Donald P McDonnell

Donald P McDonnell

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Donald P McDonnell

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Decoding the Inversion Symmetry Underlying Transcription Factor DNA-Binding Specificity and Functionality in the Genome.

iScience 2019 May 6;15:552-591. Epub 2019 Apr 6.

Receptor Biology Section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences/National Institutes of Health, 111 T.W. Alexander Dr., Research Triangle Park, NC 27709, USA. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2019.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542189PMC
May 2019

HOXB13 interaction with MEIS1 modifies proliferation and gene expression in prostate cancer.

Prostate 2019 Mar 17;79(4):414-424. Epub 2018 Dec 17.

Brady Urological Institute, Johns Hopkins University, School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1002/pros.23747DOI Listing
March 2019

Targeting mutant estrogen receptors.

Elife 2019 Jan 16;8. Epub 2019 Jan 16.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, United States.

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http://dx.doi.org/10.7554/eLife.44181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335051PMC
January 2019

Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function.

Sci Signal 2018 06 26;11(536). Epub 2018 Jun 26.

Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore (NUS) Medical School, Singapore 169857, Singapore.

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http://dx.doi.org/10.1126/scisignal.aam5855DOI Listing
June 2018

Validation of histone deacetylase 3 as a therapeutic target in castration-resistant prostate cancer.

Prostate 2018 03 15;78(4):266-277. Epub 2017 Dec 15.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina.

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http://dx.doi.org/10.1002/pros.23467DOI Listing
March 2018

Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery.

Cancer Cell 2018 02;33(2):153-155

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.ccell.2018.01.014DOI Listing
February 2018

DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin.

Endocrinology 2017 10;158(10):3212-3234

Receptor Biology Section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina 27709.

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http://dx.doi.org/10.1210/en.2017-00468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659708PMC
October 2017

Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer.

Endocr Relat Cancer 2017 07 25;24(7):339-349. Epub 2017 Apr 25.

Division of Oncology and PathologyDepartment of Clinical Sciences, Lund, Lund University, Sweden

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https://erc.bioscientifica.com/view/journals/erc/24/7/339.xm
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http://dx.doi.org/10.1530/ERC-16-0533DOI Listing
July 2017

Distinct Receptor Tyrosine Kinase Subsets Mediate Anti-HER2 Drug Resistance in Breast Cancer.

J Biol Chem 2017 Jan 30;292(2):748-759. Epub 2016 Nov 30.

From the Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710 and

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http://dx.doi.org/10.1074/jbc.M116.754960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241747PMC
January 2017

ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer.

Cell Rep 2016 Apr 31;15(2):323-35. Epub 2016 Mar 31.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.03.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833658PMC
April 2016

Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader.

Endocr Relat Cancer 2015 Oct 10;22(5):713-24. Epub 2015 Jul 10.

Department of Pharmacology and Cancer Biology Duke University School of Medicine, Box 3813, Durham, North Carolina 27710, USA

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http://erc.endocrinology-journals.org/content/22/5/713.full.
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http://erc.endocrinology-journals.org/lookup/doi/10.1530/ERC
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http://dx.doi.org/10.1530/ERC-15-0287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545300PMC
October 2015

Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus.

Mol Endocrinol 2015 Oct 25;29(10):1426-39. Epub 2015 Aug 25.

Center for Nuclear Receptors and Cell Signaling (A.M.B., Y.S., D.E.F.), Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204; R&D Compliance (S.G.), Grifols Therapeutics Inc, Research Triangle Park, North Carolina 27709; Department of Pharmacology and Cancer Biology (S.G., D.P.M.), Duke University School of Medicine, Durham, North Carolina 27710; Department of Molecular and Cellular Biology (K.R., C.C.), Baylor College of Medicine, Houston, Texas 77030; Cancer Biology and Pharmacology (Y.Y.S., E.C.), Genome Institute of Singapore, A*STAR, Singapore 138672; Department of Clinical Cancer Prevention (L.R.B.), The University of Texas MD Anderson Cancer Center, Houston, Texas 77030; Faculty of Health Sciences (E.C.), University of Macau, Taipa, Macau, China, 9999078; Department of Integrative Biology and Pharmacology (J.T.C.), School of Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030; and Genomic Medicine Program (D.E.F.), The Houston Methodist Research Institute, Houston, Texas 77030.

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http://dx.doi.org/10.1210/me.2015-1079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588732PMC
October 2015

Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging.

Angew Chem Int Ed Engl 2015 Aug 17;54(33):9659-62. Epub 2015 Jun 17.

