Publications by authors named "Dominik Feuerbach"

58 Publications

Selectivity of (±)-citalopram at nicotinic acetylcholine receptors and different inhibitory mechanisms between habenular α3β4* and α9α10 subtypes.

Authors:
Hugo R Arias Xiao-Tao Jin Sofía Gallino Can Peng Dominik Feuerbach Jesús García-Colunga Ana Belén Elgoyhen Ryan M Drenan Marcelo O Ortells

Neurochem Int 2019 12 20;131:104552. Epub 2019 Sep 20.

Facultad de Medicina, Universidad de Morón, Morón and CONICET, Argentina. Electronic address:

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December 2019

Alkaloids Purified from Inhibit the Human α3β4 Nicotinic Acetylcholine Receptor with Higher Potencies Compared with the Human α4β2 and α7 Subtypes.

Authors:
Hugo R Arias Marcelo O Ortells Dominik Feuerbach Viviana Burgos Cristian Paz

J Nat Prod 2019 07 5;82(7):1953-1960. Epub 2019 Jul 5.

Laboratory of Natural Products and Drug Discovery, Department of Basic Sciences , Universidad de La Frontera , 4780000 Temuco , Chile.

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July 2019

The Discovery of LML134, a Histamine H3 Receptor Inverse Agonist for the Clinical Treatment of Excessive Sleep Disorders.

Authors:
Thomas Troxler Dominik Feuerbach Xuechun Zhang Charles R Yang Bharat Lagu Mark Perrone Tie-Lin Wang Karin Briner Mark G Bock Yves P Auberson

ChemMedChem 2019 07 21;14(13):1238-1247. Epub 2019 May 21.

Novartis Institutes for BioMedical Research, Novartis Pharma AG, Klybeckstrasse 141, 4057, Basel, Switzerland.

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July 2019

Tricyclic antidepressants inhibit hippocampal α7* and α9α10 nicotinic acetylcholine receptors by different mechanisms.

Authors:
Hugo R Arias Elizabeth Vázquez-Gómez Andy Hernández-Abrego Sofía Gallino Dominik Feuerbach Marcelo O Ortells Ana Belén Elgoyhen Jesús García-Colunga

Int J Biochem Cell Biol 2018 07 25;100:1-10. Epub 2018 Apr 25.

Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexico.

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July 2018

Drimane Sesquiterpenoids Noncompetitively Inhibit Human α4β2 Nicotinic Acetylcholine Receptors with Higher Potency Compared to Human α3β4 and α7 Subtypes.

Authors:
Hugo R Arias Dominik Feuerbach Bernd Schmidt Matthias Heydenreich Cristian Paz Marcelo O Ortells

J Nat Prod 2018 04 10;81(4):811-817. Epub 2018 Apr 10.

Facultad de Medicina , Universidad de Morón and CONICET , Morón 1708 , Argentina.

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April 2018

Microglia M2A Polarization as Potential Link between Food Allergy and Autism Spectrum Disorders.

Authors:
Hans O Kalkman Dominik Feuerbach

Pharmaceuticals (Basel) 2017 Dec 9;10(4). Epub 2017 Dec 9.

Novartis Pharma AG, CH4002 Basel, Switzerland.

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December 2017

Selectivity of coronaridine congeners at nicotinic acetylcholine receptors and inhibitory activity on mouse medial habenula.

Authors:
Hugo R Arias Xiaotao Jin Dominik Feuerbach Ryan M Drenan

Int J Biochem Cell Biol 2017 11 16;92:202-209. Epub 2017 Oct 16.

Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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November 2017

ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157.

Authors:
Dominik Feuerbach Patrick Schindler Carmen Barske Stefanie Joller Edwige Beng-Louka Katie A Worringer Sravya Kommineni Ajamete Kaykas Daniel J Ho Chaoyang Ye Karl Welzenbach Gaelle Elain Laurent Klein Irena Brzak Anis K Mir Christopher J Farady Reiner Aichholz Simone Popp Nathalie George Ulf Neumann

Neurosci Lett 2017 Nov 18;660:109-114. Epub 2017 Sep 18.

