Donatella Taramelli

Donatella Taramelli

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Donatella Taramelli

Publications by authors named "Donatella Taramelli"

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Antiplasmodial activity of triterpenes isolated from the methanolic leaf extract of Combretum racemosum P. Beauv.

J Ethnopharmacol 2020 Jan 28;247:112203. Epub 2019 Aug 28.

Department of Pharmacognosy, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2019.112203DOI Listing
January 2020

Identification of a potent and selective gametocytocidal antimalarial agent from the stem barks of Lophira lanceolata.

Bioorg Chem 2019 Dec 26;93:103321. Epub 2019 Sep 26.

Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.103321DOI Listing
December 2019

Discovery and Pharmacophore Mapping of a Low-Nanomolar Inhibitor of P. falciparum Growth.

ChemMedChem 2019 Dec 12;14(23):1982-1994. Epub 2019 Nov 12.

Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Mangiagalli 25, 20133, Milan, Italy.

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http://dx.doi.org/10.1002/cmdc.201900526DOI Listing
December 2019

Malaria pigment accelerates MTT - formazan exocytosis in human endothelial cells.

Parasitology 2019 03 1;146(3):399-406. Epub 2018 Oct 1.

Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche,Università degli Studi di Milano,Milano,Italy.

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https://www.cambridge.org/core/product/identifier/S003118201
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http://dx.doi.org/10.1017/S0031182018001579DOI Listing
March 2019

Facile Preparation of -Glycosylated 10-Piperazinyl Artemisinin Derivatives and Evaluation of Their Antimalarial and Cytotoxic Activities.

Molecules 2018 Jul 13;23(7). Epub 2018 Jul 13.

Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.

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http://dx.doi.org/10.3390/molecules23071713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100044PMC
July 2018

Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues.

Eur J Med Chem 2018 Apr 10;150:698-718. Epub 2018 Mar 10.

Department of Biotechnology, Chemistry and Pharmacy, Dipartimento di Eccellenza 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy; European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, Via Aldo Moro 2, 53100, Siena, Italy; Centro Interuniversitario di Ricerche sulla Malaria (CIRM), University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2018.03.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902032PMC
April 2018

Malaria pigment stimulates chemokine production by human microvascular endothelium.

Acta Trop 2017 Aug 2;172:125-131. Epub 2017 May 2.

Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, via Pascal 36-20133, Milano, Italy.

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http://dx.doi.org/10.1016/j.actatropica.2017.05.002DOI Listing
August 2017

In vitro activity of artemisone and artemisinin derivatives against extracellular and intracellular Helicobacter pylori.

Int J Antimicrob Agents 2016 Jul 6;48(1):101-105. Epub 2016 May 6.

Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy.

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http://dx.doi.org/10.1016/j.ijantimicag.2016.03.018DOI Listing
July 2016

