Donald C Lo

Donald C Lo

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Donald C Lo

Donald C Lo

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Tumoricidal Stem Cell Therapy Enables Killing in Novel Hybrid Models of Heterogeneous Glioblastoma.

Neuro Oncol 2019 Aug 17. Epub 2019 Aug 17.

Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1093/neuonc/noz138DOI Listing
August 2019

Induced pluripotent stem cells for neural drug discovery.

Drug Discov Today 2019 04 18;24(4):992-999. Epub 2019 Jan 18.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2019.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476685PMC
April 2019

Neuronal IL-4Rα modulates neuronal apoptosis and cell viability during the acute phases of cerebral ischemia.

FEBS J 2018 08 24;285(15):2785-2798. Epub 2018 May 24.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1111/febs.14498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105465PMC
August 2018

Copper-Binding Small Molecule Induces Oxidative Stress and Cell-Cycle Arrest in Glioblastoma-Patient-Derived Cells.

Cell Chem Biol 2018 05 22;25(5):585-594.e7. Epub 2018 Mar 22.

Department of Biological Sciences, Columbia University, New York, NY 10027, USA; Department of Chemistry, Columbia University, New York, NY 10027, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2018.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959763PMC
May 2018

Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements.

Nat Commun 2017 09 20;8(1):623. Epub 2017 Sep 20.

Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts, 02139, USA.

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http://dx.doi.org/10.1038/s41467-017-00353-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606996PMC
September 2017

Neuroprotective Effects of Annexin A1 Tripeptide after Deep Hypothermic Circulatory Arrest in Rats.

Front Immunol 2017 30;8:1050. Epub 2017 Aug 30.

Department of Anesthesiology, Duke University Medical Center, Durham, NC, United States.

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http://dx.doi.org/10.3389/fimmu.2017.01050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582068PMC
August 2017

Differential roles of Aβ processing in hypoxia-induced axonal damage.

Neurobiol Dis 2015 May 11;77:94-105. Epub 2015 Mar 11.

Center for Drug Discovery and Department of Neurobiology, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1016/j.nbd.2015.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402275PMC
May 2015

Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective.

Proc Natl Acad Sci U S A 2015 Apr 6;112(17):E2245-52. Epub 2015 Apr 6.

Department of Biological Sciences, Columbia University, New York, NY 10027; Department of Chemistry, Columbia University, New York, NY 10027; Howard Hughes Medical Institute and Department of Systems Biology, Columbia University, New York, NY 10027

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http://dx.doi.org/10.1073/pnas.1500439112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418888PMC
April 2015

Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition.

Proc Natl Acad Sci U S A 2014 Apr 1;111(15):E1481-90. Epub 2014 Apr 1.

Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208.

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http://dx.doi.org/10.1073/pnas.1321811111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992642PMC
April 2014

Natural genetic variation of integrin alpha L (Itgal) modulates ischemic brain injury in stroke.

PLoS Genet 2013 10;9(10):e1003807. Epub 2013 Oct 10.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794904PMC
March 2014

Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models.

J Am Chem Soc 2014 Mar 14;136(12):4551-6. Epub 2014 Mar 14.

Department of Biological Sciences, Columbia University , 550 West 120th Street Northwest Corner Building, MC 4846 New York, New York 10027, United States.

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http://dx.doi.org/10.1021/ja411006aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985476PMC
March 2014

BDNF mediates neuroprotection against oxygen-glucose deprivation by the cardiac glycoside oleandrin.

J Neurosci 2014 Jan;34(3):963-8

Center for Drug Discovery and Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27704, and Department of Experimental Therapeutics, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030.

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http://dx.doi.org/10.1523/JNEUROSCI.2700-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891971PMC
January 2014

Experimental models for identifying modifiers of polyglutamine-induced aggregation and neurodegeneration.

Neurotherapeutics 2013 Jul;10(3):400-15

Department of Neurobiology and Center for Drug Discovery, Duke University Medical Center, 4321 Medical Park Drive, Durham, NC 27704, USA.

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http://dx.doi.org/10.1007/s13311-013-0195-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701774PMC
July 2013

Targeting mutant huntingtin for the development of disease-modifying therapy.

Drug Discov Today 2012 Nov 4;17(21-22):1217-23. Epub 2012 Jul 4.

