Don D Sin

Don D Sin

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Don D Sin

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Particle depletion of diesel exhaust restores allergen-induced lung-protective surfactant protein D in human lungs.

Thorax 2020 08 28;75(8):640-647. Epub 2020 May 28.

Air Pollution Exposure Laboratory, Department of Medicine, Vancouver Coastal Health Research Institute, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada

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http://dx.doi.org/10.1136/thoraxjnl-2020-214561DOI Listing
August 2020

Effects of sex and chronic cigarette smoke exposure on the mouse cecal microbiome.

PLoS One 2020 6;15(4):e0230932. Epub 2020 Apr 6.

Department of Medicine, Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230932PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135149PMC
July 2020

Smoking, ACE-2 and COVID-19: ongoing controversies.

Eur Respir J 2020 07 16;56(1). Epub 2020 Jul 16.

Centre for Heart Lung Innovation and the Division of Respiratory Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1183/13993003.01759-2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363948PMC
July 2020

Various factors affect lipopolysaccharide sensitization in cell cultures.

Biotechniques 2020 Jul 13. Epub 2020 Jul 13.

Centre for Heart Lung Innovation, University of British Columbia, St. Paul's Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.2144/btn-2020-0043DOI Listing
July 2020

CT Vascular Tree-in-bud: A Novel Prognostic Imaging Biomarker in COVID-19?

Am J Respir Crit Care Med 2020 Jul 20. Epub 2020 Jul 20.

University of Alberta, Medicine, Edmonton, Canada;

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http://dx.doi.org/10.1164/rccm.202007-2833EDDOI Listing
July 2020

COVID-19 and nicotine as a mediator of ACE-2.

Eur Respir J 2020 06 4;55(6). Epub 2020 Jun 4.

Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada

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http://dx.doi.org/10.1183/13993003.01261-2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191112PMC
June 2020

Withdrawal of inhaled corticosteroids in COPD: a European Respiratory Society guideline.

Eur Respir J 2020 Jun 4;55(6). Epub 2020 Jun 4.

Pneumology Dept, Hospital Universitari Vall d'Hebron/Vall d'Hebron Research Institute, CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, Spain

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http://dx.doi.org/10.1183/13993003.00351-2020DOI Listing
June 2020

Reply to: "Current smoking is not associated with COVID-19".

Eur Respir J 2020 06 4;55(6). Epub 2020 Jun 4.

Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada

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http://dx.doi.org/10.1183/13993003.01340-2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236832PMC
June 2020

SARS-CoV-2 receptor ACE2 gene expression and RAAS inhibitors.

Lancet Respir Med 2020 06 13;8(6):e50-e51. Epub 2020 May 13.

Centre for Heart Lung Innovation, University of British Colombia at St Paul's Hospital, Vancouver V6Z 1Y6, BC, Canada; Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/S2213-2600(20)30224-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220165PMC
June 2020

Predicting Severe COPD Exacerbations: Developing a Population Surveillance Approach with Administrative Data.

Ann Am Thorac Soc 2020 May 8. Epub 2020 May 8.

University of British Columbia, Institute for Heart and Lung Health, Vancouver, British Columbia, Canada;

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http://dx.doi.org/10.1513/AnnalsATS.202001-070OCDOI Listing
May 2020

External Radiofrequency as a Novel Extracorporeal Therapy for Emphysema.

Eur Respir J 2020 May 29. Epub 2020 May 29.

Centre for Heart Lung Innovation, St. Paul's Hospital, and Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada

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http://dx.doi.org/10.1183/13993003.01422-2020DOI Listing
May 2020

Contemporary Concise Review 2019: Chronic obstructive pulmonary disease.

Authors:
Don D Sin

Respirology 2020 Apr 10;25(4):449-454. Epub 2020 Feb 10.

UBC Centre for Heart and Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.1111/resp.13782DOI Listing
April 2020

Vitamin D Deficiency in COPD: Biomarker, Treatable Trait, or Just a Common Comorbidity?

Chest 2020 Apr;157(4):755-756

Centre for Heart Lung Innovation, St. Paul's Hospital and Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.chest.2019.12.007DOI Listing
April 2020

An Individualized Prediction Model for Long-term Lung Function Trajectory and Risk of COPD in the General Population.

Chest 2020 Mar 19;157(3):547-557. Epub 2019 Sep 19.

