Dominique Gauguier

Dominique Gauguier

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Dominique Gauguier

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Conserved properties of genetic architecture of renal and fat transcriptomes in rat models of insulin resistance.

Dis Model Mech 2019 Jun 17. Epub 2019 Jun 17.

The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK

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http://dx.doi.org/10.1242/dmm.038539DOI Listing
June 2019

Implication of gut microbiota metabolites in cardiovascular and metabolic diseases.

Cell Mol Life Sci 2018 Nov 12;75(21):3977-3990. Epub 2018 Aug 12.

Sorbonne University, University Paris Descartes, INSERM UMR_S1138, Cordeliers Research Centre, 15 rue de l'Ecole de Médecine, 75006, Paris, France.

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http://dx.doi.org/10.1007/s00018-018-2901-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182343PMC
November 2018

Integration of the human exposome with the human genome to advance medicine.

Biochimie 2018 Sep 28;152:155-158. Epub 2018 Jun 28.

INSERM UMR_S1138, Sorbonne Universités, Université Pierre & Marie Curie, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Imperial College London, Section of Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Sir Alexander Fleming Building, London, United Kingdom; McGill University and Genome Quebec Innovation Centre, Montréal, Canada.

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http://dx.doi.org/10.1016/j.biochi.2018.06.023DOI Listing
September 2018

Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota.

Microbiome 2018 04 20;6(1):73. Epub 2018 Apr 20.

Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Exhibition Road, London, SW7 2AZ, UK.

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http://dx.doi.org/10.1186/s40168-018-0461-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909246PMC
April 2018

Molecular genetics of the transcription factor GLIS3 identifies its dual function in beta cells and neurons.

Genomics 2018 03 11;110(2):98-111. Epub 2017 Sep 11.

Sorbonne Universities, University Pierre & Marie Curie, University Paris Descartes, Sorbonne Paris Cité, INSERM UMR_S1138, Cordeliers Research Centre, Paris, France; The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; McGill University and Genome Quebec Innovation Centre, 740 Doctor Penfield Avenue, Montreal, QC H3A 0G1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ygeno.2017.09.001DOI Listing
March 2018

Genomic regulation of type 2 diabetes endophenotypes: Contribution from genetic studies in the Goto-Kakizaki rat.

Biochimie 2017 Dec 24;143:56-65. Epub 2017 Aug 24.

Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, SW7 2AZ, London, UK; McGill University and Genome Quebec Innovation Centre, 740 Doctor Penfield Avenue, Montreal, QC, H3A 0G1, Canada; Sorbonne Universities, University Pierre & Marie Curie, University Paris Descartes, Sorbonne Paris Cité, INSERM UMR_S 1138, Cordeliers Research Centre, 75006, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2017.08.012DOI Listing
December 2017

Microbial-Host Co-metabolites Are Prodromal Markers Predicting Phenotypic Heterogeneity in Behavior, Obesity, and Impaired Glucose Tolerance.

Cell Rep 2017 07;20(1):136-148

Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK; Cordeliers Research Centre, INSERM UMR_S 1138, University Pierre & Marie Curie and University Paris Descartes, Sorbonne Paris Cité, Sorbonne Universities, 15 Rue de l'École de Médecine, 75006 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.06.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507771PMC
July 2017

Loss of Cardioprotective Effects at the Locus as a Result of Gene-Smoking Interactions.

Circulation 2017 Jun 1;135(24):2336-2353. Epub 2017 May 1.

From Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia (D.S., W.Z.); Center for Non-Communicable Diseases, Karachi, Pakistan (D.S., A.R., P.M.F., PROMIS); Department of Public Health and Primary Care, University of Cambridge, United Kingdom (R.Y., W.K.H., EPIC-CVD); Department of Cardiovascular Sciences, University of Leicester, United Kingdom (C.P.N., N.J.S.); Cardiology Division, Department of Medicine, Vanderbilt University, Nashville, TN (J.F.F., K.O.); Division of Cardiovascular Medicine, Radcliffe Department of Medicine & Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom (A.G., M.F.); The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (R.D.); Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY (R.D.); Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Canada (A.F.R.S., R.M.); Institute for Genetic Medicine and Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles (J.H., H.A.); Department of Epidemiology and Biostatistics, Imperial College London, United Kingdom (W.Z., J.C.C., J.K.); Department of Cardiology, Ealing Hospital NHS Trust, Middlesex, United Kingdom (W.Z., J.C.C.); Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S.); Helsinki University Central Hospital HUCH Heart and Lung Center, Helsinki, Uusimaa, Finland (J.S.); Cardiology Division, Department of Medicine and the Irving Institute for Clinical and Translational Research, Columbia University Medical Center, New York, NY (R.C.B., M.P.R.); William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (S.K., E.M., P.D.); Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands (S.S., A.D.); Department of Dietetics-Nutrition, Harokopio University, Athens, Greece (E.M., G.D.); National Institute for Health and Welfare, Helsinki, Finland (K.K., A.J., V.S., K.K., M.P.); MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, United Kingdom (J.H.Z., R.S.); INSERM, UMRS1138, Centre de Recherche des Cordeliers, Paris, France (D.G., N.W.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC (S.H.S.); Icelandic Heart Association, Kopavogur, Iceland (A.V.S., V.G.); Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, United Kingdom (N.v.Z., C.N.A.P.); Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC (A.J.C., D.W.B.); Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Germany (C.W., J.E.); DZHK (German Research Center for Cardiovascular Research) partner site Hamburg-Lübeck-Kiel, Germany (C.W., J.E.); Deutsches Herzzentrum München, Technische Universität München, Germany (T.K., L.Z., H.S.); Klinikum rechts der Isar, München, Germany (T.K.); DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Germany (L.Z., H.S.); Department of Genetics, Washington University School of Medicine, St. Louis, MO (M.A.P., M.F.F.); Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston (A.G.); Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA (A.G.); Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Sweden (L.L.); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (N.L.P.); Department of Biostatistics Boston University School of Public Health Framingham Heart Study, MA (C.C.W.); Faculty of Medicine, University of Iceland, Reykjavik (A.V.S., V.G.); University of Helsinki, Institute for Molecular Medicine, Finland (FIMM) (A.J., M.P.); Department of Medicine, Mannheim Medical Faculty, Heidelberg University, Germany (M.E.K.); Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, United Kingdom (A.S.H.); Synlab Academy, Synlab Services GmbH, Mannheim, Germany and Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria (W.M.); National Heart, Lung, and Blood Institute and the Framingham Heart Study, National Institutes of Health, Bethesda, MD (C.O'D.); Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Sweden (E.I.); Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, CA (E.I.); Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (U.D.F.); Lebanese American University, School of Medicine, Beirut (P.Z.); Department of Health Sciences, University of Leicester, United Kingdom (J.R.T.); Imperial College Healthcare NHS Trust, London, United Kingdom (J.C.C., J.K.); Cardiovascular Science, National Heart and Lung Institute, Imperial College London, United Kingdom (J.K.); Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia (P.D.); deCODE Genetics, Sturlugata 8, IS-101 Reykjavik, Iceland (G.T., K.S.); University of Iceland, School of Medicine, Reykjavik, Iceland (G.T., K.S.); Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge (S.K.); Cardiovascular Research Center, Massachusetts General Hospital, Boston (S.K.); Center for Human Genetic Research, Massachusetts General Hospital, Boston (S.K.); Department of Medicine, Harvard Medical School, Boston, MA (S.K.); Department of Genetics, University of Pennsylvania, Philadelphia (D.J.R.); and Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.T.N., D.J.R.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.022069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612779PMC
June 2017

MetaboSignal: a network-based approach for topological analysis of metabotype regulation via metabolic and signaling pathways.

Bioinformatics 2017 03;33(5):773-775

Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, SW7 2AZ London, UK.

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http://dx.doi.org/10.1093/bioinformatics/btw697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408820PMC
March 2017

Biological roles of microRNAs in the control of insulin secretion and action.

Physiol Genomics 2017 01 4;49(1):1-10. Epub 2016 Nov 4.

Sorbonne Universities, University Pierre & Marie Curie, University Paris Descartes, Sorbonne Paris Cité, INSERM UMR_S 1138, Cordeliers Research Centre, Paris, France; and

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http://www.physiology.org/doi/10.1152/physiolgenomics.00079.
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http://dx.doi.org/10.1152/physiolgenomics.00079.2016DOI Listing
January 2017

No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis.

