Donald E Ingber

Donald E Ingber

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Donald E Ingber

Publications by authors named "Donald E Ingber"

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Biomimetic smoking robot for in vitro inhalation exposure compatible with microfluidic organ chips.

Nat Protoc 2020 Feb 10;15(2):183-206. Epub 2020 Jan 10.

Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41596-019-0230-yDOI Listing
February 2020

YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow.

Dev Cell 2020 Feb 6. Epub 2020 Feb 6.

Stem Cell Program, Division of Pediatric Hematology and Oncology, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2020.01.006DOI Listing
February 2020

Tumor-Derived Extracellular Vesicles Breach the Intact Blood-Brain Barrier Transcytosis.

ACS Nano 2019 Dec 10;13(12):13853-13865. Epub 2019 Sep 10.

Vascular Biology Program , Boston Children's Hospital , Boston , Massachusetts 02115 , United States.

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http://dx.doi.org/10.1021/acsnano.9b04397DOI Listing
December 2019

An antifouling coating that enables affinity-based electrochemical biosensing in complex biological fluids.

Nat Nanotechnol 2019 Dec 11;14(12):1143-1149. Epub 2019 Nov 11.

Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41565-019-0566-zDOI Listing
December 2019

Human Colon-on-a-Chip Enables Continuous In Vitro Analysis of Colon Mucus Layer Accumulation and Physiology.

Cell Mol Gastroenterol Hepatol 2019 Nov 26. Epub 2019 Nov 26.

Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, Massachusetts; Vascular Biology Program and Department Surgery, Harvard Medical School, Boston Children's Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2019.11.008DOI Listing
November 2019

Cellular nanoscale stiffness patterns governed by intracellular forces.

Nat Mater 2019 Oct 17;18(10):1071-1077. Epub 2019 Jun 17.

Department of Biological Sciences, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1038/s41563-019-0391-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754298PMC
October 2019

Controllable Fabrication of Inhomogeneous Microcapsules for Triggered Release by Osmotic Pressure.

Small 2019 Oct 25;15(42):e1903087. Epub 2019 Aug 25.

John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.

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http://dx.doi.org/10.1002/smll.201903087DOI Listing
October 2019

Seeing Your Way to New Insights in Biology.

J Mol Biol 2019 Jun 26;431(14):2485-2486. Epub 2019 Apr 26.

Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA; Vascular Biology Program, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; "aHarvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.jmb.2019.04.033DOI Listing
June 2019

Human Intestinal Morphogenesis Controlled by Transepithelial Morphogen Gradient and Flow-Dependent Physical Cues in a Microengineered Gut-on-a-Chip.

iScience 2019 May 3;15:391-406. Epub 2019 May 3.

Department of Biomedical Engineering, Cockrell School of Engineering, The University of Texas at Austin, Austin, TX 78712, USA; Department of Oncology, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA; Department of Medical Engineering, Yonsei University College of Medicine, Seoul 03722, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2019.04.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526295PMC
May 2019

Rapid Prototyping of Thermoplastic Microfluidic Devices.

Methods Mol Biol 2018 ;1771:161-170

Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-4939-7792-5_13DOI Listing
February 2019

Modelling cancer in microfluidic human organs-on-chips.

Nat Rev Cancer 2019 02;19(2):65-81

Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41568-018-0104-6DOI Listing
February 2019

Non-invasive sensing of transepithelial barrier function and tissue differentiation in organs-on-chips using impedance spectroscopy.

Lab Chip 2019 01;19(3):452-463

BIOS Lab on a Chip group, MESA+ Institute for Nanotechnology, MIRA Institute for Biomedical Technology and Technical Medicine and Max Planck Center for Complex Fluid Dynamics, University of Twente, P. O. Box 217, 7500 AE Enschede, The Netherlands.

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http://dx.doi.org/10.1039/c8lc00129dDOI Listing
January 2019

Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems.

Clin Pharmacol Ther 2018 12 30;104(6):1240-1248. Epub 2018 Apr 30.

Janssen Pharmaceutical Research and Development, Discovery & Manufacturing Sciences, Spring House, Pennsylvania, USA.

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http://dx.doi.org/10.1002/cpt.1054DOI Listing
December 2018

A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells.