Respiratory Evaluation Sciences Program, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada; Division of Respiratory Medicine, Department of Medicine, The UBC Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada; Institute for Heart and Lung Health, Division of Respiratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; Centre for Clinical Epidemiology and Evaluation, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.chest.2019.09.003DOI Listing
March 2020

Trends in prescriptions and costs of inhaled medications in chronic obstructive pulmonary disease: a 19-year population-based study from Canada.

Int J Chron Obstruct Pulmon Dis 2019 3;14:2003-2013. Epub 2019 Sep 3.

Respiratory Evaluation Sciences Program, Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.2147/COPD.S210897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732655PMC
March 2020

Response.

Chest 2020 Mar;157(3):738-739

Respiratory Evaluation Sciences Program, Faculty of Pharmaceutical Sciences, University of British Columbia; Division of Respiratory Medicine, Department of Medicine, The UBC Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia; Institute for Heart and Lung Health, Division of Respiratory Medicine, Faculty of Medicine, University of British Columbia; Centre for Clinical Epidemiology and Evaluation, University of British Columbia.

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http://dx.doi.org/10.1016/j.chest.2019.10.058DOI Listing
March 2020

The Acute COPD Exacerbation Prediction Tool (ACCEPT): a modelling study.

Lancet Respir Med 2020 Mar 13. Epub 2020 Mar 13.

Respiratory Evaluation Sciences Program, Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada; Institute for Heart and Lung Health, Division of Respiratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; Centre for Clinical Epidemiology and Evaluation, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/S2213-2600(19)30397-2DOI Listing
March 2020

Avoiding immortal time bias in observational studies.

Eur Respir J 2020 Mar 20;55(3). Epub 2020 Mar 20.

Collaboration for Outcomes Research and Evaluation (CORE), Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1183/13993003.02494-2019DOI Listing
March 2020

Self-initiated lifestyle interventions lead to potential insight into an effective, alternative, non-surgical therapy for mitochondrial disease associated multiple symmetric lipomatosis.

Mitochondrion 2020 Mar 29;52:183-189. Epub 2020 Mar 29.

Adult Metabolic Diseases Clinic, Vancouver General Hospital, Canada; Department of Pathology, Faculty of Medicine, The University of British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.mito.2020.03.009DOI Listing
March 2020

Healthcare system encounters before COPD diagnosis: a registry-based longitudinal cohort study.

Thorax 2020 02 8;75(2):108-115. Epub 2019 Nov 8.

Respiratory Evaluation Sciences Program, Collaboration for Outcomes Research and Evaluation, The University of British Columbia Faculty of Pharmaceutical Sciences, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1136/thoraxjnl-2019-213554DOI Listing
February 2020

Asthma-COPD Overlap and Chronic Airflow Obstruction: Definitions, Management, and Unanswered Questions.

J Allergy Clin Immunol Pract 2020 Feb 16;8(2):483-495. Epub 2019 Nov 16.

Centre for Heart Lung Innovation, St Paul's Hospital and Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2019.10.044DOI Listing
February 2020

Sex differences in lymphoid follicles in COPD airways.

Respir Res 2020 Feb 7;21(1):46. Epub 2020 Feb 7.

Centre for Heart Lung Innovation, St. Paul's Hospital, & Department of Medicine, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1186/s12931-020-1311-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006095PMC
February 2020

Identification and definition of asthma-COPD overlap: The CanCOLD study.

Respirology 2020 Feb 16. Epub 2020 Feb 16.

Respiratory Epidemiology and Clinical Research Unit, Research Institute of the McGill University Health Centre, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1111/resp.13780DOI Listing
February 2020

Impact of marijuana smoking on lung function in older persons.

Eur Respir J 2020 02 20;55(2). Epub 2020 Feb 20.

The University of British Columbia, Center for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.1183/13993003.02390-2019DOI Listing
February 2020

Blood biomarkers to predict short-term pulmonary exacerbation risk in children and adolescents with CF: A pilot study.

J Cyst Fibros 2020 01 5;19(1):49-51. Epub 2019 Jun 5.

Centre for Heart Lung Innovation, University of British Columbia and St. Paul's Hospital, Vancouver, BC, Canada; Prevention Of Organ Failure (PROOF) Centre of Excellence, Vancouver, BC, Canada; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jcf.2019.05.020DOI Listing
January 2020

Twenty-five years of Respirology: Advances in COPD.

Respirology 2020 01;25(1):17-19

University of British Columbia (UBC), Division of Respiratory Medicine and UBC Centre for Heart Lung Innovation (HLI), St Paul's Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.1111/resp.13734DOI Listing
January 2020

Economic burden of multimorbidity in patients with severe asthma: a 20-year population-based study.