Sci Rep 2016 10 12;6:35278. Epub 2016 Oct 12.

Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1038/srep35278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059659PMC
October 2016

ANKS3 Co-Localises with ANKS6 in Mouse Renal Cilia and Is Associated with Vasopressin Signaling and Apoptosis In Vivo in Mice.

PLoS One 2015 1;10(9):e0136781. Epub 2015 Sep 1.

Sorbonne Universities, University Pierre and Marie Curie, University Paris Descartes, Sorbonne Paris Cité, INSERM, UMR_S1138, Cordeliers Research Centre, Paris, France; Institute of Cardiometabolism & Nutrition, Pitié-Salpêtrière Hospital, University Pierre and Marie-Curie, Paris, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136781PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556665PMC
May 2016

A multiplexed targeted assay for high-throughput quantitative analysis of serum methylamines by ultra performance liquid chromatography coupled to high resolution mass spectrometry.

Arch Biochem Biophys 2016 05 30;597:12-20. Epub 2016 Mar 30.

Sorbonne Universities, University Pierre & Marie Curie, University Paris Descartes, Sorbonne Paris Cité, INSERM, UMR_S 1138, Cordeliers Research Centre, 15 rue de l'Ecole de Médecine, 75006, Paris, France; Imperial College London, Section of Biomolecular Medicine, Division of Computational Systems Medicine, Department of Surgery and Cancer, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London, SW7 2AZ, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2016.03.029DOI Listing
May 2016

Application of quantitative metabolomics in systems genetics in rodent models of complex phenotypes.

Arch Biochem Biophys 2016 Jan 25;589:158-67. Epub 2015 Sep 25.

Sorbonne Universities, University Pierre & Marie Curie, University Paris Descartes, Sorbonne Paris Cité, INSERM UMR_S 1138, Cordeliers Research Centre, 75006 Paris, France; Institute of Cardiometabolism and Nutrition (ICAN), University Pierre & Marie Curie, 91 boulevard de l'Hôpital, 75013 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2015.09.016DOI Listing
January 2016

Adaptive expression of microRNA-125a in adipose tissue in response to obesity in mice and men.

PLoS One 2014 27;9(3):e91375. Epub 2014 Mar 27.

Institut National de la Santé et de la Recherche Médicale (INSERM) UMRS 872, Cordeliers Research Center, University Pierre & Marie Curie, Paris, France; Institute of Cardiometabolism & Nutrition, ICAN, Pitié-Salpêtrière Hospital, University Pierre & Marie-Curie, Paris, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091375PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967993PMC
December 2015

Association of coronary artery disease and chronic kidney disease in Lebanese population.

Int J Clin Exp Med 2015 15;8(9):15866-77. Epub 2015 Sep 15.

School of Medicine, Lebanese University Beirut, Lebanon ; Division of Nephrology, Department of Internal Medicine, Rafik Hariri University Hospital Beirut, Lebanon.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658979PMC
December 2015

A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.

