Dominic M Walsh

Dominic M Walsh

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Dominic M Walsh

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PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins.

Acta Neuropathol 2019 Dec 18. Epub 2019 Dec 18.

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Hale Building for Transformative Medicine, 60 Fenwood Road, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s00401-019-02114-9DOI Listing
December 2019

miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer's Patients.

Front Neurosci 2019 26;13:1208. Epub 2019 Nov 26.

Laboratory for Neurodegenerative Disease Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.3389/fnins.2019.01208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902042PMC
November 2019

Target engagement in an alzheimer trial: Crenezumab lowers amyloid β oligomers in cerebrospinal fluid.

Ann Neurol 2019 Aug 22;86(2):215-224. Epub 2019 Jun 22.

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ana.25513
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http://dx.doi.org/10.1002/ana.25513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771589PMC
August 2019

Soluble tau aggregates inhibit synaptic long-term depression and amyloid β-facilitated LTD in vivo.

Neurobiol Dis 2019 07 22;127:582-590. Epub 2019 Mar 22.

Department of Pharmacology & Therapeutics, Institute of Neuroscience, Trinity College, Dublin 2, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.03.022DOI Listing
July 2019

PrP-grafted antibodies bind certain amyloid β-protein aggregates, but do not prevent toxicity.

Brain Res 2019 05 26;1710:125-135. Epub 2018 Dec 26.

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2018.12.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431553PMC
May 2019

Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's brain.

Brain 2019 05;142(5):1441-1457

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1093/brain/awz066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487330PMC
May 2019

Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease.

Alzheimers Dement 2019 03 9;15(3):487-496. Epub 2018 Nov 9.

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, England. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476313PMC
March 2019

Production and Use of Recombinant Aβ for Aggregation Studies.

Methods Mol Biol 2018 ;1777:307-320

Laboratory for Neurodegenerative Research, Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://link.springer.com/10.1007/978-1-4939-7811-3_19
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http://dx.doi.org/10.1007/978-1-4939-7811-3_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660832PMC
February 2019

MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways.

Acta Neuropathol 2018 10 7;136(4):537-555. Epub 2018 Jul 7.

Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, 60 Fenwood Rd, 9006, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s00401-018-1880-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132948PMC
October 2018

Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer's disease brain.

Acta Neuropathol 2018 07 23;136(1):19-40. Epub 2018 Apr 23.

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Building for Transformative Medicine, 60 Fenwood Road, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s00401-018-1846-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647843PMC
July 2018

An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer's disease.

Nat Commun 2018 07 11;9(1):2676. Epub 2018 Jul 11.

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41467-018-05068-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041266PMC
July 2018

Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer's Disease Disrupt Synaptic Plasticity.

Cell Rep 2018 05;23(7):1932-1938

Department of Pharmacology & Therapeutics and Institute of Neuroscience, Trinity College, Dublin 2, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.04.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972225PMC
May 2018

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles.

Int J Mol Sci 2018 Feb 27;19(3). Epub 2018 Feb 27.

Laboratory for Neurodegenerative Disease Research, Ann Romney Center for Neurologic Diseases, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.3390/ijms19030663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877524PMC
February 2018

Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP.

J Neurosci 2017 12 3;37(49):11947-11966. Epub 2017 Nov 3.

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115,

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http://dx.doi.org/10.1523/JNEUROSCI.2009-17.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719975PMC
December 2017

Soluble Aβ aggregates can inhibit prion propagation.

Open Biol 2017 11;7(11)

MRC Prion Unit at UCL, UCL Institute of Prion Diseases, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK

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http://dx.doi.org/10.1098/rsob.170158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717343PMC
November 2017

Peripheral Interventions Enhancing Brain Glutamate Homeostasis Relieve Amyloid β- and TNFα- Mediated Synaptic Plasticity Disruption in the Rat Hippocampus.

Cereb Cortex 2017 07;27(7):3724-3735

Department of Pharmacology and Therapeutics, and Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland.

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http://dx.doi.org/10.1093/cercor/bhw193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967354PMC
July 2017

The Aggregation Paths and Products of Aβ42 Dimers Are Distinct from Those of the Aβ42 Monomer.

Biochemistry 2016 Nov 26;55(44):6150-6161. Epub 2016 Oct 26.