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:
Wesley C Van Voorhis John H Adams Roberto Adelfio Vida Ahyong Myles H Akabas Pietro Alano Aintzane Alday Yesmalie Alemán Resto Aishah Alsibaee Ainhoa Alzualde Katherine T Andrews Simon V Avery Vicky M Avery Lawrence Ayong Mark Baker Stephen Baker Choukri Ben Mamoun Sangeeta Bhatia Quentin Bickle Lotfi Bounaadja Tana Bowling Jürgen Bosch Lauren E Boucher Fabrice F Boyom Jose Brea Marian Brennan Audrey Burton Conor R Caffrey Grazia Camarda Manuela Carrasquilla Dee Carter Maria Belen Cassera Ken Chih-Chien Cheng Worathad Chindaudomsate Anthony Chubb Beatrice L Colon Daisy D Colón-López Yolanda Corbett Gregory J Crowther Noemi Cowan Sarah D'Alessandro Na Le Dang Michael Delves Joseph L DeRisi Alan Y Du Sandra Duffy Shimaa Abd El-Salam El-Sayed Michael T Ferdig José A Fernández Robledo David A Fidock Isabelle Florent Patrick V T Fokou Ani Galstian Francisco Javier Gamo Suzanne Gokool Ben Gold Todd Golub Gregory M Goldgof Rajarshi Guha W Armand Guiguemde Nil Gural R Kiplin Guy Michael A E Hansen Kirsten K Hanson Andrew Hemphill Rob Hooft van Huijsduijnen Takaaki Horii Paul Horrocks Tyler B Hughes Christopher Huston Ikuo Igarashi Katrin Ingram-Sieber Maurice A Itoe Ajit Jadhav Amornrat Naranuntarat Jensen Laran T Jensen Rays H Y Jiang Annette Kaiser Jennifer Keiser Thomas Ketas Sebastien Kicka Sunyoung Kim Kiaran Kirk Vidya P Kumar Dennis E Kyle Maria Jose Lafuente Scott Landfear Nathan Lee Sukjun Lee Adele M Lehane Fengwu Li David Little Liqiong Liu Manuel Llinás Maria I Loza Aristea Lubar Leonardo Lucantoni Isabelle Lucet Louis Maes Dalu Mancama Nuha R Mansour Sandra March Sheena McGowan Iset Medina Vera Stephan Meister Luke Mercer Jordi Mestres Alvine N Mfopa Raj N Misra Seunghyun Moon John P Moore Francielly Morais Rodrigues da Costa Joachim Müller Arantza Muriana Stephen Nakazawa Hewitt Bakela Nare Carl Nathan Nathalie Narraidoo Sujeevi Nawaratna Kayode K Ojo Diana Ortiz Gordana Panic George Papadatos Silvia Parapini Kailash Patra Ngoc Pham Sarah Prats David M Plouffe Sally-Ann Poulsen Anupam Pradhan Celia Quevedo Ronald J Quinn Christopher A Rice Mohamed Abdo Rizk Andrea Ruecker Robert St Onge Rafaela Salgado Ferreira Jasmeet Samra Natalie G Robinett Ulrich Schlecht Marjorie Schmitt Filipe Silva Villela Francesco Silvestrini Robert Sinden Dennis A Smith Thierry Soldati Andreas Spitzmüller Serge Maximilian Stamm David J Sullivan William Sullivan Sundari Suresh Brian M Suzuki Yo Suzuki S Joshua Swamidass Donatella Taramelli Lauve R Y Tchokouaha Anjo Theron David Thomas Kathryn F Tonissen Simon Townson Abhai K Tripathi Valentin Trofimov Kenneth O Udenze Imran Ullah Cindy Vallieres Edgar Vigil Joseph M Vinetz Phat Voong Vinh Hoan Vu Nao-Aki Watanabe Kate Weatherby Pamela M White Andrew F Wilks Elizabeth A Winzeler Edward Wojcik Melanie Wree Wesley Wu Naoaki Yokoyama Paul H A Zollo Nada Abla Benjamin Blasco Jeremy Burrows Benoît Laleu Didier Leroy Thomas Spangenberg Timothy Wells Paul A Willis

PLoS Pathog 2016 07 28;12(7):e1005763. Epub 2016 Jul 28.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1005763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965013PMC
July 2016

A chemical susceptibility profile of the Plasmodium falciparum transmission stages by complementary cell-based gametocyte assays.

J Antimicrob Chemother 2016 May 16;71(5):1148-58. Epub 2016 Feb 16.

Dipartimento di Malattie Infettive, Parassitarie, Immunomediate, Istituto Superiore di Sanità, Rome, Italy

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http://dx.doi.org/10.1093/jac/dkv493DOI Listing
May 2016

Synthesis and Antiplasmodial Activity of Novel Chloroquine Analogues with Bulky Basic Side Chains.

ChemMedChem 2015 Sep 24;10(9):1570-83. Epub 2015 Jul 24.

Dipartimento di Farmacia, Università degli Studi di Genova, Viale Benedetto XV 3, 16131 Genova (Italy).