Authors:
Majid Nikpay Anuj Goel Hong-Hee Won Leanne M Hall Christina Willenborg Stavroula Kanoni Danish Saleheen Theodosios Kyriakou Christopher P Nelson Jemma C Hopewell Thomas R Webb Lingyao Zeng Abbas Dehghan Maris Alver Sebastian M Armasu Kirsi Auro Andrew Bjonnes Daniel I Chasman Shufeng Chen Ian Ford Nora Franceschini Christian Gieger Christopher Grace Stefan Gustafsson Jie Huang Shih-Jen Hwang Yun Kyoung Kim Marcus E Kleber King Wai Lau Xiangfeng Lu Yingchang Lu Leo-Pekka Lyytikäinen Evelin Mihailov Alanna C Morrison Natalia Pervjakova Liming Qu Lynda M Rose Elias Salfati Richa Saxena Markus Scholz Albert V Smith Emmi Tikkanen Andre Uitterlinden Xueli Yang Weihua Zhang Wei Zhao Mariza de Andrade Paul S de Vries Natalie R van Zuydam Sonia S Anand Lars Bertram Frank Beutner George Dedoussis Philippe Frossard Dominique Gauguier Alison H Goodall Omri Gottesman Marc Haber Bok-Ghee Han Jianfeng Huang Shapour Jalilzadeh Thorsten Kessler Inke R König Lars Lannfelt Wolfgang Lieb Lars Lind Cecilia M Lindgren Marja-Liisa Lokki Patrik K Magnusson Nadeem H Mallick Narinder Mehra Thomas Meitinger Fazal-Ur-Rehman Memon Andrew P Morris Markku S Nieminen Nancy L Pedersen Annette Peters Loukianos S Rallidis Asif Rasheed Maria Samuel Svati H Shah Juha Sinisalo Kathleen E Stirrups Stella Trompet Laiyuan Wang Khan S Zaman Diego Ardissino Eric Boerwinkle Ingrid B Borecki Erwin P Bottinger Julie E Buring John C Chambers Rory Collins L Adrienne Cupples John Danesh Ilja Demuth Roberto Elosua Stephen E Epstein Tõnu Esko Mary F Feitosa Oscar H Franco Maria Grazia Franzosi Christopher B Granger Dongfeng Gu Vilmundur Gudnason Alistair S Hall Anders Hamsten Tamara B Harris Stanley L Hazen Christian Hengstenberg Albert Hofman Erik Ingelsson Carlos Iribarren J Wouter Jukema Pekka J Karhunen Bong-Jo Kim Jaspal S Kooner Iftikhar J Kullo Terho Lehtimäki Ruth J F Loos Olle Melander Andres Metspalu Winfried März Colin N Palmer Markus Perola Thomas Quertermous Daniel J Rader Paul M Ridker Samuli Ripatti Robert Roberts Veikko Salomaa Dharambir K Sanghera Stephen M Schwartz Udo Seedorf Alexandre F Stewart David J Stott Joachim Thiery Pierre A Zalloua Christopher J O'Donnell Muredach P Reilly Themistocles L Assimes John R Thompson Jeanette Erdmann Robert Clarke Hugh Watkins Sekar Kathiresan Ruth McPherson Panos Deloukas Heribert Schunkert Nilesh J Samani Martin Farrall

Nat Genet 2015 Oct 7;47(10):1121-1130. Epub 2015 Sep 7.

Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ng.3396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589895PMC
October 2015

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.

Authors:
Hou-Feng Zheng Vincenzo Forgetta Yi-Hsiang Hsu Karol Estrada Alberto Rosello-Diez Paul J Leo Chitra L Dahia Kyung Hyun Park-Min Jonathan H Tobias Charles Kooperberg Aaron Kleinman Unnur Styrkarsdottir Ching-Ti Liu Charlotta Uggla Daniel S Evans Carrie M Nielson Klaudia Walter Ulrika Pettersson-Kymmer Shane McCarthy Joel Eriksson Tony Kwan Mila Jhamai Katerina Trajanoska Yasin Memari Josine Min Jie Huang Petr Danecek Beth Wilmot Rui Li Wen-Chi Chou Lauren E Mokry Alireza Moayyeri Melina Claussnitzer Chia-Ho Cheng Warren Cheung Carolina Medina-Gómez Bing Ge Shu-Huang Chen Kwangbom Choi Ling Oei James Fraser Robert Kraaij Matthew A Hibbs Celia L Gregson Denis Paquette Albert Hofman Carl Wibom Gregory J Tranah Mhairi Marshall Brooke B Gardiner Katie Cremin Paul Auer Li Hsu Sue Ring Joyce Y Tung Gudmar Thorleifsson Anke W Enneman Natasja M van Schoor Lisette C P G M de Groot Nathalie van der Velde Beatrice Melin John P Kemp Claus Christiansen Adrian Sayers Yanhua Zhou Sophie Calderari Jeroen van Rooij Chris Carlson Ulrike Peters Soizik Berlivet Josée Dostie Andre G Uitterlinden Stephen R Williams Charles Farber Daniel Grinberg Andrea Z LaCroix Jeff Haessler Daniel I Chasman Franco Giulianini Lynda M Rose Paul M Ridker John A Eisman Tuan V Nguyen Jacqueline R Center Xavier Nogues Natalia Garcia-Giralt Lenore L Launer Vilmunder Gudnason Dan Mellström Liesbeth Vandenput Najaf Amin Cornelia M van Duijn Magnus K Karlsson Östen Ljunggren Olle Svensson Göran Hallmans François Rousseau Sylvie Giroux Johanne Bussière Pascal P Arp Fjorda Koromani Richard L Prince Joshua R Lewis Bente L Langdahl A Pernille Hermann Jens-Erik B Jensen Stephen Kaptoge Kay-Tee Khaw Jonathan Reeve Melissa M Formosa Angela Xuereb-Anastasi Kristina Åkesson Fiona E McGuigan Gaurav Garg Jose M Olmos Maria T Zarrabeitia Jose A Riancho Stuart H Ralston Nerea Alonso Xi Jiang David Goltzman Tomi Pastinen Elin Grundberg Dominique Gauguier Eric S Orwoll David Karasik George Davey-Smith Albert V Smith Kristin Siggeirsdottir Tamara B Harris M Carola Zillikens Joyce B J van Meurs Unnur Thorsteinsdottir Matthew T Maurano Nicholas J Timpson Nicole Soranzo Richard Durbin Scott G Wilson Evangelia E Ntzani Matthew A Brown Kari Stefansson David A Hinds Tim Spector L Adrienne Cupples Claes Ohlsson Celia M T Greenwood Rebecca D Jackson David W Rowe Cynthia A Loomis David M Evans Cheryl L Ackert-Bicknell Alexandra L Joyner Emma L Duncan Douglas P Kiel Fernando Rivadeneira J Brent Richards

