Publications by authors named "Dong Cho Han"

51Publications

8-Epi-xanthatin induces the apoptosis of DU145 prostate carcinoma cells through signal transducer and activator of transcription 3 inhibition and reactive oxygen species generation.

Phytother Res 2020 Nov 8. Epub 2020 Nov 8.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea.

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http://dx.doi.org/10.1002/ptr.6918DOI Listing
November 2020

Ethacrynic acid inhibits STAT3 activity through the modulation of SHP2 and PTP1B tyrosine phosphatases in DU145 prostate carcinoma cells.

Biochem Pharmacol 2020 05 19;175:113920. Epub 2020 Mar 19.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahakro, Daejeon 34141, Republic of Korea; University of Science and Technology in Korea, 217 Gajeongro, Daejeon 34113, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2020.113920DOI Listing
May 2020

Pimozide suppresses cancer cell migration and tumor metastasis through binding to ARPC2, a subunit of the Arp2/3 complex.

Cancer Sci 2019 Dec 15;110(12):3788-3801. Epub 2019 Nov 15.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.

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http://dx.doi.org/10.1111/cas.14205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890432PMC
December 2019

Benproperine, an ARPC2 inhibitor, suppresses cancer cell migration and tumor metastasis.

Biochem Pharmacol 2019 05 30;163:46-59. Epub 2019 Jan 30.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahakro, Daejeon 34141, Republic of Korea; Korea University of Science and Technology in Korea, Daejeon, Republic of Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00062952193002
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http://dx.doi.org/10.1016/j.bcp.2019.01.017DOI Listing
May 2019

2'-Hydroxycinnamaldehyde inhibits proliferation and induces apoptosis via signal transducer and activator of transcription 3 inactivation and reactive oxygen species generation.

Cancer Sci 2019 Jan 20;110(1):366-378. Epub 2018 Nov 20.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.

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http://dx.doi.org/10.1111/cas.13852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317917PMC
January 2019

2'-hydroxycinnamaldehyde inhibits cancer cell proliferation and tumor growth by targeting the pyruvate kinase M2.

Cancer Lett 2018 10 18;434:42-55. Epub 2018 Jul 18.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahakro, Daejeon, 34141, Republic of Korea; Korea University of Science and Technology in Korea, Daejeon, 34113, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.07.015DOI Listing
October 2018

Piperlongumine derivative, CG-06, inhibits STAT3 activity by direct binding to STAT3 and regulating the reactive oxygen species in DU145 prostate carcinoma cells.

Bioorg Med Chem Lett 2018 08 14;28(14):2566-2572. Epub 2018 May 14.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea; Korea University of Science and Technology, Daejeon, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.05.025DOI Listing
August 2018

KRIBB53 binds to OCT4 and enhances its degradation through the proteasome, causing apoptotic cell death of OCT4-positive testicular germ cell tumors.

Carcinogenesis 2018 05;39(6):838-849

Personalized Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Yuseong-gu, Daejeon, Korea.

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http://dx.doi.org/10.1093/carcin/bgy054DOI Listing
May 2018

Methyllucidone inhibits STAT3 activity by regulating the expression of the protein tyrosine phosphatase MEG2 in DU145 prostate carcinoma cells.

Bioorg Med Chem Lett 2018 03 8;28(5):853-857. Epub 2018 Feb 8.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea; Korea University of Science and Technology, Daejeon, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.02.012DOI Listing
March 2018

Ginkgetin induces G2-phase arrest in HCT116 colon cancer cells through the modulation of b‑Myb and miRNA34a expression.

Int J Oncol 2017 Oct 5;51(4):1331-1342. Epub 2017 Sep 5.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.

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http://dx.doi.org/10.3892/ijo.2017.4116DOI Listing
October 2017

Geranylnaringenin (CG902) inhibits constitutive and inducible STAT3 activation through the activation of SHP-2 tyrosine phosphatase.

Biochem Pharmacol 2017 10 28;142:46-57. Epub 2017 Jun 28.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea; Korea University of Science and Technology, Daejeon, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.06.131DOI Listing
October 2017

PPARγ agonists induce adipocyte differentiation by modulating the expression of Lipin-1, which acts as a PPARγ phosphatase.

Int J Biochem Cell Biol 2016 12 22;81(Pt A):57-66. Epub 2016 Oct 22.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, Republic of Korea; University of Science and Technology in Korea, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2016.10.018DOI Listing
December 2016

Cinnamaldehydes in Cancer Chemotherapy.

Phytother Res 2016 May 18;30(5):754-67. Epub 2016 Feb 18.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology in Korea, 125 Gwahakro Yoosunggu, Daejeon, 305-806, Korea.