Neuroscience Research, Novartis Institutes for Biomedical Research, Basel, Switzerland.

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November 2017

Bupropion and its photoreactive analog (±)-SADU-3-72 interact with luminal and non-luminal sites at human α4β2 nicotinic acetylcholine receptors.

Authors:
Hugo R Arias Dominik Feuerbach Marcelo O Ortells

Neurochem Int 2016 11 6;100:67-77. Epub 2016 Sep 6.

Facultad de Medicina, Universidad de Morón, Morón, CONICET, Argentina.

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November 2016

Task-related fMRI responses to a nicotinic acetylcholine receptor partial agonist in schizophrenia: A randomized trial.

Authors:
Deanna M Barch Stephen R Marder Michael P Harms L Fredrik Jarskog Robert W Buchanan Will Cronenwett Li-Shiun Chen Markus Weiss Ralph P Maguire Nicole Pezous Dominik Feuerbach Cristina Lopez-Lopez Donald R Johns Rhett B Behrje Baltazar Gomez-Mancilla

Prog Neuropsychopharmacol Biol Psychiatry 2016 11 28;71:66-75. Epub 2016 Jun 28.

Novartis Pharma AG, Basel, Switzerland; Department of Neurology and Neurosurgery, McGill University, Montreal, Québec, Canada. Electronic address:

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November 2016

The roles of inflammation and immune mechanisms in Alzheimer's disease.

Authors:
Linda J Van Eldik Maria C Carrillo Patricia E Cole Dominik Feuerbach Barry D Greenberg James A Hendrix Matthew Kennedy Nick Kozauer Richard A Margolin José L Molinuevo Reinhold Mueller Richard M Ransohoff Donna M Wilcock Lisa Bain Kelly Bales

Alzheimers Dement (N Y) 2016 Jun 30;2(2):99-109. Epub 2016 May 30.

Pfizer, Inc. Neuroscience Research Unit, Cambridge, MA, USA.

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June 2016

Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content.

Authors:
Hugo R Arias Federica Ravazzini Katarzyna M Targowska-Duda Agnieszka A Kaczor Dominik Feuerbach Juan C Boffi Piotr Draczkowski Dirk Montag Brandon M Brown Ana Belén Elgoyhen Krzysztof Jozwiak Giulia Puia

Int J Biochem Cell Biol 2016 07 26;76:19-30. Epub 2016 Apr 26.

Department of Life Science, University of Modena and Reggio Emilia, Modena, Italy.

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July 2016

Antidepressant therapies inhibit inflammation and microglial M1-polarization.

Authors:
Hans O Kalkman Dominik Feuerbach

Pharmacol Ther 2016 07 18;163:82-93. Epub 2016 Apr 18.

Neuroscience Research, NIBR, Fabrikstrasse 22-3.001.02, Basel 4002, Switzerland.

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July 2016

A Placebo-Controlled Trial of AQW051 in Patients With Moderate to Severe Levodopa-Induced Dyskinesia.

Authors:
Claudia Trenkwalder Daniela Berg Olivier Rascol Karla Eggert Andres Ceballos-Baumann Jean-Christophe Corvol Alexander Storch Lin Zhang Jean-Philippe Azulay Emmanuel Broussolle Luc Defebvre Christian Geny Michal Gostkowski Fabrizio Stocchi Christine Tranchant Pascal Derkinderen Franck Durif Alberto J Espay Andrew Feigin Jean-Luc Houeto Johannes Schwarz Thérèse Di Paolo Dominik Feuerbach Hans-Ulrich Hockey Judith Jaeger Annamaria Jakab Donald Johns Gurutz Linazasoro Paul Maruff Izabela Rozenberg Judit Sovago Markus Weiss Baltazar Gomez-Mancilla

Mov Disord 2016 07 15;31(7):1049-54. Epub 2016 Mar 15.

Novartis Institutes for BioMedical Research, Basel, Switzerland.

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July 2016

Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders.

Authors:
Hans O Kalkman Dominik Feuerbach

Cell Mol Life Sci 2016 Jul 15;73(13):2511-30. Epub 2016 Mar 15.