Nature 2015 Oct 14;526(7571):112-7. Epub 2015 Sep 14.

Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, McGill University, Montréal H3A 1A2, Canada.

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http://dx.doi.org/10.1038/nature14878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755714PMC
October 2015

The SAM domain of ANKS6 has different interacting partners and mutations can induce different cystic phenotypes.

Kidney Int 2015 Aug 3;88(2):299-310. Epub 2015 Jun 3.

1] Sorbonne Universités, UPMC Univ Paris 06, UMR_S1155, Paris, France [2] INSERM, UMR_S1155, Hôpital Tenon, Paris, France.

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http://dx.doi.org/10.1038/ki.2015.122DOI Listing
August 2015

mQTL.NMR: an integrated suite for genetic mapping of quantitative variations of (1)H NMR-based metabolic profiles.

Anal Chem 2015 Apr 2;87(8):4377-84. Epub 2015 Apr 2.

∥Department of Oncology, University of Oxford, Roosevelt Drive, Oxford OX3 7DQ, U.K.

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http://pubs.acs.org/doi/10.1021/acs.analchem.5b00145
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http://dx.doi.org/10.1021/acs.analchem.5b00145DOI Listing
April 2015

Plaque burden in HIV-infected patients is associated with serum intestinal microbiota-generated trimethylamine.

AIDS 2015 Feb;29(4):443-52

aProgram in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA bINSERM UMRS1138, Cordeliers Research Centre, Paris cInstitute of Cardiometabolism and Nutrition, University Pierre & Marie Curie, Hospital Pitié Salpetrière, Paris, France dUniversity of Rochester School of Medicine, Rochester, New York, New York eCardiothoracic Imaging Division, Department of Radiology, UTSW Medical Center, Dallas, Texas, USA fBiochimie et Hormonologie, Hôpital Tenon AP-HP Paris, CDR Saint-Antoine, Inserm UMR_S938, Université Paris 6-UPMC, Institute of Cardiometabolism and Nutrition, Paris gDepartment of Cardiology, Saint Antoine Hospital, Inserm U938, Université Paris 6-UPMC, Faculté de Médecine Pierre et Marie Curie, Paris, France.

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http://dx.doi.org/10.1097/QAD.0000000000000565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410017PMC
February 2015

T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility.

Sci Rep 2014 Dec 8;4:7351. Epub 2014 Dec 8.

1] Lebanese American University, School of Medicine, Beirut 1102 2801, Lebanon [2] Harvard School of Public Health, Boston MA 02215, USA.

