Dominik Barthelme

Dominik Barthelme

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Dominik Barthelme

Dominik Barthelme

Publications by authors named "Dominik Barthelme"

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11Publications

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Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome.

ACS Infect Dis 2017 02 5;3(2):176-181. Epub 2016 Dec 5.

Department of Chemistry, Brown University , 324 Brook Street, Box H, Providence, Rhode Island 02912, United States.

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http://dx.doi.org/10.1021/acsinfecdis.6b00172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410965PMC
February 2017

Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine.

J Mol Biol 2016 05 1;428(9 Pt B):1861-9. Epub 2015 Dec 1.

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.jmb.2015.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860136PMC
May 2016

An ALS disease mutation in Cdc48/p97 impairs 20S proteasome binding and proteolytic communication.

Protein Sci 2015 Sep 14;24(9):1521-7. Epub 2015 Jul 14.

Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139.

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http://dx.doi.org/10.1002/pro.2740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570545PMC
September 2015

Substrate-guided optimization of the syringolins yields potent proteasome inhibitors with activity against leukemia cell lines.

Bioorg Med Chem 2015 Sep 26;23(18):6218-22. Epub 2015 Jul 26.

Department of Chemistry, Brown University, 324 Brook Street, Providence, RI 02912, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.07.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562813PMC
September 2015

Architecture and assembly of the archaeal Cdc48*20S proteasome.

Proc Natl Acad Sci U S A 2014 Apr 7;111(17):E1687-94. Epub 2014 Apr 7.

Departments of Biology and Earth and Planetary Sciences and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1404823111
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http://dx.doi.org/10.1073/pnas.1404823111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035981PMC
April 2014

Bipartite determinants mediate an evolutionarily conserved interaction between Cdc48 and the 20S peptidase.

Proc Natl Acad Sci U S A 2013 Feb 11;110(9):3327-32. Epub 2013 Feb 11.

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.1300408110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587186PMC
February 2013

Identification of the Cdc48•20S proteasome as an ancient AAA+ proteolytic machine.

Science 2012 Aug 26;337(6096):843-6. Epub 2012 Jul 26.

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/science.1224352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923512PMC
August 2012

Ribosome recycling depends on a mechanistic link between the FeS cluster domain and a conformational switch of the twin-ATPase ABCE1.

Proc Natl Acad Sci U S A 2011 Feb 3;108(8):3228-33. Epub 2011 Feb 3.

Institute of Biochemistry, Cluster of Excellence Frankfurt-Macromolecular Complexes, Biocenter, Goethe University, Max-von-Laue Strasse 9, D-60438 Frankfurt/Main, Germany.

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http://dx.doi.org/10.1073/pnas.1015953108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044390PMC
February 2011