Domenico Alvaro

Domenico Alvaro

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Domenico Alvaro

Publications by authors named "Domenico Alvaro"

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Common features between neoplastic and preneoplastic lesions of the biliary tract and the pancreas.

World J Gastroenterol 2019 Aug;25(31):4343-4359

PancreatoBiliary Endoscopy and EUS Division, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute IRCCS, Milan 20132, Italy.

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http://dx.doi.org/10.3748/wjg.v25.i31.4343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710182PMC
August 2019

Epidemiology of primary biliary cholangitis in Italy: Evidence from a real-world database.

Dig Liver Dis 2019 05 17;51(5):724-729. Epub 2018 Nov 17.

Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Viale del Policlinico 155, 00185, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.dld.2018.11.008DOI Listing
May 2019

Cholangiocarcinoma: State-of-the-art knowledge and challenges.

Liver Int 2019 05;39 Suppl 1:5-6

Institute of Pathology, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1111/liv.14101DOI Listing
May 2019

Neoplastic Transformation of the Peribiliary Stem Cell Niche in Cholangiocarcinoma Arisen in Primary Sclerosing Cholangitis.

Hepatology 2019 Feb 4;69(2):622-638. Epub 2019 Jan 4.

Department of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.1002/hep.30210DOI Listing
February 2019

[Inflammatory and neoplastic cholangiopathies.]

Recenti Prog Med 2018 Dec;109(12):595-599

Dipartimento di Medicina Interna e Specialità Mediche, Policlinico Umberto I, Sapienza Università di Roma.

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http://www.recentiprogressi.it/articoli.php?archivio=yes&
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http://dx.doi.org/10.1701/3082.30744DOI Listing
December 2018

The Secretin/Secretin Receptor Axis Modulates Ductular Reaction and Liver Fibrosis through Changes in Transforming Growth Factor-β1-Mediated Biliary Senescence.

Am J Pathol 2018 10 21;188(10):2264-2280. Epub 2018 Jul 21.

Department of Anatomical, Histological, Forensic Medicine and Orthopaedics Sciences, Sapienza, Rome, Italy; Department of Medicine, Sapienza, Rome, Italy; Eleonora Lorillard Spencer Cenci Foundation, Rome, Italy.

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http://dx.doi.org/10.1016/j.ajpath.2018.06.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168967PMC
October 2018

Contribution of Resident Stem Cells to Liver and Biliary Tree Regeneration in Human Diseases.

Int J Mol Sci 2018 Sep 25;19(10). Epub 2018 Sep 25.

Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Via Borelli 50, 00161 Rome, Italy.

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http://dx.doi.org/10.3390/ijms19102917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213374PMC
September 2018

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.

Gut 2018 08 4;67(8):1517-1524. Epub 2017 Aug 4.

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1136/gutjnl-2016-313598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797498PMC
August 2018

Cholangiocytes: Cell transplantation.

Biochim Biophys Acta Mol Basis Dis 2018 04 19;1864(4 Pt B):1516-1523. Epub 2017 Jul 19.

Department of Internal Medicine and Medical Specialties, Division of Gastroenterology, Sapienza University of Rome, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2017.07.016DOI Listing
April 2018

Hepatic Stem/Progenitor Cell Activation Differs between Primary Sclerosing and Primary Biliary Cholangitis.

Am J Pathol 2018 03 15;188(3):627-639. Epub 2017 Dec 15.

Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.1016/j.ajpath.2017.11.010DOI Listing
March 2018

The challenge of cholangiocarcinoma diagnosis: The turning point is in extracellular vesicles?

Authors:
Domenico Alvaro

Hepatology 2017 10 26;66(4):1029-1031. Epub 2017 Aug 26.

Division of Gastroenterology, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.1002/hep.29314DOI Listing
October 2017

Knockdown of Hepatic Gonadotropin-Releasing Hormone by Vivo-Morpholino Decreases Liver Fibrosis in Multidrug Resistance Gene 2 Knockout Mice by Down-Regulation of miR-200b.

Am J Pathol 2017 Jul 12;187(7):1551-1565. Epub 2017 May 12.

