Dominic Kwiatkowski

Dominic Kwiatkowski

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Dominic Kwiatkowski

Dominic Kwiatkowski

Publications by authors named "Dominic Kwiatkowski"

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Evolutionary analysis of the most polymorphic gene family in malaria.

Wellcome Open Res 2019 3;4:193. Epub 2019 Dec 3.

Parasite Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.12688/wellcomeopenres.15590.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001760PMC
December 2019

Origins of the current outbreak of multidrug-resistant malaria in southeast Asia: a retrospective genetic study.

Lancet Infect Dis 2018 03 2;18(3):337-345. Epub 2018 Feb 2.

Wellcome Sanger Institute, Hinxton, UK; MRC Centre for Genomics and Global Health, Big Data Institute, Oxford University, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(18)30068-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835763PMC
March 2018

Panoptes: web-based exploration of large scale genome variation data.

Bioinformatics 2017 Oct;33(20):3243-3249

MRC Centre for Genomics and Global Health, University of Oxford, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1093/bioinformatics/btx410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860036PMC
October 2017

Population genetic structure and adaptation of malaria parasites on the edge of endemic distribution.

Mol Ecol 2017 Jun 15;26(11):2880-2894. Epub 2017 Mar 15.

Department of Pathogen Molecular Biology, London School of Hygiene & Tropical Medicine, Keppel St, London, WC1E 7HT, UK.

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http://dx.doi.org/10.1111/mec.14066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485074PMC
June 2017

Extreme mutation bias and high AT content in Plasmodium falciparum.

Nucleic Acids Res 2017 02;45(4):1889-1901

Malaria Programme, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.

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http://dx.doi.org/10.1093/nar/gkw1259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389722PMC
February 2017

Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia.

Elife 2017 01 9;6. Epub 2017 Jan 9.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.7554/eLife.15085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222559PMC
January 2017

Culture adaptation of malaria parasites selects for convergent loss-of-function mutants.

Sci Rep 2017 01 24;7:41303. Epub 2017 Jan 24.

London School of Hygiene and Tropical Medicine, London, UK.

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http://dx.doi.org/10.1038/srep41303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259787PMC
January 2017

Analysis of anti-malarial resistance markers in pfmdr1 and pfcrt across Southeast Asia in the Tracking Resistance to Artemisinin Collaboration.

Malar J 2016 Nov 8;15(1):541. Epub 2016 Nov 8.

Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

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http://dx.doi.org/10.1186/s12936-016-1598-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101715PMC
November 2016

Genomic Analysis Reveals a Common Breakpoint in Amplifications of the Plasmodium vivax Multidrug Resistance 1 Locus in Thailand.

J Infect Dis 2016 10 24;214(8):1235-42. Epub 2016 Jul 24.

Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Australia Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Oxford University, United Kingdom.

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http://dx.doi.org/10.1093/infdis/jiw323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034950PMC
October 2016

Severe anemia in Malawian children.

Malawi Med J 2016 09;28(3):99-107

Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi; College of Medicine, University of Malawi, Blantyre, Malawi; Emma Children's Hospital, the Global Child Health Group, Academic Medical Center, Amsterdam, The Netherlands; Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116999PMC
September 2016

Environmental Correlation Analysis for Genes Associated with Protection against Malaria.

Mol Biol Evol 2016 05 6;33(5):1188-204. Epub 2016 Jan 6.

Department of Epidemiology and Demography, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya Department of Medicine, Imperial College, London, United Kingdom INDEPTH Network, Kanda, Accra, Ghana.

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http://dx.doi.org/10.1093/molbev/msw004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839215PMC
May 2016

The ethics of sustainable genomic research in Africa.

Genome Biol 2016 Mar 8;17:44. Epub 2016 Mar 8.

The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.

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http://dx.doi.org/10.1186/s13059-016-0914-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782358PMC
March 2016

A genome wide association study of Plasmodium falciparum susceptibility to 22 antimalarial drugs in Kenya.

PLoS One 2014 8;9(5):e96486. Epub 2014 May 8.

Medical Research Council (MRC) Centre for Genomics and Global Health, University of Oxford, Oxford, United Kingdom; Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096486PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014544PMC
October 2015

Glucose-6-phosphate dehydrogenase deficiency and the risk of malaria and other diseases in children in Kenya: a case-control and a cohort study.

Lancet Haematol 2015 Oct 22;2(10):e437-44. Epub 2015 Sep 22.

Department of Epidemiology and Demography, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya; Department of Medicine, Imperial College, St Mary's Hospital, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S2352-3026(15)00152-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703047PMC
October 2015

Comparison of genomic signatures of selection on Plasmodium falciparum between different regions of a country with high malaria endemicity.

BMC Genomics 2015 Jul 16;16:527. Epub 2015 Jul 16.

West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Box LG 54, Volta Road, Legon, Accra, Ghana.

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http://dx.doi.org/10.1186/s12864-015-1746-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502944PMC
July 2015

Understandings of genomic research in developing countries: a qualitative study of the views of MalariaGEN participants in Mali.

BMC Med Ethics 2015 Jun 16;16:42. Epub 2015 Jun 16.

Malaria Research and Training Center, DEAP/FMPOS, UMI3189, Université des Sciences, des Techniques et des Technologies de Bamako, BP 1805, Bamako, Mali.

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http://dx.doi.org/10.1186/s12910-015-0035-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469103PMC
June 2015

K13-propeller polymorphisms in Plasmodium falciparum parasites from sub-Saharan Africa.

