Dong Soon Lee

Dong Soon Lee

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Dong Soon Lee

Dong Soon Lee

Publications by authors named "Dong Soon Lee"

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100Publications

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Are clonal cells circulating in the peripheral blood of myelodysplastic syndrome?: Quantitative comparison between bone marrow and peripheral blood by targeted gene sequencing and fluorescence in situ hybridization.

Leuk Res 2018 Aug 10;71:92-94. Epub 2018 Jul 10.

Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

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August 2018

Successful Treatment of Pediatric Epstein-Barr Virus-positive Aggressive Natural Killer-Cell Leukemia.

J Pediatr Hematol Oncol 2018 Jun 8. Epub 2018 Jun 8.

Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Cancer Research Institute.

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June 2018

Shifting of erythroleukemia to myelodysplastic syndrome according to the revised WHO classification: Biologic and cytogenetic features of shifted erythroleukemia.

Leuk Res 2018 Apr 30;70:13-19. Epub 2018 Apr 30.

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

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April 2018

Distinct predictive impact of FISH abnormality in proteasome inhibitors and immunomodulatory agents response: redefining high-risk multiple myeloma in Asian patients.

Cancer Med 2018 Mar 29;7(3):831-841. Epub 2018 Jan 29.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.

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March 2018

White blood cell differential count of maturation stages in bone marrow smear using dual-stage convolutional neural networks.

PLoS One 2017 11;12(12):e0189259. Epub 2017 Dec 11.

Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, Korea.

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January 2018

The high frequency of the U2AF1 S34Y mutation and its association with isolated trisomy 8 in myelodysplastic syndrome in Asians, but not in Caucasians.

Leuk Res 2017 10 7;61:96-103. Epub 2017 Sep 7.

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

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October 2017

WHIM Syndrome With a Novel CXCR4 Variant in a Korean Child.

Ann Lab Med 2017 Sep;37(5):446-449

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.

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September 2017

Genomic Profile of Chronic Lymphocytic Leukemia in Korea Identified by Targeted Sequencing.

PLoS One 2016 13;11(12):e0167641. Epub 2016 Dec 13.

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.

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June 2017

Dysregulation of Telomere Lengths and Telomerase Activity in Myelodysplastic Syndrome.

Ann Lab Med 2017 May;37(3):195-203

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.

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May 2017

Gradual increase of chronic lymphocytic leukemia incidence in Korea, 1999-2010: comparison to plasma cell myeloma.

Leuk Lymphoma 2016 28;57(3):585-9. Epub 2015 Aug 28.

a Department of Laboratory Medicine , Seoul National University College of Medicine , Seoul , Republic of Korea.

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December 2016

8p11 Myeloproliferative Syndrome with t(7;8) Translocation Presenting as Acute Myeloid Leukemia: A Case Report and Literature Review.

Acta Haematol 2016 18;136(2):71-5. Epub 2016 May 18.

Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

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December 2016

Short telomere length and its correlation with gene mutations in myelodysplastic syndrome.

J Hematol Oncol 2016 07 28;9(1):62. Epub 2016 Jul 28.

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

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July 2016

Decreased sensitivity of the automatic white precursor cell channel (WPC) for blast flagging in patients with leukopenia.

Clin Biochem 2016 Jun 19;49(9):675-681. Epub 2016 Jan 19.

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, South Korea. Electronic address:

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June 2016

Monitoring of the Clonal Fraction by Fluorescence In Situ Hybridization in Myelodysplastic Syndrome: Comparison With International Working Group Treatment Response Criteria.

Arch Pathol Lab Med 2016 Jun;140(6):560-9

From the Departments of Laboratory Medicine (Drs Park and Lee), Internal Medicine (Dr Yoon), and the Cancer Research Institute (Drs Yoon and Lee), Seoul National University College of Medicine, Seoul, Korea; Department of Laboratory Medicine, National Cancer Center, Goyang-si, Korea (Dr Kong); and the Department of Laboratory Medicine, Hallym University College of Medicine, Anyang, Korea (Dr Kim).

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June 2016

Burden of cytogenetically abnormal plasma cells in light chain amyloidosis and their prognostic relevance.

Leuk Res 2016 May 10;44:45-52. Epub 2016 Mar 10.

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, South Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea. Electronic address:

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May 2016

Increased expression of interferon signaling genes in the bone marrow microenvironment of myelodysplastic syndromes.

