targeting inhibitors of MRSA.

Bioorg Chem 2021 Jun 12;114:105096. Epub 2021 Jun 12.

Sauvage Laboratory for Smart Materials, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China; Shenzhen Key Laboratory of Flexible Printed Electronics Technology, School of Materials Science and Engineering, Harbin Institute of Technology, Shenzhen 518055 China. Electronic address:

A new class of antibacterial ethanol-bridged purine azole hybrids as potential dual-targeting inhibitors was developed. Bioactivity evaluation showed that some of the target compounds had prominent antibacterial activity against the tested bacteria, notably, metronidazole hybrid 3a displayed significant inhibitory activity against MRSA (MIC = 6 μM), and had no obvious toxicity on normal mammalian cells (RAW 264.7). In addition, compound 3a also did not induce drug resistance of MRSA obviously, even after fifteen passages. Molecular modeling studies showed that the highly active molecule 3a could insert into the base pairs of topoisomerase IA-DNA as well as topoisomerase IV-DNA through hydrogen bonding. Furthermore, a preliminary study on the antibacterial mechanism revealed that the active molecule 3a could rupture the bacterial membrane of MRSA and insert into MRSA DNA to block its replication, thus possibly exhibiting strong antibacterial activity. These results strongly indicated that the highly active hybrid 3a could be used as a potential dual-targeting inhibitor of MRSA for further development of valuable antimicrobials.
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http://dx.doi.org/10.1016/j.bioorg.2021.105096DOI Listing
June 2021

Integrated Analysis of Transcriptomics to Identify Hub Genes in Primary Sjögren's Syndrome.

Oral Dis 2021 Jun 19. Epub 2021 Jun 19.

Department of Oral Implantology, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, Fujian, China.

Objective: The treatment of patients with primary Sjogren's syndrome is a clinical challenge. Gene expression profile analysis and comprehensive network methods for complex diseases can provide insight into molecular characteristics in the clinical context.

Materials And Methods: We downloaded gene expression datasets from the Gene Expression Omnibus (GEO) database. We screened differentially expressed genes (DEG) between the pSS patients and the controls by the robust rank aggregation (RRA) method. We explored DEGs' potential function using gene function annotation and PPI network analysis.

Results: GSE23117, GSE40611, GSE80805, and GSE127952 were included, including 38 patients and 30 controls. The RRA integrated analysis determined 294 significant DEGs (241 upregulated and 53 down-regulated), and the most significant gene aberrantly expressed in SS was CXCL9 (P-value = 6.39E-15), followed by CXCL13 (P-value = 1.53E-13). Immune response (GO:0006955; P-value = 4.29E-32) was the most significantly enriched biological process in GO (gene ontology) analysis. KEGG pathway enrichment analysis showed that cytokine-cytokine receptor interaction (hsa04060; P-value = 6.46E-10) and chemokine signaling pathway (hsa04062; P-value = 9.54E-09) were significantly enriched. We defined PTPRC, CD86, and LCP2 as the hub genes based on the PPI results.

Conclusion: Our integrated analysis identified gene signatures and helped understand molecular changes in pSS.
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http://dx.doi.org/10.1111/odi.13943DOI Listing
June 2021

Promoting effect of rapamycin on osteogenic differentiation of maxillary sinus membrane stem cells.

PeerJ 2021 1;9:e11513. Epub 2021 Jun 1.

Research Center of Dental and Craniofacial Implants, Fujian Medical University, Fuzhou, Fujian, China.

Background: Stem cells located in the maxillary sinus membrane can differentiate into osteocytes. Our study aimed to evaluate the effect of rapamycin (RAPA) on the osteogenic differentiation of maxillary sinus membrane stem cells (MSMSCs).

Methods: Colony-forming unit assay, immunophenotype identification assay, and multi-differentiation assay confirmed characteristics of MSMSCs obtained from SD rats. Transmission electron microscopy (TEM) and flow cytometry (FCM) identified the initial autophagic level of MSMSCs induced by RAPA. Real-time quantitative PCR (qPCR) evaluated subsequent autophagic levels and osteogenic differentiation. Alkaline phosphatase (ALP) activity assay and alizarin red staining (ARS) evaluated subsequent osteogenic differentiation. We performed a histological examination to clarify in vivo osteogenesis with ectopic bone mass from BALB/c nude mice.

