Publications by authors named "Donald Bottaro"

76Publications

Circulating Tumor Cell Subtypes and T-cell Populations as Prognostic Biomarkers to Combination Immunotherapy in Patients with Metastatic Genitourinary Cancer.

Authors:
Heather J Chalfin Tiziano Pramparo Amir Mortazavi Scot A Niglio Joseph D Schonhoft Adam Jendrisak Yen-Lin Chu Robin Richardson Rachel Krupa Amanda K L Anderson Yipeng Wang Ryan Dittamore Sumanta K Pal Primo N Lara Mark N Stein David I Quinn Seth M Steinberg Lisa M Cordes Lisa Ley Marissa Mallek Olena Sierra Ortiz Rene Costello Jacqueline Cadena Carlos Diaz James L Gulley William L Dahut Howard Streicher John J Wright Jane B Trepel Donald P Bottaro Andrea B Apolo

Clin Cancer Res 2020 Dec 1. Epub 2020 Dec 1.

NCI, Bethesda, Maryland.

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December 2020

Phase I Study of Cabozantinib and Nivolumab Alone or With Ipilimumab for Advanced or Metastatic Urothelial Carcinoma and Other Genitourinary Tumors.

Authors:
Andrea B Apolo Rosa Nadal Daniel M Girardi Scot A Niglio Lisa Ley Lisa M Cordes Seth M Steinberg Olena Sierra Ortiz Jacqueline Cadena Carlos Diaz Marissa Mallek Nicole N Davarpanah Rene Costello Jane B Trepel Min-Jung Lee Maria J Merino Mohammad Hadi Bagheri Paul Monk William D Figg James L Gulley Piyush K Agarwal Vladimir Valera Heather J Chalfin Jennifer Jones Howard Streicher John J Wright Yangmin M Ning Howard L Parnes William L Dahut Donald P Bottaro Primo N Lara Biren Saraiya Sumanta K Pal Mark N Stein Amir Mortazavi

J Clin Oncol 2020 Nov 11;38(31):3672-3684. Epub 2020 Sep 11.

Division of Medical Oncology, Department of Internal Medicine, College of Medicine, The Ohio State University, and the Comprehensive Cancer Center, Columbus, OH.

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November 2020

Cabozantinib in patients with platinum-refractory metastatic urothelial carcinoma: an open-label, single-centre, phase 2 trial.

Authors:
Andrea B Apolo Rosa Nadal Yusuke Tomita Nicole N Davarpanah Lisa M Cordes Seth M Steinberg Liang Cao Howard L Parnes Rene Costello Maria J Merino Les R Folio Liza Lindenberg Mark Raffeld Jeffrey Lin Min-Jung Lee Sunmin Lee Sylvia V Alarcon Akira Yuno Nancy A Dawson Kimaada Allette Arpita Roy Dinuka De Silva Molly M Lee Tristan M Sissung William D Figg Piyush K Agarwal John J Wright Yangmin M Ning James L Gulley William L Dahut Donald P Bottaro Jane B Trepel

Lancet Oncol 2020 08 6;21(8):1099-1109. Epub 2020 Jul 6.

Developmental Therapeutics Branch, Magnuson Clinical Center, Bethesda, MD, USA.

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August 2020

Clinical Evolution of Epithelial-Mesenchymal Transition in Human Carcinomas.

Authors:
Tony Navas Robert J Kinders Scott M Lawrence Katherine V Ferry-Galow Suzanne Borgel Melinda G Hollingshead Apurva K Srivastava Sergio Y Alcoser Hala R Makhlouf Rodrigo Chuaqui Deborah F Wilsker Mariam M Konaté Sarah B Miller Andrea Regier Voth Li Chen Tomas Vilimas Jyothi Subramanian Lawrence Rubinstein Shivaani Kummar Alice P Chen Donald P Bottaro James H Doroshow Ralph E Parchment

Cancer Res 2020 01 15;80(2):304-318. Epub 2019 Nov 15.

Clinical Pharmacodynamic Biomarkers Program, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland.

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January 2020

Updated Recommendations on the Diagnosis, Management, and Clinical Trial Eligibility Criteria for Patients With Renal Medullary Carcinoma.

Authors:
Pavlos Msaouel Andrew L Hong Elizabeth A Mullen Michael B Atkins Cheryl Lyn Walker Chung-Han Lee Marcus A Carden Giannicola Genovese W Marston Linehan Priya Rao Maria J Merino Howard Grodman Jeffrey S Dome Conrad V Fernandez James I Geller Andrea B Apolo Najat C Daw H Courtney Hodges Marva Moxey-Mims Darmood Wei Donald P Bottaro Michael Staehler Jose A Karam W Kimryn Rathmell Nizar M Tannir

Clin Genitourin Cancer 2019 02 12;17(1):1-6. Epub 2018 Sep 12.