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http://dx.doi.org/10.1002/cmdc.201500195DOI Listing
September 2015

Modified quaternary ammonium salts as potential antimalarial agents.

Bioorg Med Chem 2015 Aug 3;23(15):4681-7. Epub 2015 Jun 3.

Dipartimento di Scienze Farmaceutiche - Sezione di Chimica Generale e Organica 'A.Marchesini', Università di Milano, Via Venezian 21, 20133 Milano, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.05.055DOI Listing
August 2015

Stability of the antimalarial drug dihydroartemisinin under physiologically relevant conditions: implications for clinical treatment and pharmacokinetic and in vitro assays.

Antimicrob Agents Chemother 2015 Jul 27;59(7):4046-52. Epub 2015 Apr 27.

Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università di Milano, Milan, Italy

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http://dx.doi.org/10.1128/AAC.00183-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468699PMC
July 2015

cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission.

PLoS Pathog 2015 May 7;11(5):e1004815. Epub 2015 May 7.

Inserm U1016, CNRS UMR8104, Institut Cochin, Paris, France; Laboratoire de Biologie de la Transmission de Plasmodium, Faculté de Médicine, Université Paris Descartes-Sorbonne Paris Cité, Paris, France; Institut Pasteur, Unité de Génétique et Génomique des Insectes Vecteurs, CNRS URA 3012, Paris, France.

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http://dx.doi.org/10.1371/journal.ppat.1004815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423841PMC
May 2015

Involvement of Nod2 in the innate immune response elicited by malarial pigment hemozoin.

Microbes Infect 2015 Mar 21;17(3):184-94. Epub 2014 Nov 21.

Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università degli Studi di Milano, Milano MI 20133, Italy.

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http://dx.doi.org/10.1016/j.micinf.2014.11.001DOI Listing
March 2015

Clofazimine analogs with antileishmanial and antiplasmodial activity.

Bioorg Med Chem 2015 Jan 26;23(1):55-65. Epub 2014 Nov 26.

Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2014.11.028DOI Listing
January 2015

Inhibition of metalloproteinase-9 secretion and gene expression by artemisinin derivatives.

Acta Trop 2014 Dec 19;140:77-83. Epub 2014 Aug 19.

Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milano, Italy.

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http://dx.doi.org/10.1016/j.actatropica.2014.08.008DOI Listing
December 2014

Further optimization of plakortin pharmacophore: structurally simple 4-oxymethyl-1,2-dioxanes with promising antimalarial activity.

Eur J Med Chem 2013 27;70:875-86. Epub 2013 Oct 27.

Dipartimento di Farmacia, Università di Napoli "Federico II", Via D. Montesano 49, I-80131 Napoli, Italy; Italian Malaria Network - Centro Interuniversitario di Ricerche sulla Malaria (CIRM), Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Via del Giochetto, 06126 Perugia, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S02235234130069
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http://dx.doi.org/10.1016/j.ejmech.2013.10.050DOI Listing
September 2014

CRIMALDDI: platform technologies and novel anti-malarial drug targets.

Malar J 2013 Nov 5;12:396. Epub 2013 Nov 5.

Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.

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http://dx.doi.org/10.1186/1475-2875-12-396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827883PMC
November 2013

A Plasmodium falciparum screening assay for anti-gametocyte drugs based on parasite lactate dehydrogenase detection.

J Antimicrob Chemother 2013 Sep 3;68(9):2048-58. Epub 2013 May 3.

Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20133 Milan, Italy.

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http://dx.doi.org/10.1093/jac/dkt165DOI Listing
September 2013

Pathogenesis of malaria in tissues and blood.

Mediterr J Hematol Infect Dis 2012 4;4(1):e2012061. Epub 2012 Oct 4.

University Division of Infectious and Tropical Diseases, University of Brescia and Spedali Civili General Hospital, Brescia (Italy), Piazza Spedali Civili, 1 - 25123-Brescia, Italy.

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http://www.mjhid.org/article/view/2012.061
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http://dx.doi.org/10.4084/MJHID.2012.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499994PMC
November 2012

Dihydroartemisinin inhibits the human erythroid cell differentiation by altering the cell cycle.