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http://dx.doi.org/10.1002/ptr.5592DOI Listing
May 2016

Sugiol inhibits STAT3 activity via regulation of transketolase and ROS-mediated ERK activation in DU145 prostate carcinoma cells.

Biochem Pharmacol 2015 Sep 23;97(1):38-50. Epub 2015 Jul 23.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology 125Gwahakro Yoosunggu, Daejeon 305-806, Republic of Korea; Biomolecular Science, University of Science and Technology in Korea, 125 Gwahakro Yoosunggu, Daejeon 305-806, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2015.06.033DOI Listing
September 2015

Fisetin, a dietary flavonoid, induces apoptosis of cancer cells by inhibiting HSF1 activity through blocking its binding to the hsp70 promoter.

Carcinogenesis 2015 Jun 3;36(6):696-706. Epub 2015 Apr 3.

Genomics Structure Research Center, Korea Research Institute of Bioscience and Biotechnology and Department of BioMolecular Science, University of Science and Technology in Korea and

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http://dx.doi.org/10.1093/carcin/bgv045DOI Listing
June 2015

Artocarpus altilis (Parkinson) Fosberg Extracts and Geranyl Dihydrochalcone Inhibit STAT3 Activity in Prostate Cancer DU145 Cells.

Phytother Res 2015 May 13;29(5):749-56. Epub 2015 Feb 13.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology, 125 Gwahakro Yoosunggu, Daejeon, 305-600, Republic of Korea.

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http://doi.wiley.com/10.1002/ptr.5311
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http://dx.doi.org/10.1002/ptr.5311DOI Listing
May 2015

Ginkgetin inhibits the growth of DU-145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity.

Cancer Sci 2015 Apr 20;106(4):413-20. Epub 2015 Feb 20.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea; Korea University of Science and Technology, Daejeon, Korea.

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http://dx.doi.org/10.1111/cas.12608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409885PMC
April 2015

Inhibition of STAT3 activation by KT-18618 via the disruption of the interaction between JAK3 and STAT3.

Biochem Pharmacol 2014 May 4;89(1):62-73. Epub 2014 Mar 4.

Laboratory of Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahakro, Daejeon 305-806, Republic of Korea; University of Science and Technology in Korea, 125 Gwahakro, Daejeon 305-806, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2014.02.017DOI Listing
May 2014

Rhodanine-based PRL-3 inhibitors blocked the migration and invasion of metastatic cancer cells.

Bioorg Med Chem Lett 2013 Jul 9;23(13):3769-74. Epub 2013 May 9.

Laboratory of Chemical Genomics and Biology, Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology, 125 Gwahakro, Yoosunggu, Daejeon 305-600, Republic of Korea.

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http://dx.doi.org/10.1016/j.bmcl.2013.04.092DOI Listing
July 2013

Emodin inhibits migration and invasion of DLD-1 (PRL-3) cells via inhibition of PRL-3 phosphatase activity.

Bioorg Med Chem Lett 2012 Jan 9;22(1):323-6. Epub 2011 Nov 9.

Laboratory of Chemical Genomics and Biology, Korea Research Institute of Bioscience and Biotechnology, 1125 Gwahakro, Yoosunggu, Daejeon 305-600, Republic of Korea.

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http://dx.doi.org/10.1016/j.bmcl.2011.11.008DOI Listing
January 2012

Phosphatase of regenerating liver-3 promotes migration and invasion by upregulating matrix metalloproteinases-7 in human colorectal cancer cells.

Int J Cancer 2012 Aug 11;131(3):E190-203. Epub 2012 Jan 11.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology, Yuseonggu, Daejon, Republic of Korea.

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http://dx.doi.org/10.1002/ijc.27381DOI Listing
August 2012

Cosmomycin C inhibits signal transducer and activator of transcription 3 (STAT3) pathways in MDA-MB-468 breast cancer cell.

Bioorg Med Chem 2011 Dec 17;19(24):7582-9. Epub 2011 Oct 17.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahakro, Yoosung, Daejeon 305-806, Republic of Korea.

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http://linkinghub.elsevier.com/retrieve/pii/S096808961100833
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http://dx.doi.org/10.1016/j.bmc.2011.10.025DOI Listing
December 2011

Biological evaluation of KRIBB3 analogs as a microtubule polymerization inhibitor.

Bioorg Med Chem Lett 2011 Feb 13;21(3):977-9. Epub 2010 Dec 13.

Bio-Therapeutics Research Institute, KRIBB, Ochang, Republic of Korea.

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http://dx.doi.org/10.1016/j.bmcl.2010.12.044DOI Listing
February 2011

2-Hydroxycurcuminoid induces apoptosis of human tumor cells through the reactive oxygen species-mitochondria pathway.