Results: MSMSCs possessed an active proliferation and multi-differentiation capacity, showing a phenotype of mesenchymal stem cells. The autophagic level increased with increasing RAPA (0, 10, 100, 1,000 nM) and decreased over time. ALP activity and calcium nodules forming in four RAPA-treated groups on three-time points (7, 14, 21 d) showed significant differences. , , and expressed most in 100 nM RAPA group on 7 and 14 d. Osteogenesis-related genes except for expression between four groups tended to be consistent on 21 d. 100 nM and 10 nM RAPA-treated groups showed more bone formation in vivo.

Conclusion: RAPA can promote osteogenic differentiation of MSMSCs, indicating a possible relationship between osteogenic differentiation and autophagy.
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http://dx.doi.org/10.7717/peerj.11513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176927PMC
June 2021

Magnetically driven rotary microfilter fabricated by two-photon polymerization for multimode filtering of particles.

Opt Lett 2021 Jun;46(12):2968-2971

In this Letter, a magnetically driven rotary microfilter that enables switching the modes of filtering and passing is fabricated in microfluidic devices via two-photon polymerization using a femtosecond laser for selective filtering of particles. The high-quality integration of a microfilter is ensured by accurately formulating the magnetic photoresist and optimizing the processing parameters. By changing the direction of the external magnetic field, the fabricated microfilter can be remotely manipulated to rotate by desired angles, thereby achieving the "filtering" or "passing" mode on demand. Taking advantage of this property, the magnetically rotary microfilter realizes multi-mode filtering functions such as capturing 8 µm particles/passing the 2.5 µm particles and passing both particles. More importantly, the responsive characteristic increases the reusability of the microchip. The lab-on-chip devices integrated with remotely rotary microfilters by the femtosecond laser two-photon polymerization with the functional photoresist will offer extensive applications in chemical and biological studies.
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http://dx.doi.org/10.1364/OL.428751DOI Listing
June 2021

Withdrawal Notice: Roles of Aryl-hydrocarbon Receptor in Metabolism and Proliferative Behaviors Of Bone Marrow Mscs: Implications For Targeted Therapy

Curr Top Med Chem 2021 06 11. Epub 2021 Jun 11.

Department of Hematology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.

The article has been withdrawn at the request of the authors of the journal Current Topics in Medicinal Chemistry.

Bentham Science apologizes to the readers of the journal for any inconvenience this may cause.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham Science Disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submit-ting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.
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http://dx.doi.org/10.2174/1568026621666210611163043DOI Listing
June 2021

Oncostatin M promotes hepatic progenitor cell activation and hepatocarcinogenesis via macrophage-derived tumor necrosis factor-α.

Cancer Lett 2021 Jun 5;517:46-54. Epub 2021 Jun 5.

Tumor Immunology and Gene Therapy Center, Third Affiliated Hospital of Second Military Medical University, Shanghai, 200438, China. Electronic address:

Hepatocellular carcinoma (HCC) usually occurs at the late stage of chronic liver injury. Oncostatin M (OSM) is a tumor-associated cytokine highly expressed in cirrhosis and HCC patients; however, its role in hepatocarcinogenesis has not been clearly elucidated. In this study, we investigated the effect of OSM on HCC occurrence in a rat model of N-diethylnitrosamine-induced HCC. OSM overexpression significantly increased the number of tumor nodules and shortened the overall survival of the rats. Notably, OSM promoted HPC activation in vivo but did not directly regulate the proliferation of the HPC cell line in vitro. Further, OSM induced tumor necrosis factor-α (TNF-α) secretion and CD68 macrophage accumulation, which were positively correlated with HPC activation. Additionally, TNF-α or macrophage depletion inhibited the promoting effect of OSM on hepatocarcinogenesis and HPC activation. Furthermore, OSM expression in the peritumoral tissues of HCC was positively correlated with poor overall survival of patients. In conclusion, OSM plays an important role in hepatocarcinogenesis by regulating the liver inflammation environment. Hence, OSM could be used as a potential target for HCC prevention and therapy or as an indicator of HCC prognosis.
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http://dx.doi.org/10.1016/j.canlet.2021.05.039DOI Listing
June 2021

Myeloid-specific SIRT1 deletion exacerbates airway inflammatory response in a mouse model of allergic asthma.

Aging (Albany NY) 2021 06 7;13(11):15479-15490. Epub 2021 Jun 7.

Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.