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acs.biochem.6b00453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461814PMC
November 2016

IgG Conformer's Binding to Amyloidogenic Aggregates.

PLoS One 2015 14;10(9):e0137344. Epub 2015 Sep 14.

The Laboratory of Neurodegenerative Research, Brigham and Women's Hospital, Harvard Institutes of Medicine, Boston, Massachusetts, United States of America; The Conway Institute, University College Dublin, Belfield, Dublin, Republic of Ireland; Human Immunology and Cancer Program, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137344PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569075PMC
June 2016

Non-Fibrillar Oligomeric Amyloid-β within Synapses.

J Alzheimers Dis 2016 05;53(3):787-800

The University of Edinburgh Centre for Cognitive and Neural Systems, Centre for Dementia Prevention and the Euan MacDonald Centre for Motor Neurone Disease Research, Edinburgh, UK.

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http://dx.doi.org/10.3233/JAD-160007DOI Listing
May 2016

A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration.

Nat Rev Neurosci 2016 Apr;17(4):251-60

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrn.2016.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701169PMC
April 2016

Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance.

Neurobiol Dis 2016 Jan 22;85:111-121. Epub 2015 Oct 22.

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778388PMC
January 2016

The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species.

Alzheimers Dement 2015 Nov 4;11(11):1286-305. Epub 2015 Apr 4.

Laboratory for Neurodegenerative Research, Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2015.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592782PMC
November 2015

Anti-Aβ antibodies incapable of reducing cerebral Aβ oligomers fail to attenuate spatial reference memory deficits in J20 mice.

Neurobiol Dis 2015 Oct 26;82:372-384. Epub 2015 Jul 26.

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, United States. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641028PMC
October 2015

Targeted Magnetic Nanoparticles for Remote Magnetothermal Disruption of Amyloid-β Aggregates.

Adv Healthc Mater 2015 Oct 19;4(14):2100-2109. Epub 2015 Aug 19.

Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/adhm.201500487DOI Listing
October 2015

Real-Time Monitoring of Alzheimer's-Related Amyloid Aggregation via Probe Enhancement-Fluorescence Correlation Spectroscopy.

ACS Chem Neurosci 2015 Sep 31;6(9):1503-8. Epub 2015 Jul 31.

Department of Systems Biology, Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acschemneuro.5b00176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814290PMC
September 2015

Lessons from a Rare Familial Dementia: Amyloid and Beyond.

J Parkinsons Dis Alzheimers Dis 2015 Aug;2(1)

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.13188/2376-922X.1000009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578630PMC
August 2015

The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) Oligomers.

J Biol Chem 2015 Jul 8;290(27):16502-16. Epub 2015 May 8.

the Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115

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http://www.jbc.org/content/290/27/16502.full.pdf
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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.652263
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http://dx.doi.org/10.1074/jbc.M115.652263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505405PMC
July 2015

Tau immunization: a cautionary tale?

Neurobiol Aging 2015 Mar 30;36(3):1316-32. Epub 2014 Dec 30.

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.11.022DOI Listing
March 2015

A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid.

Alzheimers Res Ther 2015 22;7(1):14. Epub 2015 Mar 22.

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School Boston, 77 Avenue Louis Pasteur, Harvard Institute Medical, Room 730, Boston, MA 02115 USA.

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http://alzres.com/content/7/1/14
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http://dx.doi.org/10.1186/s13195-015-0100-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369838PMC
March 2015

Simvastatin treatment preserves synaptic plasticity in AβPPswe/PS1dE9 mice.

J Alzheimers Dis 2014 ;39(2):315-29

School of Biomolecular and Biomedical Sciences, Conway Institute, University College Dublin, Belfield, Dublin, Ireland.

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http://dx.doi.org/10.3233/JAD-130257DOI Listing
October 2014

Aβ dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies.

Biochem J 2014 Aug;461(3):413-26

*Laboratory for Neurodegenerative Research, Center for Neurologic Diseases, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, U.S.A.

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http://biochemj.org/lookup/doi/10.1042/BJ20140219
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http://dx.doi.org/10.1042/BJ20140219DOI Listing
August 2014

The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons.

Hum Mol Genet 2014 Jul 12;23(13):3523-36. Epub 2014 Feb 12.

Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA

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http://dx.doi.org/10.1093/hmg/ddu064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049307PMC
July 2014

APP homodimers transduce an amyloid-β-mediated increase in release probability at excitatory synapses.

Cell Rep 2014 Jun 15;7(5):1560-1576. Epub 2014 May 15.

Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel; Sagol School of Neuroscience, Tel Aviv University, 69978 Tel Aviv, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.04.024DOI Listing
June 2014

Simultaneous measurement of a range of particle sizes during Aβ1-42 fibrillogenesis quantified using fluorescence correlation spectroscopy.

Biochem Biophys Res Commun 2014 May 24;448(2):195-9. Epub 2014 Apr 24.

Department of Chemistry, National University of Ireland Maynooth, Maynooth, Co. Kildare, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.04.088DOI Listing
May 2014

Transthyretin aggregate-specific antibodies recognize cryptic epitopes on patient-derived amyloid fibrils.

Rejuvenation Res 2014 Apr;17(2):97-104

1 The Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts.

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http://dx.doi.org/10.1089/rej.2013.1524DOI Listing
April 2014

Peripheral administration of a humanized anti-PrP antibody blocks Alzheimer's disease Aβ synaptotoxicity.

J Neurosci 2014 Apr;34(18):6140-5

Department of Pharmacology and Therapeutics and Institute of Neuroscience, Trinity College, Dublin 2, Republic of Ireland, Medical Research Council Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, London WC1N 3BG, United Kingdom, Laboratory for Neurodegenerative Research, Center for Neurologic Diseases, Brigham & Women's Hospital, Harvard Institute of Medicine, Boston, Massachusetts 02115, and Biotherapeutics Group, Medical Research Council Technology, Mill Hill, London, United Kingdom NW7 1AD.

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http://dx.doi.org/10.1523/JNEUROSCI.3526-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004804PMC
April 2014

mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo.

Nat Commun 2014 Mar 4;5:3374. Epub 2014 Mar 4.

Department of Pharmacology and Therapeutics, and Trinity College Institute of Neuroscience, Biotechnology Building, Trinity College Dublin, Dublin 2, Ireland.

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http://dx.doi.org/10.1038/ncomms4374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354159PMC
March 2014

Neurotransmitter receptor and time dependence of the synaptic plasticity disrupting actions of Alzheimer's disease Aβ in vivo.

Philos Trans R Soc Lond B Biol Sci 2014 Jan 2;369(1633):20130147. Epub 2013 Dec 2.

Department of Pharmacology and Therapeutics, Institute of Neuroscience, Trinity College, , Biotechnology Building, Dublin 2, Republic of Ireland.

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http://dx.doi.org/10.1098/rstb.2013.0147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843879PMC
January 2014

De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease.

Hum Mol Genet 2013 Aug 11;22(15):3077-92. Epub 2013 Apr 11.

Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/hmg/ddt164DOI Listing
August 2013

Alzheimer brain-derived amyloid β-protein impairs synaptic remodeling and memory consolidation.

Neurobiol Aging 2013 May 22;34(5):1315-27. Epub 2012 Nov 22.

Laboratory for Neurodegenerative Research, School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin, Republic of Ireland.

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http://dx.doi.org/10.1016/j.neurobiolaging.2012.10.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570694PMC
May 2013

New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF.

Alzheimers Dement 2013 Mar 30;9(2):99-112. Epub 2013 Jan 30.

Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.jalz.2012.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604133PMC
March 2013

Alzheimer's disease and the amyloid β-protein.

Prog Mol Biol Transl Sci 2012 ;107:101-24

Laboratory for Neurodegenerative Research, Center for Neurologic Diseases, Brigham & Women's Hospital, Harvard Institutes of Medicine, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/B978-0-12-385883-2.00012-6DOI Listing
August 2012

The levels of water-soluble and triton-soluble Aβ are increased in Alzheimer's disease brain.

Brain Res 2012 Apr 24;1450:138-47. Epub 2012 Feb 24.

Laboratory for Neurodegenerative Research, School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin 4, Ireland.

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http://dx.doi.org/10.1016/j.brainres.2012.02.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319647PMC
April 2012

β-Amyloid carrying the Dutch mutation has diverse effects on calpain-mediated toxicity in hippocampal neurons.