Department of Genitourinary Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX. Electronic address:

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February 2019

Novel antibody reagents for characterization of drug- and tumor microenvironment-induced changes in epithelial-mesenchymal transition and cancer stem cells.

Authors:
Tony Navas Thomas D Pfister Simona Colantonio Amina Aziz Lynda Dieckman Richard G Saul Jan Kaczmarczyk Suzanne Borgel Sergio Y Alcoser Melinda G Hollingshead Young H Lee Donald P Bottaro Tara Hiltke Gordon Whiteley Naoko Takebe Robert J Kinders Ralph E Parchment Joseph E Tomaszewski James H Doroshow

PLoS One 2018 21;13(6):e0199361. Epub 2018 Jun 21.

Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland, United States of America.

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April 2019

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma.

Authors:
Christopher J Ricketts Aguirre A De Cubas Huihui Fan Christof C Smith Martin Lang Ed Reznik Reanne Bowlby Ewan A Gibb Rehan Akbani Rameen Beroukhim Donald P Bottaro Toni K Choueiri Richard A Gibbs Andrew K Godwin Scott Haake A Ari Hakimi Elizabeth P Henske James J Hsieh Thai H Ho Rupa S Kanchi Bhavani Krishnan David J Kwiatkowski Wembin Lui Maria J Merino Gordon B Mills Jerome Myers Michael L Nickerson Victor E Reuter Laura S Schmidt C Simon Shelley Hui Shen Brian Shuch Sabina Signoretti Ramaprasad Srinivasan Pheroze Tamboli George Thomas Benjamin G Vincent Cathy D Vocke David A Wheeler Lixing Yang William Y Kim A Gordon Robertson Paul T Spellman W Kimryn Rathmell W Marston Linehan

Cell Rep 2018 Jun;23(12):3698

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June 2018

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma.

Authors:
Christopher J Ricketts Aguirre A De Cubas Huihui Fan Christof C Smith Martin Lang Ed Reznik Reanne Bowlby Ewan A Gibb Rehan Akbani Rameen Beroukhim Donald P Bottaro Toni K Choueiri Richard A Gibbs Andrew K Godwin Scott Haake A Ari Hakimi Elizabeth P Henske James J Hsieh Thai H Ho Rupa S Kanchi Bhavani Krishnan David J Kwiatkowski Wembin Lui Maria J Merino Gordon B Mills Jerome Myers Michael L Nickerson Victor E Reuter Laura S Schmidt C Simon Shelley Hui Shen Brian Shuch Sabina Signoretti Ramaprasad Srinivasan Pheroze Tamboli George Thomas Benjamin G Vincent Cathy D Vocke David A Wheeler Lixing Yang William Y Kim A Gordon Robertson Paul T Spellman W Kimryn Rathmell W Marston Linehan

Cell Rep 2018 04;23(1):313-326.e5

Urologic Oncology Branch, National Cancer Institute, Center for Cancer Research, Bethesda, MD 20892, USA. Electronic address:

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April 2018

Molecular Pharmacodynamics-Guided Scheduling of Biologically Effective Doses: A Drug Development Paradigm Applied to MET Tyrosine Kinase Inhibitors.

Authors:
Apurva K Srivastava Melinda G Hollingshead Jeevan Prasaad Govindharajulu Joseph M Covey Dane Liston Melanie A Simpson James O Peggins Donald P Bottaro John J Wright Robert J Kinders James H Doroshow Ralph E Parchment

Mol Cancer Ther 2018 03 14;17(3):698-709. Epub 2018 Feb 14.

Clinical Pharmacodynamics Biomarker Program, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland.

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March 2018

Targeting the hepatocyte growth factor/Met pathway in cancer.

Authors:
Dinuka M De Silva Arpita Roy Takashi Kato Fabiola Cecchi Young H Lee Kunio Matsumoto Donald P Bottaro

Biochem Soc Trans 2017 08 3;45(4):855-870. Epub 2017 Jul 3.

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, U.S.A.

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August 2017

Effective implementation of novel MET pharmacodynamic assays in translational studies.

Authors:
Apurva K Srivastava Tony Navas William G Herrick Melinda G Hollingshead Donald P Bottaro James H Doroshow Ralph E Parchment

Ann Transl Med 2017 Jan;5(1)

Laboratory of Human Toxicology and Pharmacology, Applied/Developmental Research Directorate, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.