Sirtuin 1 (SIRT1) is a class III histone deacetylase that exerts an anti-inflammatory effect in airway diseases. Activated macrophages play an important role in asthma. However, the roles of SIRT1 on allergic airway inflammation in macrophages remain largely unexplored. In this study, we aimed to determine the roles of SIRT1 on allergic airway inflammation in macrophages. The effect of myeloid-specific SIRT1 deletion (-) on airway inflammation was assessed by using models of asthma following allergen exposure and culture of primary bone marrow-derived macrophages (BMDMs) exposed to house dust mite (HDM). We observed that - mice substantially enhanced airway inflammation and mucus production in response to allergen exposure. Expression of chemokine ligand (CXCL) 2, interleukin (IL)-1β, and tumor necrosis factor (TNF)-α were reduced in BMDMs with myeloid-specific deletion of after stimulation of HDM. Moreover, SIRT1 suppressed the inflammatory cytokines expression in BMDMs partially via the ERK/p38 MAPK pathways. Our study demonstrated that SIRT1 suppresses the allergic airway inflammation in macrophages, and suggested that activation of SIRT1 in macrophages may represent therapeutic strategy for asthma.
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http://dx.doi.org/10.18632/aging.203104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221322PMC
June 2021

Nickel-catalyzed migratory alkyl-alkyl cross-coupling reaction.

Chem Sci 2020 Sep 9;11(38):10461-10464. Epub 2020 Sep 9.

The Institute for Advanced Studies, Wuhan University Wuhan 430072 China

The selective cross-coupling of activated electrophiles with unactivated ones has been regarded as a challenging task in cross-electrophile couplings. Herein we describe a migratory cross-coupling strategy, which can overcome this obstacle to access the desired cross-coupling products. Accordingly, a selective migratory cross-coupling of two alkyl electrophiles has been accomplished by nickel catalysis. Remarkably, this alkyl-alkyl cross-coupling reaction provides a platform to prepare 2°-2° carbon-carbon bonds from 1° and 2° carbon coupling partners. Preliminary mechanistic studies suggest that chain-walking occurs at both alkyl halides in this reaction, thus a catalytic cycle with the key step involving two alkylnickel(ii) species is proposed for this transformation.
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http://dx.doi.org/10.1039/d0sc03217dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162388PMC
September 2020

A good preoperative immune prognostic index is predictive of better long-term outcomes after laparoscopic gastrectomy compared with open gastrectomy for stage II gastric cancer in elderly patients.

Surg Endosc 2021 Jun 2. Epub 2021 Jun 2.

Department of Gastric Surgery, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Fuzhou, 350001, Fujian, China.

Background: It remains inconclusive whether laparoscopic gastrectomy (LG) has better long-term outcomes when compared with open gastrectomy (OG) for elderly gastric cancer (EGC). We attempted to explore the influence of the immune prognostic index (IPI) on the prognosis of EGCs treated by LG or OG to identify a population among EGC who may benefit from LG.

Methods: We included 1539 EGCs treated with radical gastrectomy from January 2007 to December 2016. Propensity score matching was applied at a ratio of 1:1 to compare the LG and OG groups. The IPI based on dNLR ≥ cut-off value (dNLR) and sLDH ≥ cut-off value (sLDH) was developed, characterizing two groups (IPI = 0, good, 0 factors; IPI = 1, poor, 1 or 2 factors).

Results: Of the 528 EGCs (LG: 264 and OG: 264), 271 were in the IPI = 0 group, and 257 were in the IPI = 1 group. In the entire cohort, the IPI = 0 group was associated with good 5-year overall survival (OS) (p = 0.001) and progression-free survival (PFS) (p = 0.003) compared to the IPI = 1 group; no significant differences in 5-year OS and PFS between the LG and OG groups were observed. In the IPI = 1 cohort, there was no significant difference in OS or PFS between the LG and OG groups across all tumor stages. However, in the IPI = 0 cohort, LG was associated with longer OS (p = 0.015) and PFS (p = 0.018) than OG in stage II EGC, but not in stage I or III EGC. Multivariate analysis showed that IPI = 0 was an independent protective factor for stage II EGC receiving LG, but not for those receiving OG.

Conclusion: The IPI is related to the long-term prognosis of EGC. Compared with OG, LG may improve the 5-year survival rate of stage II EGC with a good IPI score. This hypothesis needs to be further confirmed by prospective studies.
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http://dx.doi.org/10.1007/s00464-021-08461-7DOI Listing
June 2021

Variations in Gut Microbiome are Associated with Prognosis of Hypertriglyceridemia-Associated Acute Pancreatitis.

Biomolecules 2021 May 6;11(5). Epub 2021 May 6.