Toxicology 2012 Oct 5;300(1-2):57-66. Epub 2012 Jun 5.

Dipartimento di Sanità Pubblica-Microbiologia-Virologia, Università degli Studi di Milano, Via Pascal 36, 20133 Milano, Italy.

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http://dx.doi.org/10.1016/j.tox.2012.05.024DOI Listing
October 2012

Synthesis and comparison of antiplasmodial activity of (+), (-) and racemic 7-chloro-4-(N-lupinyl)aminoquinoline.

Bioorg Med Chem 2012 Oct 31;20(19):5980-5. Epub 2012 Jul 31.

Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S096808961200602
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http://dx.doi.org/10.1016/j.bmc.2012.07.041DOI Listing
October 2012

Synthesis and antiplasmodial activity of new heteroaryl derivatives of 7-chloro-4-aminoquinoline.

Bioorg Med Chem 2012 Oct 2;20(19):5965-79. Epub 2012 Aug 2.

Dipartimento Scienze Farmaceutiche, Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy.

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http://dx.doi.org/10.1016/j.bmc.2012.07.040DOI Listing
October 2012

Antiplasmodial activities of 4-aminoquinoline-statine compounds.

Bioorg Med Chem Lett 2012 Sep 27;22(18):5915-8. Epub 2012 Jul 27.

Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2012.07.069DOI Listing
September 2012

Curcumin enhances non-opsonic phagocytosis of Plasmodium falciparum through up-regulation of CD36 surface expression on monocytes/macrophages.

J Antimicrob Chemother 2012 Aug 17;67(8):1895-904. Epub 2012 Apr 17.

Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine-LSHTM, Keppel Street, London WC1E 7HT, UK.

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http://dx.doi.org/10.1093/jac/dks132DOI Listing
August 2012

Natural haemozoin modulates matrix metalloproteinases and induces morphological changes in human microvascular endothelium.

Cell Microbiol 2011 Aug 27;13(8):1275-85. Epub 2011 Jun 27.

Dipartimento di Genetica, Biologia e Biochimica, Università di Torino, Torino, Italy.

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http://dx.doi.org/10.1111/j.1462-5822.2011.01620.xDOI Listing
August 2011

Synthesis and antiplasmodial activity of bicyclic dioxanes as simplified dihydroplakortin analogues.

J Med Chem 2011 Aug 29;54(16):5949-53. Epub 2011 Jul 29.

European Research Centre for Drug Discovery and Development (NatSynDrugs), 53100 Siena, Italy.

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http://dx.doi.org/10.1021/jm200686dDOI Listing
August 2011

The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria.

Malar J 2011 Mar 15;10 Suppl 1:S10. Epub 2011 Mar 15.

Faculty of Infectious and Tropical Diseases, Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK.

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http://dx.doi.org/10.1186/1475-2875-10-S1-S10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059458PMC
March 2011

Antimalarials based on the dioxane scaffold of plakortin. A concise synthesis and SAR studies.

Bioorg Med Chem 2011 Jan 11;19(1):312-20. Epub 2010 Nov 11.

Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli 'Federico II', Via D. Montesano, 49, I-80131 Napoli, Italy.

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http://dx.doi.org/10.1016/j.bmc.2010.11.014DOI Listing
January 2011

Selective toxicity of dihydroartemisinin on human CD34+ erythroid cell differentiation.

Toxicology 2010 Oct 3;276(2):128-34. Epub 2010 Aug 3.

Dipartimento di Sanità Pubblica-Microbiologia-Virologia, Università degli Studi di Milano, Milan, Italy.

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http://dx.doi.org/10.1016/j.tox.2010.07.016DOI Listing
October 2010

Synthesis, antimalarial activity, and cellular toxicity of new arylpyrrolylaminoquinolines.

Bioorg Med Chem 2010 Sep 6;18(18):6625-33. Epub 2010 Aug 6.