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January 2017

Hepatocyte growth factor/MET in cancer progression and biomarker discovery.

Authors:
Kunio Matsumoto Masataka Umitsu Dinuka M De Silva Arpita Roy Donald P Bottaro

Cancer Sci 2017 Mar;108(3):296-307

Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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March 2017

A Phase I/II Multicenter Study of Single-Agent Foretinib as First-Line Therapy in Patients with Advanced Hepatocellular Carcinoma.

Authors:
Thomas C C Yau Riccardo Lencioni Wattana Sukeepaisarnjaroen Yee Chao Chia-Jui Yen Wirote Lausoontornsiri Pei-Jer Chen Theeranun Sanpajit Aaron Camp Donna S Cox Robert C Gagnon Yuan Liu Kristen E Raffensperger Diptee A Kulkarni Howard Kallender Lone Harild Ottesen Ronnie T P Poon Donald P Bottaro

Clin Cancer Res 2017 May 7;23(10):2405-2413. Epub 2016 Nov 7.

Urologic Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland.

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May 2017

MET Inhibition in Clear Cell Renal Cell Carcinoma.

Authors:
Zuoquan Xie Young H Lee Marta Boeke Lucia B Jilaveanu Zongzhi Liu Donald P Bottaro Harriet M Kluger Brian Shuch

J Cancer 2016 18;7(10):1205-14. Epub 2016 Jun 18.

1. Department of Urology, Yale School of Medicine.

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July 2016

Tumor and Plasma Met Levels in Non-Metastatic Prostate Cancer.

Authors:
Deborah R Kaye Peter A Pinto Fabiola Cecchi Joseph Reilly Alice Semerjian Daniel C Rabe Gopal Gupta Peter L Choyke Donald P Bottaro

PLoS One 2016 14;11(6):e0157130. Epub 2016 Jun 14.

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, 20892, United States of America.

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July 2017

The hepatocyte growth factor isoform NK2 activates motogenesis and survival but not proliferation due to lack of Akt activation.

Authors:
Ognoon Mungunsukh Young H Lee Donald P Bottaro Regina M Day

Cell Signal 2016 08 17;28(8):1114-23. Epub 2016 May 17.

The Uniformed Services University of the Health Sciences, Department of Pharmacology, 4301 Jones Bridge Road, Bethesda, MD 20814, USA. Electronic address:

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August 2016

Pharmacodynamic Response of the MET/HGF Receptor to Small-Molecule Tyrosine Kinase Inhibitors Examined with Validated, Fit-for-Clinic Immunoassays.

Authors:
Apurva K Srivastava Melinda G Hollingshead Jennifer Weiner Tony Navas Yvonne A Evrard Sonny A Khin Jiuping Jay Ji Yiping Zhang Suzanne Borgel Thomas D Pfister Robert J Kinders Donald P Bottaro W Marston Linehan Joseph E Tomaszewski James H Doroshow Ralph E Parchment

Clin Cancer Res 2016 07 21;22(14):3683-94. Epub 2016 Mar 21.

Laboratory of Human Toxicology and Pharmacology, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland.

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July 2016

Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma.

Authors:
Fengju Chen Yiqun Zhang Yasin Şenbabaoğlu Giovanni Ciriello Lixing Yang Ed Reznik Brian Shuch Goran Micevic Guillermo De Velasco Eve Shinbrot Michael S Noble Yiling Lu Kyle R Covington Liu Xi Jennifer A Drummond Donna Muzny Hyojin Kang Junehawk Lee Pheroze Tamboli Victor Reuter Carl Simon Shelley Benny A Kaipparettu Donald P Bottaro Andrew K Godwin Richard A Gibbs Gad Getz Raju Kucherlapati Peter J Park Chris Sander Elizabeth P Henske Jane H Zhou David J Kwiatkowski Thai H Ho Toni K Choueiri James J Hsieh Rehan Akbani Gordon B Mills A Ari Hakimi David A Wheeler Chad J Creighton

Cell Rep 2016 Mar 3;14(10):2476-89. Epub 2016 Mar 3.

Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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March 2016

Stable Ectopic Expression of ST6GALNAC5 Induces Autocrine MET Activation and Anchorage-Independence in MDCK Cells.

Authors:
Chia Chu Donald P Bottaro Michael J Betenbaugh Joseph Shiloach

PLoS One 2016 5;11(2):e0148075. Epub 2016 Feb 5.

Biotechnology Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

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July 2016

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.