Neuroscience Research, NIBR, Fabrikstrasse 22-3.001.02, 4002, Basel, Switzerland.

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July 2016

Exploring the positive allosteric modulation of human α7 nicotinic receptors from a single-channel perspective.

Authors:
Natalia D Andersen Beatriz E Nielsen Jeremías Corradi María F Tolosa Dominik Feuerbach Hugo R Arias Cecilia Bouzat

Neuropharmacology 2016 08 27;107:189-200. Epub 2016 Feb 27.

Universidad Nacional del Sur/CONICET, Instituto de Investigaciones Bioquímicas de Bahía Blanca, Bahía Blanca 8000, Argentina. Electronic address:

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August 2016

The antidepressant-like activity of nicotine, but not of 3-furan-2-yl-N-p-tolyl-acrylamide, is regulated by the nicotinic receptor β4 subunit.

Authors:
Hugo R Arias Katarzyna M Targowska-Duda Dominik Feuerbach Krzysztof Jozwiak

Neurochem Int 2015 Aug 23;87:110-6. Epub 2015 Jun 23.

Department of Chemistry, Laboratory of Medicinal Chemistry and Neuroengineering, Medical University of Lublin, Lublin, Poland.

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August 2015

Coronaridine congeners inhibit human α3β4 nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites.

Authors:
Hugo R Arias Katarzyna M Targowska-Duda Dominik Feuerbach Krzysztof Jozwiak

Int J Biochem Cell Biol 2015 Aug 27;65:81-90. Epub 2015 May 27.

Department of Chemistry, Medical University of Lublin, Lublin, Poland.

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August 2015

Functional and structural interaction of (-)-lobeline with human α4β2 and α4β4 nicotinic acetylcholine receptor subtypes.

Authors:
Hugo R Arias Dominik Feuerbach Marcelo Ortells

Int J Biochem Cell Biol 2015 Jul 18;64:15-24. Epub 2015 Mar 18.

Faculty of Medicine and CONICET, University of Morón, Argentina.

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July 2015

Pharmacological and molecular studies on the interaction of varenicline with different nicotinic acetylcholine receptor subtypes. Potential mechanism underlying partial agonism at human α4β2 and α3β4 subtypes.

Authors:
Hugo R Arias Dominik Feuerbach Katarzyna Targowska-Duda Agnieszka A Kaczor Antti Poso Krzysztof Jozwiak

Biochim Biophys Acta 2015 Feb 2;1848(2):731-41. Epub 2014 Dec 2.

Department of Chemistry, Laboratory of Medicinal Chemistry and Neuroengineering, Medical University of Lublin, Lublin, Poland.

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February 2015

From ergolines to indoles: improved inhibitors of the human H3 receptor for the treatment of narcolepsy.

Authors:
Yves P Auberson Thomas Troxler Xuechun Zhang Charles R Yang Dominik Feuerbach Yu-Chih Liu Bharat Lagu Mark Perrone Lijun Lei Xiaoxia Shen Dushan Zhang Chunxiu Wang Tie-Lin Wang Karin Briner Mark G Bock

ChemMedChem 2015 Feb 12;10(2):266-75. Epub 2014 Nov 12.

Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4058 Basel (Switzerland).

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February 2015

AQW051, a novel, potent and selective α7 nicotinic ACh receptor partial agonist: pharmacological characterization and phase I evaluation.

Authors:
Dominik Feuerbach Nicole Pezous Markus Weiss Kasra Shakeri-Nejad Kurt Lingenhoehl Daniel Hoyer Konstanze Hurth Graeme Bilbe Christopher R Pryce Kevin McAllister Frederique Chaperon Klaus Kucher Donald Johns Thomas Blaettler Cristina Lopez Lopez

Br J Pharmacol 2015 Mar 12;172(5):1292-304. Epub 2015 Jan 12.

Novartis Institutes for BioMedical Research, Basel, Switzerland.

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March 2015

AQW051, a novel and selective nicotinic acetylcholine receptor α7 partial agonist, reduces l-Dopa-induced dyskinesias and extends the duration of l-Dopa effects in parkinsonian monkeys.

