Publications by authors named "Dominique Frueh"

39Publications

Covariance NMR Processing and Analysis for Protein Assignment.

Methods Mol Biol 2018 ;1688:353-373

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 701 Hunterian, 725 N Wolfe St., Baltimore, MD, 21205, USA.

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July 2018

Molecular impact of covalent modifications on nonribosomal peptide synthetase carrier protein communication.

J Biol Chem 2017 06 28;292(24):10002-10013. Epub 2017 Apr 28.

From the Department of Biophysics and Biophysical Chemistry and

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June 2017

Covariance nuclear magnetic resonance methods for obtaining protein assignments and novel correlations.

Concepts Magn Reson Part A Bridg Educ Res 2017 Mar 16;46A(2). Epub 2018 Sep 16.

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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March 2017

Molecular Cross-Talk between Nonribosomal Peptide Synthetase Carrier Proteins and Unstructured Linker Regions.

Chembiochem 2017 04 22;18(7):629-632. Epub 2017 Feb 22.

Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD, 21205, USA.

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April 2017

(15)N Heteronuclear Chemical Exchange Saturation Transfer MRI.

J Am Chem Soc 2016 09 26;138(35):11136-9. Epub 2016 Aug 26.

F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute , Baltimore, Maryland 21205, United States.

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September 2016

Effortless assignment with 4D covariance sequential correlation maps.

J Magn Reson 2015 Nov 21;260:83-8. Epub 2015 Sep 21.

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 701 Hunterian, 725 N Wolfe St, Baltimore, MD 21205, United States.

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November 2015

Solution Structure of a Nonribosomal Peptide Synthetase Carrier Protein Loaded with Its Substrate Reveals Transient, Well-Defined Contacts.

J Am Chem Soc 2015 Sep 15;137(37):12100-9. Epub 2015 Sep 15.

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine , Hunterian 701, 725 North Wolfe Street, Baltimore, Maryland 21205, United States ;

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September 2015

Assignment of methyl NMR resonances of a 52 kDa protein with residue-specific 4D correlation maps.

J Biomol NMR 2015 Jul 8;62(3):281-90. Epub 2015 May 8.

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 701 Hunterian, 725 North Wolfe St., Baltimore, MD, 21205, USA.

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July 2015

A nuclear magnetic resonance method for probing molecular influences of substrate loading in nonribosomal peptide synthetase carrier proteins.

Biochemistry 2015 Feb 29;54(5):1154-6. Epub 2015 Jan 29.

Department of Biophysics & Biophysical Chemistry, Johns Hopkins University School of Medicine , 701 Hunterian Building, 725 North Wolfe Street, Baltimore, Maryland 21205, United States.

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February 2015

A 3D time-shared NOESY experiment designed to provide optimal resolution for accurate assignment of NMR distance restraints in large proteins.

J Biomol NMR 2014 Dec 9;60(4):265-74. Epub 2014 Nov 9.

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 701 Hunterian, 725 North Wolfe St., Baltimore, MD, 21205, USA.

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December 2014

Facilitated assignment of large protein NMR signals with covariance sequential spectra using spectral derivatives.

J Am Chem Soc 2014 Sep 16;136(38):13106-9. Epub 2014 Sep 16.

Department of Biophysics & Biophysical Chemistry, Johns Hopkins University School of Medicine , 701 Hunterian, 725 North Wolfe Street, Baltimore, Maryland 21205, United States.

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September 2014

Practical aspects of NMR signal assignment in larger and challenging proteins.

Prog Nucl Magn Reson Spectrosc 2014 Apr 15;78:47-75. Epub 2013 Dec 15.

Johns Hopkins University School of Medicine, Biophysics and Biophysical Chemistry, 725 N. Wolfe Street, 701 Hunterian, Baltimore, MD 21205-2105, United States. Electronic address:

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April 2014

SARA: a software environment for the analysis of relaxation data acquired with accordion spectroscopy.

J Biomol NMR 2014 Feb 10;58(2):83-99. Epub 2014 Jan 10.

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 701 Hunterian, 725 North Wolfe St., Baltimore, MD, 21205, USA.

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February 2014

NMR methods for structural studies of large monomeric and multimeric proteins.

Curr Opin Struct Biol 2013 Oct 11;23(5):734-9. Epub 2013 Jul 11.

Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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October 2013

Hidden in plain sight: subtle effects of the 8-oxoguanine lesion on the structure, dynamics, and thermodynamics of a 15-base pair oligodeoxynucleotide duplex.

Biochemistry 2011 Oct 8;50(39):8463-77. Epub 2011 Sep 8.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, United States.

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October 2011

Global dynamic conformational changes in the suppressor domain of IP3 receptor by stepwise binding of the two lobes of calmodulin.

FASEB J 2011 Mar 17;25(3):840-50. Epub 2010 Nov 17.

Department of Biochemistry and Center for Advanced Medical Education by BK21 Project, School of Medicine, Inha University, Chungsuk Bldg., Rm. 505, Shinheung-dong, Chung-gu, Incheon, Korea, 400-712.

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March 2011

Nitrogen-detected CAN and CON experiments as alternative experiments for main chain NMR resonance assignments.

J Biomol NMR 2010 Aug 17;47(4):271-82. Epub 2010 Jun 17.

Department of Biochemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

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August 2010

CACA-TOCSY with alternate 13C-12C labeling: a 13Calpha direct detection experiment for mainchain resonance assignment, dihedral angle information, and amino acid type identification.

J Biomol NMR 2010 May 10;47(1):55-63. Epub 2010 Apr 10.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.

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May 2010

High-resolution 3D CANCA NMR experiments for complete mainchain assignments using C(alpha) direct detection.

J Am Chem Soc 2010 Mar;132(9):2945-51

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.

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March 2010