Thorax 2019 12 18;74(12):1113-1119. Epub 2019 Sep 18.

Division of Respiratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1136/thoraxjnl-2019-213223DOI Listing
December 2019

The pharmacogenomics of inhaled corticosteroids and lung function decline in COPD.

Eur Respir J 2019 12 4;54(6). Epub 2019 Dec 4.

The University of British Columbia Center for Heart Lung Innovation, St Paul's Hospital Vancouver, BC, Canada.

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http://dx.doi.org/10.1183/13993003.00521-2019DOI Listing
December 2019

The effects of marijuana smoking on lung function in older people.

Eur Respir J 2019 12 19;54(6). Epub 2019 Dec 19.

The University of British Columbia, Center for Heart Lung Innovation, St Pauls's Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.1183/13993003.00826-2019DOI Listing
December 2019

Long-Term Trajectories of Mild Asthma in Adulthood and Risk Factors of Progression.

J Allergy Clin Immunol Pract 2018 Nov - Dec;6(6):2024-2032.e5. Epub 2018 May 7.

Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada; Centre for Clinical Epidemiology and Evaluation, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2018.04.027DOI Listing
November 2019

Impaired Sleep Quality in COPD Is Associated With Exacerbations: The CanCOLD Cohort Study.

Chest 2019 11 28;156(5):852-863. Epub 2019 May 28.

Respiratory Epidemiology and Clinical Research Unit, Research Institute of the McGill University Health Centre, McGill University, Montreal, QC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2019.04.132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945650PMC
November 2019

Proteomic Profiling to Identify Blood Biomarkers Predictive of Response to Azithromycin in Children and Adolescents With Cystic Fibrosis.

Chest 2019 10 12;156(4):667-673. Epub 2019 Jun 12.

Centre for Heart Lung Innovation, Department of Medicine, University of British Columbia, Vancouver, BC, Canada; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2019.05.017DOI Listing
October 2019

BMI is associated with FEV decline in chronic obstructive pulmonary disease: a meta-analysis of clinical trials.

Respir Res 2019 Oct 29;20(1):236. Epub 2019 Oct 29.

Centre for Heart Lung Innovation, St. Paul's Hospital & Division of Respiratory Medicine, University of British Columbia, Rm 166-1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.

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http://dx.doi.org/10.1186/s12931-019-1209-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819522PMC
October 2019

Benralizumab for the Prevention of COPD Exacerbations.

N Engl J Med 2019 09 20;381(11):1023-1034. Epub 2019 May 20.

From the Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia (G.J.C.); Pulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, Boston (B.R.C.); the Institute for Lung Health, Leicester National Institute for Health Research Biomedical Research Centre, Department of Respiratory Sciences, University of Leicester, Leicester (C.E.B.), the University of Manchester, Manchester University NHS Hospital Trust, Manchester (D.S.), and the Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford (M.B.) - all in the United Kingdom; Respiratory Institute, Hospital Clinic, University of Barcelona, Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red (CIBER) Enfermedades Respiratorias, Barcelona (A.A.); the Department of Medical Sciences, University of Ferrara, Ferrara, Italy (A.P.); the Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada (D.D.S.); the Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-Universität Marburg, German Center for Lung Research (DZL), Marburg, Germany (C.F.V.); University of Pittsburgh School of Medicine, Pittsburgh (F.C.S.); the Department of Respiratory Medicine, Bispebjerg University Hospital, Copenhagen (V.B.); Kishiwada City Hospital, Osaka, Japan (M.K.); the Departamento de Investigación en Tabaquismo y EPOC, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosio Villegas, Mexico City (A.R.-V.); the Division of Respiratory and Chest Medicine, E-Da Hospital and I-Shou University, Kaohsiung, Taiwan (Y.-F.W.); the Department of Respiratory Medicine and Allergology, Skane University Hospital, Lund University, Lund, Sweden (L.B.); and AstraZeneca, Gaithersburg, MD (V.H.S., M.J., S.O., N.M., P.N., M.G., U.J.M.).

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http://dx.doi.org/10.1056/NEJMoa1905248DOI Listing
September 2019

Diet and COPD: Are we what we eat?

Authors:
Don D Sin

EClinicalMedicine 2019 Sep 15;14:5-6. Epub 2019 Aug 15.

