Dominic Esposito

Dominic Esposito

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Dominic Esposito

Dominic Esposito

Publications by authors named "Dominic Esposito"

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The small molecule BI-2852 induces a nonfunctional dimer of KRAS.

Proc Natl Acad Sci U S A 2020 Feb 11. Epub 2020 Feb 11.

National Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702;

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http://dx.doi.org/10.1073/pnas.1918164117DOI Listing
February 2020

Coexpression of ABCB1 and ABCG2 in a Cell Line Model Reveals Both Independent and Additive Transporter Function.

Drug Metab Dispos 2019 07 2;47(7):715-723. Epub 2019 May 2.

Laboratory of Cell Biology (A.N.R., B.G.T., S.C.F., L.M.H., H.K., D.C., R.W.R., M.M.G.) and Women's Malignancies Branch (J.-M.L.), National Institutes of Health, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland; and Protein Expression Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland (D.E.)

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http://dx.doi.org/10.1124/dmd.118.086181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548982PMC
July 2019

Structures of N-terminally processed KRAS provide insight into the role of N-acetylation.

Sci Rep 2019 Jul 19;9(1):10512. Epub 2019 Jul 19.

NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, 21701, USA.

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http://dx.doi.org/10.1038/s41598-019-46846-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642148PMC
July 2019

Feasibility of using NF1-GRD and AAV for gene replacement therapy in NF1-associated tumors.

Gene Ther 2019 06 24;26(6):277-286. Epub 2019 May 24.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/s41434-019-0080-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588423PMC
June 2019

New weapons to penetrate the armor: Novel reagents and assays developed at the NCI RAS Initiative to enable discovery of RAS therapeutics.

Semin Cancer Biol 2019 02 9;54:174-182. Epub 2018 Feb 9.

NCI RAS Initiative, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc. PO Box B, Frederick, MD, USA.

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http://dx.doi.org/10.1016/j.semcancer.2018.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085166PMC
February 2019

Quantitative biophysical analysis defines key components modulating recruitment of the GTPase KRAS to the plasma membrane.

J Biol Chem 2019 02 17;294(6):2193-2207. Epub 2018 Dec 17.

From the NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland 21702,

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.005669
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http://dx.doi.org/10.1074/jbc.RA118.005669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369290PMC
February 2019

Production of Farnesylated and Methylated Proteins in an Engineered Insect Cell System.

Methods Mol Biol 2019 ;2009:259-277

Protein Expression Laboratory, NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

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http://dx.doi.org/10.1007/978-1-4939-9532-5_20DOI Listing
January 2019

Production of authentic geranylgeranylated KRAS4b using an engineered baculovirus system.

Protein Expr Purif 2018 11 22;151:99-105. Epub 2018 Jun 22.

Protein Expression Laboratory, NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc. PO Box B, Frederick, MD, 21702, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pep.2018.06.012DOI Listing
November 2018

Mutant IL-7Rα and mutant NRas are sufficient to induce murine T cell acute lymphoblastic leukemia.

Leukemia 2018 08 15;32(8):1795-1882. Epub 2018 Feb 15.

Cytokines and Immunity Section, Cancer and Inflammation Program, National Cancer Institute (NCI), National Institutes of Health (NIH), Frederick, MD, USA.

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http://dx.doi.org/10.1038/s41375-017-0001-0DOI Listing
August 2018

Optimizing Expression and Solubility of Proteins in E. coli Using Modified Media and Induction Parameters.

Methods Mol Biol 2017 ;1586:65-82

Protein Expression Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, P.O. Box B, Frederick, MD, 21702-1201, USA.

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http://link.springer.com/10.1007/978-1-4939-6887-9_5
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http://dx.doi.org/10.1007/978-1-4939-6887-9_5DOI Listing
February 2018

Engineering the transposition-based baculovirus expression vector system for higher efficiency protein production from insect cells.

J Biotechnol 2016 Nov 9;238:1-8. Epub 2016 Sep 9.

Protein Expression Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc. PO Box B, Frederick, MD 21702, United States. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067234PMC
http://dx.doi.org/10.1016/j.jbiotec.2016.09.002DOI Listing
November 2016

Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ.

Proc Natl Acad Sci U S A 2016 11 17;113(44):E6766-E6775. Epub 2016 Oct 17.

NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21701;

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http://dx.doi.org/10.1073/pnas.1615316113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098621PMC
November 2016

Mammalian cell transient expression, non-affinity purification, and characterization of human recombinant IGFBP7, an IGF-1 targeting therapeutic protein.

Int Immunopharmacol 2015 Dec 23;29(2):476-487. Epub 2015 Oct 23.

Biopharmaceutical Development Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, United States. Electronic address:

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http://dx.doi.org/10.1016/j.intimp.2015.10.008DOI Listing
December 2015

Combinatorial assembly of clone libraries using site-specific recombination.