Department of Gastroenterology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

Hypertriglyceridemia-associated acute pancreatitis (HTGAP) is linked with increased severity and morbidity. Intestinal flora plays an important role in the progression of acute pancreatitis (AP). However, pathogenetic association between gut microbiota and HTGAP remains unknown. In this study, we enrolled 30 HTGAP patients and 30 patients with AP that is evoked by other causes. The V3-V4 regions of 16S rRNA sequences of the gut microbiota were analyzed. Clinical characteristics, microbial diversity, taxonomic profile, microbiome composition, microbiological phenotype, and functional pathways were compared between the two groups. Our results showed that the HTGAP group had a higher proportion of severe AP (46.7% vs. 20.0%), organ failure (56.7% vs. 30.0%), and a longer hospital stay (18.0 days vs. 6.5 days). HTGAP group also had poorer microbial diversity, higher abundances of and , but lower abundances of , , and as compared with non-HTGAP group. Correlation analysis revealed that gut bacterial taxonomic and functional changes were linked with local and systemic complications, ICU admission, and mortality. This study revealed that alterations of gut microbiota were associated with disease severity and poor prognosis in HTGAP patients, indicating a potential pathophysiological link between gut microbiota and hypertriglyceridemia related acute pancreatitis.
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http://dx.doi.org/10.3390/biom11050695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148198PMC
May 2021

High-Performance Ultrafine Bubble Aeration on Janus Aluminum Foil Prepared by Laser Microfabrication.

Langmuir 2021 Jun 1;37(23):6947-6952. Epub 2021 Jun 1.

CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, Anhui 230026, China.

Aeration is a mass transfer process, in which gas is dispersed into a liquid by utilizing air inflation or agitation. Typically, a microporous device is often used for aeration. Increasing the gas flow rate and decreasing the pore size reduce the bubble size, but the surface wettability of the gas/solid interface also has a significant impact on the bubble size, which is rarely studied. In this study, a superhydrophilic/superhydrophobic Janus aluminum foil (JAF) is fabricated by laser microstructuring and low surface energy modification. The gas-repelling superhydrophilic surface not only facilitates ultrafine bubble generation but also allows the bubbles to detach from the aerator surface quickly, while the superhydrophobic surface prevents water from infiltrating into the aeration chamber and reduces the mass transfer resistance. The micropores with different diameters are obtained by adjusting the laser processing parameters. The pore prepared by the laser is uniform, consequently leading to the uniform bubble size. When the pore diameter is set to 30 μm, the diameter of bubbles released from the superhydrophilic surface of the JAF is only 0.326 mm, and the gas dissolution rate is about six times that of the double-sided superhydrophobic aluminum foil. This simple, low-cost, and controllable method of the laser processing JAF has broad applications in wastewater treatment, energy production, and aquaculture.
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http://dx.doi.org/10.1021/acs.langmuir.1c00437DOI Listing
June 2021

In Situ Electric-Induced Switchable Transparency and Wettability on Laser-Ablated Bioinspired Paraffin-Impregnated Slippery Surfaces.

Adv Sci (Weinh) 2021 07 29;8(14):e2100701. Epub 2021 May 29.

CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, 230026, China.

Switchable wetting and optical properties on a surface is synergistically realized by mechanical or temperature stimulus. Unfortunately, in situ controllable wettability together with programmable transparency on 2D/3D surfaces is rarely explored. Herein, Joule-heat-responsive paraffin-impregnated slippery surface (JR-PISS) is reported by the incorporation of lubricant paraffin, superhydrophobic micropillar-arrayed elastomeric membrane, and embedded transparent silver nanowire thin-film heater. Owing to its good flexibility, in situ controllable locomotion for diverse liquids on planar/curved JR-PISS is unfolded by alternately applying/discharging low electric-trigger of 6 V. Simultaneously, optical visibility can be reversibly converted between opaque and transparent modes. The switching principle is that in the presence of Joule-heat, solid paraffin would be melt and swell within 20 s to enable a slippery surface for decreasing light scattering and frictional force derived from contact angle hysteresis (F ). Once Joule-heat is discharged, undulating rough surface would reconfigure by cold-shrinkage of paraffin within 8 s to render light blockage and high F . Upon its portable merit, in situ thermal management, programmable visibility, as well as steering functionalized droplets by electric-activated JR-PISSs are successfully deployed. Compared with previous Nepenthes-inspired slippery surfaces, the current JR-PISS is more competent for in situ harnessing optical and wetting properties on-demand.
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http://dx.doi.org/10.1002/advs.202100701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292917PMC
July 2021

Guiding the Patterned Growth of Neuronal Axons and Dendrites Using Anisotropic Micropillar Scaffolds.

Adv Healthc Mater 2021 Jun 21;10(12):e2100094. Epub 2021 May 21.

Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education Institutes, CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, 230026, China.