UBC Centre for Heart Lung Innovation (HLI), St. Paul's Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.eclinm.2019.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833342PMC
September 2019

What's in the CART? A decision rule to predict short-term mortality during COPD exacerbations.

Authors:
Don D Sin

Respirology 2019 08 15;24(8):716-717. Epub 2019 Apr 15.

UBC Centre for Heart Lung Innovation (HLI), St. Paul's Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.1111/resp.13561DOI Listing
August 2019

Effect of short-term oral prednisone therapy on blood gene expression: a randomised controlled clinical trial.

Respir Res 2019 Aug 5;20(1):176. Epub 2019 Aug 5.

The University of British Columbia Centre for Heart Lung Innovation (HLI), St Paul's Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.

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http://dx.doi.org/10.1186/s12931-019-1147-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683462PMC
August 2019

Phenotyping and outcomes of hospitalized COPD patients using rapid molecular diagnostics on sputum samples.

Int J Chron Obstruct Pulmon Dis 2019;14:311-319. Epub 2019 Jan 23.

Centre for Heart Lung Innovation, James Hogg Research Centre, St Paul's Hospital, Vancouver, BC, Canada,

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http://dx.doi.org/10.2147/COPD.S188186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350828PMC
July 2019

Inhaled corticosteroids and the risk of lung cancer in COPD: a population-based cohort study.

Eur Respir J 2019 06 5;53(6). Epub 2019 Jun 5.

Collaboration for Outcomes Research and Evaluation (CORE), Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1183/13993003.01257-2018DOI Listing
June 2019

Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Authors:
Nick Shrine Anna L Guyatt A Mesut Erzurumluoglu Victoria E Jackson Brian D Hobbs Carl A Melbourne Chiara Batini Katherine A Fawcett Kijoung Song Phuwanat Sakornsakolpat Xingnan Li Ruth Boxall Nicola F Reeve Ma'en Obeidat Jing Hua Zhao Matthias Wielscher Stefan Weiss Katherine A Kentistou James P Cook Benjamin B Sun Jian Zhou Jennie Hui Stefan Karrasch Medea Imboden Sarah E Harris Jonathan Marten Stefan Enroth Shona M Kerr Ida Surakka Veronique Vitart Terho Lehtimäki Richard J Allen Per S Bakke Terri H Beaty Eugene R Bleecker Yohan Bossé Corry-Anke Brandsma Zhengming Chen James D Crapo John Danesh Dawn L DeMeo Frank Dudbridge Ralf Ewert Christian Gieger Amund Gulsvik Anna L Hansell Ke Hao Joshua D Hoffman John E Hokanson Georg Homuth Peter K Joshi Philippe Joubert Claudia Langenberg Xuan Li Liming Li Kuang Lin Lars Lind Nicholas Locantore Jian'an Luan Anubha Mahajan Joseph C Maranville Alison Murray David C Nickle Richard Packer Margaret M Parker Megan L Paynton David J Porteous Dmitry Prokopenko Dandi Qiao Rajesh Rawal Heiko Runz Ian Sayers Don D Sin Blair H Smith María Soler Artigas David Sparrow Ruth Tal-Singer Paul R H J Timmers Maarten Van den Berge John C Whittaker Prescott G Woodruff Laura M Yerges-Armstrong Olga G Troyanskaya Olli T Raitakari Mika Kähönen Ozren Polašek Ulf Gyllensten Igor Rudan Ian J Deary Nicole M Probst-Hensch Holger Schulz Alan L James James F Wilson Beate Stubbe Eleftheria Zeggini Marjo-Riitta Jarvelin Nick Wareham Edwin K Silverman Caroline Hayward Andrew P Morris Adam S Butterworth Robert A Scott Robin G Walters Deborah A Meyers Michael H Cho David P Strachan Ian P Hall Martin D Tobin Louise V Wain

Nat Genet 2019 Jun;51(6):1067

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/s41588-019-0438-3DOI Listing
June 2019

Karma of Cardiovascular Disease Risk Factors for Prevention and Management of Major Cardiovascular Events in the Context of Acute Exacerbations of Chronic Obstructive Pulmonary Disease.

Front Cardiovasc Med 2019 25;6:79. Epub 2019 Jun 25.

Heart Disease Prevention Program, Division of Cardiology, University of California, Irvine, Irvine, CA, United States.

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http://dx.doi.org/10.3389/fcvm.2019.00079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603127PMC
June 2019

Smooth Muscle Cells Contribute the Majority of Foam Cells in ApoE (Apolipoprotein E)-Deficient Mouse Atherosclerosis.

