Donald N Forthal

Donald N Forthal

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Donald N Forthal

Donald N Forthal

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Antibody Responses Elicited by Immunization with BG505 Trimer Immune Complexes.

J Virol 2019 Oct 30;93(20). Epub 2019 Sep 30.

Department of Medicine, University of California Irvine, School of Medicine, Irvine, California, USA

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http://dx.doi.org/10.1128/JVI.01188-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798112PMC
October 2019

Antibody-dependent cellular cytotoxicity in HIV infection.

AIDS 2018 11;32(17):2439-2451

Department of Microbiology, Infectious Diseases and Immunology, Université de Montréal, Centre de Recherche du CHUM.

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http://dx.doi.org/10.1097/QAD.0000000000002011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497078PMC
November 2018

Human immunodeficiency virus type-1 (HIV-1) evades antibody-dependent phagocytosis.

PLoS Pathog 2017 12 27;13(12):e1006793. Epub 2017 Dec 27.

Department of Medicine, Division of Infectious Diseases, University of California, Irvine School of Medicine, Irvine, California, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1006793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760106PMC
December 2017

Relationship between Vaccine-Induced Antibody Capture of Infectious Virus and Infection Outcomes following Repeated Low-Dose Rectal Challenges with Simian Immunodeficiency Virus SIVmac251.

J Virol 2016 10 12;90(19):8487-95. Epub 2016 Sep 12.

Division of Infectious Diseases, Departments of Medicine and Molecular Biology & Biochemistry, University of California, Irvine, California, USA

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http://dx.doi.org/10.1128/JVI.00812-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021405PMC
October 2016

Association of VH4-59 Antibody Variable Gene Usage with Recognition of an Immunodominant Epitope on the HIV-1 Gag Protein.

PLoS One 2015 30;10(7):e0133509. Epub 2015 Jul 30.

Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, Tennessee, United States of America; Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, United States of America; Vanderbilt Vaccine Center, Microbiology and Immunology, Vanderbilt University, Nashville, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133509PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520566PMC
May 2016

Low frequency of broadly neutralizing HIV antibodies during chronic infection even in quaternary epitope targeting antibodies containing large numbers of somatic mutations.

Mol Immunol 2016 Feb 31;70:94-103. Epub 2015 Dec 31.

Department of Pathology, Microbiology and Immunology Vanderbilt University Medical Center, Nashville, TN 37232, United States; The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, United States. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2015.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762738PMC
February 2016

Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgM.

Biochim Biophys Acta 2015 Oct 5;1854(10 Pt A):1536-44. Epub 2015 Mar 5.

Department of Biotechnology, Vienna Institute of BioTechnology at BOKU, University of Natural Resources and Life Sciences, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2015.02.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582045PMC
October 2015

Glycan modulation and sulfoengineering of anti-HIV-1 monoclonal antibody PG9 in plants.

Proc Natl Acad Sci U S A 2015 Oct 28;112(41):12675-80. Epub 2015 Sep 28.

Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, A-1190 Vienna, Austria;

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http://dx.doi.org/10.1073/pnas.1509090112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611627PMC
October 2015

Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: complete protection of rhesus monkeys from mucosal SHIV challenge.

Vaccine 2015 Apr 11;33(17):2086-95. Epub 2015 Mar 11.

Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX, USA; Southwest National Primate Research Center, San Antonio, TX, USA; Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2015.02.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411954PMC
April 2015

Multimodality vaccination against clade C SHIV: partial protection against mucosal challenges with a heterologous tier 2 virus.

Vaccine 2014 Nov 20;32(48):6527-36. Epub 2014 Sep 20.

Texas Biomedical Research Institute, San Antonio, TX, USA; Southwest National Primate Research Center, San Antonio, TX, USA; Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2014.08.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4343195PMC
November 2014

Functions of Antibodies.

Authors:
Donald N Forthal

Microbiol Spectr 2014 Aug;2(4):1-17

Chief, Infectious Diseases, University of California, Irvine, 3044 Hewitt Hall, Irvine, CA 92617, 949-824-3366.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159104PMC
August 2014

Functions of Antibodies.

Authors:
Donald N Forthal

Microbiol Spectr 2014 Aug;2(4):AID-0019-2014

Department of Infectious Diseases, University of California, Irvine, Irvine, CA 92617.

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http://www.asmscience.org/content/book/10.1128/9781555817411
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http://dx.doi.org/10.1128/microbiolspec.AID-0019-2014DOI Listing
August 2014

A human antibody to the CD4 binding site of gp120 capable of highly potent but sporadic cross clade neutralization of primary HIV-1.

PLoS One 2013 26;8(8):e72054. Epub 2013 Aug 26.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America ; Division of Infectious Diseases, University of California Irvine, Irvine, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072054PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753353PMC
April 2014

Antibody-dependent enhancement and the risk of HIV infection.

Curr HIV Res 2013 Jul;11(5):421-6

Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, 3044 Hewitt Hall, UC Irvine, Irvine, CA 92697, USA.

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http://www.researchgate.net/profile/Brett_Lidbury/publicatio
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http://dx.doi.org/10.2174/1570162x113116660062DOI Listing
July 2013

Antibody-dependent cell-mediated virus inhibition antibody activity does not correlate with risk of HIV-1 superinfection.