Methods Mol Biol 2014 ;1116:193-208

Protein Expression Laboratory, SAIC Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

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http://dx.doi.org/10.1007/978-1-62703-764-8_14DOI Listing
September 2014

Dragging ras back in the ring.

Cancer Cell 2014 Mar;25(3):272-81

Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, P.O. Box B, Frederick, MD 21702, USA; UCSF Helen Diller Family Comprehensive Cancer Center, Room 371, 1450 3(rd) Street, P.O. Box 589001, San Francisco, CA 94158-9001, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.02.017DOI Listing
March 2014

Heterogeneity and breadth of host antibody response to KSHV infection demonstrated by systematic analysis of the KSHV proteome.

PLoS Pathog 2014 Mar 27;10(3):e1004046. Epub 2014 Mar 27.

Viral Oncology Section, AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968157PMC
March 2014

Transcription signatures encoded by ultraconserved genomic regions in human prostate cancer.

Mol Cancer 2013 Feb 14;12:13. Epub 2013 Feb 14.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1186/1476-4598-12-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626580PMC
February 2013

MicroRNA-1 is a candidate tumor suppressor and prognostic marker in human prostate cancer.

Nucleic Acids Res 2012 Apr 30;40(8):3689-703. Epub 2011 Dec 30.

Laboratory of Human Carcinogenesis, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1093/nar/gkr1222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333883PMC
April 2012

Optimizing transient recombinant protein expression in mammalian cells.

Methods Mol Biol 2012 ;801:251-68

Protein Expression Laboratory, SAIC-Frederick, Inc., Frederick, MD, USA.

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http://link.springer.com/10.1007/978-1-61779-352-3_16
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http://dx.doi.org/10.1007/978-1-61779-352-3_16DOI Listing
February 2012

Purify First: rapid expression and purification of proteins from XMRV.

Protein Expr Purif 2011 Apr 10;76(2):238-47. Epub 2010 Dec 10.

Protein Expression Laboratory, SAIC-Frederick Inc., NCI-Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/j.pep.2010.12.003DOI Listing
April 2011

Widening the bottleneck: increasing success in protein expression and purification.

J Struct Biol 2010 Oct 29;172(1):14-20. Epub 2010 Jul 29.

Protein Expression Laboratory, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD 21702, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10478477100021
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http://dx.doi.org/10.1016/j.jsb.2010.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950748PMC
October 2010

Long-range enhancers on 8q24 regulate c-Myc.

Proc Natl Acad Sci U S A 2010 Feb 26;107(7):3001-5. Epub 2010 Jan 26.

Laboratory of Molecular Technology, National Cancer Institute-Frederick, Frederick, MD 21702, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0906067107
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http://dx.doi.org/10.1073/pnas.0906067107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840341PMC
February 2010

The completion of the Mammalian Gene Collection (MGC).

Authors:
Gary Temple Daniela S Gerhard Rebekah Rasooly Elise A Feingold Peter J Good Cristen Robinson Allison Mandich Jeffrey G Derge Jeanne Lewis Debonny Shoaf Francis S Collins Wonhee Jang Lukas Wagner Carolyn M Shenmen Leonie Misquitta Carl F Schaefer Kenneth H Buetow Tom I Bonner Linda Yankie Ming Ward Lon Phan Alex Astashyn Garth Brown Catherine Farrell Jennifer Hart Melissa Landrum Bonnie L Maidak Michael Murphy Terence Murphy Bhanu Rajput Lillian Riddick David Webb Janet Weber Wendy Wu Kim D Pruitt Donna Maglott Adam Siepel Brona Brejova Mark Diekhans Rachel Harte Robert Baertsch Jim Kent David Haussler Michael Brent Laura Langton Charles L G Comstock Michael Stevens Chaochun Wei Marijke J van Baren Kourosh Salehi-Ashtiani Ryan R Murray Lila Ghamsari Elizabeth Mello Chenwei Lin Christa Pennacchio Kirsten Schreiber Nicole Shapiro Amber Marsh Elizabeth Pardes Troy Moore Anita Lebeau Mike Muratet Blake Simmons David Kloske Stephanie Sieja James Hudson Praveen Sethupathy Michael Brownstein Narayan Bhat Joseph Lazar Howard Jacob Chris E Gruber Mark R Smith John McPherson Angela M Garcia Preethi H Gunaratne Jiaqian Wu Donna Muzny Richard A Gibbs Alice C Young Gerard G Bouffard Robert W Blakesley Jim Mullikin Eric D Green Mark C Dickson Alex C Rodriguez Jane Grimwood Jeremy Schmutz Richard M Myers Martin Hirst Thomas Zeng Kane Tse Michelle Moksa Merinda Deng Kevin Ma Diana Mah Johnson Pang Greg Taylor Eric Chuah Athena Deng Keith Fichter Anne Go Stephanie Lee Jing Wang Malachi Griffith Ryan Morin Richard A Moore Michael Mayo Sarah Munro Susan Wagner Steven J M Jones Robert A Holt Marco A Marra Sun Lu Shuwei Yang James Hartigan Marcus Graf Ralf Wagner Stanley Letovksy Jacqueline C Pulido Keith Robison Dominic Esposito James Hartley Vanessa E Wall Ralph F Hopkins Osamu Ohara Stefan Wiemann

A rapid method for titrating baculovirus stocks using the Sf-9 Easy Titer cell line.

