Don L Gibbons

Don L Gibbons

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Don L Gibbons

Don L Gibbons

Publications by authors named "Don L Gibbons"

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Ntrk1 Promotes Resistance to PD-1 Checkpoint Blockade in Mesenchymal Kras/p53 Mutant Lung Cancer.

Cancers (Basel) 2019 Apr 2;11(4). Epub 2019 Apr 2.

Department of Thoracic/Head & Neck Medical Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.

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https://www.mdpi.com/2072-6694/11/4/462
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http://dx.doi.org/10.3390/cancers11040462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521201PMC
April 2019

A novel ex vivo tumor system identifies Src-mediated invasion and metastasis in mesenchymal tumor cells in non-small cell lung cancer.

Sci Rep 2019 Mar 20;9(1):4819. Epub 2019 Mar 20.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1038/s41598-019-41301-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427036PMC
March 2019

TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins.

Nat Commun 2018 07 16;9(1):2731. Epub 2018 Jul 16.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

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http://www.nature.com/articles/s41467-018-05013-x
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http://dx.doi.org/10.1038/s41467-018-05013-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048095PMC
July 2018

Prognostic Value of PD-L1 mRNA Sequencing Expression Profile in Non-Small Cell Lung Cancer.

Ann Thorac Surg 2018 06 3;105(6):1621-1626. Epub 2018 Mar 3.

Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1016/j.athoracsur.2018.01.081DOI Listing
June 2018

Pan-Cancer Molecular Classes Transcending Tumor Lineage Across 32 Cancer Types, Multiple Data Platforms, and over 10,000 Cases.

Clin Cancer Res 2018 05 9;24(9):2182-2193. Epub 2018 Feb 9.

Dan L. Duncan Comprehensive Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-3378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932236PMC
May 2018

Pan-cancer survey of epithelial-mesenchymal transition markers across the Cancer Genome Atlas.

Dev Dyn 2018 03 4;247(3):555-564. Epub 2017 May 4.

Dan L. Duncan Comprehensive Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, Texas.

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http://doi.wiley.com/10.1002/dvdy.24485
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http://dx.doi.org/10.1002/dvdy.24485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503821PMC
March 2018

The fibrotic tumor stroma.

J Clin Invest 2018 01 2;128(1):16-25. Epub 2018 Jan 2.

Department of Thoracic/Head and Neck Medical Oncology and.

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http://dx.doi.org/10.1172/JCI93554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749516PMC
January 2018

Pan-urologic cancer genomic subtypes that transcend tissue of origin.

Nat Commun 2017 08 4;8(1):199. Epub 2017 Aug 4.

Dan L. Duncan Comprehensive Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1038/s41467-017-00289-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543131PMC
August 2017

The BATTLE-2 Study: A Biomarker-Integrated Targeted Therapy Study in Previously Treated Patients With Advanced Non-Small-Cell Lung Cancer.

J Clin Oncol 2016 Oct;34(30):3638-3647

Vassiliki Papadimitrakopoulou, J. Jack Lee, Ignacio I. Wistuba, Anne S. Tsao, Frank V. Fossella, Neda Kalhor, Sanjay Gupta, Lauren Averett Byers, Julie G. Izzo, Ximing Tang, Ferdinandos Skoulidis, Don L. Gibbons, Li Shen, Caimiao Wei, Lixia Diao, S. Andrew Peng, Jing Wang, Alda L. Tam, John V. Heymach, and Waun Ki Hong, The University of Texas MD Anderson Cancer Center, Houston, TX; Scott N. Gettinger, Sarah B. Goldberg, Ja Seok Koo, and Roy S. Herbst, Yale University, New Haven, CT; Vincent A. Miller, Foundation Medicine, Cambridge, MA; Kevin R. Coombes, Ohio State University College of Medicine, Columbus, OH; and David J. Mauro and Eric H. Rubin, Merck, North Wales, PA.

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http://dx.doi.org/10.1200/JCO.2015.66.0084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065110PMC
October 2016

Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression.

Oncoimmunology 2016 26;5(11):e1234570. Epub 2016 Sep 26.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1080/2162402X.2016.1234570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139626PMC
September 2016

Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma.

Clin Cancer Res 2016 07 5;22(14):3630-42. Epub 2016 Feb 5.

Department of Thoracic and Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947453PMC
July 2016

A genetic cell context-dependent role for ZEB1 in lung cancer.

Nat Commun 2016 07 26;7:12231. Epub 2016 Jul 26.

Thoracic Disease Research Unit, Division of Pulmonary and Critical Care Medicine, Cancer Center and College of Medicine, Mayo Clinic, 200 First Street SW, Stabile Building Room st8-08 Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1038/ncomms12231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963474PMC
July 2016

Musashi-2 (MSI2) supports TGF-β signaling and inhibits claudins to promote non-small cell lung cancer (NSCLC) metastasis.

Proc Natl Acad Sci U S A 2016 06 6;113(25):6955-60. Epub 2016 Jun 6.

Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, 19111; Department of Medical Oncology, University of New Mexico Cancer Center, Albuquerque, NM 87131; Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111

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http://dx.doi.org/10.1073/pnas.1513616113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922167PMC
June 2016

Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma.

Mol Cancer Res 2016 Mar 2;14(3):287-95. Epub 2015 Dec 2.

Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794404PMC
March 2016

The microRNA-200/Zeb1 axis regulates ECM-dependent β1-integrin/FAK signaling, cancer cell invasion and metastasis through CRKL.

Sci Rep 2016 Jan 5;6:18652. Epub 2016 Jan 5.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1038/srep18652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700473PMC
January 2016

The mutually regulatory loop of epithelial-mesenchymal transition and immunosuppression in cancer progression.