The patterning of axonal and dendritic growth is an important topic in neural tissue engineering and critical for generating directed neuronal networks in vitro. Evidence shows that artificial micro/nanotopography can better mimic the environment for neuronal growth in vivo. However, the potential mechanisms by which neurons interact with true three dimensional (3D) topographical cues and form directional networks are unclear. Herein, 3D micropillar scaffolds are designed to guide the growth of neural stem cells and hippocampal neurons in vitro. Discontinuous and anisotropic micropillars are fabricated by femtosecond direct laser writing to form patterned scaffolds with various spacings and heights, which are found to affect the branching and orientation of axons and dendrites. Interestingly, axons and dendrites tend to grow on an array of 3D micropillar scaffolds of the same height and form functionally connected neuronal networks, as reflected by synchronous neuronal activity visualized by calcium imaging. This method may represent a promising tool for studying neuron behavior and directed neuronal networks in a 3D environment.
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http://dx.doi.org/10.1002/adhm.202100094DOI Listing
June 2021

[Measurement and analysis of leg length in adults with unilateral developmental dysplasia of the hip].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 May;35(5):533-538

Department of Orthopaedics, the First Medical Center, Chinese PLA General Hospital, Beijing, 100853, P.R.China.

Objective: To measure and analyze the radiographic characteristics of the leg length discrepancy in adult patients with unilateral developmental dysplasia of the hip (DDH).

Methods: The clinical data of 112 patients with unilateral DDH who met the selection criteria between January 2016 and June 2018 were retrospectively analyzed. There were 16 males and 96 females with an age of 20-76 years (mean, 42.9 years). According to the Crowe classification, there were 25 hips of type Ⅰ, 26 hips of type Ⅱ, 15 hips of type Ⅲ, and 46 hips of type Ⅳ (26 hips of type ⅣA without secondary acetabular formation, and 20 hips of type ⅣB with secondary acetabular formation). Full-length X-ray films of the lower limbs in the standing position were used to measure the following parameters: greater trochanter leg length (GTLL), greater trochanter femoral length (GTFL), lesser trochanter leg length (LTLL), lesser trochanter femoral length (LTFL), tibial length (TL), and intertrochanteric distance (ITD). The above parameters on the healthy and affected sides were compared and the difference of each parameter between the healthy and affected sides was calculated. Taking the difference of 5 mm between the healthy side and the affected side as the threshold value, the number of cases with the healthy side was greater than 5 mm and the affected side was greater than 5 mm were counted respectively. The difference of the imaging parameters between the healthy side and the affected side were compared between different Crowe types and between type ⅣA and type ⅣB.

Results: There was no significant difference in GTLL and LTFL between healthy and affected sides ( >0.05); LTLL and TL of affected side were longer than healthy side, GTFL and ITD were shorter than healthy side, and the differences were significant ( <0.05). The constituent ratio of long cases on the affected side of TL and LTLL was greater than the constituent ratio of long cases on the healthy side, while the constituent ratio of long cases on the healthy side of GTFL and ITD was greater than the constituent ratio of long cases on the affected side; there was no obvious difference in the constituent ratio of long cases on the healthy side or the affected side of GTLL and LTFL. The comparison between different Crowe types showed that only the difference in TL between type Ⅰ and type Ⅳ was significant ( <0.05), the difference of each imaging parameter among the other types showing no significant difference ( >0.05). Compared with type ⅣB, the differences of GTLL, TL, and ITD of type ⅣA were bigger, and the differences were significant ( <0.05); the differences of other parameters between type ⅣA and type ⅣB were not significant ( >0.05).

Conclusion: In adult unilateral DDH patients, the leg length on the healthy side and the affected side is different, and the difference mainly comes from the TL and ITD, which should be paid attention to in preoperative planning.
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http://dx.doi.org/10.7507/1002-1892.202010033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175197PMC
May 2021

Inhibitory Effects of Hayata Extract ECB on Melanoma-Induced Hyperplasia of Blood Vessels in Zebrafish Embryos.

Evid Based Complement Alternat Med 2021 26;2021:5543259. Epub 2021 Apr 26.

Inner Mongolia Key Laboratory of Toxicant Monitoring and Toxicant and Toxicology, College of Animal Science and Technology, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia 028000, China.