Biotechniques 2009 Sep;47(3):785-8

Protein Expression Laboratory, Advanced Technology Program, SAIC-Frederick, National Cancer Institute at Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.2144/000113238DOI Listing
September 2009

Lentivirus-mediated bifunctional cell labeling for in vivo melanoma study.

Pigment Cell Melanoma Res 2009 Jun 19;22(3):283-95. Epub 2009 Jan 19.

Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1111/j.1755-148X.2009.00545.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726997PMC
June 2009

Gateway cloning for protein expression.

Methods Mol Biol 2009 ;498:31-54

Protein Expression Laboratory, National Cancer Institute, SAIC-Frederick, Frederick, MD, USA.

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http://dx.doi.org/10.1007/978-1-59745-196-3_3DOI Listing
February 2009

Identification of highly expressed, soluble proteins using an improved, high-throughput pooled ORF expression technology.

Biotechniques 2008 Sep;45(3):307-15

Laboratory of Proteomics and Analytical Technologies, Advanced Technology Program, SAIC-Frederick, National Cancer Institute at Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.2144/000112916DOI Listing
September 2008

Improved recombinational stability of lentiviral expression vectors using reduced-genome Escherichia coli.

Biotechniques 2007 Oct;43(4):466, 468, 470

SAIC-Frederick Inc., Frederick, MD 21702, USA.

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http://dx.doi.org/10.2144/000112585DOI Listing
October 2007

Enhancement of soluble protein expression through the use of fusion tags.

Curr Opin Biotechnol 2006 Aug 15;17(4):353-8. Epub 2006 Jun 15.

Protein Expression Laboratory, Research Technology Program, SAIC-Frederick, Inc, NCI-Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/j.copbio.2006.06.003DOI Listing
August 2006

Purification, crystallization and preliminary X-ray diffraction of human S100A15.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 May 21;62(Pt 5):467-70. Epub 2006 Apr 21.

X-ray Crystallography Facility, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1107/S1744309106012838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219979PMC
May 2006

Enhanced soluble protein expression using two new fusion tags.

Protein Expr Purif 2006 Mar 24;46(1):122-9. Epub 2005 Aug 24.

Protein Expression Laboratory, SAIC-Frederick, Inc., National Cancer Institute at Frederick, 1050 Boyles Street, Building 327 Frederick, MD 21702, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10465928050026
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http://dx.doi.org/10.1016/j.pep.2005.07.028DOI Listing
March 2006

Pooled ORF expression technology (POET): using proteomics to screen pools of open reading frames for protein expression.

Mol Cell Proteomics 2005 Nov 19;4(11):1647-52. Epub 2005 Aug 19.

Protein Expression Laboratory, Research Technology Program, SAIC-Frederick, Inc./NCI, National Institutes of Health, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1074/mcp.M500128-MCP200DOI Listing
November 2005

Cardiac glycosides inhibit TNF-alpha/NF-kappaB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor.

Proc Natl Acad Sci U S A 2005 Jul 27;102(27):9631-6. Epub 2005 Jun 27.

Department of Anatomy, Physiology, and Genetics and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

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http://dx.doi.org/10.1073/pnas.0504097102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160519PMC
July 2005

Gateway cloning is compatible with protein secretion from Pichia pastoris.

Protein Expr Purif 2005 Apr;40(2):424-8

Protein Expression Laboratory, SAIC Frederick, Inc., National Cancer Institute, P.O. Box B, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/j.pep.2004.12.006DOI Listing
April 2005

A novel cell-free protein synthesis system.

J Biotechnol 2004 Jun;110(3):257-63

SAIC-National Cancer Institute at Frederick, 1050 Boyles Street, Building 327, Frederick, MD 21702-1201, USA.

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http://dx.doi.org/10.1016/j.jbiotec.2004.02.014DOI Listing
June 2004

Blocking oligonucleotides improve sequencing through inverted repeats.

Biotechniques 2003 Nov;35(5):914-6, 918, 920

National Cancer Institute, Frederick, MD, USA.

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http://dx.doi.org/10.2144/03355bm02DOI Listing
November 2003