Arterioscler Thromb Vasc Biol 2019 05;39(5):876-887

From the Departments of Medicine (Y.W., J.A.D., S.A., E.A., B.S., J.E.J., D.D.S., G.A.F.), Centre for Heart Lung Innovation, Providence Healthcare Research Institute, St Paul's Hospital, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1161/ATVBAHA.119.312434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482082PMC
May 2019

Precision health: treating the individual patient with chronic obstructive pulmonary disease.

Med J Aust 2019 05 11;210(9):424-428. Epub 2019 Apr 11.

University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.5694/mja2.50138DOI Listing
May 2019

Introduction to precision medicine in COPD.

Eur Respir J 2019 04 11;53(4). Epub 2019 Apr 11.

UBC Centre for Heart Lung Innovation, University of British Columbia and St. Paul's Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.1183/13993003.02460-2018DOI Listing
April 2019

Accelerated lung aging and chronic obstructive pulmonary disease.

Expert Rev Respir Med 2019 04 21;13(4):369-380. Epub 2019 Feb 21.

a Centre for Heart and Lung Innovation , St. Paul's Hospital & University of British Columbia , Vancouver , BC , Canada.

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https://www.tandfonline.com/doi/full/10.1080/17476348.2019.1
Publisher Site
http://dx.doi.org/10.1080/17476348.2019.1580576DOI Listing
April 2019

Ectopic adiposity and cardiometabolic health in COPD.

Int J Chron Obstruct Pulmon Dis 2018;13:3331-3340. Epub 2018 Oct 15.

Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval, Québec, QC, Canada,

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https://www.dovepress.com/ectopic-adiposity-and-cardiometabo
Publisher Site
http://dx.doi.org/10.2147/COPD.S168963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197246PMC
March 2019

Inhaled corticosteroids and fractures in chronic obstructive pulmonary disease: current understanding and recommendations.

Curr Opin Pulm Med 2019 03;25(2):165-172

Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1097/MCP.0000000000000554DOI Listing
March 2019

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Authors:
Nick Shrine Anna L Guyatt A Mesut Erzurumluoglu Victoria E Jackson Brian D Hobbs Carl A Melbourne Chiara Batini Katherine A Fawcett Kijoung Song Phuwanat Sakornsakolpat Xingnan Li Ruth Boxall Nicola F Reeve Ma'en Obeidat Jing Hua Zhao Matthias Wielscher Stefan Weiss Katherine A Kentistou James P Cook Benjamin B Sun Jian Zhou Jennie Hui Stefan Karrasch Medea Imboden Sarah E Harris Jonathan Marten Stefan Enroth Shona M Kerr Ida Surakka Veronique Vitart Terho Lehtimäki Richard J Allen Per S Bakke Terri H Beaty Eugene R Bleecker Yohan Bossé Corry-Anke Brandsma Zhengming Chen James D Crapo John Danesh Dawn L DeMeo Frank Dudbridge Ralf Ewert Christian Gieger Amund Gulsvik Anna L Hansell Ke Hao Joshua D Hoffman John E Hokanson Georg Homuth Peter K Joshi Philippe Joubert Claudia Langenberg Xuan Li Liming Li Kuang Lin Lars Lind Nicholas Locantore Jian'an Luan Anubha Mahajan Joseph C Maranville Alison Murray David C Nickle Richard Packer Margaret M Parker Megan L Paynton David J Porteous Dmitry Prokopenko Dandi Qiao Rajesh Rawal Heiko Runz Ian Sayers Don D Sin Blair H Smith María Soler Artigas David Sparrow Ruth Tal-Singer Paul R H J Timmers Maarten Van den Berge John C Whittaker Prescott G Woodruff Laura M Yerges-Armstrong Olga G Troyanskaya Olli T Raitakari Mika Kähönen Ozren Polašek Ulf Gyllensten Igor Rudan Ian J Deary Nicole M Probst-Hensch Holger Schulz Alan L James James F Wilson Beate Stubbe Eleftheria Zeggini Marjo-Riitta Jarvelin Nick Wareham Edwin K Silverman Caroline Hayward Andrew P Morris Adam S Butterworth Robert A Scott Robin G Walters Deborah A Meyers Michael H Cho David P Strachan Ian P Hall Martin D Tobin Louise V Wain

Nat Genet 2019 03 25;51(3):481-493. Epub 2019 Feb 25.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/s41588-018-0321-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397078PMC
March 2019

A letter from 'O Canada'.