Abbott Laboratories, Neuroscience Discovery, Ludwigshafen, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S13596446120023
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http://dx.doi.org/10.1016/j.drudis.2012.06.017DOI Listing
November 2012

Development of a low-pressure microtargeting biolistic device for transfection of retinal explants.

Mol Vis 2011 16;17:2947-55. Epub 2011 Nov 16.

Center for Drug Discovery and Department of Neurobiology, Duke University Medical Center, Durham, NC 27704, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224834PMC
April 2012

Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons.

Neurobiol Aging 2012 Mar 11;33(3):621.e17-33. Epub 2011 Apr 11.

Neurotoxicology Group, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2011.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135676PMC
March 2012

In vitro and in vivo neuroprotective activity of the cardiac glycoside oleandrin from Nerium oleander in brain slice-based stroke models.

J Neurochem 2011 Nov 26;119(4):805-14. Epub 2011 Sep 26.

Center for Drug Discovery and Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27514, USA.

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http://www.phoenixbiotechnology.com/documents/JournalOfNeuro
Web Search
http://doi.wiley.com/10.1111/j.1471-4159.2011.07439.x
Publisher Site
http://dx.doi.org/10.1111/j.1471-4159.2011.07439.xDOI Listing
November 2011

Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins.

Nat Chem Biol 2010 Dec 31;6(12):900-6. Epub 2010 Oct 31.

Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, New York, New York, USA.

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http://www.nature.com/articles/nchembio.467
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http://dx.doi.org/10.1038/nchembio.467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018711PMC
December 2010

Composite primary neuronal high-content screening assay for Huntington's disease incorporating non-cell-autonomous interactions.

J Biomol Screen 2010 Aug 25;15(7):806-19. Epub 2010 Jun 25.

Center for Drug Discovery and Department of Neurobiology, Duke University Medical Center, Durham, NC 27704, USA.

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http://dx.doi.org/10.1177/1087057110373392DOI Listing
August 2010

CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease.

Hum Mol Genet 2010 May 10;19(9):1756-65. Epub 2010 Feb 10.

McGovern Institute for Brain Research, MIT, 43 Vassar Street, Building 46-6133, Cambridge, MA, USA.

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http://dx.doi.org/10.1093/hmg/ddq055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850620PMC
May 2010

Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors.

Bioorg Med Chem Lett 2009 Nov 9;19(21):6122-6. Epub 2009 Sep 9.

Laboratory for Drug Discovery in Neurodegeneration, Harvard NeuroDiscovery Center, Brigham and Women's Hospital and Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785710PMC
November 2009

Kinetic isolation of a slowly recovering component of short-term depression during exhaustive use at excitatory hippocampal synapses.

J Neurophysiol 2008 Aug 25;100(2):781-95. Epub 2008 Jun 25.

Departamento de Neurociencias, Centro de Investigación Médica Aplicada, Universidad de Navarra, Pio XII, 55, 31008 Pamplona, Spain.

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http://dx.doi.org/10.1152/jn.90429.2008DOI Listing
August 2008

High throughput screening for neurodegeneration and complex disease phenotypes.

Comb Chem High Throughput Screen 2008 Mar;11(3):238-48

Department of Biological Sciences, Columbia University, 614 Fairchild Center MC2406, 1212 Amsterdam Avenue, New York, NY 10027, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735222PMC
http://dx.doi.org/10.2174/138620708783877753DOI Listing
March 2008

Selective inhibitors of death in mutant huntingtin cells.

Nat Chem Biol 2007 Feb 31;3(2):99-100. Epub 2006 Dec 31.

Department of Biological Sciences, Columbia University, Fairchild Center, MC 2406, 1212 Amsterdam Avenue, New York, New York 10027, USA.

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http://dx.doi.org/10.1038/nchembio852DOI Listing
February 2007

Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1.

Nat Neurosci 2006 May 16;9(5):611-21. Epub 2006 Apr 16.

Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1038/nn1680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892311PMC
May 2006

Limit on the role of activity in controlling the release-ready supply of synaptic vesicles.

J Neurosci 2002 Nov;22(22):9708-20

Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757839PMC
November 2002

Increased expression of brain-derived neurotrophic factor induces formation of basal dendrites and axonal branching in dentate granule cells in hippocampal explant cultures.

J Neurosci 2002 Nov;22(22):9754-63

Department of Medicine (Neurology), Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757848PMC
November 2002