Publications by authors named "Dominic Hoepfner"

42Publications

Author Correction: Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol.

Authors:
Yue Fu David Estoppey Silvio Roggo Dominik Pistorius Florian Fuchs Christian Studer Ashraf S Ibrahim Thomas Aust Frederic Grandjean Manuel Mihalic Klaus Memmert Vivian Prindle Etienne Richard Ralph Riedl Sven Schuierer Eric Weber Jürg Hunziker Frank Petersen Jianshi Tao Dominic Hoepfner

Nat Commun 2020 07 31;11(1):3913. Epub 2020 Jul 31.

Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, CH-4056, Basel, Switzerland.

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July 2020

Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol.

Authors:
Yue Fu David Estoppey Silvio Roggo Dominik Pistorius Florian Fuchs Christian Studer Ashraf S Ibrahim Thomas Aust Frederic Grandjean Manuel Mihalic Klaus Memmert Vivian Prindle Etienne Richard Ralph Riedl Sven Schuierer Eric Weber Jürg Hunziker Frank Petersen Jianshi Tao Dominic Hoepfner

Nat Commun 2020 07 7;11(1):3387. Epub 2020 Jul 7.

Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, CH-4056, Basel, Switzerland.

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July 2020

Kendomycin Cytotoxicity against Bacterial, Fungal, and Mammalian Cells Is Due to Cation Chelation.

Authors:
Dale Tranter Ireos Filipuzzi Thomas Lochmann Britta Knapp Juho Kellosalo David Estoppey Dominik Pistorius Axel Meissner Ville O Paavilainen Dominic Hoepfner

J Nat Prod 2020 04 17;83(4):965-971. Epub 2020 Mar 17.

Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland.

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April 2020

IRF2 is a master regulator of human keratinocyte stem cell fate.

Authors:
Nicolas Mercado Gabi Schutzius Christian Kolter David Estoppey Sebastian Bergling Guglielmo Roma Caroline Gubser Keller Florian Nigsch Adrian Salathe Remi Terranova John Reece-Hoyes John Alford Carsten Russ Judith Knehr Dominic Hoepfner Alexandra Aebi Heinz Ruffner Tanner C Beck Sajjeev Jagannathan Calla M Olson Hadley E Sheppard Selma Z Elsarrag Tewis Bouwmeester Mathias Frederiksen Felix Lohmann Charles Y Lin Susan Kirkland

Nat Commun 2019 10 14;10(1):4676. Epub 2019 Oct 14.

Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, CH-4056, Basel, Switzerland.

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October 2019

Auxin-Inducible Depletion of the Essentialome Suggests Inhibition of TORC1 by Auxins and Inhibition of Vrg4 by SDZ 90-215, a Natural Antifungal Cyclopeptide.

Authors:
Nathan A Snyder Adam Kim Louis Kester Andrew N Gale Christian Studer Dominic Hoepfner Silvio Roggo Stephen B Helliwell Kyle W Cunningham

G3 (Bethesda) 2019 03 7;9(3):829-840. Epub 2019 Mar 7.

Department of Biology, Johns Hopkins University, 3400 N. Charles Street, Baltimore, Maryland 21218

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March 2019

Discovery of a ZIP7 inhibitor from a Notch pathway screen.

Authors:
Erin Nolin Sara Gans Luis Llamas Somnath Bandyopadhyay Scott M Brittain Paula Bernasconi-Elias Kyle P Carter Joseph J Loureiro Jason R Thomas Markus Schirle Yi Yang Ning Guo Guglielmo Roma Sven Schuierer Martin Beibel Alicia Lindeman Frederic Sigoillot Amy Chen Kevin X Xie Samuel Ho John Reece-Hoyes Wilhelm A Weihofen Kayla Tyskiewicz Dominic Hoepfner Richard I McDonald Nicolette Guthrie Abhishek Dogra Haibing Guo Jian Shao Jian Ding Stephen M Canham Geoff Boynton Elizabeth L George Zhao B Kang Christophe Antczak Jeffery A Porter Owen Wallace John A Tallarico Amy E Palmer Jeremy L Jenkins Rishi K Jain Simon M Bushell Christy J Fryer

Nat Chem Biol 2019 02 14;15(2):179-188. Epub 2019 Jan 14.

Novartis Institutes for Biomedical Research, Cambridge, MA, USA.