Dipartimento di Scienze Farmaceutiche Pietro Pratesi, Università degli Studi di Milano, Via Mangiagalli, 25, 20133 Milan, Italy.

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http://dx.doi.org/10.1016/j.bmc.2010.08.001DOI Listing
September 2010

Antiplasmodial triterpenoids from the fruits of neem, Azadirachta indica.

J Nat Prod 2010 Aug;73(8):1448-52

Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, Via D. Montesano, 49, I-80131, Napoli, Italy.

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http://dx.doi.org/10.1021/np100325qDOI Listing
August 2010

The lipid moiety of haemozoin (Malaria Pigment) and P. falciparum parasitised red blood cells bind synthetic and native endothelin-1.

J Biomed Biotechnol 2010 24;2010:854927. Epub 2010 Feb 24.

Dipartimento di Sanità Pubblica-Microbiologia-Virologia, Università degli Studi di Milano, via Pascal 36, 20133 Milan, Italy.

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http://dx.doi.org/10.1155/2010/854927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829634PMC
May 2010

Novel antimalarial aminoquinolines: heme binding and effects on normal or Plasmodium falciparum-parasitized human erythrocytes.

Antimicrob Agents Chemother 2009 Oct 3;53(10):4339-44. Epub 2009 Aug 3.

Dipartimento di Scienze Molecolari Applicate ai Biosistemi (DISMAB), Facoltà di Farmacia, Università degli Studi di Milano, Milan, Italy.

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http://dx.doi.org/10.1128/AAC.00536-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764181PMC
October 2009

Antiplasmodial activity of Punica granatum L. fruit rind.

J Ethnopharmacol 2009 Sep 3;125(2):279-85. Epub 2009 Jul 3.

Department of Pharmacological Sciences, University of Camerino, Italy.

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http://dx.doi.org/10.1016/j.jep.2009.06.025DOI Listing
September 2009

Two complementary fluorimetric assays for the determination of aminoquinoline binding and uptake by human erythrocytes in vitro.

Anal Biochem 2009 Feb 13;385(2):371-3. Epub 2008 Nov 13.

Institute of General Physiology and Biochemistry G Esposito, Department of Public Health-Microbiology-Virology, Faculty of Pharmacy, University of Milan, Milan, Italy.

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http://dx.doi.org/10.1016/j.ab.2008.11.009DOI Listing
February 2009

Spatial distribution of heme species in erythrocytes infected with Plasmodium falciparum by use of resonance Raman imaging and multivariate analysis.

Anal Bioanal Chem 2008 Dec 5;392(7-8):1277-82. Epub 2008 Oct 5.

Department of Materials and Natural Resources, University of Trieste, Via Valerio 2, 34100, Trieste, Italy.

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http://dx.doi.org/10.1007/s00216-008-2414-0DOI Listing
December 2008

Antimalarial activity of novel pyrrolizidinyl derivatives of 4-aminoquinoline.

Bioorg Med Chem Lett 2008 Jul 16;18(13):3737-40. Epub 2008 May 16.

Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2008.05.042DOI Listing
July 2008

Novel amodiaquine congeners as potent antimalarial agents.

Bioorg Med Chem 2008 Jul 16;16(14):6813-23. Epub 2008 Jun 16.

Istituto di Chimica Farmaceutica e Tossicologica 'Pietro Pratesi', University of Milan, Via Mangiagalli 25, 20133 Milan, Italy.

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http://dx.doi.org/10.1016/j.bmc.2008.05.068DOI Listing
July 2008

Atovaquone-statine "double-drugs" with high antiplasmodial activity.

ChemMedChem 2008 Mar;3(3):418-20

Institute of Medicinal Chemistry Pietro Pratesi, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy.

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http://dx.doi.org/10.1002/cmdc.200700166DOI Listing
March 2008

Anti-plasmodial activity of Ailanthus excelsa.

Fitoterapia 2008 Feb 29;79(2):112-6. Epub 2007 Nov 29.

Department of Pharmacological Sciences, University of Milan, Milan, Italy.