Department of Internal Medicine, Texas A&M Health Science Center, College of Medicine, Temple, Texas; Department of Research, Central Texas Veterans Health Care System, Temple, Texas; Baylor Scott & White Health Digestive Disease Research Center, Temple, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500827PMC
July 2017

Gallstones: Bad Company for the Steatotic Liver.

Authors:
Domenico Alvaro

Gastroenterology 2017 05 27;152(6):1284-1286. Epub 2017 Mar 27.

University Sapienza of Rome, Division of Gastroenterology, Department of Internal Medicine and Medical Specialties, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.03.020DOI Listing
May 2017

Human biliary tree stem/progenitor cells immunomodulation: Role of hepatocyte growth factor.

Hepatol Res 2017 Apr 16;47(5):465-479. Epub 2016 Aug 16.

Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.

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http://dx.doi.org/10.1111/hepr.12772DOI Listing
April 2017

Cholangiocarcinoma stem-like subset shapes tumor-initiating niche by educating associated macrophages.

J Hepatol 2017 01 1;66(1):102-115. Epub 2016 Sep 1.

Center for Autoimmune Liver Diseases, Humanitas Clinical and Research Center, Rozzano, Italy; Program for Autoimmune Liver Diseases, International Center for Digestive Health, Department of Medicine and Surgery, University of Milan-Bicocca, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522599PMC
January 2017

New insights in IBS-like disorders: Pandora's box has been opened; a review.

Gastroenterol Hepatol Bed Bench 2017 ;10(2):79-89

Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495893PMC
January 2017

Current Status on Cholangiocarcinoma and Gallbladder Cancer.

Liver Cancer 2016 Nov 29;6(1):59-65. Epub 2016 Nov 29.

Institute of Cancer Sciences, University of Manchester and Department of Medical Oncology, The Christie, Manchester, United Kingdom.

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http://dx.doi.org/10.1159/000449493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159725PMC
November 2016

Liver Capsule: Biliary Tree Stem Cell Subpopulations.

Hepatology 2016 08 15;64(2):644. Epub 2016 Apr 15.

Anatomical, Histological, Forensic Medicine and Orthopedic Sciences, Sapienza, University of Rome, Rome, Italy.

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http://dx.doi.org/10.1002/hep.28546DOI Listing
August 2016

Two-week Triple Therapy with either Standard or High-dose Esomeprazole for First-line H. pylori Eradication.

J Gastrointestin Liver Dis 2016 Jun;25(2):147-50

Gastroenterology and Digestive Endoscopy, Nuovo Regina Margherita Hospital, Rome, Italy.

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http://dx.doi.org/10.15403/jgld.2014.1121.252.2w3DOI Listing
June 2016

Stem/Progenitor Cell Niches Involved in Hepatic and Biliary Regeneration.

Stem Cells Int 2016 10;2016:3658013. Epub 2016 Jan 10.

Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Via Borelli 50, 00161 Rome, Italy.

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http://dx.doi.org/10.1155/2016/3658013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737003PMC
February 2016

Activation of biliary tree stem cells within peribiliary glands in primary sclerosing cholangitis.

J Hepatol 2015 Nov 25;63(5):1220-8. Epub 2015 Jun 25.

Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2015.06.018DOI Listing
November 2015

High-dose esomeprazole and amoxicillin dual therapy for first-line Helicobacter pylori eradication: a proof of concept study.

Ann Gastroenterol 2015 Oct-Dec;28(4):448-51

Department of Gastroenterology "Salvini" Hospital, Garbagnate, Milan (Germana de Nucci, Gianpiero Manes), Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585390PMC
October 2015

Profiles of cancer stem cell subpopulations in cholangiocarcinomas.

Am J Pathol 2015 Jun 17;185(6):1724-39. Epub 2015 Apr 17.

Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy; Eleonora Lorillard Spencer-Cenci Foundation, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2015.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450332PMC
June 2015

PTPN3 mutations and HBV may exert synergistic effects in the origin of the intrahepatic cholangiocarcinoma.