Authors:
W Marston Linehan Paul T Spellman Christopher J Ricketts Chad J Creighton Suzanne S Fei Caleb Davis David A Wheeler Bradley A Murray Laura Schmidt Cathy D Vocke Myron Peto Abu Amar M Al Mamun Eve Shinbrot Anurag Sethi Samira Brooks W Kimryn Rathmell Angela N Brooks Katherine A Hoadley A Gordon Robertson Denise Brooks Reanne Bowlby Sara Sadeghi Hui Shen Daniel J Weisenberger Moiz Bootwalla Stephen B Baylin Peter W Laird Andrew D Cherniack Gordon Saksena Scott Haake Jun Li Han Liang Yiling Lu Gordon B Mills Rehan Akbani Mark D M Leiserson Benjamin J Raphael Pavana Anur Donald Bottaro Laurence Albiges Nandita Barnabas Toni K Choueiri Bogdan Czerniak Andrew K Godwin A Ari Hakimi Thai H Ho James Hsieh Michael Ittmann William Y Kim Bhavani Krishnan Maria J Merino Kenna R Mills Shaw Victor E Reuter Ed Reznik Carl S Shelley Brian Shuch Sabina Signoretti Ramaprasad Srinivasan Pheroze Tamboli George Thomas Satish Tickoo Kenneth Burnett Daniel Crain Johanna Gardner Kevin Lau David Mallery Scott Morris Joseph D Paulauskis Robert J Penny Candace Shelton W Troy Shelton Mark Sherman Eric Thompson Peggy Yena Melissa T Avedon Jay Bowen Julie M Gastier-Foster Mark Gerken Kristen M Leraas Tara M Lichtenberg Nilsa C Ramirez Tracie Santos Lisa Wise Erik Zmuda John A Demchok Ina Felau Carolyn M Hutter Margi Sheth Heidi J Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean C Zenklusen Jiashan Zhang Brenda Ayala Julien Baboud Sudha Chudamani Jia Liu Laxmi Lolla Rashi Naresh Todd Pihl Qiang Sun Yunhu Wan Ye Wu Adrian Ally Miruna Balasundaram Saianand Balu Rameen Beroukhim Tom Bodenheimer Christian Buhay Yaron S N Butterfield Rebecca Carlsen Scott L Carter Hsu Chao Eric Chuah Amanda Clarke Kyle R Covington Mahmoud Dahdouli Ninad Dewal Noreen Dhalla Harsha V Doddapaneni Jennifer A Drummond Stacey B Gabriel Richard A Gibbs Ranabir Guin Walker Hale Alicia Hawes D Neil Hayes Robert A Holt Alan P Hoyle Stuart R Jefferys Steven J M Jones Corbin D Jones Divya Kalra Christie Kovar Lora Lewis Jie Li Yussanne Ma Marco A Marra Michael Mayo Shaowu Meng Matthew Meyerson Piotr A Mieczkowski Richard A Moore Donna Morton Lisle E Mose Andrew J Mungall Donna Muzny Joel S Parker Charles M Perou Jeffrey Roach Jacqueline E Schein Steven E Schumacher Yan Shi Janae V Simons Payal Sipahimalani Tara Skelly Matthew G Soloway Carrie Sougnez Angela Tam Donghui Tan Nina Thiessen Umadevi Veluvolu Min Wang Matthew D Wilkerson Tina Wong Junyuan Wu Liu Xi Jane Zhou Jason Bedford Fengju Chen Yao Fu Mark Gerstein David Haussler Katayoon Kasaian Phillip Lai Shiyun Ling Amie Radenbaugh David Van Den Berg John N Weinstein Jingchun Zhu Monique Albert Iakovina Alexopoulou Jeremiah J Andersen J Todd Auman John Bartlett Sheldon Bastacky Julie Bergsten Michael L Blute Lori Boice Roni J Bollag Jeff Boyd Erik Castle Ying-Bei Chen John C Cheville Erin Curley Benjamin Davies April DeVolk Rajiv Dhir Laura Dike John Eckman Jay Engel Jodi Harr Ronald Hrebinko Mei Huang Lori Huelsenbeck-Dill Mary Iacocca Bruce Jacobs Michael Lobis Jodi K Maranchie Scott McMeekin Jerome Myers Joel Nelson Jeremy Parfitt Anil Parwani Nicholas Petrelli Brenda Rabeno Somak Roy Andrew L Salner Joel Slaton Melissa Stanton R Houston Thompson Leigh Thorne Kelinda Tucker Paul M Weinberger Cynthia Winemiller Leigh Anne Zach Rosemary Zuna

N Engl J Med 2016 Jan 4;374(2):135-45. Epub 2015 Nov 4.

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January 2016