Bioorg Med Chem Lett 2011 Jan 28;21(2):747-51. Epub 2010 Nov 28.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, 52 Uendong, Yoosung, Daejeon 305-806, Republic of Korea.

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http://dx.doi.org/10.1016/j.bmcl.2010.11.114DOI Listing
January 2011

Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells.

Cancer Res 2009 Jan;69(1):193-202

Laboratory of Chemical Biology and Chemical Genomics, Korea Research Institute of Bioscience and Biotechnology, 52 Uendong Yoosunggu, Daejeon, Korea.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-2575DOI Listing
January 2009

Obovatol inhibits colorectal cancer growth by inhibiting tumor cell proliferation and inducing apoptosis.

Bioorg Med Chem 2008 Sep 19;16(18):8397-402. Epub 2008 Aug 19.

Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology, 52 Uendong, Yuseonggu, Daejon 305-600, Republic of Korea.

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http://dx.doi.org/10.1016/j.bmc.2008.08.033DOI Listing
September 2008

KRIBB3, a novel microtubule inhibitor, induces mitotic arrest and apoptosis in human cancer cells.

Biochem Pharmacol 2008 Jan 30;75(2):383-94. Epub 2007 Aug 30.

Molecular Cancer Research Center, Korea Research Institute of Bioscience and Biotechnology, 52 Eoeun-dong Yuseong-gu, Daejeon 305-806, Republic of Korea.

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http://dx.doi.org/10.1016/j.bcp.2007.08.027DOI Listing
January 2008

Synthesis and biological evaluation of cinnamyl compounds as potent antitumor agents.

Bioorg Med Chem Lett 2007 Oct 25;17(19):5423-7. Epub 2007 Jul 25.

Korea Research Institute of Bioscience and Biotechnology, 52 Uendong Yoosung, Daejeon 305-333, Republic of Korea.

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http://dx.doi.org/10.1016/j.bmcl.2007.07.033DOI Listing
October 2007

Apoptosis induction of 2'-hydroxycinnamaldehyde as a proteasome inhibitor is associated with ER stress and mitochondrial perturbation in cancer cells.

Biochem Pharmacol 2007 Aug 24;74(4):557-65. Epub 2007 May 24.

Department of Dental Microbiology, School of Dentistry, Kyungpook National University, Daegu 700-412, Republic of Korea.

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http://dx.doi.org/10.1016/j.bcp.2007.05.016DOI Listing
August 2007

Inhibitory effect of obovatal on the migration and invasion of HT1080 cells via the inhibition of MMP-2.

Bioorg Med Chem 2007 Jun 30;15(12):4085-90. Epub 2007 Mar 30.

Korea Research Institute of Bioscience and Biotechnology, 52 Uendong, Yusung, Taejon 305-600, Republic of Korea.

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http://dx.doi.org/10.1016/j.bmc.2007.03.081DOI Listing
June 2007

Biflavonoids inhibited phosphatase of regenerating liver-3 (PRL-3).

Nat Prod Res 2006 Apr;20(4):341-6

Korea Research Institute of Bioscience and Biotechnology, 52 Uendong, Yusung, Taejon 305-600, Republic of Korea.

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http://dx.doi.org/10.1080/14786410500463312DOI Listing
April 2006

Synthesis and biological evaluation of dimeric cinnamaldehydes as potent antitumor agents.

Bioorg Med Chem 2006 Apr 15;14(8):2498-506. Epub 2005 Dec 15.

Korea Research Institute of Bioscience and Biotechnology, 52 Uendong Yoosung, Taejeon 305-600, Republic of Korea.

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http://dx.doi.org/10.1016/j.bmc.2005.11.028DOI Listing
April 2006

Confirmation of a linkage between H-Ras and MMP-13 expression as well as MMP-9 by chemical genomic approach.

Int J Cancer 2006 May;118(9):2172-81

Korea Research Institute of Bioscience and Biotechnology, Yoosunggu, Taejon 305-600, Korea.

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http://dx.doi.org/10.1002/ijc.21610DOI Listing
May 2006

Differential regulation of anti-inflammatory proteins in human rheumatoid synoviocyte MH7A cell by celecoxib and ibuprofen.

Life Sci 2006 Apr 9;78(19):2204-12. Epub 2005 Nov 9.

Korea Research Institute of Bioscience and Biotechnology, Taejeon, Republic of Korea.

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http://dx.doi.org/10.1016/j.lfs.2005.09.029DOI Listing
April 2006

Blocking tumor cell migration and invasion with biphenyl isoxazole derivative KRIBB3, a synthetic molecule that inhibits Hsp27 phosphorylation.

