Publications

The high frequency of the U2AF1 S34Y mutation and its association with isolated trisomy 8 in myelodysplastic syndrome in Asians, but not in Caucasians.
Leuk Res 2017 Oct 7;61:96-103. Epub 2017 Sep 7.
Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:


Clinicopathological categorization of Epstein-Barr virus-positive T/NK-cell lymphoproliferative disease: an analysis of 42 cases with an emphasis on prognostic implications.
Leuk Lymphoma 2017 Jan 9;58(1):53-63. Epub 2016 May 9.
a Department of Pathology , Seoul National University Hospital, Seoul National University College of Medicine , Seoul , South Korea.


Monitoring of the Clonal Fraction by Fluorescence In Situ Hybridization in Myelodysplastic Syndrome: Comparison With International Working Group Treatment Response Criteria.
Arch Pathol Lab Med 2016 Jun;140(6):560-9
From the Departments of Laboratory Medicine (Drs Park and Lee), Internal Medicine (Dr Yoon), and the Cancer Research Institute (Drs Yoon and Lee), Seoul National University College of Medicine, Seoul, Korea; Department of Laboratory Medicine, National Cancer Center, Goyang-si, Korea (Dr Kong); and the Department of Laboratory Medicine, Hallym University College of Medicine, Anyang, Korea (Dr Kim).



Cytogenetic heterogeneity and their serial dynamic changes during acquisition of cytogenetic aberrations in cultured mesenchymal stem cells.
Mutat Res 2015 Jul 18;777:60-8. Epub 2015 Apr 18.
Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

CALR, JAK2, and MPL mutation profiles in patients with four different subtypes of myeloproliferative neoplasms: primary myelofibrosis, essential thrombocythemia, polycythemia vera, and myeloproliferative neoplasm, unclassifiable.
Am J Clin Pathol 2015 May;143(5):635-44
From the Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.

A challenging diagnosis: crystal-storing histiocytosis in plasma cell myeloma.
Am J Clin Pathol 2015 Feb;143(2):300-4
From the Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea;



Fluorescence in situ hybridization panel for monitoring of minimal residual disease in patients with double minute chromosomes.
Blood Cells Mol Dis 2014 Apr 7;52(4):208-13. Epub 2013 Nov 7.
Department of Laboratory Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Republic of Korea; Department of Laboratory Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Republic of Korea. Electronic address:

Elevated telomerase activity in essential thrombocythemia with extreme thrombocytosis.
Clin Biochem 2014 Apr 17;47(6):389-92. Epub 2014 Jan 17.
Department of Tumor Biology, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

The application of an in situ karyotyping technique for mesenchymal stromal cells: a validation and comparison study with classical G-banding.
Exp Mol Med 2013 Dec 20;45:e68. Epub 2013 Dec 20.
1] Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea [2] Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.





Impact of cytokine gene polymorphisms on risk and treatment outcomes of aplastic anemia.
Ann Hematol 2011 May 16;90(5):515-21. Epub 2010 Oct 16.
Department of Internal Medicine, Seoul National University Hospital, 101 Daehang-ro, Jongno-gu, Seoul, 110-744, South Korea.



Prognosis of secondary acute myeloid leukemia is affected by the type of the preceding hematologic disorders and the presence of trisomy 8.
Jpn J Clin Oncol 2010 Nov 29;40(11):1037-45. Epub 2010 Jun 29.
Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea.







Clinical course of non-severe aplastic anemia in adults.
Int J Hematol 2010 Jun 5;91(5):770-5. Epub 2010 Jun 5.
Department of Internal Medicine, Seoul National University Hospital, College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, 110-744, Republic of Korea.





Natural polyphenols antagonize the antimyeloma activity of proteasome inhibitor bortezomib by direct chemical interaction.
Br J Haematol 2009 Aug 3;146(3):270-81. Epub 2009 Jun 3.
Department of Molecular and Clinical Oncology, Seoul National University College of Medicine, Seoul, Korea.


Chromosomal instability is a risk factor for poor prognosis of adenocarcinoma of the lung: Fluorescence in situ hybridization analysis of paraffin-embedded tissue from Korean patients.
Lung Cancer 2009 Apr 23;64(1):66-70. Epub 2008 Sep 23.
Department of Internal Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, South Korea.

Introducing pulsed low-intensity ultrasound to culturing human umbilical cord-derived mesenchymal stem cells.
Biotechnol Lett 2009 Mar 5;31(3):329-35. Epub 2008 Nov 5.
Department of Laboratory Medicine, Seoul National University Boramae Hospital, 425 Shindaebang-dong, Dongjak-gu, Seoul, 156-707, South Korea.


The growth inhibitory effect of lapatinib, a dual inhibitor of EGFR and HER2 tyrosine kinase, in gastric cancer cell lines.
Cancer Lett 2008 Dec 6;272(2):296-306. Epub 2008 Sep 6.
Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea.


Tumor necrosis factor alpha promoter polymorphism associated with increased susceptibility to secondary hemophagocytic lymphohistiocytosis in the Korean population.
Cytokine 2006 Oct 12;36(1-2):45-50. Epub 2006 Dec 12.
Department of Laboratory Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea.


Korean patients with chronic lymphocytic leukemia show the similar types of chromosomal aberrations as those in Europe and North America.
Leuk Res 2006 Jun 17;30(6):695-9. Epub 2005 Nov 17.
Department of Laboratory Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, and Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.


AKAP12/Gravin is inactivated by epigenetic mechanism in human gastric carcinoma and shows growth suppressor activity.
Oncogene 2004 Sep;23(42):7095-103
National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon-dong, Chongro-gu, Seoul 110-799, Korea.



TNF α mediated IL-6 secretion is regulated by JAK/STAT pathway but not by MEK phosphorylation and AKT phosphorylation in U266 multiple myeloma cells.
Biomed Res Int 2013 16;2013:580135. Epub 2013 Sep 16.
Cancer Research Institute, College of Medicine, Seoul National University, 101 Daehak-ro, Jongro-gu, Seoul 110-799, Republic of Korea.


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