Respirology 2019 02 17;24(2):186-187. Epub 2018 Oct 17.

UBC Centre for Heart Lung Innovation (HLI), St. Paul's Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.1111/resp.13425DOI Listing
February 2019

Emergency department management of acute exacerbations of chronic obstructive pulmonary disease: factors predicting readmission.

Int J Chron Obstruct Pulmon Dis 2018 23;13:1647-1654. Epub 2018 May 23.

Centre for Heart Lung Innovation, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.2147/COPD.S163250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973381PMC
January 2019

What triggers acute exacerbations of COPD? Why not ask the patient!

Respirology 2019 01 14;24(1):7-8. Epub 2018 Aug 14.

Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.1111/resp.13384DOI Listing
January 2019

A Streamlined Method for Quantification of Apolipoprotein A1 in Human Plasma by LC-MS/MS.

Clin Chem 2018 12;64(12):1782-1784

Department of Pathology and Laboratory Medicine University of British Columbia Vancouver, Canada

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http://dx.doi.org/10.1373/clinchem.2018.293530DOI Listing
December 2018

Inhaled corticosteroids in COPD: the final verdict is….

Eur Respir J 2018 12 13;52(6). Epub 2018 Dec 13.

Centre for Heart Lung Innovation, St Paul's Hospital and Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada.

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http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01940
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http://dx.doi.org/10.1183/13993003.01940-2018DOI Listing
December 2018

Underdiagnosis and Overdiagnosis of Chronic Obstructive Pulmonary Disease.

Am J Respir Crit Care Med 2018 11;198(9):1130-1139

1 The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1164/rccm.201804-0621CIDOI Listing
November 2018

Blood and sputum protein biomarkers for chronic obstructive pulmonary disease (COPD).

Expert Rev Proteomics 2018 11 29;15(11):923-935. Epub 2018 Oct 29.

a Centre for Heart and Lung Innovation , St. Paul's Hospital & University of British Columbia , Vancouver , Canada.

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https://www.tandfonline.com/doi/full/10.1080/14789450.2018.1
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http://dx.doi.org/10.1080/14789450.2018.1539670DOI Listing
November 2018

Relative impact characteristic curve: a graphical tool to visualize and quantify the clinical utility and population-level consequences of implementing markers.

Ann Epidemiol 2018 10 30;28(10):717-723.e3. Epub 2018 Jul 30.

Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.annepidem.2018.07.014DOI Listing
October 2018

What are the long-term effects of smoked marijuana on lung health?

Authors:
Wan C Tan Don D Sin

CMAJ 2018 10;190(42):E1243-E1244

Centre for Heart Lung Innovation (Tan, Sin), University of British Columbia; St. Paul's Hospital (Tan, Sin), Vancouver, BC.

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http://www.cmaj.ca/lookup/doi/10.1503/cmaj.181307
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http://dx.doi.org/10.1503/cmaj.181307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199161PMC
October 2018

Phenotyping COPD exacerbations using imaging and blood-based biomarkers.

Int J Chron Obstruct Pulmon Dis 2018 8;13:217-229. Epub 2018 Jan 8.

Centre for Heart Lung Innovation, James Hogg Research Centre, St Paul's Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.2147/COPD.S152484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764289PMC
September 2018

The Impact of Care Specialty on Survival-Adjusted Medical Costs of COPD Patients After a Hospitalization: a longitudinal analysis.

J Gen Intern Med 2018 09 2;33(9):1528-1535. Epub 2018 Apr 2.

Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.

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http://dx.doi.org/10.1007/s11606-018-4406-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109016PMC
September 2018

COPD and cardiovascular diseases: now is the time for action!

Thorax 2018 09 5;73(9):799-800. Epub 2018 Apr 5.

Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1136/thoraxjnl-2018-211553DOI Listing
September 2018

COPD in China: From Crisis to Hope….

Chest 2018 09;154(3):474-475

Centre for Heart Lung Innovation, St. Paul's Hospital & Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2018.07.012DOI Listing
September 2018

Relationship of Absolute Telomere Length With Quality of Life, Exacerbations, and Mortality in COPD.

Chest 2018 08 12;154(2):266-273. Epub 2018 Jul 12.

Centre for Heart Lung Innovation, St. Paul's Hospital, and Department of Medicine (Respiratory Division), University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2018.05.022DOI Listing
August 2018

The diagnostic performance of patient symptoms in screening for COPD.