Melanoma is a serious malignant form of skin cancer. Euphorbiaceae compound B (ECB, 2,4-dihydroxy-6-methoxy-3-methylacetophenone) is an acetophenone compound that is isolated from Hayata (EEH), an herbaceous perennial, and has antitumor activity. Here, we transplanted human melanoma cells into zebrafish embryos to establish a zebrafish/melanoma model. We showed that this model can be used to evaluate the therapeutic effect of EEH and ECB and discussed its potential mechanism of action. The results showed that ECB was an active ingredient of EEH in inhibiting melanoma-induced hyperplasia of blood vessels in zebrafish embryos, similar to the angiogenic inhibitor vatalanib. ECB inhibited the number and length of subintestinal veins ( < 0.05), as well as the distribution of melanoma in zebrafish embryos ( < 0.05). More importantly, unlike vatalanib, ECB only inhibited melanoma-induced abnormal and excessive growth of blood vessels in xenografts. In addition, ECB inhibited the mRNA expression of and in zebrafish. Both and are essential genes that regulate blood vessel formation and upregulate the expression of and genes in zebrafish. Together, the above-mentioned results indicate that ECB has a potential antimelanoma effect , which may be mediated by inhibiting vascular endothelial growth factor receptors.
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http://dx.doi.org/10.1155/2021/5543259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096565PMC
April 2021

Clinical characteristics and outcome of tumor-associated acute pancreatitis: a single-center cohort study.

Ann Transl Med 2021 Apr;9(8):639

Department of Gastroenterology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Background: What features should alert clinicians to suspect underlying tumors in patients with acute pancreatitis (AP) was largely unknown. This study aimed to assess the clinical characteristics and outcome in patients with tumor-associated AP.

Methods: Patients who presented with AP and were diagnosed with tumor after admission were included according to the inclusion and exclusion criteria and followed up by hospital notes, telephone, WeChat and/or e-mail. The clinical characteristics and outcome were analyzed with multivariable logistic regression and were compared with AP patients without tumor.

Results: Out of a cohort of 1,792 AP patients we identified 103 who had a neoplastic etiology. The 103 patients had a median age of 57 (range, 13-81) and 65 were males. AP was mild in 92 patients, moderately severe in 7 and severe in 4. The three most common tumors included pancreatic cancer (PC) (40), periampullary carcinoma (PAC) (25), and neoplastic pancreatic cysts (NPC) (22). The following ranked features were predictive of a tumor etiology: dilation of main pancreatic duct (MPD) (OR 417.83, 95% CI: 80.40-2,171.42), vascular invasion (OR 82.04, 95% CI: 6.05-1,113.14), mild AP (8.29, 95% CI: 1.98-34.73), and anemia (OR 5.73, 95% CI: 2.02-16.26). The median survival period of AP patients with PC, PAC, and NPC was 10.0 (7.0-23.5), 21.0 (5.0-37.0), and 35.0 (30.0-96.0) months, respectively.

Conclusions: Mild AP patients with dilation of MPD, vascular invasion, and anemia were more frequently suggested a tumor etiology. Thus, clinical vigilance is needed for timely detection of tumor-associated pancreatitis with these characteristics.
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http://dx.doi.org/10.21037/atm-20-7196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106109PMC
April 2021

3D Multiscale Micro-/Nanofolds by Femtosecond Laser Intermittent Ablation and Constrained Heating on a Shape Memory Polymer.

ACS Appl Mater Interfaces 2021 May 7;13(19):23210-23219. Epub 2021 May 7.

CAS Key Laboratory of Mechanical Behavior and Design of Materials, Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education Institutes, Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, Anhui 230027, China.

Spontaneous wrinkling of films with a thickness gradient offers a new opportunity for constructing various 3D hierarchical surface morphologies. Unfortunately, accurately and facilely controlling the gradient film thickness to yield multiscale and 3D hierarchical micro-/nanostructures is still difficult. Here, a rapid, facile, and highly controllable fabricating strategy for realizing 3D multiscale hierarchical micro-/nanofolds on a shape memory polymer (SMP) surface is reported. First, the nanoparticle film with gradient thickness is rapidly (100 ms to 4 s) and facilely obtained by laser intermittent ablation on the SMP, termed as laser ablation-induced gradient thickness film. Following one-time constrained heating, the 3D micropillars grow out of the substrate based on the "self-growing effect," and the nanoparticle gradient film on its top shrinks into multiscale micro-/nanofolds simultaneously. Significantly, the evolution process and the underlying mechanism of the 3D micro-/nanofolds are systematically investigated. Fundamental basis enables us to accurately regulate the gradient thickness of nanoparticle films and feature size of folds by varying laser scanning times and scanning path. Finally, desirable patterns on micro-/nanofolds can be readily realized by programmable laser cleaning technology, and the tunable adhesion of the water droplet on the multiscale structured surface is demonstrated, which is promising for microdroplet manipulation.
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http://dx.doi.org/10.1021/acsami.1c04049DOI Listing
May 2021

Hypertriglyceridemia Acute Pancreatitis: Animal Experiment Research.

