Publications by authors named "Donald Metcalf"

100Publications

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction.

Nat Commun 2020 06 19;11(1):3150. Epub 2020 Jun 19.

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.

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http://dx.doi.org/10.1038/s41467-020-16819-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305203PMC
June 2020

Hhex Regulates Hematopoietic Stem Cell Self-Renewal and Stress Hematopoiesis via Repression of Cdkn2a.

Stem Cells 2017 08 19;35(8):1948-1957. Epub 2017 Jun 19.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1002/stem.2648DOI Listing
August 2017

MOZ and BMI1 act synergistically to maintain hematopoietic stem cells.

Exp Hematol 2017 03 24;47:83-97.e8. Epub 2016 Oct 24.

The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.10.006DOI Listing
March 2017

Growth and Differentiation Factors.

Authors:
Donald Metcalf

Microbiol Spectr 2016 08;4(4)

†Deceased.

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http://dx.doi.org/10.1128/microbiolspec.MCHD-0004-2015DOI Listing
August 2016

MOZ (KAT6A) is essential for the maintenance of classically defined adult hematopoietic stem cells.

Blood 2016 11 23;128(19):2307-2318. Epub 2016 Sep 23.

The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1182/blood-2015-10-676072DOI Listing
November 2016

Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a.

Genes Dev 2016 Jan;30(1):78-91

Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia;

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http://dx.doi.org/10.1101/gad.268425.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701980PMC
January 2016

Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis.

Blood 2015 Jul 2;126(2):167-75. Epub 2015 Jun 2.

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology and.

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http://dx.doi.org/10.1182/blood-2014-12-615898DOI Listing
July 2015

Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β.

J Exp Med 2015 Jun 25;212(6):927-38. Epub 2015 May 25.

Division of Inflammation, Division of Cancer and Hematology, Division of Immunology, and ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia

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http://dx.doi.org/10.1084/jem.20142384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451132PMC
June 2015

Early lineage priming by trisomy of Erg leads to myeloproliferation in a Down syndrome model.

PLoS Genet 2015 May 14;11(5):e1005211. Epub 2015 May 14.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1371/journal.pgen.1005211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431731PMC
May 2015

Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production.

Cell 2014 Dec;159(7):1549-62

ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.11.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520319PMC
December 2014

Lymphoid tissue and plasmacytoid dendritic cells and macrophages do not share a common macrophage-dendritic cell-restricted progenitor.

Immunity 2014 Jul;41(1):104-15

The Walter and Eliza Hall Institute, Parkville, VIC 3050, Australia; Department of Medical Biology, The University of Melbourne, VIC 3010, Australia; Burnet Institute, Melbourne, VIC 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2014.05.020DOI Listing
July 2014

A reporter mouse reveals lineage-specific and heterogeneous expression of IRF8 during lymphoid and myeloid cell differentiation.

J Immunol 2014 Aug 14;193(4):1766-77. Epub 2014 Jul 14.

Virology and Cellular Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852;

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http://dx.doi.org/10.4049/jimmunol.1301939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119573PMC
August 2014

Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.

PLoS Pathog 2014 May 8;10(5):e1004134. Epub 2014 May 8.

Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria Australia; Department of Medical Biology, The University of Melbourne, Parkville, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1371/journal.ppat.1004134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014316PMC
May 2014

Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation.

Proc Natl Acad Sci U S A 2014 Apr 7;111(16):5884-9. Epub 2014 Apr 7.

Divisions of Cancer and Haematology, and Molecular Medicine, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.

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http://dx.doi.org/10.1073/pnas.1404354111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000844PMC
April 2014

Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways.

Nat Commun 2014 Mar 17;5:3455. Epub 2014 Mar 17.

1] The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia [2] Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.

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http://www.nature.com/articles/ncomms4455
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http://dx.doi.org/10.1038/ncomms4455DOI Listing
March 2014

The colony-stimulating factors and cancer.

Authors:
Donald Metcalf

Cancer Immunol Res 2013 Dec;1(6):351-6

Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, Victoria, Australia; Department of Medical Biology, University of Melbourne, Parkville 3010, Victoria, Australia. Telephone: 61-3-9345-2555;

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http://dx.doi.org/10.1158/2326-6066.CIR-13-0151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918448PMC
December 2013

Transgenic expression of GM-CSF in T cells causes disseminated histiocytosis.

Am J Pathol 2014 Jan 30;184(1):184-99. Epub 2013 Oct 30.

Inflammation Division, the Reid Rheumatology Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia; Department of Medical Biology, University of Melbourne, Parkville, Australia; Rheumatology Unit, Melbourne Health, PO Royal Melbourne Hospital, Parkville, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029440130066
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http://dx.doi.org/10.1016/j.ajpath.2013.09.014DOI Listing
January 2014

Reversible growth factor dependency and autonomy during murine myelomonocytic leukemia induced by oncogenes.