Respir Res 2018 08 3;19(1):147. Epub 2018 Aug 3.

Respiratory Evaluation Sciences Program, Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1186/s12931-018-0853-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090694PMC
August 2018

Chronic Obstructive Pulmonary Disease as a Risk Factor for Cardiovascular Disease. A View from the SUMMIT.

Am J Respir Crit Care Med 2018 07;198(1):2-4

2 Centre for Heart Lung Innovation St. Paul's Hospital Vancouver, British Columbia, Canada and.

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http://dx.doi.org/10.1164/rccm.201802-0347EDDOI Listing
July 2018

Serial blood eosinophils and clinical outcome in patients with chronic obstructive pulmonary disease.

Respir Res 2018 07 13;19(1):134. Epub 2018 Jul 13.

Department of Pulmonary and Critical Care Medicine, Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-018-0840-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044087PMC
July 2018

Imaging End Points in COPD Clinical Trials: Are We There Yet?

Chest 2018 07;154(1):3-5

UBC Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada; Department of Medicine (Division of Respirology), University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2018.01.050DOI Listing
July 2018

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.

Authors:
Annah B Wyss Tamar Sofer Mi Kyeong Lee Natalie Terzikhan Jennifer N Nguyen Lies Lahousse Jeanne C Latourelle Albert Vernon Smith Traci M Bartz Mary F Feitosa Wei Gao Tarunveer S Ahluwalia Wenbo Tang Christopher Oldmeadow Qing Duan Kim de Jong Mary K Wojczynski Xin-Qun Wang Raymond Noordam Fernando Pires Hartwig Victoria E Jackson Tianyuan Wang Ma'en Obeidat Brian D Hobbs Tianxiao Huan Hongsheng Gui Margaret M Parker Donglei Hu Lauren S Mogil Gleb Kichaev Jianping Jin Mariaelisa Graff Tamara B Harris Ravi Kalhan Susan R Heckbert Lavinia Paternoster Kristin M Burkart Yongmei Liu Elizabeth G Holliday James G Wilson Judith M Vonk Jason L Sanders R Graham Barr Renée de Mutsert Ana Maria Baptista Menezes Hieab H H Adams Maarten van den Berge Roby Joehanes Albert M Levin Jennifer Liberto Lenore J Launer Alanna C Morrison Colleen M Sitlani Juan C Celedón Stephen B Kritchevsky Rodney J Scott Kaare Christensen Jerome I Rotter Tobias N Bonten Fernando César Wehrmeister Yohan Bossé Shujie Xiao Sam Oh Nora Franceschini Jennifer A Brody Robert C Kaplan Kurt Lohman Mark McEvoy Michael A Province Frits R Rosendaal Kent D Taylor David C Nickle L Keoki Williams Esteban G Burchard Heather E Wheeler Don D Sin Vilmundur Gudnason Kari E North Myriam Fornage Bruce M Psaty Richard H Myers George O'Connor Torben Hansen Cathy C Laurie Patricia A Cassano Joohon Sung Woo Jin Kim John R Attia Leslie Lange H Marike Boezen Bharat Thyagarajan Stephen S Rich Dennis O Mook-Kanamori Bernardo Lessa Horta André G Uitterlinden Hae Kyung Im Michael H Cho Guy G Brusselle Sina A Gharib Josée Dupuis Ani Manichaikul Stephanie J London

Nat Commun 2018 07 30;9(1):2976. Epub 2018 Jul 30.

Epidemiology Branch National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC, 27709, USA.

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http://dx.doi.org/10.1038/s41467-018-05369-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065313PMC
July 2018

Crisis of COPD in China: the future is now.

Authors:
Yilan Sun Don D Sin

Lancet Respir Med 2018 06 9;6(6):404-405. Epub 2018 Apr 9.

Centre for Heart Lung Innovation, St Paul's Hospital and Division of Respiratory Medicine, University of British Columbia, Vancouver, BC V6Z 1Y6, Canada. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(18)30133-4DOI Listing
June 2018

Severity of Airflow Obstruction and Work Loss in a Nationwide Population of Working Age.

Sci Rep 2018 06 26;8(1):9674. Epub 2018 Jun 26.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

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http://dx.doi.org/10.1038/s41598-018-27999-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018711PMC
June 2018

The genetics of smoking in individuals with chronic obstructive pulmonary disease.

Respir Res 2018 04 10;19(1):59. Epub 2018 Apr 10.

