Donald Ogilvie

Donald Ogilvie

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Donald Ogilvie

Donald Ogilvie

Publications by authors named "Donald Ogilvie"

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DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors.

Cancer Cell 2019 Mar;35(3):519-533.e8

Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Cancer Research Centre, 555 Wilmslow Road, Manchester M20 4GJ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428690PMC
March 2019

Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores - A cautionary disclosure.

Bioorg Med Chem Lett 2019 Feb 2;29(4):560-562. Epub 2019 Jan 2.

Drug Discovery Unit, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, Macclesfield SK10 4TG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.12.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376317PMC
February 2019

Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1.

J Med Chem 2017 10 21;60(19):7984-7999. Epub 2017 Sep 21.

Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester , Wilmslow Road, Manchester, M20 4BX, U.K.

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http://dx.doi.org/10.1021/acs.jmedchem.7b00462DOI Listing
October 2017

Development and evaluation of 4-(pyrrolidin-3-yl)benzonitrile derivatives as inhibitors of lysine specific demethylase 1.

Bioorg Med Chem Lett 2017 10 24;27(20):4755-4759. Epub 2017 Aug 24.

Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1016/j.bmcl.2017.08.052DOI Listing
October 2017

Development of 5-hydroxypyrazole derivatives as reversible inhibitors of lysine specific demethylase 1.

Bioorg Med Chem Lett 2017 07 8;27(14):3190-3195. Epub 2017 May 8.

Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1016/j.bmcl.2017.05.018DOI Listing
July 2017

A high-throughput screening-compatible homogeneous time-resolved fluorescence assay measuring the glycohydrolase activity of human poly(ADP-ribose) glycohydrolase.

Anal Biochem 2016 06 29;503:58-64. Epub 2016 Mar 29.

Cancer Research UK Manchester Institute Drug Discovery Unit, University of Manchester, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1016/j.ab.2016.03.016DOI Listing
June 2016

Rethinking 'academic' drug discovery: the Manchester Institute perspective.

Drug Discov Today 2015 May 24;20(5):525-35. Epub 2014 Dec 24.

Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1016/j.drudis.2014.12.011DOI Listing
May 2015

Elevated plasma 2-hydroxyglutarate in acute myeloid leukaemia: association with the IDH1 SNP rs11554137 and severe renal impairment.

Br J Haematol 2014 Jul 10;166(1):145-8. Epub 2014 Mar 10.

Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1111/bjh.12826DOI Listing
July 2014

A fluorescence-based assay for the apurinic/apyrimidinic-site cleavage activity of human tyrosyl-DNA phosphodiesterase 1.

Anal Biochem 2013 Sep 18;440(1):1-5. Epub 2013 May 18.

Cancer Research UK Drug Discovery Unit, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1016/j.ab.2013.05.003DOI Listing
September 2013

Generation of assays and antibodies to facilitate the study of human 5'-tyrosyl DNA phosphodiesterase.

Anal Biochem 2013 May 12;436(2):145-50. Epub 2013 Feb 12.

Cancer Research UK Drug Discovery Unit, Paterson Institute for Cancer Research, University of Manchester, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1016/j.ab.2013.02.001DOI Listing
May 2013

Anti-tumour and anti-vascular effects of cediranib (AZD2171) alone and in combination with other anti-tumour therapies.

Cancer Chemother Pharmacol 2013 Apr 26;71(4):1021-32. Epub 2013 Jan 26.

Translational Sciences, AstraZeneca Oncology, Alderley Park, Macclesfield SK10 4TF, UK.

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http://dx.doi.org/10.1007/s00280-013-2097-xDOI Listing
April 2013

Novel steroid inhibitors of glucose 6-phosphate dehydrogenase.

J Med Chem 2012 May 27;55(9):4431-45. Epub 2012 Apr 27.

Cancer Research UK Drug Discovery Unit, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester, M20 4 BX, UK.

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http://dx.doi.org/10.1021/jm300317kDOI Listing
May 2012

The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells.

Cancer Cell 2012 Apr 29;21(4):473-87. Epub 2012 Mar 29.

Cancer Research UK Leukaemia Biology Laboratory, Paterson Institute for Cancer Research, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1016/j.ccr.2012.03.014DOI Listing
April 2012

Novel 3-alkoxy-1H-pyrazolo[3,4-d]pyrimidines as EGFR and erbB2 receptor tyrosine kinase inhibitors.

Bioorg Med Chem Lett 2008 Feb 23;18(3):959-62. Epub 2007 Dec 23.

AstraZeneca, Centre de Recherches, Z.I. la Pompelle, BP1050, 51689 Reims Cedex 2, France.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X0701491
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http://dx.doi.org/10.1016/j.bmcl.2007.12.035DOI Listing
February 2008