Nat Biotechnol 2018 10 20;36(9):865-874. Epub 2018 Aug 20.

Disease Biophysics Group, Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.4226DOI Listing
October 2018

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips.

J Vis Exp 2018 10 20(140). Epub 2018 Oct 20.

Wyss Institute for Biologically Inspired Engineering, Harvard University; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University; Vascular Biology Program and Department of Surgery, Boston Children's Hospital and Harvard Medical School.

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https://www.jove.com/video/58151/scalable-fabrication-stretc
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http://dx.doi.org/10.3791/58151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235575PMC
October 2018

Collective Shape Actuation of Polymer Double Emulsions by Solvent Evaporation.

ACS Appl Mater Interfaces 2018 Sep 12;10(38):31865-31869. Epub 2018 Sep 12.

Vascular Biology Program, Departments of Pathology and Surgery , Children's Hospital Boston and Harvard Medical School , Boston , Massachusetts 02115 , United States.

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http://pubs.acs.org/doi/10.1021/acsami.8b13216
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http://dx.doi.org/10.1021/acsami.8b13216DOI Listing
September 2018

From mechanobiology to developmentally inspired engineering.

Authors:
Donald E Ingber

Philos Trans R Soc Lond B Biol Sci 2018 09 24;373(1759). Epub 2018 Sep 24.

Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA

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http://dx.doi.org/10.1098/rstb.2017.0323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158204PMC
September 2018

Modulation of the Cellular Uptake of DNA Origami through Control over Mass and Shape.

Nano Lett 2018 06 22;18(6):3557-3564. Epub 2018 May 22.

Department of Cancer Biology , Dana-Farber Cancer Institute , 450 Brookline Avenue , Boston , Massachusetts 02215 , United States.

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http://dx.doi.org/10.1021/acs.nanolett.8b00660DOI Listing
June 2018

Developmentally inspired human 'organs on chips'.

Authors:
Donald E Ingber

Development 2018 05 18;145(16). Epub 2018 May 18.

Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA

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http://dx.doi.org/10.1242/dev.156125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124544PMC
May 2018

Microfluidic Organ-on-a-Chip Models of Human Intestine.

Cell Mol Gastroenterol Hepatol 2018 24;5(4):659-668. Epub 2018 Apr 24.

Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jcmgh.2017.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924739PMC
April 2018

Human Lung Small Airway-on-a-Chip Protocol.

Methods Mol Biol 2017 ;1612:345-365

Wyss Institute for Biologically Inspired Engineering, Center for Life Science Building, 5th Floor, 3 Blackfan Circle, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/978-1-4939-7021-6_25DOI Listing
March 2018

Physiologically Based Pharmacokinetic and Pharmacodynamic Analysis Enabled by Microfluidically Linked Organs-on-Chips.

Annu Rev Pharmacol Toxicol 2018 01;58:37-64

Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02115, USA; email:

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http://dx.doi.org/10.1146/annurev-pharmtox-010716-104748DOI Listing
January 2018

PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury.

Proc Natl Acad Sci U S A 2018 01 17;115(5):E982-E991. Epub 2018 Jan 17.

Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1718600115
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http://dx.doi.org/10.1073/pnas.1718600115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798377PMC
January 2018

Art Advancing Science: Filmmaking Leads to Molecular Insights at the Nanoscale.

ACS Nano 2017 12 18;11(12):12156-12166. Epub 2017 Oct 18.

Wyss Institute for Biologically Inspired Engineering, Harvard University , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acsnano.7b05266DOI Listing
December 2017

A Biologically Inspired, Functionally Graded End Effector for Soft Robotics Applications.

Soft Robot 2017 Dec 12;4(4):317-323. Epub 2017 Oct 12.

2 Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University , Cambridge, Massachusetts.

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http://dx.doi.org/10.1089/soro.2017.0002DOI Listing
December 2017

New anticoagulant coatings and hemostasis assessment tools to avoid complications with pediatric left ventricular assist devices.

J Thorac Cardiovasc Surg 2017 10 24;154(4):1364-1366. Epub 2017 Apr 24.

Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Mass; Vascular Biology Program and Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, Mass; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Mass. Electronic address:

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http://dx.doi.org/10.1016/j.jtcvs.2017.03.149DOI Listing
October 2017

Mechanical induction of dentin-like differentiation by adult mouse bone marrow stromal cells using compressive scaffolds.

