Publications by authors named "Dominique Fausto de Souza"

3 Publications

  • Page 1 of 1

Acetylsalicylic Acid Exerts Potent Antitumor and Antiangiogenic Effects in Cutaneous and Uveal Melanoma Cell Lines.

Ocul Oncol Pathol 2020 Dec 4;6(6):442-455. Epub 2020 Nov 4.

Henry C. Witelson Ocular Pathology Laboratory, McGill University, Montreal, Québec, Canada.

Introduction: Acetylsalicylic acid (ASA) has been investigated for a potential anticancer role in several cancers, such as colorectal, ovarian, and endometrial cancer. Moreover, ASA has been shown to abrogate various processes that contribute to tumor growth and progression.

Objective: The aim of this study was to evaluate the effects of ASA on cutaneous melanoma (CM) and uveal melanoma (UM).

Methods: Human CM and UM cells were treated with 5 mM ASA and assessed for changes in cellular functions. Antiangiogenic effects of ASA were determined using an ELISA-based assay for 10 proangiogenic cytokines, and then validated by Western blot. Finally, proteomic analysis of ASA-treated cells was performed to elucidate the changes that may be responsible for ASA-mediated effects in melanoma cells.

Results: Treatment with ASA significantly inhibited the proliferation, invasion, and migration capabilities, and caused a significant decrease in angiogenin and PIGF secretion in both CM and UM. Mass spectrometry revealed 179 protein changes associated with ASA in the CM and UM cell lines.

Conclusions: These results suggest that ASA may be effective as an adjuvant therapy in metastatic CM and UM. Future studies are needed to determine the regulating targets that are responsible for the antitumor effects of ASA.
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http://dx.doi.org/10.1159/000510582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772880PMC
December 2020

Ledderhose disease: an unusual presentation.

J Clin Aesthet Dermatol 2010 Sep;3(9):45-7

Plantar fibromatosis, or Ledderhose disease, is a rare hyperproliferative disorder of the plantar aponeurosis. It may occur at any age with the greatest prevalence at middle age and beyond. This disorder is more common in men than woman and it is sometimes associated with other forms of fibromatosis. A 28-year-old Brazilian woman with a six-year history of painless bilateral plantar nodules is described in this article.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945849PMC
September 2010

Idiopathic eruptive macular pigmentation associated with pregnancy.

Int J Dermatol 2010 Jul;49(7):810-2

Sector of Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Brazil.

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http://dx.doi.org/10.1111/j.1365-4632.2009.04356.xDOI Listing
July 2010