PLoS One 2015 24;10(3):e0120602. Epub 2015 Mar 24.

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.

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February 2016

Plasma cell neoplasms: genetics, pathobiology, and new therapeutic strategies.

Biomed Res Int 2014 28;2014:941820. Epub 2014 Dec 28.

Department of Hematology, Tokai Central Hospital, Japan.

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September 2015

Cytogenetic heterogeneity and their serial dynamic changes during acquisition of cytogenetic aberrations in cultured mesenchymal stem cells.

Mutat Res 2015 Jul 18;777:60-8. Epub 2015 Apr 18.

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

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July 2015

CALR, JAK2, and MPL mutation profiles in patients with four different subtypes of myeloproliferative neoplasms: primary myelofibrosis, essential thrombocythemia, polycythemia vera, and myeloproliferative neoplasm, unclassifiable.

Am J Clin Pathol 2015 May;143(5):635-44

From the Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.

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May 2015

A challenging diagnosis: crystal-storing histiocytosis in plasma cell myeloma.

Am J Clin Pathol 2015 Feb;143(2):300-4

From the Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea;

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February 2015

MYD88 L265P mutations are correlated with 6q deletion in Korean patients with Waldenström macroglobulinemia.

Biomed Res Int 2014 7;2014:363540. Epub 2014 May 7.

Department of Laboratory Medicine, Seoul National University College of Medicine, 101 Daehangno, Jongno-gu, Seoul 110-744, Republic of Korea.

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January 2015

TNF α mediated IL-6 secretion is regulated by JAK/STAT pathway but not by MEK phosphorylation and AKT phosphorylation in U266 multiple myeloma cells.

Biomed Res Int 2013 16;2013:580135. Epub 2013 Sep 16.

Cancer Research Institute, College of Medicine, Seoul National University, 101 Daehak-ro, Jongro-gu, Seoul 110-799, Republic of Korea.

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June 2014

Fluorescence in situ hybridization panel for monitoring of minimal residual disease in patients with double minute chromosomes.

Blood Cells Mol Dis 2014 Apr 7;52(4):208-13. Epub 2013 Nov 7.

Department of Laboratory Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Republic of Korea; Department of Laboratory Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Republic of Korea. Electronic address:

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April 2014

Elevated telomerase activity in essential thrombocythemia with extreme thrombocytosis.

Clin Biochem 2014 Apr 17;47(6):389-92. Epub 2014 Jan 17.

Department of Tumor Biology, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

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April 2014

The application of an in situ karyotyping technique for mesenchymal stromal cells: a validation and comparison study with classical G-banding.

Exp Mol Med 2013 Dec 20;45:e68. Epub 2013 Dec 20.

1] Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea [2] Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.

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December 2013

Quantitative comparison of CDKN2B methylation in pediatric and adult myelodysplastic syndromes.

Acta Haematol 2013 3;130(2):115-21. Epub 2013 Apr 3.

Department of Laboratory Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea.

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October 2013

A case report of Fanconi anemia diagnosed by genetic testing followed by prenatal diagnosis.

Ann Lab Med 2012 Sep 13;32(5):380-4. Epub 2012 Aug 13.

Department of Laboratory Medicine, Seoul National University Hospital, Seoul, Korea.

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September 2012

Effects of granulocyte-colony stimulating factor and the expression of its receptor on various malignant cells.

Korean J Hematol 2012 Sep 25;47(3):219-24. Epub 2012 Sep 25.

Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea.

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September 2012

Quantity of clonal cells detected by conventional cytogenetic analysis correlates with bone marrow blasts and survival in myelodysplastic syndromes.

Leuk Res 2012 Feb 13;36(2):163-8. Epub 2011 Sep 13.

Department of Laboratory Medicine, Seoul National University College of Medicine, Jongno-gu, Seoul, South Korea.

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February 2012

Acute lymphoblastic leukemia in elderly patients: a single institution's experience.

Korean J Intern Med 2011 Sep 13;26(3):328-39. Epub 2011 Sep 13.

Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.

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September 2011

PAX5 deletion is common and concurrently occurs with CDKN2A deletion in B-lineage acute lymphoblastic leukemia.

Blood Cells Mol Dis 2011 Jun 5;47(1):62-6. Epub 2011 May 5.

Department of Laboratory Medicine, Seoul National University Hospital, Seoul, South Korea.