Stem Cell Res 2017 10 17;24:55-60. Epub 2017 Aug 17.

Vascular Biology Program and Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02138, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18735061173016
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http://dx.doi.org/10.1016/j.scr.2017.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796538PMC
October 2017

Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro.

Cell Rep 2017 Oct;21(2):508-516

Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA; Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02139, USA; Vascular Biology Program and Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247173133
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http://dx.doi.org/10.1016/j.celrep.2017.09.043DOI Listing
October 2017

Ultrasound-sensitive nanoparticle aggregates for targeted drug delivery.

Biomaterials 2017 Sep 6;139:187-194. Epub 2017 Jun 6.

Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Vascular Biology Program and Dept. of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2017.06.003DOI Listing
September 2017

The Wyss institute: A new model for medical technology innovation and translation across the academic-industrial interface.

Bioeng Transl Med 2017 09 5;2(3):247-257. Epub 2017 Sep 5.

Wyss Institute for Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle CLSB5, Boston, MA 02115.

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http://dx.doi.org/10.1002/btm2.10076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689495PMC
September 2017

Theory and associated phenomenology for intrinsic mortality arising from natural selection.

PLoS One 2017 29;12(3):e0173677. Epub 2017 Mar 29.

New England Complex Systems Institute, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0173677PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371302PMC
August 2017

Reproductive endocrinology: Cycling through the menstrual cycle - an out-of-body experience.

Authors:
Donald E Ingber

Nat Rev Endocrinol 2017 07 26;13(7):380-382. Epub 2017 May 26.

Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts 02115, USA; at The Vascular Biology Program, Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA; and at the Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nrendo.2017.65DOI Listing
July 2017

Organs-on-Chips with combined multi-electrode array and transepithelial electrical resistance measurement capabilities.

Lab Chip 2017 06;17(13):2294-2302

Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA. and Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02138, USA and Vascular Biology Program and Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1039/c7lc00412eDOI Listing
June 2017

Direct Bonding of Chitosan Biomaterials to Tissues Using Transglutaminase for Surgical Repair or Device Implantation.

Tissue Eng Part A 2017 02 19;23(3-4):135-142. Epub 2016 Dec 19.

1 Wyss Institute for Biologically Inspired Engineering, Harvard University , Boston, Massachusetts.

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http://dx.doi.org/10.1089/ten.TEA.2016.0266DOI Listing
February 2017

Commendation for Exposing Key Advantage of Organ Chip Approach.

Cell Syst 2016 11;3(5):411

Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA; Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02139, USA; Vascular Biology Program, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2016.11.009DOI Listing
November 2016

Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip.

Cell Syst 2016 11 27;3(5):456-466.e4. Epub 2016 Oct 27.

Wyss Institute for Biologically Inspired Engineering, Boston, MA 02115, USA; Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02139, USA; Vascular Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Surgery, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://www.cell.com/cell-systems/pdf/S2405-4712(16)30322-2.p
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http://ac.els-cdn.com/S2405471216303222/1-s2.0-S240547121630
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http://www.cell.com/cms/attachment/2073615291/2068775128/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S240547121630322
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http://dx.doi.org/10.1016/j.cels.2016.10.003DOI Listing
November 2016

Purified and Recombinant Hemopexin: Protease Activity and Effect on Neutrophil Chemotaxis.

Mol Med 2016 Sep 8;22:22-31. Epub 2016 Jan 8.

Department of Pediatrics and Medicine, Infectious Disease Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.2119/molmed.2016.00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004720PMC
September 2016

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device.

J Vis Exp 2016 Aug 30(114). Epub 2016 Aug 30.

Wyss Institute for Biologically Inspired Engineering at Harvard University; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School; John A. Paulson School of Engineering and Applied Sciences, Harvard University.

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http://dx.doi.org/10.3791/54344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091968PMC
August 2016

A Broad-Spectrum Infection Diagnostic that Detects Pathogen-Associated Molecular Patterns (PAMPs) in Whole Blood.

EBioMedicine 2016 Jul 13;9:217-227. Epub 2016 Jun 13.

Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, United States; Vascular Biology Program, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States; Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S23523964163025
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http://dx.doi.org/10.1016/j.ebiom.2016.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972566PMC
July 2016

Modeling Hematopoiesis and Responses to Radiation Countermeasures in a Bone Marrow-on-a-Chip.

Tissue Eng Part C Methods 2016 05 20;22(5):509-15. Epub 2016 Apr 20.

1 Wyss Institute for Biologically Inspired Engineering, Harvard University , Boston, Massachusetts.

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http://dx.doi.org/10.1089/ten.TEC.2015.0507DOI Listing
May 2016

Reverse Engineering Human Pathophysiology with Organs-on-Chips.

Authors:
Donald E Ingber

Cell 2016 Mar;164(6):1105-1109

Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA; Vascular Biology Program, Departments of Pathology & Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02138, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674163019
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http://dx.doi.org/10.1016/j.cell.2016.02.049DOI Listing
March 2016

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro.

Nat Methods 2016 Feb 21;13(2):151-7. Epub 2015 Dec 21.

Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nmeth.3697DOI Listing
February 2016

Acceleration of Lung Regeneration by Platelet-Rich Plasma Extract through the Low-Density Lipoprotein Receptor-Related Protein 5-Tie2 Pathway.

Am J Respir Cell Mol Biol 2016 Jan;54(1):103-13

1 Vascular Biology Program, Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1165/rcmb.2015-0045OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455682PMC
January 2016

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip.

Proc Natl Acad Sci U S A 2016 Jan 14;113(1):E7-15. Epub 2015 Dec 14.

Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138

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http://dx.doi.org/10.1073/pnas.1522193112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711860PMC
January 2016

A shear gradient-activated microfluidic device for automated monitoring of whole blood haemostasis and platelet function.

Nat Commun 2016 Jan 6;7:10176. Epub 2016 Jan 6.

Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02115, USA.

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http://www.nature.com/articles/ncomms10176
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http://dx.doi.org/10.1038/ncomms10176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729824PMC
January 2016

Shear-Activated Nanoparticle Aggregates Combined With Temporary Endovascular Bypass to Treat Large Vessel Occlusion.

Stroke 2015 Dec 22;46(12):3507-13. Epub 2015 Oct 22.

From the New England Center for Stroke Research, Department of Radiology, University of Massachusetts, Worcester (M.G.M., M.J.G., S.V., E.T.L., O.W.B., A.S.P., J.-Y.C., A.K.W.); Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA (N.K., O.U., A.-L.P., C.J., D.B., M.K., B.R.B., D.E.I.); Department of Biomedical Engineering, Technion, Israel (N.K.); Vascular Biology Program, Boston Children's Hospital and Harvard University, Boston, MA (D.E.I.); and Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA (D.E.I.).

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http://stroke.ahajournals.org/content/46/12/3507.full.pdf
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http://stroke.ahajournals.org/lookup/doi/10.1161/STROKEAHA.1
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http://dx.doi.org/10.1161/STROKEAHA.115.011063DOI Listing
December 2015

Optimization of Pathogen Capture in Flowing Fluids with Magnetic Nanoparticles.

Small 2015 Nov 21;11(42):5657-66. Epub 2015 Sep 21.

Wyss Institute for Biologically Inspired Engineering at Harvard University, 3 Blackfan Circle, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1002/smll.201501820DOI Listing
November 2015

Improved treatment of systemic blood infections using antibiotics with extracorporeal opsonin hemoadsorption.

Biomaterials 2015 Oct 26;67:382-92. Epub 2015 Jul 26.

Wyss Institute for Biologically Inspired Engineering, Boston, MA 02115, USA; Vascular Biology Program, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Harvard School of Engineering and Applied Sciences, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2015.07.046DOI Listing
October 2015

Generation of biocompatible droplets for in vivo and in vitro measurement of cell-generated mechanical stresses.

Methods Cell Biol 2015 8;125:373-90. Epub 2015 Jan 8.

Department of Mechanical Engineering, University of California, Santa Barbara, CA, USA.

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http://dx.doi.org/10.1016/bs.mcb.2014.11.008DOI Listing
September 2015

Control of cancer formation by intrinsic genetic noise and microenvironmental cues.

Nat Rev Cancer 2015 Aug 9;15(8):499-509. Epub 2015 Jul 9.