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http://dx.doi.org/10.1038/srep07351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376673PMC
December 2014

Regenerating 1 and 3b gene expression in the pancreas of type 2 diabetic Goto-Kakizaki (GK) rats.

PLoS One 2014 26;9(2):e90045. Epub 2014 Feb 26.

Institut National de la Santé et de la Recherche Médicale (INSERM) UMRS 872, Team 6, Centre de Recherche des Cordeliers (CRC), Université Pierre et Marie Curie, Paris 6, Paris, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090045PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936001PMC
October 2014

[Genome sequencing and genetic mapping to dissect the genetic basis of complex traits].

Med Sci (Paris) 2013 Jun-Jul;29(6-7):671-4. Epub 2013 Jul 12.

Wellcome Trust Centre for Human Genetics, Oxford, UK.

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http://dx.doi.org/10.1051/medsci/2013296024DOI Listing
September 2013

Large-scale association analysis identifies new risk loci for coronary artery disease.

Authors:
Panos Deloukas Stavroula Kanoni Christina Willenborg Martin Farrall Themistocles L Assimes John R Thompson Erik Ingelsson Danish Saleheen Jeanette Erdmann Benjamin A Goldstein Kathleen Stirrups Inke R König Jean-Baptiste Cazier Asa Johansson Alistair S Hall Jong-Young Lee Cristen J Willer John C Chambers Tõnu Esko Lasse Folkersen Anuj Goel Elin Grundberg Aki S Havulinna Weang K Ho Jemma C Hopewell Niclas Eriksson Marcus E Kleber Kati Kristiansson Per Lundmark Leo-Pekka Lyytikäinen Suzanne Rafelt Dmitry Shungin Rona J Strawbridge Gudmar Thorleifsson Emmi Tikkanen Natalie Van Zuydam Benjamin F Voight Lindsay L Waite Weihua Zhang Andreas Ziegler Devin Absher David Altshuler Anthony J Balmforth Inês Barroso Peter S Braund Christof Burgdorf Simone Claudi-Boehm David Cox Maria Dimitriou Ron Do Alex S F Doney NourEddine El Mokhtari Per Eriksson Krista Fischer Pierre Fontanillas Anders Franco-Cereceda Bruna Gigante Leif Groop Stefan Gustafsson Jörg Hager Göran Hallmans Bok-Ghee Han Sarah E Hunt Hyun M Kang Thomas Illig Thorsten Kessler Joshua W Knowles Genovefa Kolovou Johanna Kuusisto Claudia Langenberg Cordelia Langford Karin Leander Marja-Liisa Lokki Anders Lundmark Mark I McCarthy Christa Meisinger Olle Melander Evelin Mihailov Seraya Maouche Andrew D Morris Martina Müller-Nurasyid Kjell Nikus John F Peden N William Rayner Asif Rasheed Silke Rosinger Diana Rubin Moritz P Rumpf Arne Schäfer Mohan Sivananthan Ci Song Alexandre F R Stewart Sian-Tsung Tan Gudmundur Thorgeirsson C Ellen van der Schoot Peter J Wagner George A Wells Philipp S Wild Tsun-Po Yang Philippe Amouyel Dominique Arveiler Hanneke Basart Michael Boehnke Eric Boerwinkle Paolo Brambilla Francois Cambien Adrienne L Cupples Ulf de Faire Abbas Dehghan Patrick Diemert Stephen E Epstein Alun Evans Marco M Ferrario Jean Ferrières Dominique Gauguier Alan S Go Alison H Goodall Villi Gudnason Stanley L Hazen Hilma Holm Carlos Iribarren Yangsoo Jang Mika Kähönen Frank Kee Hyo-Soo Kim Norman Klopp Wolfgang Koenig Wolfgang Kratzer Kari Kuulasmaa Markku Laakso Reijo Laaksonen Ji-Young Lee Lars Lind Willem H Ouwehand Sarah Parish Jeong E Park Nancy L Pedersen Annette Peters Thomas Quertermous Daniel J Rader Veikko Salomaa Eric Schadt Svati H Shah Juha Sinisalo Klaus Stark Kari Stefansson David-Alexandre Trégouët Jarmo Virtamo Lars Wallentin Nicholas Wareham Martina E Zimmermann Markku S Nieminen Christian Hengstenberg Manjinder S Sandhu Tomi Pastinen Ann-Christine Syvänen G Kees Hovingh George Dedoussis Paul W Franks Terho Lehtimäki Andres Metspalu Pierre A Zalloua Agneta Siegbahn Stefan Schreiber Samuli Ripatti Stefan S Blankenberg Markus Perola Robert Clarke Bernhard O Boehm Christopher O'Donnell Muredach P Reilly Winfried März Rory Collins Sekar Kathiresan Anders Hamsten Jaspal S Kooner Unnur Thorsteinsdottir John Danesh Colin N A Palmer Robert Roberts Hugh Watkins Heribert Schunkert Nilesh J Samani