J Biol Chem 2005 Dec 18;280(50):41439-48. Epub 2005 Oct 18.

Korea Research Institute of Bioscience and Biotechnology, 52 Uendong Yoosunggu, Daejeon 305-600, Korea.

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http://dx.doi.org/10.1074/jbc.M507209200DOI Listing
December 2005

Dehydrotrametenolic acid selectively inhibits the growth of H-ras transformed rat2 cells and induces apoptosis through caspase-3 pathway.

Life Sci 2006 Jan 19;78(6):607-13. Epub 2005 Aug 19.

Korea Research Institute of Bioscience and Biotechnology, 52 Uendong, Yusung, Taejon, Republic of Korea.

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http://dx.doi.org/10.1016/j.lfs.2005.05.066DOI Listing
January 2006

Cyclopentenediones, inhibitors of farnesyl protein transferase and anti-tumor compounds, isolated from the fruit of Lindera erythrocarpa Makino.

Bioorg Med Chem 2005 Nov 1;13(22):6182-7. Epub 2005 Aug 1.

Korea Research Institute of Bioscience and Biotechnology, 52 Uendong Yoosung, Taejeon 305-600, Republic of Korea.

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http://dx.doi.org/10.1016/j.bmc.2005.06.029DOI Listing
November 2005

Anti-tumor abietane diterpenes from the cones of Sequoia sempervirens.

Bioorg Med Chem Lett 2005 Apr;15(8):2019-21

Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology in Korea, 52 Uendong Yoosunggu Taejeon, 305-600 Republic of Korea.

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http://dx.doi.org/10.1016/j.bmcl.2005.02.057DOI Listing
April 2005

Inhibitory effect of 2'-hydroxycinnamaldehyde on nitric oxide production through inhibition of NF-kappa B activation in RAW 264.7 cells.

Biochem Pharmacol 2005 Mar 16;69(5):791-9. Epub 2005 Jan 16.

College of Pharmacy, Chungbuk National University, Heungduk-gu, Cheongju 361-763, South Korea.

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http://dx.doi.org/10.1016/j.bcp.2004.11.013DOI Listing
March 2005

Inhibitory activity of diarylheptanoids on farnesyl protein transferase.

Nat Prod Res 2004 Aug;18(4):295-9

Korea Research Institute of Bioscience and Biotechnology, 52 Uendong, Yusung, Taejon 305-600, Republic of Korea.

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http://dx.doi.org/10.1080/14786410310001620691DOI Listing
August 2004

2'-benzoyloxycinnamaldehyde induces apoptosis in human carcinoma via reactive oxygen species.

J Biol Chem 2004 Feb 3;279(8):6911-20. Epub 2003 Dec 3.

Korea Research Institute of Bioscience and Biotechnology, 52 Uendong Yoosunggu, Taejeon 305-600, Korea.

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http://dx.doi.org/10.1074/jbc.M309708200DOI Listing
February 2004

Anti-tumor activity of the farnesyl-protein transferase inhibitors arteminolides, isolated from Artemisa.

Bioorg Med Chem 2003 Oct;11(21):4545-9

Korea Research Institute of Bioscience and Biotechnology, 52 Uendong Yoosunggu, Taejeon 305-600, South Korea.

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http://dx.doi.org/10.1016/j.bmc.2003.08.008DOI Listing
October 2003

EphB1 associates with Grb7 and regulates cell migration.

J Biol Chem 2002 Nov 9;277(47):45655-61. Epub 2002 Sep 9.

Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA.

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http://dx.doi.org/10.1074/jbc.M203165200DOI Listing
November 2002

Biological effects of G1 phase arrest compound, sesquicillin, in human breast cancer cell lines.

Bioorg Med Chem 2002 Oct;10(10):3129-34

Korea Research Institute of Bioscience and Biotechnology, PO Box 115, Yoosung, Taejon, Republic of Korea.

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http://dx.doi.org/10.1016/s0968-0896(02)00225-0DOI Listing
October 2002

Association of Grb7 with phosphoinositides and its role in the regulation of cell migration.

J Biol Chem 2002 Aug 20;277(32):29069-77. Epub 2002 May 20.

Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA.

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http://dx.doi.org/10.1074/jbc.M203085200DOI Listing
August 2002

The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells.

Proc Natl Acad Sci U S A 2002 Mar 12;99(6):3546-51. Epub 2002 Mar 12.

Department of Bioengineering and The Whitaker Institute of Biomedical Engineering, University of California at San Diego, La Jolla, CA 92093-0427, USA.

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http://dx.doi.org/10.1073/pnas.052018099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC122560PMC
March 2002