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http://dx.doi.org/10.1016/j.fitote.2007.11.003DOI Listing
February 2008

Modulation of glyceraldehyde 3 phosphate dehydrogenase activity and tyr-phosphorylation of Band 3 in human erythrocytes treated with ferriprotoporphyrin IX.

Biochem Pharmacol 2007 Nov 17;74(9):1383-9. Epub 2007 Jul 17.

Institute of General Physiology and Biochemistry G. Esposito, University of Milan, via Trentacoste 2, 20134 Milan, Italy.

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http://dx.doi.org/10.1016/j.bcp.2007.07.012DOI Listing
November 2007

Differential effects on angiogenesis of two antimalarial compounds, dihydroartemisinin and artemisone: implications for embryotoxicity.

Toxicology 2007 Nov 19;241(1-2):66-74. Epub 2007 Aug 19.

Dipartimento di Sanità Pubblica-Microbiologia-Virologia, Università degli Studi di Milano, via Pascal 36, 20133 Milano, Milan, Italy.

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http://dx.doi.org/10.1016/j.tox.2007.08.084DOI Listing
November 2007

The Fe2+-mediated decomposition, PfATP6 binding, and antimalarial activities of artemisone and other artemisinins: the unlikelihood of C-centered radicals as bioactive intermediates.

ChemMedChem 2007 Oct;2(10):1480-97

Department of Chemistry, Open Laboratory of Chemical Biology, Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, PR China.

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https://air.unimi.it/retrieve/handle/2434/38467/179742/Hayne
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http://doi.wiley.com/10.1002/cmdc.200700108
Publisher Site
http://dx.doi.org/10.1002/cmdc.200700108DOI Listing
October 2007

Effects of malaria heme products on red blood cell deformability.

Am J Trop Med Hyg 2007 Oct;77(4):617-22

Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

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October 2007

Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore.

J Med Chem 2007 Feb 31;50(4):595-8. Epub 2007 Jan 31.

Dipartimento Farmaco Chimico Tecnologico and European Research Centre for Drug Discovery and Development, Universita' di Siena, via Aldo Moro, 53100 Siena, Italy.

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http://dx.doi.org/10.1021/jm061429pDOI Listing
February 2007

High antiplasmodial activity of novel plasmepsins I and II inhibitors.

J Med Chem 2006 Dec;49(25):7440-9

Department of Pharmacological Sciences, School of Pharmacy, University of Milan, Milan 20100, Italy.

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http://dx.doi.org/10.1021/jm061033dDOI Listing
December 2006

Prevalence of pfcrt point mutations and level of chloroquine resistance in Plasmodium falciparum isolates from Africa.

Infect Genet Evol 2006 Jul 8;6(4):262-8. Epub 2005 Sep 8.

Department of Infectious, Parasitic and Immunomediated Diseases, Vector-Borne Diseases and International Health Section, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy.

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http://dx.doi.org/10.1016/j.meegid.2005.07.002DOI Listing
July 2006

Synthesis and antimalarial activities of some furoxan sulfones and related furazans.

Eur J Med Chem 2005 Dec 24;40(12):1335-40. Epub 2005 Jun 24.

Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Università degli Studi del Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2005.05.001DOI Listing
December 2005

Damicoside from Axinella damicornis: the influence of a glycosylated galactose 4-OH group on the immunostimulatory activity of alpha-galactoglycosphingolipids.

J Med Chem 2005 Nov;48(23):7411-7

Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, via D. Montesano 49, 80131 Napoli, Italy.

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http://dx.doi.org/10.1021/jm050506yDOI Listing
November 2005

4-Aminoquinoline quinolizidinyl- and quinolizidinylalkyl-derivatives with antimalarial activity.

Bioorg Med Chem 2005 Sep;13(18):5338-45

Institute of Medicinal Chemistry, University of Milan, Viale Abruzzi, 42, 20131 Milan, Italy.