Mol Med 2012 Mar 27;18:178-85. Epub 2012 Mar 27.

Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.

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http://dx.doi.org/10.2119/molmed.2011.00366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320137PMC
March 2012

Aβ oligomers inhibit synapse remodelling necessary for memory consolidation.

Neurobiol Aging 2011 Dec 25;32(12):2211-8. Epub 2010 Jan 25.

Laboratory for Neurodegenerative Research, University College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1016/j.neurobiolaging.2010.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891223PMC
December 2011

Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites.

Nat Commun 2011 Jun 7;2:336. Epub 2011 Jun 7.

Laboratory for Neurodegenerative Research, School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin 4, Republic of Ireland.

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http://dx.doi.org/10.1038/ncomms1341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156817PMC
June 2011

Isolation of low-n amyloid β-protein oligomers from cultured cells, CSF, and brain.

Methods Mol Biol 2011 ;670:33-44

Center for Neurologic Diseases, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-60761-744-0_3DOI Listing
May 2011

Macroautophagy is not directly involved in the metabolism of amyloid precursor protein.

J Biol Chem 2010 Nov 23;285(48):37415-26. Epub 2010 Sep 23.

Laboratory for Neurodegenerative Research, School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin 4, Ireland.

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http://dx.doi.org/10.1074/jbc.M110.186411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988347PMC
November 2010

Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils.

J Neurosci 2010 Oct;30(43):14411-9

Laboratory for Neurodegenerative Research, Conway Institute, University College Dublin, Belfield, Dublin 4, Republic of Ireland.

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http://dx.doi.org/10.1523/JNEUROSCI.3537-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987723PMC
October 2010

Biological markers of amyloid beta-related mechanisms in Alzheimer's disease.

Exp Neurol 2010 Jun 6;223(2):334-46. Epub 2009 Oct 6.

Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience (TCIN), Laboratory of Neuroimaging and Biomarker Research, Trinity College Dublin, Trinity Centre for Health Sciences, The Adelaide and Meath Hospital Incorporating The National Children's Hospital (AMiNCH), Dublin, Ireland.

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http://dx.doi.org/10.1016/j.expneurol.2009.09.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896007PMC
June 2010

The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia.

Brain 2010 May 19;133(Pt 5):1328-41. Epub 2010 Apr 19.

Laboratory for Neurodegenerative Research, School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin 4, Republic of Ireland.

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http://dx.doi.org/10.1093/brain/awq065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859152PMC
May 2010

Amyloid β-protein aggregation produces highly reproducible kinetic data and occurs by a two-phase process.

ACS Chem Neurosci 2010 Jan 9;1(1):13-8. Epub 2009 Oct 9.

Chemistry Department and Molecular Protein Science, Lund University, P.O. Box 124, SE221 00 Lund, Sweden.

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http://dx.doi.org/10.1021/cn900015vDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368626PMC
January 2010

Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life.

Neurobiol Dis 2009 Nov 4;36(2):293-302. Epub 2009 Aug 4.

Laboratory for Neurodegenerative Research, School of Biomolecular and Biomedical Sciences, Conway Institute for Biomedical and Biomolecular Research, University College Dublin, Belfield, Dublin 4, Republic of Ireland.

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http://dx.doi.org/10.1016/j.nbd.2009.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782414PMC
November 2009

An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1.

Biochemistry 2009 Nov;48(46):10894-904

Laboratory for Neurodegenerative Research, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Republic of Ireland.

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http://dx.doi.org/10.1021/bi901237kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489158PMC
November 2009

Alzheimer's disease: synaptic dysfunction and Abeta.

Mol Neurodegener 2009 Nov 23;4:48. Epub 2009 Nov 23.

Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1186/1750-1326-4-48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788538PMC
November 2009

A facile method for expression and purification of the Alzheimer's disease-associated amyloid beta-peptide.

FEBS J 2009 Mar;276(5):1266-81

Laboratory for Neurodegenerative Research, School of Biomolecular and Biomedical Science, Conway Institute, Belfield, University College Dublin, Republic of Ireland.

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http://dx.doi.org/10.1111/j.1742-4658.2008.06862.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702495PMC
March 2009

gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons.

Brain Res 2009 Mar 18;1262:89-99. Epub 2009 Jan 18.