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February 2019

CRISPR/Cas9-Based Chemogenomic Profiling in Mammalian Cells.

Authors:
Dominic Hoepfner Gregory McAllister Gregory R Hoffman

Methods Mol Biol 2019 ;1888:153-174

Novartis Institutes for BioMedical Research, Cambridge, MA, USA.

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June 2019

Design and Synthesis of Metabolically Stable tRNA Synthetase Inhibitors Derived from Cladosporin.

Authors:
Marion Rusch Arnaud Thevenon Dominic Hoepfner Thomas Aust Christian Studer Maude Patoor Patrick Rollin Madeleine Livendahl Beatrice Ranieri Esther Schmitt Carsten Spanka Karl Gademann Laure C Bouchez

Chembiochem 2019 03 4;20(5):644-649. Epub 2019 Feb 4.

NIBR-Novartis Institute for Biomedical Research, Fabrikstrasse 22-1.051.17, 4054, Basel, Switzerland.

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March 2019

Previously Uncharacterized Vacuolar-type ATPase Binding Site Discovered from Structurally Similar Compounds with Distinct Mechanisms of Action.

Authors:
Andrew C Wang Helen T Pham Jennifer M Lipps Scott M Brittain Edmund Harrington Yuan Wang Fred J King Carsten Russ Xuewen Pan Dominic Hoepfner John Tallarico Yan Feng Rishi K Jain Markus Schirle Jason R Thomas

ACS Chem Biol 2019 01 18;14(1):20-26. Epub 2018 Dec 18.

Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue , Cambridge , Massachusetts 02139 , United States.

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January 2019

Cladosporin Derivatives Obtained by Biotransformation Provide Guidance for the Focused Derivatization of this Antimalarial Lead Compound.

Authors:
Andreas Fredenhagen Kirsten Schroer Harald Schröder Dominic Hoepfner Mathieu Ligibel Liliane Porchet Zemp Caroline Radoch Ernst Freund Aldo Meishammer

Chembiochem 2019 03 11;20(5):650-654. Epub 2018 Dec 11.

Novartis Institutes for BioMedical Research, Global Discovery Chemistry WKL-122.P.37, Postfach, 4002, Basel, Switzerland.

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March 2019

Yeast Chemogenomic Profiling Reveals Iron Chelation To Be the Principle Cell Inhibitory Mode of Action of Gossypol.

Authors:
Thomas A K Prescott Tiphaine Jaeg Dominic Hoepfner

J Med Chem 2018 08 6;61(16):7381-7386. Epub 2018 Aug 6.

Developmental & Molecular Pathways , Novartis Institutes for BioMedical Research, Novartis Pharma AG , Fabrikstrasse 22 , CH-4056 Basel , Switzerland.

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August 2018

Biosynthesis of fragin is controlled by a novel quorum sensing signal.

Authors:
Christian Jenul Simon Sieber Christophe Daeppen Anugraha Mathew Martina Lardi Gabriella Pessi Dominic Hoepfner Markus Neuburger Anthony Linden Karl Gademann Leo Eberl

Nat Commun 2018 03 30;9(1):1297. Epub 2018 Mar 30.

Department of Plant and Microbial Biology, University of Zurich, 8008, Zurich, Switzerland.

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March 2018

Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties.

Authors:
Verena Pries Christina Nöcker Danish Khan Philipp Johnen Zebin Hong Ashutosh Tripathi Anna-Lena Keller Michael Fitz Francesca Perruccio Ireos Filipuzzi Sasikala Thavam Thomas Aust Ralph Riedl Slava Ziegler Fulvia Bono Gabriel Schaaf Vytas A Bankaitis Herbert Waldmann Dominic Hoepfner

Cell Chem Biol 2018 03 4;25(3):279-290.e7. Epub 2018 Jan 4.

Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, 4056 Basel, Switzerland. Electronic address:

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March 2018

CRISPR-UMI: single-cell lineage tracing of pooled CRISPR-Cas9 screens.

Authors:
Georg Michlits Maria Hubmann Szu-Hsien Wu Gintautas Vainorius Elena Budusan Sergei Zhuk Thomas R Burkard Maria Novatchkova Martin Aichinger Yiqing Lu John Reece-Hoyes Roberto Nitsch Daniel Schramek Dominic Hoepfner Ulrich Elling

Nat Methods 2017 Dec 16;14(12):1191-1197. Epub 2017 Oct 16.

Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC), Vienna, Austria.

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December 2017

Stendomycin selectively inhibits TIM23-dependent mitochondrial protein import.

Authors:
Ireos Filipuzzi Janos Steffen Mitchel Germain Laetitia Goepfert Michael A Conti Christoph Potting Raffaele Cerino Martin Pfeifer Philipp Krastel Dominic Hoepfner Julie Bastien Carla M Koehler Stephen B Helliwell

Nat Chem Biol 2017 Dec 9;13(12):1239-1244. Epub 2017 Oct 9.

Novartis Institutes for BioMedical Research, Basel, Switzerland.

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December 2017

A reversible haploid mouse embryonic stem cell biobank resource for functional genomics.

Authors:
Ulrich Elling Reiner A Wimmer Andreas Leibbrandt Thomas Burkard Georg Michlits Alexandra Leopoldi Thomas Micheler Dana Abdeen Sergei Zhuk Irene M Aspalter Cornelia Handl Julia Liebergesell Maria Hubmann Anna-Maria Husa Manuela Kinzer Nicole Schuller Ellen Wetzel Nina van de Loo Jorge Arturo Zepeda Martinez David Estoppey Ralph Riedl Fengtang Yang Beiyuan Fu Thomas Dechat Zoltán Ivics Chukwuma A Agu Oliver Bell Dieter Blaas Holger Gerhardt Dominic Hoepfner Alexander Stark Josef M Penninger

Nature 2017 10 27;550(7674):114-118. Epub 2017 Sep 27.

Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC), Dr. Bohr Gasse 3, Vienna, Austria.

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October 2017

Direct Interaction of Chivosazole F with Actin Elicits Cell Responses Similar to Latrunculin A but Distinct from Chondramide.

Authors:
Ireos Filipuzzi Jason Ray Thomas Verena Pries David Estoppey Michael Salcius Christian Studer Markus Schirle Dominic Hoepfner

ACS Chem Biol 2017 09 15;12(9):2264-2269. Epub 2017 Aug 15.

Novartis Institutes for BioMedical Research , Novartis Pharma AG, Forum 1 Novartis Campus, CH-4056 Basel, Switzerland.

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September 2017

Two low complexity ultra-high throughput methods to identify diverse chemically bioactive molecules using Saccharomyces cerevisiae.

Authors:
Katarina Petrovic Martin Pfeifer Christian N Parker Sven Schuierer John Tallarico Dominic Hoepfner N Rao Movva Gunther Scheel Stephen B Helliwell

Microbiol Res 2017 Jun 21;199:10-18. Epub 2017 Feb 21.

Novartis Institutes for Biomedical Research, Novartis AG, Basel, Switzerland. Electronic address:

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June 2017

The Natural Product Cavinafungin Selectively Interferes with Zika and Dengue Virus Replication by Inhibition of the Host Signal Peptidase.

Authors:
David Estoppey Chia Min Lee Marco Janoschke Boon Heng Lee Kah Fei Wan Hongping Dong Philippe Mathys Ireos Filipuzzi Tim Schuhmann Ralph Riedl Thomas Aust Olaf Galuba Gregory McAllister Carsten Russ Martin Spiess Tewis Bouwmeester Ghislain M C Bonamy Dominic Hoepfner

Cell Rep 2017 04;19(3):451-460

Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, 4056 Basel, Switzerland; Biozentrum, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland. Electronic address:

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April 2017

Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells.

Authors:
David Estoppey Jeffrey W Hewett Chantale T Guy Edmund Harrington Jason R Thomas Markus Schirle Rachel Cuttat Annick Waldt Bertran Gerrits Zinger Yang Sven Schuierer Xuewen Pan Kevin Xie Walter Carbone Judith Knehr Alicia Lindeman Carsten Russ Elizabeth Frias Gregory R Hoffman Malini Varadarajan Nadire Ramadan John S Reece-Hoyes Qiong Wang Xin Chen Gregory McAllister Guglielmo Roma Tewis Bouwmeester Dominic Hoepfner

Sci Rep 2017 02 16;7:42728. Epub 2017 Feb 16.

Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, CH-4056 Basel, Switzerland.

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February 2017