Nat Genet 2013 Jan 2;45(1):25-33. Epub 2012 Dec 2.

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http://dx.doi.org/10.1038/ng.2480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679547PMC
January 2013

Chromosomal mapping of pancreatic islet morphological features and regulatory hormones in the spontaneously diabetic (Type 2) Goto-Kakizaki rat.

Mamm Genome 2010 Oct 29;21(9-10):499-508. Epub 2010 Sep 29.

The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK.

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http://dx.doi.org/10.1007/s00335-010-9285-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974204PMC
October 2010

Genomic organization and mutation screening of the human ortholog of Pkdr1 associated with polycystic kidney disease in the rat.

Eur J Med Genet 2008 Jul-Aug;51(4):325-31. Epub 2008 Mar 16.

The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S17697212080004
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http://dx.doi.org/10.1016/j.ejmg.2008.02.007DOI Listing
October 2008

[Novel tools for chromosomal mapping and identification of genes underlying complex traits in the rat].

Med Sci (Paris) 2008 May;24(5):545-7

Wellcome Trust Centre for Human Genetics, Université d'Oxford, Oxford OX3 7BN, Royaume-Uni.

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http://dx.doi.org/10.1051/medsci/2008245545DOI Listing
May 2008

Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition.

Obesity (Silver Spring) 2008 Mar 17;16(3):522-30. Epub 2008 Jan 17.

Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK.

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http://dx.doi.org/10.1038/oby.2007.110DOI Listing
March 2008

Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes.

Proc Natl Acad Sci U S A 2007 Sep 29;104(36):14412-7. Epub 2007 Aug 29.

Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0703247104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1958818PMC
September 2007

Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models.

Nat Genet 2007 May 15;39(5):666-72. Epub 2007 Apr 15.

Imperial College London, Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, UK.

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http://dx.doi.org/10.1038/ng2026DOI Listing
May 2007

Genetic and environmental effects on complex traits in mice.

Genetics 2006 Oct 3;174(2):959-84. Epub 2006 Aug 3.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1534/genetics.106.060004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1602068PMC
October 2006

Genome-wide genetic association of complex traits in heterogeneous stock mice.

Nat Genet 2006 Aug 9;38(8):879-87. Epub 2006 Jul 9.

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1038/ng1840DOI Listing
August 2006

Mapping diabetes QTL in an intercross derived from a congenic strain of the Brown Norway and Goto-Kakizaki rats.

Mamm Genome 2006 Jun 12;17(6):538-47. Epub 2006 Jun 12.

The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK.

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http://link.springer.com/10.1007/s00335-005-0168-y
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http://dx.doi.org/10.1007/s00335-005-0168-yDOI Listing
June 2006

Glycomics investigation into insulin action.

Biochim Biophys Acta 2006 Apr 10;1760(4):652-68. Epub 2006 Jan 10.

Division of Molecular Biosciences, Imperial College, London, South Kensington, UK.

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http://dx.doi.org/10.1016/j.bbagen.2005.12.013DOI Listing
April 2006

Genomic organization of the rat Clock gene and sequence analysis in inbred rat strains.

Genomics 2006 Feb 11;87(2):208-17. Epub 2006 Jan 11.

The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1016/j.ygeno.2005.10.006DOI Listing
February 2006

Chromosomal mapping of quantitative trait loci controlling elastin content in rat aorta.