Departments of Molecular, Cellular, and Developmental Biology, Chemistry, and Pharmacology, Yale University, New Haven, CT 065111 (USA).

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http://dx.doi.org/10.1002/anie.201503720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547777PMC
August 2015

Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer.

Mol Oncol 2015 Jun 21;9(6):1155-68. Epub 2015 Feb 21.

Department of Surgery, Duke University Medical Center, Durham, NC, USA; Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA; Department of Pathology, Duke University Medical Center, Durham, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2015.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493866PMC
June 2015

Oral Selective Estrogen Receptor Downregulators (SERDs), a Breakthrough Endocrine Therapy for Breast Cancer.

J Med Chem 2015 Jun 3;58(12):4883-7. Epub 2015 Jun 3.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina 27710, United States.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.5b00760
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http://dx.doi.org/10.1021/acs.jmedchem.5b00760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708081PMC
June 2015

Aryl hydrocarbon receptor knock-out exacerbates choroidal neovascularization via multiple pathogenic pathways.

J Pathol 2015 Jan 10;235(1):101-12. Epub 2014 Oct 10.

Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA.

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http://dx.doi.org/10.1002/path.4433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277859PMC
January 2015

Delineation of a FOXA1/ERα/AGR2 regulatory loop that is dysregulated in endocrine therapy-resistant breast cancer.

Mol Cancer Res 2014 Dec 6;12(12):1829-39. Epub 2014 Aug 6.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272635PMC
December 2014

Cholesterol and breast cancer pathophysiology.

Trends Endocrinol Metab 2014 Dec 4;25(12):649-55. Epub 2014 Nov 4.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2014.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268141PMC
December 2014

From empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs).

Steroids 2014 Nov 30;90:30-8. Epub 2014 Jul 30.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, United States. Electronic address:

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http://dx.doi.org/10.1016/j.steroids.2014.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192009PMC
November 2014

Copper signaling axis as a target for prostate cancer therapeutics.

Cancer Res 2014 Oct;74(20):5819-31

Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-3527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203427PMC
October 2014

Use of phage display to identify novel mineralocorticoid receptor-interacting proteins.

Mol Endocrinol 2014 Sep 7;28(9):1571-84. Epub 2014 Jul 7.

MIMR-PHI Medical Research Institute (J.Y., P.J.F., J.M., C.D.C., M.J.Y.), Department of Medicine (J.Y., P.J.F., M.J.Y.), Monash University, Clayton, Victoria 3168, Australia; Department of Endocrinology, Metabolism, Rheumatology, and Nephrology (H.S.), Oita University, Yufu 879-5593, Japan; and Department of Pharmacology and Cancer Biology (D.P.M.), Duke University Medical Center, Durham, North Carolina 27710.

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http://dx.doi.org/10.1210/me.2014-1101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414797PMC
September 2014

Obesity, cholesterol metabolism, and breast cancer pathogenesis.

Cancer Res 2014 Sep 24;74(18):4976-82. Epub 2014 Jul 24.

Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167494PMC
September 2014

4,4'-Unsymmetrically substituted 3,3'-biphenyl alpha helical proteomimetics as potential coactivator binding inhibitors.

Bioorg Med Chem 2014 Jan 8;22(2):917-26. Epub 2013 Nov 8.

Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Ave., Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2013.10.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243926PMC
January 2014

Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology.

Proc Natl Acad Sci U S A 2013 Oct 8;110(43):E4069-78. Epub 2013 Oct 8.

Departments of Ophthalmology, Pathology, and Pharmacology and Cancer Biology, Duke University, Durham, NC 27710.

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http://dx.doi.org/10.1073/pnas.1307574110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808645PMC
October 2013

Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen-resistant breast cancer: implications for treatment of advanced disease.

Clin Cancer Res 2013 May 27;19(9):2420-31. Epub 2013 Mar 27.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-3771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643989PMC
May 2013

The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: implications for the treatment and prevention of osteoporosis.

Bone 2013 Mar 17;53(1):42-50. Epub 2012 Nov 17.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.bone.2012.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552054PMC
March 2013

Androgens promote prostate cancer cell growth through induction of autophagy.

Mol Endocrinol 2013 Feb 18;27(2):280-95. Epub 2012 Dec 18.

Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204, USA.

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https://academic.oup.com/mend/article-lookup/doi/10.1210/me.
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http://dx.doi.org/10.1210/me.2012-1260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683804PMC
February 2013

3,3'-Disubstituted bipolar biphenyls as inhibitors of nuclear receptor coactivator binding.

Bioorg Med Chem Lett 2012 Nov 13;22(21):6587-90. Epub 2012 Sep 13.

Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.bmcl.2012.09.007DOI Listing
November 2012

Molecular pathways: the metabolic regulator estrogen-related receptor α as a therapeutic target in cancer.

Clin Cancer Res 2012 Nov 27;18(22):6089-95. Epub 2012 Sep 27.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-3221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500439PMC
November 2012

Research resource: Transcriptional profiling in a cellular model of breast cancer reveals functional and mechanistic differences between clinically relevant SERM and between SERM/estrogen complexes.

Mol Endocrinol 2012 Jul 8;26(7):1235-48. Epub 2012 May 8.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Box 3813, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1210/me.2012-1031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385791PMC
July 2012

The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer.

Cancer Cell 2011 Oct;20(4):500-10

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.ccr.2011.08.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199323PMC
October 2011

The turnover of estrogen receptor α by the selective estrogen receptor degrader (SERD) fulvestrant is a saturable process that is not required for antagonist efficacy.

Biochem Pharmacol 2011 Jul 9;82(2):122-30. Epub 2011 Apr 9.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.bcp.2011.03.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109090PMC
July 2011

Research resource: nuclear receptor atlas of human retinal pigment epithelial cells: potential relevance to age-related macular degeneration.

Mol Endocrinol 2011 Feb 14;25(2):360-72. Epub 2011 Jan 14.

Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1210/me.2010-0392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386542PMC
February 2011

Identification of ligand-selective peptide antagonists of the mineralocorticoid receptor using phage display.

Mol Endocrinol 2011 Jan 24;25(1):32-43. Epub 2010 Nov 24.

Prince Henry's Institute of Medical Research, Clayton, Victoria 3168, Australia.

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http://dx.doi.org/10.1210/me.2010-0193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417296PMC
January 2011

The molecular mechanisms underlying the pharmacological actions of ER modulators: implications for new drug discovery in breast cancer.

Curr Opin Pharmacol 2010 Dec;10(6):620-8

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.coph.2010.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981619PMC
December 2010

Mechanisms of progesterone receptor inhibition of inflammatory responses in cellular models of breast cancer.

Mol Endocrinol 2010 Dec 27;24(12):2292-302. Epub 2010 Oct 27.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1210/me.2010-0289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999472PMC
December 2010

An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy.

J Biol Chem 2010 Nov 8;285(46):35567-77. Epub 2010 Sep 8.

Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1074/jbc.M110.146845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975181PMC
November 2010

The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis.

Endocrinology 2010 Aug 25;151(8):3675-85. Epub 2010 May 25.

Department of Pharmacology, Duke University Medical Center, Pharmacology and Cancer Biology, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1210/en.2010-0080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940523PMC
August 2010

Expression, purification and primary crystallographic study of human androgen receptor in complex with DNA and coactivator motifs.

Protein Expr Purif 2010 May 6;71(1):21-7. Epub 2009 Dec 6.

Laboratory of Structural Sciences, Van Andel Research Institute, 333 Bostwick Avenue, NE Grand Rapids, MI 49503, USA.

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http://dx.doi.org/10.1016/j.pep.2009.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830347PMC
May 2010

Multimodal regulation of E2F1 gene expression by progestins.

Mol Cell Biol 2010 Apr 1;30(8):1866-77. Epub 2010 Feb 1.

Duke University Medical Center, Department of Pharmacology and Cancer Biology, Durham, NC 27710, USA.

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http://dx.doi.org/10.1128/MCB.01060-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849472PMC
April 2010

ERRgamma regulates cardiac, gastric, and renal potassium homeostasis.

Mol Endocrinol 2010 Feb 4;24(2):299-309. Epub 2009 Dec 4.

Gene Expression Laboratory and the Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1210/me.2009-0114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817599PMC
February 2010

Activation of the aryl-hydrocarbon receptor inhibits invasive and metastatic features of human breast cancer cells and promotes breast cancer cell differentiation.

Mol Endocrinol 2010 Feb 23;24(2):359-69. Epub 2009 Dec 23.

The Hamner Institutes for Health Sciences, Genomic Biology and Bioinformatics, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1210/me.2009-0346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817602PMC
February 2010

Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators.

Mol Endocrinol 2010 Jan 9;24(1):33-46. Epub 2009 Nov 9.

Duke University Medical Center, Department of Pharmacology and Cancer Biology, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1210/me.2009-0339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802893PMC
January 2010

Minireview: Nuclear receptors, hematopoiesis, and stem cells.

Mol Endocrinol 2010 Jan 24;24(1):1-10. Epub 2009 Nov 24.