Proc Natl Acad Sci U S A 2013 Oct 30;110(42):17029-34. Epub 2013 Sep 30.

Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.

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http://dx.doi.org/10.1073/pnas.1317055110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800987PMC
October 2013

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.

Immunity 2013 Sep 5;39(3):443-53. Epub 2013 Sep 5.

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3050, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2013.06.018DOI Listing
September 2013

Concordant mast cell and basophil production by individual hematopoietic blast colony-forming cells.

Proc Natl Acad Sci U S A 2013 May 13;110(22):9031-5. Epub 2013 May 13.

Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Victoria, Australia.

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http://dx.doi.org/10.1073/pnas.1307711110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670339PMC
May 2013

Hematopoietic overexpression of the transcription factor Erg induces lymphoid and erythro-megakaryocytic leukemia.

Proc Natl Acad Sci U S A 2012 Sep 30;109(38):15437-42. Epub 2012 Aug 30.

Cancer and Hematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, VIC, Australia.

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http://dx.doi.org/10.1073/pnas.1213454109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458381PMC
September 2012

A promising new treatment for refractory aplastic anemia.

Authors:
Donald Metcalf

N Engl J Med 2012 Jul;367(1):74-5

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http://dx.doi.org/10.1056/NEJMe1204395DOI Listing
July 2012

Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival.

Blood 2012 Jun 28;119(24):5850-8. Epub 2012 Feb 28.

Cancer and Hematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.

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http://dx.doi.org/10.1182/blood-2011-12-398834DOI Listing
June 2012

Characterization of thrombopoietin (TPO)-responsive progenitor cells in adult mouse bone marrow with in vivo megakaryocyte and erythroid potential.

Proc Natl Acad Sci U S A 2012 Feb 30;109(7):2364-9. Epub 2012 Jan 30.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1073/pnas.1121385109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289343PMC
February 2012

Thrombocytopenia and erythrocytosis in mice with a mutation in the gene encoding the hemoglobin β minor chain.

Proc Natl Acad Sci U S A 2012 Jan 27;109(2):576-81. Epub 2011 Dec 27.

Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia.

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http://dx.doi.org/10.1073/pnas.1119146109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258592PMC
January 2012

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.

J Exp Med 2011 Sep 12;208(10):2017-31. Epub 2011 Sep 12.

Molecular Medicine Division, Cancer and Hematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.

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http://www.jem.org/lookup/doi/10.1084/jem.20110750
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http://dx.doi.org/10.1084/jem.20110750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182050PMC
September 2011

Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice.

Blood 2011 Sep 14;118(9):2454-61. Epub 2011 Jun 14.

Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.

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http://dx.doi.org/10.1182/blood-2011-03-344739DOI Listing
September 2011

IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3.

Immunol Cell Biol 2012 Jan 26;90(1):124-9. Epub 2011 Apr 26.

Department of Inflammation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

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http://doi.wiley.com/10.1038/icb.2011.29
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http://dx.doi.org/10.1038/icb.2011.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146962PMC
January 2012

Thrombopoietin and hematopoietic stem cells.

Cell Cycle 2011 May 15;10(10):1582-9. Epub 2011 May 15.

The Walter and Eliza Hall Institute, Parkville, Victoria, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127159PMC
http://dx.doi.org/10.4161/cc.10.10.15619DOI Listing
May 2011

Neutrophils require SHP1 to regulate IL-1β production and prevent inflammatory skin disease.

J Immunol 2011 Jan 15;186(2):1131-9. Epub 2010 Dec 15.

Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1002702
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http://dx.doi.org/10.4049/jimmunol.1002702DOI Listing
January 2011

Regulation of hematopoietic stem cells by their mature progeny.

Proc Natl Acad Sci U S A 2010 Dec 29;107(50):21689-94. Epub 2010 Nov 29.

Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1016166108
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http://dx.doi.org/10.1073/pnas.1016166108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003054PMC
December 2010

Multipotential hematopoietic blast colony-forming cells exhibit delays in self-generation and lineage commitment.

Proc Natl Acad Sci U S A 2010 Sep 30;107(37):16257-61. Epub 2010 Aug 30.

Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.

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http://dx.doi.org/10.1073/pnas.1011881107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941309PMC
September 2010

Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance.

Blood 2010 Oct 14;116(17):3197-207. Epub 2010 Jul 14.

Molecular Genetics of CancerDivision, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, Victoria, Australia.

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http://dx.doi.org/10.1182/blood-2010-04-281071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995351PMC
October 2010

The colony-stimulating factors and cancer.

Authors:
Donald Metcalf

Nat Rev Cancer 2010 06;10(6):425-34

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1038/nrc2843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345291PMC
June 2010

Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome.