Hypertension 2005 Mar 24;45(3):460-6. Epub 2005 Jan 24.

The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, United Kingdom.

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http://dx.doi.org/10.1161/01.HYP.0000155213.83719.7cDOI Listing
March 2005

Characteristics of the aortic elastic network and related phenotypes in seven inbred rat strains.

Am J Physiol Heart Circ Physiol 2005 Feb 7;288(2):H769-77. Epub 2004 Oct 7.

Institut National de la Santé et de la Recherche Médicale U460, Cardiovascular Remodelling, Hôpital Bichat, Paris, France.

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http://dx.doi.org/10.1152/ajpheart.00544.2004DOI Listing
February 2005

The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex.

Eur J Immunol 2005 Jan;35(1):261-72

Institute of Basic Medical Sciences, University of Oslo, N-0317 Oslo, Norway.

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http://dx.doi.org/10.1002/eji.200425429DOI Listing
January 2005

Chromosomal mapping of genetic loci controlling absence epilepsy phenotypes in the WAG/Rij rat.

Epilepsia 2004 Aug;45(8):908-15

The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, England, United Kingdom.

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http://dx.doi.org/10.1111/j.0013-9580.2004.13104.xDOI Listing
August 2004

Gender differences in hypertrophy, insulin resistance and ischemic injury in the aging type 2 diabetic rat heart.

J Mol Cell Cardiol 2004 Aug;37(2):547-55

University Laboratory of Physiology, University of Oxford, Oxford, OX1 3PT, England, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S002228280400155
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http://dx.doi.org/10.1016/j.yjmcc.2004.05.014DOI Listing
August 2004

Studies of congenic lines in the Brown Norway rat model of Th2-mediated immunopathological disorders show that the aurothiopropanol sulfonate-induced immunological disorder (Aiid3) locus on chromosome 9 plays a major role compared to Aiid2 on chromosome 10.

J Immunol 2004 May;172(10):6354-61

Centre de Physiopathologie de Toulouse Purpan, Département Génétique Fonctionnelle des Maladies des Epithéliums, Institut National de la Santé et de la Recherche Médicale, Unité 563, Hôpital Purpan and Université Paul Sabatier, Toulouse, France.

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http://dx.doi.org/10.4049/jimmunol.172.10.6354DOI Listing
May 2004

Genetics and functional genomics of type 2 diabetes mellitus.

Genome Biol 2003 24;4(12):241. Epub 2003 Nov 24.

The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://genomebiology.biomedcentral.com/articles/10.1186/gb-2
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http://dx.doi.org/10.1186/gb-2003-4-12-241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC329413PMC
March 2004

Initial steps of insulin signaling and glucose transport are defective in the type 2 diabetic rat heart.

Cardiovasc Res 2004 Feb;61(2):288-96

University Laboratory of Physiology, University of Oxford, Oxford, England, UK.

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http://dx.doi.org/10.1016/j.cardiores.2003.11.021DOI Listing
February 2004

Marker-assisted congenic screening (MACS): a database tool for the efficient production and characterization of congenic lines.

Mamm Genome 2003 May;14(5):350-6

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK.

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http://link.springer.com/10.1007/s00335-002-3058-6
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May 2003

Approaches to the analysis of complex quantitative phenotypes and marker map construction based on the analysis of rat models of hypertension.

Methods Mol Biol 2002 ;195:225-51

Wellcome Trust Centre for Human Genetics, Oxford, UK.

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http://dx.doi.org/10.1385/1-59259-176-0:225DOI Listing
December 2002

Thymectomy and radiation-induced type 1 diabetes in nonlymphopenic BB rats.

Diabetes 2002 Oct;51(10):2975-81

Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.2337/diabetes.51.10.2975DOI Listing
October 2002

The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man.

Diabetes 2002 Jul;51(7):2012-7

IRIBHM (Institut de Recherches en Biologie Humaine et Moléculaire), IBMM (Institut de Biologie et de Médecine Moléculaires), ULB (Université Libre de Bruxelles), rue des Professeurs Jeener et Brachet 122, 6041 Gosselies, Belgium.

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http://dx.doi.org/10.2337/diabetes.51.7.2012DOI Listing
July 2002