Dig Dis Sci 2021 May 3. Epub 2021 May 3.

Department of Gastroenterology, Peking Union Medical College Hospital and Chinese Academy of Medical Sciences, Beijing, China.

In recent years, the number of acute pancreatitis cases caused by hypertriglyceridemia has increased gradually, which has caught the attention of the medical community. However, because the exact mechanism of hypertriglyceridemic acute pancreatitis (HTG-AP) is not clear, treatment and prevention in clinical practice face enormous challenges. Animal models are useful for elucidating the pathogenesis of diseases and developing and testing novel interventions. Therefore, animal experiments have become the key research means for us to understand and treat this disease. We searched almost all HTG-AP animal models by collecting many studies and finally collated common animals such as rats, mice and included some rare animals that are not commonly used, summarizing the methods to model spontaneous pancreatitis and induce pancreatitis. We sorted them on the basis of three aspects, including the selection of different animals, analyzed the characteristics of different animals, different approaches to establish hypertriglyceridemic pancreatitis and their relative advantages and disadvantages, and introduced the applications of these models in studies of pathogenesis and drug therapy. We hope this review can provide relevant comparisons and analyses for researchers who intend to carry out animal experiments and will help researchers to select and establish more suitable animal experimental models according to their own experimental design.
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http://dx.doi.org/10.1007/s10620-021-06928-0DOI Listing
May 2021

Corrigendum to "Myricetin inhibits TNF-α-induced inflammation in A549 cells via the SIRT1/NF-κB pathway" [Pulm. Pharmacol. Therapeut. 65 (2020) 102000].

Pulm Pharmacol Ther 2021 Jun 15;68:102031. Epub 2021 Apr 15.

Institute of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China. Electronic address:

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http://dx.doi.org/10.1016/j.pupt.2021.102031DOI Listing
June 2021

The variation of antibiotic resistance genes and their links with microbial communities during full-scale food waste leachate biotreatment processes.

J Hazard Mater 2021 08 1;416:125744. Epub 2021 Apr 1.

Shanghai Engineering Research Center of Biotransformation of Organic Solid Waste, School of Ecological and Environmental Sciences, East China Normal University, Shanghai 200241, PR China; Shanghai Key Laboratory for Urban Ecological Processes and Eco-Restoration, School of Ecological and Environmental Sciences, East China Normal University, Shanghai 200241, PR China; Engineering Research Center for Nanophotonics and Advanced Instrument, Ministry of Education, East China Normal University, Shanghai 200062, PR China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, PR China. Electronic address:

The prevalence of antibiotic resistance genes (ARGs) has been widely reported in various environments. However, little is known of them in food waste (FW) leachate with high organic content and how their distribution is influenced by biotreatment processes. Here, twelve ARGs, two integrase genes and bacterial communities were investigated during two full-scale FW biotreatment processes. High ARGs abundances (absolute: 1.03 × 10-2.82 × 10copies/mL; relative: 0.076-2.778copies/16S rRNA) were observed across all samples. Although biotreatment effectively reduced absolute abundance of ARGs, additional bacteria acquiring ARGs caused an increase in their relative abundance, which further increased the transmission risk of ARGs. mexF, blaCTX-M, sul1 played crucial roles and sul1 might be considered as an indicator for the prediction of total ARGs. It is worrying that the discharge (effluent and sludge) included highly abundant ARGs (5.09 × 10-4.83 × 10copies/d), integrons (1.11 × 10-6.04 × 10copies/d) and potential pathogens (such as Pseudomonas and Streptococcus), which should be given more attentions. blaCTX-M and tetQ possessed most potential hosts, Proteobacteria-L and Firmicutes-W were predominant contributors of ARGs-hosts at genus level. This study suggested FW leachate biotreatment systems could be reservoirs of ARGs and facilitated the proliferation of them. The exploration of effective removal methods and formulation of emission standard are necessary for future ARGs mitigation.
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http://dx.doi.org/10.1016/j.jhazmat.2021.125744DOI Listing
August 2021

Antioxidant and C5a-blocking strategy for hepatic ischemia-reperfusion injury repair.

J Nanobiotechnology 2021 Apr 15;19(1):107. Epub 2021 Apr 15.

Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, People's Republic of China.