Blood 2010 May 9;115(19):3966-9. Epub 2009 Dec 9.

Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.

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http://dx.doi.org/10.1182/blood-2009-09-242107DOI Listing
May 2010

A convenient method for preparation of an engineered mouse interleukin-3 analog with high solubility and wild-type bioactivity.

Growth Factors 2010 Apr;28(2):104-10

Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.3109/08977190903443048DOI Listing
April 2010

Murine hematopoietic blast colony-forming cells and their progeny have distinctive membrane marker profiles.

Proc Natl Acad Sci U S A 2009 Nov 23;106(45):19102-7. Epub 2009 Oct 23.

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1073/pnas.0910354106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776469PMC
November 2009

Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage.

Proc Natl Acad Sci U S A 2009 Aug 31;106(33):13814-9. Epub 2009 Jul 31.

Divisions of Molecular Medicine and Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, Australia.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0906556106
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http://dx.doi.org/10.1073/pnas.0906556106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728977PMC
August 2009

Blimp1 is limiting for transformation in a mouse plasmacytoma model.

Blood 2009 Jun 27;113(23):5911-9. Epub 2009 Mar 27.

Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.

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http://www.bloodjournal.org/content/113/23/5911.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2008-08-17
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http://dx.doi.org/10.1182/blood-2008-08-172866DOI Listing
June 2009

Hematopoietic defects in the Ts1Cje mouse model of Down syndrome.

Blood 2009 Feb 24;113(9):1929-37. Epub 2008 Dec 24.

Molecular Medicine, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2008-06-16
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http://dx.doi.org/10.1182/blood-2008-06-161422DOI Listing
February 2009

A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis.

Blood 2008 Dec 29;112(13):5193-201. Epub 2008 Sep 29.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1182/blood-2008-02-139535DOI Listing
December 2008

The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells.

Nat Immunol 2008 Jul 25;9(7):810-9. Epub 2008 May 25.

Division of Molecular Medicine, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1038/ni.1617DOI Listing
July 2008

Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation.

Exp Hematol 2008 Jul 8;36(7):786-98. Epub 2008 Apr 8.

Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1016/j.exphem.2008.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556307PMC
July 2008

Hematopoietic cytokines.

Authors:
Donald Metcalf

Blood 2008 Jan;111(2):485-91

Walter and Eliza Hall Institute of Medical Research, Victoria, Australia.

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http://dx.doi.org/10.1182/blood-2007-03-079681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2200848PMC
January 2008

The preleukemic state of mice reconstituted with Mixl1-transduced marrow cells.

Proc Natl Acad Sci U S A 2007 Dec 3;104(50):20013-8. Epub 2007 Dec 3.

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1073/pnas.0710339104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148414PMC
December 2007

Clonogenic mast cell progenitors and their excess numbers in chimeric BALB/c mice with inactivated GATA-1.

Proc Natl Acad Sci U S A 2007 Nov 13;104(47):18642-7. Epub 2007 Nov 13.

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0709625104
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http://dx.doi.org/10.1073/pnas.0709625104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2141830PMC
November 2007

Concise review: hematopoietic stem cells and tissue stem cells: current concepts and unanswered questions.

Authors:
Donald Metcalf

Stem Cells 2007 Oct 9;25(10):2390-5. Epub 2007 Aug 9.

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1634/stemcells.2007-0544DOI Listing
October 2007

On hematopoietic stem cell fate.

Authors:
Donald Metcalf

Immunity 2007 Jun;26(6):669-73

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia.

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http://dx.doi.org/10.1016/j.immuni.2007.05.012DOI Listing
June 2007

Programmed anuclear cell death delimits platelet life span.

Cell 2007 Mar;128(6):1173-86

Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia.

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http://linkinghub.elsevier.com/retrieve/pii/S009286740700196
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http://dx.doi.org/10.1016/j.cell.2007.01.037DOI Listing
March 2007

Enforced expression of the homeobox gene Mixl1 impairs hematopoietic differentiation and results in acute myeloid leukemia.

Proc Natl Acad Sci U S A 2006 Oct 23;103(44):16460-5. Epub 2006 Oct 23.

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1073/pnas.0607776103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637604PMC
October 2006

A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia.

Proc Natl Acad Sci U S A 2006 Sep 11;103(38):14146-51. Epub 2006 Sep 11.

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1073/pnas.0606439103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1599926PMC
September 2006

Granulocyte colony-stimulating factor and neutrophils--forgotten mediators of inflammatory disease.

Nat Clin Pract Rheumatol 2006 Sep;2(9):500-10

Reid Rheumatology Laboratory, Division of Autoimmunity and Transplantation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

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http://search.proquest.com/openview/c31859bc34c20edf5722ccf2
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http://www.nature.com/doifinder/10.1038/ncprheum0291
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http://dx.doi.org/10.1038/ncprheum0291DOI Listing
September 2006

Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes.