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June 2011

Impact of cytokine gene polymorphisms on risk and treatment outcomes of aplastic anemia.

Ann Hematol 2011 May 16;90(5):515-21. Epub 2010 Oct 16.

Department of Internal Medicine, Seoul National University Hospital, 101 Daehang-ro, Jongno-gu, Seoul, 110-744, South Korea.

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May 2011

Stochastic acquisition of a stem cell-like state and drug tolerance in leukemia cells stressed by radiation.

Int J Hematol 2011 Jan 18;93(1):27-35. Epub 2010 Dec 18.

Catholic High-Performance Cell Therapy Center, College of Medicine, The Catholic University of Korea, 505, Banpo-Dong, Seocho-Ku, Seoul 137-701, Republic of Korea.

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January 2011

Prognosis of secondary acute myeloid leukemia is affected by the type of the preceding hematologic disorders and the presence of trisomy 8.

Jpn J Clin Oncol 2010 Nov 29;40(11):1037-45. Epub 2010 Jun 29.

Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea.

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November 2010

Circulating hepatocyte growth factor as an independent prognostic factor of disseminated intravascular coagulation.

Thromb Res 2010 Jun 24;125(6):e285-93. Epub 2010 Feb 24.

Department of Laboratory Medicine and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.

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June 2010

Clinical course of non-severe aplastic anemia in adults.

Int J Hematol 2010 Jun 5;91(5):770-5. Epub 2010 Jun 5.

Department of Internal Medicine, Seoul National University Hospital, College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, 110-744, Republic of Korea.

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June 2010

Concurrent langerhans cell histiocytosis and B-lineage lymphoid proliferation in the bone marrow.

Korean J Lab Med 2009 Oct;29(5):402-5

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.

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October 2009

Natural polyphenols antagonize the antimyeloma activity of proteasome inhibitor bortezomib by direct chemical interaction.

Br J Haematol 2009 Aug 3;146(3):270-81. Epub 2009 Jun 3.

Department of Molecular and Clinical Oncology, Seoul National University College of Medicine, Seoul, Korea.

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August 2009

Chromosomal instability is a risk factor for poor prognosis of adenocarcinoma of the lung: Fluorescence in situ hybridization analysis of paraffin-embedded tissue from Korean patients.

Lung Cancer 2009 Apr 23;64(1):66-70. Epub 2008 Sep 23.

Department of Internal Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, South Korea.

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April 2009

Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract.

Exp Mol Med 2009 Apr;41(4):277-87

Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, Suwon 440-746, Korea.

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April 2009

Introducing pulsed low-intensity ultrasound to culturing human umbilical cord-derived mesenchymal stem cells.

Biotechnol Lett 2009 Mar 5;31(3):329-35. Epub 2008 Nov 5.

Department of Laboratory Medicine, Seoul National University Boramae Hospital, 425 Shindaebang-dong, Dongjak-gu, Seoul, 156-707, South Korea.

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March 2009

Bio-cell chip fabrication and applications.

Methods Mol Biol 2009 ;509:145-58

Department of Biomedical Engineering, College of Medicine, Seoul National University, Seoul, Korea.

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March 2009

The growth inhibitory effect of lapatinib, a dual inhibitor of EGFR and HER2 tyrosine kinase, in gastric cancer cell lines.

Cancer Lett 2008 Dec 6;272(2):296-306. Epub 2008 Sep 6.

Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea.

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December 2008

Investigation of bone marrow involvement in malignant lymphoma using fluorescence in situ hybridization: possible utility in the detection of micrometastasis.

Cancer Genet Cytogenet 2008 Oct;186(1):1-5

Department of Laboratory Medicine, Dongguk University, College of Medicine, Siksa-dong, Ilsandong-gu, Goyang, Gyeonggi-do, Republic of Korea.

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October 2008

Association of human leukocyte antigen-DRB1 alleles with disease susceptibility and severity of aplastic anemia in Korean patients.

Hum Immunol 2008 Jun 16;69(6):354-9. Epub 2008 May 16.

Department of Laboratory Medicine, Konkuk University College of Medicine, Seoul, Korea.

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June 2008

Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1.

Blood 2008 Mar 3;111(6):3131-6. Epub 2008 Jan 3.

Department of Pharmacology, Seoul National University College of Medicine, Seoul, Korea.