The University of British Columbia Center for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.1186/s12931-018-0762-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892035PMC
April 2018

Favorable longitudinal change of lung function in patients with asthma-COPD overlap from a COPD cohort.

Respir Res 2018 03 2;19(1):36. Epub 2018 Mar 2.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, 150, Seongan-ro, Gangdong-gu, Seoul, 134-701, South Korea.

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http://dx.doi.org/10.1186/s12931-018-0737-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833074PMC
March 2018

Reply.

J Allergy Clin Immunol 2018 02 6;141(2):831. Epub 2017 Dec 6.

Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, British Columbia, Canada; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.10.013DOI Listing
February 2018

The role of beta-blockers in the management of chronic obstructive pulmonary disease.

Expert Rev Respir Med 2018 02 27;12(2):125-135. Epub 2017 Dec 27.

a Centre for Heart Lung Innovation, St. Paul´s Hospital, & Department of Medicine , University of British Columbia , Vancouver , BC , Canada.

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http://dx.doi.org/10.1080/17476348.2018.1419869DOI Listing
February 2018

Inhaled Corticosteroids and Fractures in COPD: Can We Finally Put This to Bed?

Authors:
Yu Ji Cho Don D Sin

Chest 2018 02;153(2):293-294

Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada; Department of Medicine (Respiratory Division), University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2017.08.027DOI Listing
February 2018

Response.

Chest 2018 02;153(2):578-579

Collaboration for Outcomes Research and Evaluation (CORE), Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada; Centre for Health Evaluation and Outcome Sciences, St. Paul's Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.chest.2017.12.006DOI Listing
February 2018

Characterizing undiagnosed chronic obstructive pulmonary disease: a systematic review and meta-analysis.

Respir Res 2018 02 7;19(1):26. Epub 2018 Feb 7.

Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.

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http://dx.doi.org/10.1186/s12931-018-0731-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803996PMC
February 2018

Meta-analysis of exome array data identifies six novel genetic loci for lung function.

Authors:
Victoria E Jackson Jeanne C Latourelle Louise V Wain Albert V Smith Megan L Grove Traci M Bartz Ma'en Obeidat Michael A Province Wei Gao Beenish Qaiser David J Porteous Patricia A Cassano Tarunveer S Ahluwalia Niels Grarup Jin Li Elisabeth Altmaier Jonathan Marten Sarah E Harris Ani Manichaikul Tess D Pottinger Ruifang Li-Gao Allan Lind-Thomsen Anubha Mahajan Lies Lahousse Medea Imboden Alexander Teumer Bram Prins Leo-Pekka Lyytikäinen Gudny Eiriksdottir Nora Franceschini Colleen M Sitlani Jennifer A Brody Yohan Bossé Wim Timens Aldi Kraja Anu Loukola Wenbo Tang Yongmei Liu Jette Bork-Jensen Johanne M Justesen Allan Linneberg Leslie A Lange Rajesh Rawal Stefan Karrasch Jennifer E Huffman Blair H Smith Gail Davies Kristin M Burkart Josyf C Mychaleckyj Tobias N Bonten Stefan Enroth Lars Lind Guy G Brusselle Ashish Kumar Beate Stubbe Mika Kähönen Annah B Wyss Bruce M Psaty Susan R Heckbert Ke Hao Taina Rantanen Stephen B Kritchevsky Kurt Lohman Tea Skaaby Charlotta Pisinger Torben Hansen Holger Schulz Ozren Polasek Archie Campbell John M Starr Stephen S Rich Dennis O Mook-Kanamori Åsa Johansson Erik Ingelsson André G Uitterlinden Stefan Weiss Olli T Raitakari Vilmundur Gudnason Kari E North Sina A Gharib Don D Sin Kent D Taylor George T O'Connor Jaakko Kaprio Tamara B Harris Oluf Pederson Henrik Vestergaard James G Wilson Konstantin Strauch Caroline Hayward Shona Kerr Ian J Deary R Graham Barr Renée de Mutsert Ulf Gyllensten Andrew P Morris M Arfan Ikram Nicole Probst-Hensch Sven Gläser Eleftheria Zeggini Terho Lehtimäki David P Strachan Josée Dupuis Alanna C Morrison Ian P Hall Martin D Tobin Stephanie J London

Wellcome Open Res 2018 12;3. Epub 2018 Jan 12.

Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Dept of Health and Human Services, Research Triangle Park, NC, 27709, USA.

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http://dx.doi.org/10.12688/wellcomeopenres.12583.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081985PMC
January 2018