Nat Immunol 2006 Jun 7;7(6):663-71. Epub 2006 May 7.

The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Vaccine Technology, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1038/ni1340DOI Listing
June 2006

Loss of PU.1: one of the many roads to myeloid leukemia.

Authors:
Donald Metcalf

Cell Cycle 2006 Apr 1;5(7):673-4. Epub 2006 Apr 1.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.4161/cc.5.7.2619DOI Listing
April 2006

Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance.

Nat Immunol 2006 May 26;7(5):466-74. Epub 2006 Mar 26.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1038/ni1321DOI Listing
May 2006

MYC levels govern hematopoietic tumor type and latency in transgenic mice.

Blood 2006 Jul 14;108(2):653-61. Epub 2006 Mar 14.

The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1182/blood-2006-01-0172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895495PMC
July 2006

Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia.

Proc Natl Acad Sci U S A 2006 Jan 23;103(5):1486-91. Epub 2006 Jan 23.

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia.

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http://dx.doi.org/10.1073/pnas.0510616103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360594PMC
January 2006

Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity.

Nat Immunol 2006 Jan 27;7(1):33-9. Epub 2005 Nov 27.

Centre for Functional Genomics and Human Disease, Monash Institute of Medical Research, Monash University, Clayton 3168, Australia.

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http://www.nature.com/articles/ni1287
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http://dx.doi.org/10.1038/ni1287DOI Listing
January 2006

FADD and caspase-8 are required for cytokine-induced proliferation of hemopoietic progenitor cells.

Blood 2005 Sep 19;106(5):1581-9. Epub 2005 May 19.

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville VIC 3050, Australia.

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http://dx.doi.org/10.1182/blood-2005-01-0284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895211PMC
September 2005

Suppressor of cytokine signaling-1 in T cells and macrophages is critical for preventing lethal inflammation.

Blood 2005 Sep 17;106(5):1668-75. Epub 2005 May 17.

St Vincent's Institute, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia.

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http://dx.doi.org/10.1182/blood-2004-08-3049DOI Listing
September 2005

PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis.

J Exp Med 2005 May;201(9):1487-502

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1084/jem.20050075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213186PMC
May 2005

Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling.

Proc Natl Acad Sci U S A 2005 Feb 3;102(7):2328-33. Epub 2005 Feb 3.

The Walter and Eliza Hall Institute of Medical Research, Cooperative Research Centre for Cellular Growth Factors, Parkville, Victoria 3052, Australia.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0409675102
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http://dx.doi.org/10.1073/pnas.0409675102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC549009PMC
February 2005

SOCS2 negatively regulates growth hormone action in vitro and in vivo.

J Clin Invest 2005 Feb;115(2):397-406

Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research (WEHI) and the Cooperative Centre for Cellular Growth Factors, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1172/JCI22710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC546423PMC
February 2005

Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene.

Blood 2005 May 21;105(9):3480-7. Epub 2005 Jan 21.

Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1182/blood-2004-12-4806DOI Listing
May 2005

Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors.

J Exp Med 2005 Jan;201(2):221-31

The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia.

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http://dx.doi.org/10.1084/jem.20041535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212785PMC
January 2005

Murine megakaryocyte progenitor cells and their susceptibility to suppression by G-CSF.

Stem Cells 2005 ;23(1):55-62

Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1634/stemcells.2004-0164DOI Listing
June 2005

Development of hydrocephalus in mice lacking SOCS7.

Proc Natl Acad Sci U S A 2004 Oct 19;101(43):15446-51. Epub 2004 Oct 19.

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1073/pnas.0406870101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC524464PMC
October 2004

Critical role for granulocyte colony-stimulating factor in inflammatory arthritis.

Proc Natl Acad Sci U S A 2004 Aug 22;101(31):11398-403. Epub 2004 Jul 22.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0404328101
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http://dx.doi.org/10.1073/pnas.0404328101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC509212PMC
August 2004

SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis.

Immunity 2004 Feb;20(2):153-65

Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research and The Cooperative Research Centre for Cellular Growth Factors, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1016/s1074-7613(04)00022-6DOI Listing
February 2004

Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling.

J Biol Chem 2004 Jan 29;279(3):2125-34. Epub 2003 Oct 29.

Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1074/jbc.M310103200DOI Listing
January 2004

The lethal effects of transplantation of Socs1-/- bone marrow cells into irradiated adult syngeneic recipients.

Proc Natl Acad Sci U S A 2003 Jul 23;100(14):8436-41. Epub 2003 Jun 23.

Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, 1G Royal Parade, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1073/pnas.1032925100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC166247PMC
July 2003