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March 2008

Protective role of CYP1A1*2A in the development of multiple myeloma.

Acta Haematol 2008 20;119(1):60-4. Epub 2008 Feb 20.

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.

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March 2008

Plasma level of stromal derived factor-1 (SDF-1) is increased in disseminated intravascular coagulation patients who have poor outcomes: in vitro effect of SDF-1 on coagulopathy.

Thromb Res 2007 18;120(4):559-66. Epub 2007 Jan 18.

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

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October 2007

MTHFR 677CC/1298CC genotypes are highly associated with chronic myelogenous leukemia: a case-control study in Korea.

Leuk Res 2007 Sep 6;31(9):1213-7. Epub 2006 Dec 6.

Department of Laboratory Medicine, Ewha Womans University College of Medicine, Seoul, South Korea.

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September 2007

Association of HLA class II genes with idiopathic pulmonary arterial hypertension in Koreans.

Lung 2007 May-Jun;185(3):145-9. Epub 2007 Apr 4.

Department of Internal Medicine, Chosun University College of Medicine, Gwangju, Korea.

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August 2007

Fluorescence in situ hybridization (FISH) using snap frozen buffy coat.

Ann Clin Lab Sci 2007 ;37(1):85-8

Department of Laboratory Medicine, Seoul National University College of Medicine, and Korea Cancer Center Hospital Seoul, 110-744, Korea.

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April 2007

[Clinical usefulness of plasma interleukin-6 and interleukin-10 in disseminated intravascular coagulation].

Korean J Lab Med 2007 Apr;27(2):83-8

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.

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April 2007

Utility of the fibrinogen/C-reactive protein ratio for the diagnosis of disseminated intravascular coagulation.

Acta Haematol 2007 8;117(1):34-9. Epub 2006 Nov 8.

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.

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February 2007

Green tea extract inhibits paraquat-induced pulmonary fibrosis by suppression of oxidative stress and endothelin-l expression.

Lung 2006 Sep-Oct;184(5):287-95

Department of Internal Medicine, College of Medicine, Wonkwang University, Iksan, Republic of Korea.

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February 2007

Application of high throughput cell array technology to FISH: investigation of the role of deletion of p16 gene in leukemias.

J Biotechnol 2007 Jan 29;127(3):355-60. Epub 2006 Jul 29.

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.

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January 2007

Tumor necrosis factor alpha promoter polymorphism associated with increased susceptibility to secondary hemophagocytic lymphohistiocytosis in the Korean population.

Cytokine 2006 Oct 12;36(1-2):45-50. Epub 2006 Dec 12.

Department of Laboratory Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea.

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October 2006

[Comparison of the rate of detection of immunoglobulin heavy chain gene rearrangement by fluoresecence in situ hybridization probes in multiple myeloma.].

Korean J Lab Med 2006 Oct;26(5):317-22

Department of Laboratory Medicine, College of Medicine, Seoul National University, Seoul, Korea.

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October 2006

Korean patients with chronic lymphocytic leukemia show the similar types of chromosomal aberrations as those in Europe and North America.

Leuk Res 2006 Jun 17;30(6):695-9. Epub 2005 Nov 17.

Department of Laboratory Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, and Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

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June 2006

Deletion of any part of the BCR or ABL gene on the derivative chromosome 9 is a poor prognostic marker in chronic myelogenous leukemia.

Cancer Genet Cytogenet 2006 Apr;166(1):65-73

Department of Laboratory Medicine, Hallym University College of Medicine, 39 Hallymdaehak-gil, Chuncheon, 200-702, Seoul, Korea.

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April 2006

[Association of NQO1 Polymorphism with Multiple Myeloma Risk in Koreans.].

Korean J Lab Med 2006 Apr;26(2):71-6

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.

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April 2006

Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs.

Am J Respir Crit Care Med 2005 Oct 7;172(8):987-93. Epub 2005 Jul 7.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Pochon CHA University, Seongnam, Korea.

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October 2005

The presence of TEL/AML1 rearrangement and cryptic deletion of the TEL gene in adult acute lymphoblastic leukemia (ALL).

Cancer Genet Cytogenet 2005 Oct;162(2):176-8

Department of Laboratory Medicine and Cancer Research Institute, Seoul National University College of Medicine, 28 Yongun-dong, Chongro-gu, Seoul 110-744, Korea.

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October 2005