Wyss Institute for Biologically Inspired Engineering at Harvard University, 3 Blackfan Circle, CLSB 5, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrc3959DOI Listing
August 2015

Mesenchymal condensation-dependent accumulation of collagen VI stabilizes organ-specific cell fates during embryonic tooth formation.

Dev Dyn 2015 Jun 24;244(6):713-23. Epub 2015 Apr 24.

Vascular Biology Program, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/dvdy.24264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449280PMC
June 2015

Programed Death is Favored by Natural Selection in Spatial Systems.

Phys Rev Lett 2015 Jun 12;114(23):238103. Epub 2015 Jun 12.

New England Complex Systems Institute, 210 Broadway, Suite 101, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1103/PhysRevLett.114.238103DOI Listing
June 2015

Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis.

J Exp Med 2015 May 13;212(5):665-80. Epub 2015 Apr 13.

Program in Children's Regenerative Medicine, Department of Pediatric Surgery, Center for Stem Cell and Regenerative Medicine, The Brown Foundation Institute of Molecular Medicine, and Immunology Program, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030 Program in Children's Regenerative Medicine, Department of Pediatric Surgery, Center for Stem Cell and Regenerative Medicine, The Brown Foundation Institute of Molecular Medicine, and Immunology Program, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030 Program in Children's Regenerative Medicine, Department of Pediatric Surgery, Center for Stem Cell and Regenerative Medicine, The Brown Foundation Institute of Molecular Medicine, and Immunology Program, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030

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http://dx.doi.org/10.1084/jem.20142235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419354PMC
May 2015

Measuring direct current trans-epithelial electrical resistance in organ-on-a-chip microsystems.

Lab Chip 2015 Feb;15(3):745-52

BIOS/Lab-on-Chip Group, MESA+ Institute for Nanotechnology & MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, P. O. Box 217, 7500 AE Enschede, The Netherlands.

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http://dx.doi.org/10.1039/c4lc01219dDOI Listing
February 2015

Targeted drug delivery to flow-obstructed blood vessels using mechanically activated nanotherapeutics.

JAMA Neurol 2015 Jan;72(1):119-22

Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts4Vascular Biology Program, Children's Hospital and Harvard Medical School, Boston, Massachusetts5School of Engineering and Applied Sciences, Harvard Universit.

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http://dx.doi.org/10.1001/jamaneurol.2014.2886DOI Listing
January 2015

Nanoparticle targeting of anti-cancer drugs that alter intracellular signaling or influence the tumor microenvironment.

Adv Drug Deliv Rev 2014 Dec 9;79-80:107-18. Epub 2014 May 9.

Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA; Vascular Biology Program, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA; School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0169409X140009
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http://dx.doi.org/10.1016/j.addr.2014.05.005DOI Listing
December 2014

A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling.

Nat Biotechnol 2014 Nov 12;32(11):1134-40. Epub 2014 Oct 12.

1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA. [3] Harvard Medical School, Boston, Massachusetts, USA. [4] Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.3020DOI Listing
November 2014

An extracorporeal blood-cleansing device for sepsis therapy.

Nat Med 2014 Oct 14;20(10):1211-6. Epub 2014 Sep 14.

1] Wyss Institute for Biologically Inspired Engineering, Boston, Massachusetts, USA. [2] Vascular Biology Program, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3] Harvard School of Engineering and Applied Sciences, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.3640DOI Listing
October 2014

Reply: To PMID 23711562.

Neonatology 2014 8;105(1):26. Epub 2013 Nov 8.

Division of Neonatology, Boston Medical Center, Boston, Mass., USA.

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http://dx.doi.org/10.1159/000355357DOI Listing
September 2014

Mononuclear cells from dedifferentiation of mouse myotubes display remarkable regenerative capability.

Stem Cells 2014 Sep;32(9):2492-501

College of Laboratory Medicine, Southwest Hospital, Third Military Medical University, Chongqing, People's Republic of China; Department of Anesthesia Perioperative and Pain Medicine, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/stem.1742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422173PMC
September 2014

Stationary nanoliter droplet array with a substrate of choice for single adherent/nonadherent cell incubation and analysis.

Proc Natl Acad Sci U S A 2014 Aug 22;111(31):11293-8. Epub 2014 Jul 22.