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http://dx.doi.org/10.1016/j.bmc.2005.06.047DOI Listing
September 2005

High-density lipoproteins attenuate interleukin-6 production in endothelial cells exposed to pro-inflammatory stimuli.

Biochim Biophys Acta 2005 Sep;1736(2):136-43

Center E. Grossi Paoletti, Department of Pharmacological Sciences, Via Balzaretti 9, 20133 Milano, Italy.

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http://dx.doi.org/10.1016/j.bbalip.2005.08.003DOI Listing
September 2005

Regulation of human erythrocyte glyceraldehyde-3-phosphate dehydrogenase by ferriprotoporphyrin IX.

FEBS Lett 2005 Sep;579(22):5095-9

Institute of General Physiology and Biochemistry G. Esposito, Facoltá di Farmacia, University of Milan, Milan, Italy.

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http://dx.doi.org/10.1016/j.febslet.2005.07.081DOI Listing
September 2005

Insights into the mechanism of action of ferroquine. Relationship between physicochemical properties and antiplasmodial activity.

Mol Pharm 2005 May-Jun;2(3):185-93

Laboratoire de Catalyse de Lille-UMR CNRS 8010, ENSCL, Bâtiment C7, Université des Sciences et Technologies, B.P. 90108, 59652, Villeneuve d'Ascq cedex, France.

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http://pubs.acs.org/doi/abs/10.1021/mp0500061
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http://dx.doi.org/10.1021/mp0500061DOI Listing
August 2005

Destabilisation and subsequent lysis of human erythrocytes induced by Plasmodium falciparum haem products.

Eur J Haematol 2005 Apr;74(4):324-32

Institute of General Physiology and Biochemistry G. Esposito, University of Milan, Milan, Italy.

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http://dx.doi.org/10.1111/j.1600-0609.2004.00352.xDOI Listing
April 2005

4-Alkyl- and 4-phenylcoumarins from Mesua ferrea as promising multidrug resistant antibacterials.

Phytochemistry 2004 Nov;65(21):2867-79

Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Via Venezian 21, 20133 Milano, Italy.

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http://dx.doi.org/10.1016/j.phytochem.2004.07.001DOI Listing
November 2004

Evidence that haem iron in the malaria parasite is not needed for the antimalarial effects of artemisinin.

FEBS Lett 2004 Sep;575(1-3):91-4

Istituto di Microbiologia, Universita' di Milano, Via Pascal 36, 20133 Milan, Italy.

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http://doi.wiley.com/10.1016/j.febslet.2004.08.039
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http://dx.doi.org/10.1016/j.febslet.2004.08.039DOI Listing
September 2004

Plasmepsin II inhibition and antiplasmodial activity of Primaquine-Statine 'double-drugs'.

Bioorg Med Chem Lett 2004 Jun;14(11):2931-4

Institute of Medicinal Chemistry, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2004.03.030DOI Listing
June 2004

Accelerated senescence of human erythrocytes cultured with Plasmodium falciparum.

Blood 2003 Jul 20;102(2):705-11. Epub 2003 Mar 20.

Istituto di Fisiologia Generale e Chimica Biologica Giovanni Esposito, Facoltà di Farmacia, Via Trentacoste 2, 20134-Milano, Italy.

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http://dx.doi.org/10.1182/blood-2002-08-2437DOI Listing
July 2003

Activity against Plasmodium falciparum of cycloperoxide compounds obtained from the sponge Plakortis simplex.

J Antimicrob Chemother 2002 Dec;50(6):883-8

Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, via D. Montesano 49, I-80131 Napoli, Italy.

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http://dx.doi.org/10.1093/jac/dkg008DOI Listing
December 2002

Endothelin-1 production by a microvascular endothelial cell line treated with Plasmodium falciparum parasitized red blood cells.

Clin Sci (Lond) 2002 Aug;103 Suppl 48:464S-466S

Institute of Microbiology, University of Milan, Via Pascal 36, 20133 Milan, Italy.

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http://dx.doi.org/10.1042/CS103S464SDOI Listing
August 2002