J Acquir Immune Defic Syndr 2013 May;63(1):31-3

Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, Irvine, CA 92967, USA.

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http://dx.doi.org/10.1097/QAI.0b013e3182874d41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625514PMC
May 2013

In vitro anti-HIV-1 activity of salicylidene acylhydrazide compounds.

Int J Antimicrob Agents 2012 Oct 20;40(4):354-60. Epub 2012 Jul 20.

Department of Medicine (Infectious Diseases), University of California, Irvine School of Medicine, 3044 Hewitt Hall, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1016/j.ijantimicag.2012.05.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438335PMC
October 2012

Association of Fcγ receptor IIIa genotype with the rate of HIV infection after gp120 vaccination.

Blood 2012 Oct 22;120(14):2836-42. Epub 2012 Aug 22.

Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, Irvine, CA 92697, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2012-05-43
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http://dx.doi.org/10.1182/blood-2012-05-431361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466964PMC
October 2012

Evaluation of heterologous vaginal SHIV SF162p4 infection following vaccination with a polyvalent Clade B virus-like particle vaccine.

AIDS Res Hum Retroviruses 2012 Sep 21;28(9):1063-72. Epub 2012 Mar 21.

Center for Vaccine Research, University of Pittsburgh, Pennsylvania 15261, USA.

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http://www.liebertpub.com/doi/10.1089/aid.2011.0351
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http://dx.doi.org/10.1089/AID.2011.0351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423648PMC
September 2012

IgG2 inhibits HIV-1 internalization by monocytes, and IgG subclass binding is affected by gp120 glycosylation.

AIDS 2011 Nov;25(17):2099-104

Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, USA.

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http://dx.doi.org/10.1097/QAD.0b013e32834b64bdDOI Listing
November 2011

Fc-glycosylation influences Fcγ receptor binding and cell-mediated anti-HIV activity of monoclonal antibody 2G12.

J Immunol 2010 Dec 1;185(11):6876-82. Epub 2010 Nov 1.

Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, Irvine, CA 92697, USA.

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1002600
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http://dx.doi.org/10.4049/jimmunol.1002600DOI Listing
December 2010

Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L.

J Virol 2010 Feb 11;84(3):1302-13. Epub 2009 Nov 11.

Department of Immunology and Microbial Science and the International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1128/JVI.01272-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812338PMC
February 2010

Fc receptor-mediated antiviral antibodies.

Curr Opin HIV AIDS 2009 Sep;4(5):388-93

Department of Medicine, Division of Infectious Diseases, University of California, Irvine School of Medicine, Irvine, California, USA.

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http://dx.doi.org/10.1097/COH.0b013e32832f0a89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882066PMC
September 2009

Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers.

PLoS Pathog 2009 May 15;5(5):e1000433. Epub 2009 May 15.

Department of Immunology and Microbial Science, and IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1371/journal.ppat.1000433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674935PMC
May 2009

FcgammaRIIa genotype predicts progression of HIV infection.

J Immunol 2007 Dec;179(11):7916-23

Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, Irvine, CA 92697, USA.

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http://dx.doi.org/10.4049/jimmunol.179.11.7916DOI Listing
December 2007

Fc receptor but not complement binding is important in antibody protection against HIV.

Nature 2007 Sep;449(7158):101-4

Department of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nature06106DOI Listing
September 2007

Recombinant gp120 vaccine-induced antibodies inhibit clinical strains of HIV-1 in the presence of Fc receptor-bearing effector cells and correlate inversely with HIV infection rate.

J Immunol 2007 May;178(10):6596-603

Division of Infectious Diseases, Department of Medicine, University of California, Irvine, CA 92697, USA.

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http://dx.doi.org/10.4049/jimmunol.178.10.6596DOI Listing
May 2007

Rhesus macaque polyclonal and monoclonal antibodies inhibit simian immunodeficiency virus in the presence of human or autologous rhesus effector cells.

J Virol 2006 Sep;80(18):9217-25

Department of Medicine, Division of Infectious Diseases, School of Medicine, University of California-Irvine, Irvine, CA 92697-4028, USA.

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http://dx.doi.org/10.1128/JVI.02746-05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1563916PMC
September 2006

Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection.

J Infect Dis 2005 Mar 27;191(5):654-65. Epub 2005 Jan 27.

University of California at Davis Medical Center, USA.

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http://dx.doi.org/10.1086/428404DOI Listing
March 2005

Interactions between natural killer cells and antibody Fc result in enhanced antibody neutralization of human immunodeficiency virus type 1.

J Virol 2005 Feb;79(4):2042-9

Department of Medicine, Division of Infectious Diseases, University of California, Irvine, School of Medicine, Route 81, 101 City Dr., Orange, CA 92868, USA.

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http://dx.doi.org/10.1128/JVI.79.4.2042-2049.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC546539PMC
February 2005

CD8+ T-cell mediated tumor protection by Pseudomonas exotoxin fused to ovalbumin in C57BL/6 mice.

Surgery 2003 Apr;133(4):404-10

Department of Surgery, Medical Center, University of California-Irvine, 101 The City Drive, Orange, CA 92868, USA.

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http://dx.doi.org/10.1067/msy.2003.112DOI Listing
April 2003