Department of Biomedical Engineering andRussell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa 32000, Israel;

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http://dx.doi.org/10.1073/pnas.1404472111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128147PMC
August 2014

Microfluidic organs-on-chips.

Nat Biotechnol 2014 Aug;32(8):760-72

1] Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts, USA. [2] Vascular Biology Program, Departments of Pathology &Surgery, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.

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http://www.nature.com/articles/nbt.2989
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http://dx.doi.org/10.1038/nbt.2989DOI Listing
August 2014

Bone marrow-on-a-chip replicates hematopoietic niche physiology in vitro.

Nat Methods 2014 Jun 4;11(6):663-9. Epub 2014 May 4.

1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] Vascular Biology Program, Departments of Pathology and Surgery, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts, USA. [3] School of Engineering and Applied Science, Harvard University, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nmeth.2938DOI Listing
June 2014

Developmentally-inspired shrink-wrap polymers for mechanical induction of tissue differentiation.

Adv Mater 2014 May 18;26(20):3253-7. Epub 2014 Feb 18.

Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA; Harvard School of Engineering and Applied Sciences, Cambridge, MA, 02138, USA.

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http://dx.doi.org/10.1002/adma.201304995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146397PMC
May 2014

Interview with Donald E Ingber.

Authors:
Donald E Ingber

Nanomedicine (Lond) 2014 May;9(7):949-54

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http://dx.doi.org/10.2217/nnm.14.31DOI Listing
May 2014

Paxillin controls endothelial cell migration and tumor angiogenesis by altering neuropilin 2 expression.

J Cell Sci 2014 Apr 12;127(Pt 8):1672-83. Epub 2014 Feb 12.

Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1242/jcs.132316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986673PMC
April 2014

Quantifying cell-generated mechanical forces within living embryonic tissues.

Nat Methods 2014 Feb 8;11(2):183-9. Epub 2013 Dec 8.

1] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA. [2] Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts, USA. [3] Vascular Biology Program, Children's Hospital, Boston, Massachusetts, USA. [4] Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.

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https://www.seas.harvard.edu/softmat/downloads/2013-15.pdf
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http://www.nature.com/doifinder/10.1038/nmeth.2761
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http://dx.doi.org/10.1038/nmeth.2761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939080PMC
February 2014

Mechanotransduction of fluid stresses governs 3D cell migration.

Proc Natl Acad Sci U S A 2014 Feb 3;111(7):2447-52. Epub 2014 Feb 3.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1316848111
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http://dx.doi.org/10.1073/pnas.1316848111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932905PMC
February 2014

A microdevice for rapid optical detection of magnetically captured rare blood pathogens.

Lab Chip 2014 Jan;14(1):182-8

Wyss Institute for Biologically Inspired Engineering at Harvard University, 3 Blackfan Circle, CLSB 517, Boston, MA 02118, USA.

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http://dx.doi.org/10.1039/c3lc50935dDOI Listing
January 2014

Silencing HoxA1 by intraductal injection of siRNA lipidoid nanoparticles prevents mammary tumor progression in mice.

Sci Transl Med 2014 Jan;6(217):217ra2

Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scitranslmed.3007048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546412PMC
January 2014

A combinatorial cell-laden gel microarray for inducing osteogenic differentiation of human mesenchymal stem cells.

Sci Rep 2014 Jan 29;4:3896. Epub 2014 Jan 29.

1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA [2] Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA [3] Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1038/srep03896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905276PMC
January 2014

Mechanobiology and developmental control.

Annu Rev Cell Dev Biol 2013 ;29:27-61

Vascular Biology Program, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115; email:

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http://dx.doi.org/10.1146/annurev-cellbio-101512-122340DOI Listing
December 2013

Microfabrication of human organs-on-chips.

Nat Protoc 2013 Nov 10;8(11):2135-57. Epub 2013 Oct 10.

1] Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts, USA. [2] Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/nprot.2013.137DOI Listing
November 2013

Intraductal injection for localized drug delivery to the mouse mammary gland.

J Vis Exp 2013 Oct 4(80). Epub 2013 Oct 4.

Vascular Biology Program, Department of Surgery, Boston Children's Hospital and Harvard Medical School.

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http://dx.doi.org/10.3791/50692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938324PMC
October 2013