Background: Nonspecific liver uptake of nanomaterials after intravenous injection has hindered nanomedicine for clinical translation. However, nanomaterials' propensity for liver distribution might enable their use in hepatic ischemia-reperfusion injury (IRI) repair. During hepatic IRI, reactive oxygen species (ROS) are generated and the fifth component of complement (C5a) is activated. In addition, C5a is confirmed to exacerbate the vicious cycle of oxidative stress and inflammatory damage. For these reasons, we have investigated the development of nanomaterials with liver uptake to scavenge ROS and block C5a for hepatic IRI repair.

Results: To achieve this goal, a traditional nanoantioxidant of nanoceria was surface conjugated with the anti-C5a aptamers ([email protected]) to scavenge the ROS and reduce C5a-mediated inflammation. High uptake of [email protected] in the liver was confirmed by preclinical positron emission tomography (PET) imaging. The clinical symptoms of hepatic IRI were effectively alleviated by [email protected] with ROS scavenging and C5a blocking in mice model. The released pro-inflammatory cytokines were significantly reduced, and subsequent inflammatory reaction involved in the liver was inhibited.

Conclusions: The synthesized [email protected] has great potential of medical application in hepatic IRI repair, which could also be applied for other ischemic-related diseases.
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http://dx.doi.org/10.1186/s12951-021-00858-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050892PMC
April 2021

Tunable Sponge-Like Hierarchically Porous Hydrogels with Simultaneously Enhanced Diffusivity and Mechanical Properties.

Adv Mater 2021 May 8;33(20):e2008235. Epub 2021 Apr 8.

Department of Materials Science and Engineering, University of California, Los Angeles, Los Angeles, CA, 90 095, USA.

Crosslinked polymers and gels are important in soft robotics, solar vapor generation, energy storage, drug delivery, catalysis, and biosensing. However, their attractive mass transport and volume-changing abilities are diffusion-limited, requiring miniaturization to avoid slow response. Typical approaches to improving diffusion in hydrogels sacrifice mechanical properties by increasing porosity or limit the total volumetric flux by directionally confining the pores. Despite tremendous efforts, simultaneous enhancement of diffusion and mechanical properties remains a long-standing challenge hindering broader practical applications of hydrogels. In this work, cononsolvency photopolymerization is developed as a universal approach to overcome this swelling-mechanical property trade-off. The as-synthesized poly(N-isopropylacrylamide) hydrogel, as an exemplary system, presents a unique open porous network with continuous microchannels, leading to record-high volumetric (de)swelling speeds, almost an order of magnitude higher than reported previously. This swelling enhancement comes with a simultaneous improvement in Young's modulus and toughness over conventional hydrogels fabricated in pure solvents. The resulting fast mass transport enables in-air operation of the hydrogel via rapid water replenishment and ultrafast actuation. The method is compatible with 3D printing. The generalizability is demonstrated by extending the technique to poly(N-tertbutylacrylamide-co-polyacrylamide) and polyacrylamide hydrogels, non-temperature-responsive polymer systems, validating the present hypothesis that cononsolvency is a generic phenomenon driven by competitive adsorption.
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http://dx.doi.org/10.1002/adma.202008235DOI Listing
May 2021

Modeling the Radiative Effect on Microphysics in Cirrus Clouds Against Satellite Observations.

J Geophys Res Atmos 2021 Feb 19;126(4):e2020JD033923. Epub 2021 Feb 19.

NASA Goddard Space Flight Center Greenbelt MD USA.

The radiative effect on microphysics (REM) plays an important role in the dew/frost formation near the surface. How REM impacts cirrus clouds is investigated in this study, using bin microphysical model simulations and coincident data of the CloudSat and Global Precipitation Measurement (GPM) satellites. REM affects ice crystal spectrum with two types: radiative cooling and warming. Radiative cooling, as predicted by the bin-model simulations, favors the formation of horizontally oriented ice crystals (HOICs), but radiative warming does not. Hence, a test of REM can be transformed to a test of HOICs, because HOICs can be measured by the microwave polarization observations of the GPM Microwave Imager (GMI) at 166 GHz. To analyze the GMI data for their HOIC distribution, clouds are sorted into four groups with different optical depth and altitude, based on the radiative cooling/warming ratio (or eta) computed with satellite-retrieved ice water content. Their HOIC distributions (e.g., the midlevel thick clouds have more HOICs than the high-level ones) agree well with those predicted by the bin-model simulations. The general agreement between the GMI observations and bin-model simulations suggests that REM is common in cirrus clouds and impacts cirrus clouds significantly.
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http://dx.doi.org/10.1029/2020JD033923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988659PMC
February 2021
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