J Infect Dis 2015 Apr 2;211(8):1352-5. Epub 2014 Nov 2.

Wellcome Trust Sanger Institute, Hinxton Malaria Research and Training Centre, Department of Epidemiology of Parasitic Diseases, Faculty of Pharmacy, University of Science, Techniques and Technologies of Bamako, Mali.

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http://dx.doi.org/10.1093/infdis/jiu608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827505PMC
April 2015

Malaria genomics: tracking a diverse and evolving parasite population.

Int Health 2015 Mar;7(2):82-4

Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA and Oxford University, Henry Wellcome Building for Molecular Physiology, Old Road Campus, Headington, Oxford, OX3 7BN, UK

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http://dx.doi.org/10.1093/inthealth/ihv007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379983PMC
March 2015

G6PD gene variants and its association with malaria in a Sri Lankan population.

Malar J 2015 Feb 22;14:93. Epub 2015 Feb 22.

Department of Parasitology, Faculty of Medicine, University of Colombo, 25, Kynsey Road, Colombo 08, Sri Lanka.

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http://dx.doi.org/10.1186/s12936-015-0603-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4343272PMC
February 2015

Optimized whole-genome amplification strategy for extremely AT-biased template.

DNA Res 2014 Dec 19;21(6):661-71. Epub 2014 Sep 19.

Wellcome Trust Sanger Institute, Hinxton, UK MRC Centre for Genomics and Global Health, University of Oxford, Oxford OX3 7BN, UK Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1093/dnares/dsu028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263299PMC
December 2014

Generation of antigenic diversity in Plasmodium falciparum by structured rearrangement of Var genes during mitosis.

PLoS Genet 2014 Dec 18;10(12):e1004812. Epub 2014 Dec 18.

Malaria Programme, Wellcome Trust Sanger Institute, Hinxton, United Kingdom; MRC Centre for Genomics and Global Health, University of Oxford, Oxford, United Kingdom.

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http://dx.plos.org/10.1371/journal.pgen.1004812
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http://dx.doi.org/10.1371/journal.pgen.1004812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270465PMC
December 2014

Monitoring parasite diversity for malaria elimination in sub-Saharan Africa.

Science 2014 Sep;345(6202):1297-8

Malaria Research and Training Centre (MRTC), Department of Epidemiology of Parasitic Diseases, Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali. Wellcome Trust Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.1126/science.1259423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541720PMC
September 2014

Knowing who to trust: exploring the role of 'ethical metadata' in mediating risk of harm in collaborative genomics research in Africa.

BMC Med Ethics 2014 Aug 13;15:62. Epub 2014 Aug 13.

Department of Medicine, University of Cape Town, Anzio Road Observatory, Cape Town 7925, South Africa.

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http://dx.doi.org/10.1186/1472-6939-15-62DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146449PMC
August 2014

Spread of artemisinin resistance in Plasmodium falciparum malaria.

N Engl J Med 2014 Jul;371(5):411-23

The authors' affiliations are listed in the Appendix.

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http://dx.doi.org/10.1056/NEJMoa1314981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143591PMC
July 2014

Human candidate polymorphisms in sympatric ethnic groups differing in malaria susceptibility in Mali.

PLoS One 2013 2;8(10):e75675. Epub 2013 Oct 2.

Malaria Research and Training Center / Department of Epidemiology of Parasitic Diseases / Faculty of Medicine, Pharmacy and Odonto - Stomatology, BP 1805, Bamako, USTTB, Mali ; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075675PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788813PMC
June 2014

Genome-wide analysis of selection on the malaria parasite Plasmodium falciparum in West African populations of differing infection endemicity.

Mol Biol Evol 2014 Jun 18;31(6):1490-9. Epub 2014 Mar 18.

Pathogen Molecular Biology Department, London School of Hygiene and Tropical Medicine, London, United KingdomMedical Research Council Unit, Fajara, Banjul, The Gambia

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http://dx.doi.org/10.1093/molbev/msu106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032133PMC
June 2014

Natural selection and infectious disease in human populations.

Nat Rev Genet 2014 Jun 29;15(6):379-93. Epub 2014 Apr 29.

1] Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA. [2] Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA. [3] Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

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http://search.proquest.com/openview/f0ddd58e5fa662772806ff56
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http://dx.doi.org/10.1038/nrg3734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912034PMC
June 2014

Adaptive introgression between Anopheles sibling species eliminates a major genomic island but not reproductive isolation.

Nat Commun 2014 Jun 25;5:4248. Epub 2014 Jun 25.

1] Department of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK [2] Malaria Programme, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1RQ, UK.

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http://dx.doi.org/10.1038/ncomms5248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086683PMC
June 2014

A transcriptional switch underlies commitment to sexual development in malaria parasites.

Nature 2014 Mar 23;507(7491):248-52. Epub 2014 Feb 23.

1] Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA [2] Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA [3] Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA (B.F.C.K.); Department of Molecular Biology and Center for Infectious Disease Dynamics, The Pennsylvania State University, State College, Pennsylvania 16802, USA (V.M.C., M.L.).

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http://dx.doi.org/10.1038/nature12920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040541PMC
March 2014

Detecting and characterizing genomic signatures of positive selection in global populations.

Am J Hum Genet 2013 Jun 23;92(6):866-81. Epub 2013 May 23.

NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore 117456, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore.

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http://dx.doi.org/10.1016/j.ajhg.2013.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675259PMC
June 2013