Authors:
Thérèse Di Paolo Laurent Grégoire Dominik Feuerbach Walid Elbast Markus Weiss Baltazar Gomez-Mancilla

Parkinsonism Relat Disord 2014 Nov 22;20(11):1119-23. Epub 2014 May 22.

Novartis Institutes for BioMedical Research Basel, Basel, Switzerland; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, QC, Canada. Electronic address:

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November 2014

Bupropion-induced inhibition of α7 nicotinic acetylcholine receptors expressed in heterologous cells and neurons from dorsal raphe nucleus and hippocampus.

Authors:
Elizabeth Vázquez-Gómez Hugo R Arias Dominik Feuerbach Marcela Miranda-Morales Stefan Mihailescu Katarzyna M Targowska-Duda Krzysztof Jozwiak Jesús García-Colunga

Eur J Pharmacol 2014 Oct 9;740:103-11. Epub 2014 Jul 9.

Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla 3001, Querétaro 76230, México. Electronic address:

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October 2014

Ergoline-derived inverse agonists of the human h3 receptor for the treatment of narcolepsy.

Authors:
Yves P Auberson Thomas Troxler Xuechun Zhang Charles R Yang Markus Fendt Dominik Feuerbach Yu-Chih Liu Bharat Lagu Andreas Lerchner Mark Perrone Lijun Lei Chao Zhang Chunxiu Wang Tie-Lin Wang Mark G Bock

ChemMedChem 2014 Aug 21;9(8):1683-96. Epub 2014 May 21.

Novartis Institutes for BioMedical Research, Forum 1, Novartis Campus, 4056 Basel (Switzerland).

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August 2014

Antidepressant activity in mice elicited by 3-furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic acetylcholine receptor.

Authors:
Katarzyna M Targowska-Duda Dominik Feuerbach Grazyna Biala Krzysztof Jozwiak Hugo R Arias

Neurosci Lett 2014 May 5;569:126-30. Epub 2014 Apr 5.

Department of Medical Education, California Northstate University College of Medicine, 9700 West Taron Drive, Elk Grove, CA 95757, USA. Electronic address:

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May 2014

Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior.

Authors:
Christine E Gee Daniel Peterlik Christoph Neuhäuser Rochdi Bouhelal Klemens Kaupmann Grit Laue Nicole Uschold-Schmidt Dominik Feuerbach Kaspar Zimmermann Silvio Ofner John F Cryan Herman van der Putten Markus Fendt Ivo Vranesic Ralf Glatthar Peter J Flor

J Biol Chem 2014 Apr 4;289(16):10975-87. Epub 2014 Mar 4.

From the Novartis Institutes for BioMedical Research, Novartis AG, CH-4057 Basel, Switzerland.

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April 2014

Differential pharmacological activity of JN403 between α7 and muscle nicotinic acetylcholine receptors.

Authors:
Hugo R Arias Maria Jose De Rosa Ignacio Bergé Dominik Feuerbach Cecilia Bouzat

Biochemistry 2013 Nov 11;52(47):8480-8. Epub 2013 Nov 11.

Department of Medical Education, California Northstate University College of Medicine , Elk Grove, California 95757, United States.

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November 2013

Novel 2-(substituted benzyl)quinuclidines inhibit human α7 and α4β2 nicotinic receptors by different mechanisms.

Authors:
Hugo R Arias Jhon J López Dominik Feuerbach Angélica Fierro Marcelo O Ortells Edwin G Pérez

Int J Biochem Cell Biol 2013 Nov 14;45(11):2420-30. Epub 2013 Aug 14.

Department of Medical Education, California Northstate University College of Medicine, Elk Grove, CA 95757, USA. Electronic address:

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November 2013

(-)-Reboxetine inhibits muscle nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites.

Authors:
Hugo R Arias Marcelo O Ortells Dominik Feuerbach

Neurochem Int 2013 Nov 31;63(5):423-31. Epub 2013 Jul 31.

Department of Medical Education, California Northstate University College of Medicine, Elk Grove, CA, USA. Electronic address:

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November 2013