Laboratory for Neurodegenerative Research, The Conway Institute for Biomolecular and Biomedical Research, School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Republic of Ireland.

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http://linkinghub.elsevier.com/retrieve/pii/S000689930900052
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http://dx.doi.org/10.1016/j.brainres.2009.01.008DOI Listing
March 2009

Inhibition of amyloid beta protein fibrillation by polymeric nanoparticles.

J Am Chem Soc 2008 Nov 28;130(46):15437-43. Epub 2008 Oct 28.

Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland.

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http://dx.doi.org/10.1021/ja8041806DOI Listing
November 2008

Intracerebroventricular Administration of Amyloid β-protein Oligomers Selectively Increases Dorsal Hippocampal Dialysate Glutamate Levels in the Awake Rat.

Sensors (Basel) 2008 Nov 19;8(11):7428-7437. Epub 2008 Nov 19.

Applied Neurotherapeutics Research Group, Conway Institute, University College Dublin, Dublin 4, Ireland.

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http://dx.doi.org/10.3390/s8117428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787453PMC
November 2008

Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases.

Mol Med 2008 Jul-Aug;14(7-8):451-64

School of Medicine and Dentistry, The Queen's University of Belfast, Belfast, Northern Ireland.

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http://dx.doi.org/10.2119/2007-00100.IrvineDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2274891PMC
September 2008

Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin.

Neurobiol Dis 2008 Sep 17;31(3):442-50. Epub 2008 Jun 17.

Laboratory for Neurodegenerative Research, The Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Republic of Ireland.

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http://dx.doi.org/10.1016/j.nbd.2008.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160758PMC
September 2008

Soluble amyloid-beta peptides potently disrupt hippocampal synaptic plasticity in the absence of cerebrovascular dysfunction in vivo.

Brain 2008 Sep 4;131(Pt 9):2414-24. Epub 2008 Aug 4.

Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland.

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http://dx.doi.org/10.1093/brain/awn174DOI Listing
September 2008

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.

Nat Med 2008 Aug 22;14(8):837-42. Epub 2008 Jun 22.

Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nm1782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772133PMC
August 2008

A beta oligomers - a decade of discovery.

J Neurochem 2007 Jun 5;101(5):1172-84. Epub 2007 Feb 5.

Laboratory for Neurodegenerative Research, The Conway Institute, University College Dublin, Belfield, Dublin, Republic of Ireland.

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http://dx.doi.org/10.1111/j.1471-4159.2006.04426.xDOI Listing
June 2007

Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers.

Ann Neurol 2006 Dec;60(6):668-76

Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1002/ana.21051DOI Listing
December 2006

Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.

J Physiol 2006 Apr 9;572(Pt 2):477-92. Epub 2006 Feb 9.

Department of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1113/jphysiol.2005.103754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779683PMC
April 2006

Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo.

Nat Med 2005 May 17;11(5):556-61. Epub 2005 Apr 17.

Trinity College Institute of Neuroscience, Department of Pharmacology and Therapeutics, Trinity College, Dublin 2, Ireland.

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http://dx.doi.org/10.1038/nm1234DOI Listing
May 2005

Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.

J Neurosci 2005 Mar;25(10):2455-62

Department of Neurology, Harvard Medical School, and Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts 02115-5716, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.4391-04.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6725159PMC
March 2005

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function.

Nat Neurosci 2005 Jan 19;8(1):79-84. Epub 2004 Dec 19.

Geriatric Research, Education and Clinical Center, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA.

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http://dx.doi.org/10.1038/nn1372DOI Listing
January 2005

Species-specific immune response to immunization with human versus rodent A beta peptide.

Neurobiol Aging 2004 Oct;25(9):1141-51

Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2003.12.008DOI Listing
October 2004

Deciphering the molecular basis of memory failure in Alzheimer's disease.

Neuron 2004 Sep;44(1):181-93

Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.neuron.2004.09.010DOI Listing
September 2004

Amyloid beta-protein induced electrophysiological changes are dependent on aggregation state: N-methyl-D-aspartate (NMDA) versus non-NMDA receptor/channel activation.

Neurosci Lett 2004 Aug;366(3):320-5

Department of Medicine at Harvard Medical School, Division of Endocrinology, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.neulet.2004.05.060DOI Listing
August 2004