Oncoimmunology 2015 May 3;4(5):e1002731. Epub 2015 Feb 3.

Department of Thoracic/Head and Neck Medical Oncology; The University of Texas MD Anderson Cancer Center ; Houston, TX USA ; Department of Molecular and Cellular Oncology; The University of Texas MD Anderson Cancer Center ; Houston, TX USA.

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http://dx.doi.org/10.1080/2162402X.2014.1002731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485725PMC
May 2015

A HER 1-2 punch: dual EGFR targeting deals resistance a deadly blow.

Cancer Discov 2014 Sep;4(9):991-4

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990388PMC
September 2014

Molecular dynamics reveal BCR-ABL1 polymutants as a unique mechanism of resistance to PAN-BCR-ABL1 kinase inhibitor therapy.

Proc Natl Acad Sci U S A 2014 Mar 18;111(9):3550-5. Epub 2014 Feb 18.

Department of Thoracic, Head/Neck Medical Oncology and Department of Molecular and Cellular Oncology, MD Anderson Cancer Center, Houston, TX 77030.

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http://dx.doi.org/10.1073/pnas.1321173111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948238PMC
March 2014

Gene expression profile of A549 cells from tissue of 4D model predicts poor prognosis in lung cancer patients.

Int J Cancer 2014 Feb 3;134(4):789-98. Epub 2013 Sep 3.

Department of Surgery, The Methodist Hospital Research Institute, Houston, TX.

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http://dx.doi.org/10.1002/ijc.28428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070715PMC
February 2014

Smoking, p53 mutation, and lung cancer.

Mol Cancer Res 2014 Jan;12(1):3-13

University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Box 0432, Houston, Texas 77030.

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http://dx.doi.org/10.1158/1541-7786.MCR-13-0539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925633PMC
January 2014

Through the open door: Preferential binding of dasatinib to the active form of BCR-ABL unveiled by in silico experiments.

Mol Oncol 2013 Oct 15;7(5):968-75. Epub 2013 Jun 15.

Molecular Simulations Engineering (MOSE) Laboratory - DEA, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy.

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http://dx.doi.org/10.1016/j.molonc.2013.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528448PMC
October 2013

The role of epithelial-mesenchymal transition programming in invasion and metastasis: a clinical perspective.

Cancer Manag Res 2013 31;5:187-95. Epub 2013 Jul 31.

The Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA ; Department of Medicine, Baylor College of Medicine, Houston, TX, USA ; Department of Bioinformatics and Computational Biology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.2147/CMAR.S35171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754282PMC
August 2013

ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression.

J Clin Invest 2012 Sep 1;122(9):3170-83. Epub 2012 Aug 1.

Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1172/JCI63608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428095PMC
September 2012

The rise and fall of gatekeeper mutations? The BCR-ABL1 T315I paradigm.

Cancer 2012 Jan 5;118(2):293-9. Epub 2011 Jul 5.

Department of Thoracic, Head/Neck Medical Oncology and Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1002/cncr.26225DOI Listing
January 2012

The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice.

J Clin Invest 2011 Apr 14;121(4):1373-85. Epub 2011 Mar 14.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1172/JCI42579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069760PMC
April 2011

Treatment of non-small-cell lung cancer with erlotinib or gefitinib.

N Engl J Med 2011 Mar;364(10):947-55

Louisiana State University Health Sciences Center and Hematology-Oncology Clinic, Baton Rouge, LA 70805, USA.

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http://dx.doi.org/10.1056/NEJMct0807960DOI Listing
March 2011

Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression.

Genes Dev 2009 Sep;23(18):2140-51

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1101/gad.1820209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751985PMC
September 2009

Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma.

PLoS One 2009 30;4(4):e5401. Epub 2009 Apr 30.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005401PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671160PMC
August 2009

Distinct biological roles for the notch ligands Jagged-1 and Jagged-2.

J Biol Chem 2009 Jun 27;284(26):17766-74. Epub 2009 Apr 27.

Department of Thoracic/Head and Neck Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1074/jbc.M109.003111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719415PMC
June 2009

Five-gene signature in non-small-cell lung cancer.

N Engl J Med 2007 Apr;356(15):1582-3; author reply 1583

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April 2007

Multistep regulation of membrane insertion of the fusion peptide of Semliki Forest virus.

J Virol 2004 Apr;78(7):3312-8

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC371068PMC
http://dx.doi.org/10.1128/jvi.78.7.3312-3318.2004DOI Listing
April 2004

Conformational change and protein-protein interactions of the fusion protein of Semliki Forest virus.

Nature 2004 Jan;427(6972):320-5

Virologie Moléculaire & Structurale, UMR 2472/1157 CNRS-INRA, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.

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http://dx.doi.org/10.1038/nature02239DOI Listing
January 2004

Visualization of the target-membrane-inserted fusion protein of Semliki Forest virus by combined electron microscopy and crystallography.

Cell 2003 Sep;114(5):573-83

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/s0092-8674(03)00683-4DOI Listing
September 2003

The fusion peptide of Semliki Forest virus associates with sterol-rich membrane domains.

J Virol 2002 Apr;76(7):3267-75

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC136022PMC
http://dx.doi.org/10.1128/jvi.76.7.3267-3275.2002DOI Listing
April 2002

Molecular dissection of the Semliki Forest virus homotrimer reveals two functionally distinct regions of the fusion protein.

J Virol 2002 Feb;76(3):1194-205

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC135824PMC
http://dx.doi.org/10.1128/jvi.76.3.1194-1205.2002DOI Listing
February 2002