Division of Cellular Therapy, Department of Medicine, Duke University, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1210/me.2009-0332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802897PMC
January 2010

The homeodomain protein HOXB13 regulates the cellular response to androgens.

Mol Cell 2009 Nov;36(3):405-16

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.molcel.2009.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788777PMC
November 2009

Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha.

Mol Endocrinol 2009 Aug 23;23(8):1171-82. Epub 2009 Apr 23.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1210/me.2009-0024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718748PMC
August 2009

Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists.

Proc Natl Acad Sci U S A 2009 Jul 2;106(29):12178-83. Epub 2009 Jul 2.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1073/pnas.0900185106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715477PMC
July 2009

Purification and characterization of recombinant human mineralocorticoid receptor.

Mol Cell Endocrinol 2009 Apr 9;302(1):81-5. Epub 2008 Dec 9.

Prince Henry's Institute of Medical Research, Clayton, Melbourne, Victoria 3168, Australia.

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http://dx.doi.org/10.1016/j.mce.2008.11.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702660PMC
April 2009

Glucose metabolism as a target of histone deacetylase inhibitors.

Mol Endocrinol 2009 Mar 23;23(3):388-401. Epub 2008 Dec 23.

Duke University Medical Center, Pharmacology and Cancer Biology, Box 3813, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1210/me.2008-0179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654518PMC
March 2009

Estrogen-related receptor alpha induces the expression of vascular endothelial growth factor in breast cancer cells.

J Steroid Biochem Mol Biol 2009 Mar 3;114(1-2):106-12. Epub 2009 Mar 3.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813, Durham, NC 27710, United States.

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http://dx.doi.org/10.1016/j.jsbmb.2009.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680788PMC
March 2009

Estrogen-related receptor alpha is critical for the growth of estrogen receptor-negative breast cancer.

Cancer Res 2008 Nov;68(21):8805-12

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-1594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633645PMC
November 2008

27-Hydroxycholesterol: a potential endogenous regulator of estrogen receptor signaling.

Trends Pharmacol Sci 2008 Oct 22;29(10):510-4. Epub 2008 Aug 22.

Duke University Medical Center, Department of Pharmacology and Cancer Biology, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.tips.2008.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702440PMC
October 2008

Differential effects of prostate cancer therapeutics on neuroendocrine transdifferentiation.

Mol Cancer Ther 2008 Mar;7(3):659-69

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-07-0480DOI Listing
March 2008

27-hydroxycholesterol is an endogenous selective estrogen receptor modulator.

Mol Endocrinol 2008 Jan 13;22(1):65-77. Epub 2007 Sep 13.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1210/me.2007-0383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194632PMC
January 2008

The nuclear receptor-coactivator interaction surface as a target for peptide antagonists of the peroxisome proliferator-activated receptors.

Mol Endocrinol 2007 Oct 26;21(10):2361-77. Epub 2007 Jun 26.

Duke University Medical Center, Department of Pharmacology and Cancer Biology, Box 3813, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1210/me.2007-0201DOI Listing
October 2007

Definition of functionally important mechanistic differences among selective estrogen receptor down-regulators.

Cancer Res 2007 Oct;67(19):9549-60

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, 27710, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1590DOI Listing
October 2007

The molecular mechanisms underlying the proinflammatory actions of thiazolidinediones in human macrophages.

Mol Endocrinol 2007 Aug 8;21(8):1756-68. Epub 2007 May 8.

Duke University Medical Center, Department of Pharmacology and Cancer Biology, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1210/me.2007-0060DOI Listing
August 2007

The vitamin D receptor interacts preferentially with DRIP205-like LxxLL motifs.

Arch Biochem Biophys 2007 Apr 8;460(2):206-12. Epub 2007 Jan 8.

Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, USA.

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http://dx.doi.org/10.1016/j.abb.2006.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1924797PMC
April 2007

Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression.

J Biol Chem 2006 Dec 1;281(52):39897-906. Epub 2006 Nov 1.

Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.

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http://dx.doi.org/10.1074/jbc.M608657200DOI Listing
December 2006

International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors.

Pharmacol Rev 2006 Dec;58(4):782-97

Molecular Endocrinology Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1124/pr.58.4.9DOI Listing
December 2006

Mechanism-based discovery as an approach to identify the next generation of estrogen receptor modulators.

FASEB J 2006 Dec;20(14):2432-4

Department of Pharmacology and Cancer Biology, Duke University Medical Center, 6259 LSRC, Box 3813, Durham, NC 27710, USA.

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http://dx.doi.org/10.1096/fj.06-1202ufmDOI Listing
December 2006