Gastroenterology 2014 Sep 27;147(3):719-20. Epub 2014 Jul 27.

Department of Medico-Surgical Sciences and Biotechnologies, Polo Pontino and Eleonora Lorillard Spencer-Cenci Foundation, Rome, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S00165085140085
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http://dx.doi.org/10.1053/j.gastro.2014.05.046DOI Listing
September 2014

Secretin stimulates biliary cell proliferation by regulating expression of microRNA 125b and microRNA let7a in mice.

Gastroenterology 2014 Jun 25;146(7):1795-808.e12. Epub 2014 Feb 25.

Research, Central Texas Veterans Health Care System, Temple, Texas; Scott & White Digestive Disease Research Center, Scott & White, Temple, Texas; Department of Medicine, Division of Gastroenterology, Texas A&M Health Science Center College of Medicine, Temple, Texas. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085140024
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http://dx.doi.org/10.1053/j.gastro.2014.02.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035389PMC
June 2014

Concise review: clinical programs of stem cell therapies for liver and pancreas.

Stem Cells 2013 Oct;31(10):2047-60

Diabetes Research Institute Miller School of Medicine, University of Miami, Miami, Florida, USA; Department of Histology Embryology and Applied Biology, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1002/stem.1457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812254PMC
October 2013

Cholangiocarcinoma: increasing burden of classifications.

Hepatobiliary Surg Nutr 2013 Oct;2(5):272-80

Department of Medico-Surgical Sciences and Biotechnologies, Polo Pontino, Rome, Italy; ; Eleonora Lorillard Spencer-Cenci Foundation, Rome, Italy.

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http://dx.doi.org/10.3978/j.issn.2304-3881.2013.10.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924690PMC
October 2013

Recent advances on the mechanisms regulating cholangiocyte proliferation and the significance of the neuroendocrine regulation of cholangiocyte pathophysiology.

Ann Transl Med 2013 Oct;1(3):27

1 Department of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences, University of Rome "Sapienza", Rome, Italy ; 2 Eleonora Lorillard Spencer-Cenci Foundation, Rome, Italy ; 3 Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy ; 4 Department of Health Science, University of Rome "Foro Italico", Italy ; 5 Department of Medico-Surgical Sciences and Biotechnologies, Polo Pontino, Sapienza, University of Rome "Sapienza", Rome, Italy.

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http://dx.doi.org/10.3978/j.issn.2305-5839.2012.10.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200672PMC
October 2013

Biliary tree stem cells, precursors to pancreatic committed progenitors: evidence for possible life-long pancreatic organogenesis.

Stem Cells 2013 Sep;31(9):1966-79

Department of Cell Biology and Physiology, Program in Molecular Biology and Biotechnology, Lineberger Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1002/stem.1460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796013PMC
September 2013

The fetal liver as cell source for the regenerative medicine of liver and pancreas.

Ann Transl Med 2013 Jul;1(2):13

1 Department of Medico-Surgical Sciences and Biotechnologies, Polo Pontino, 2 Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, 3 Department of Obstetrics and Gynecology, Sapienza University of Rome, Rome, Italy ; 4 Department of Health Sciences, University of Rome "Foro Italico", Rome, Italy ; 5 Eleonora Lorillard Spencer-Cenci Foundation, Rome, Italy.

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http://dx.doi.org/10.3978/j.issn.2305-5839.2012.10.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200630PMC
July 2013

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

Nat Genet 2013 Jun 21;45(6):670-5. Epub 2013 Apr 21.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://petercroucher.com/wp-content/uploads/2013/10/51_Natur
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http://www.nature.com/doifinder/10.1038/ng.2616
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http://dx.doi.org/10.1038/ng.2616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667736PMC
June 2013

Expression of vascular endothelial growth factors and their receptors by hepatic progenitor cells in human liver diseases.

Hepatobiliary Surg Nutr 2013 Apr;2(2):68-77

Department of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences, University of Rome "Sapienza", Rome, Italy;

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http://www.thehbsn.org/article/view/1170
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http://dx.doi.org/10.3978/j.issn.2304-3881.2012.10.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924658PMC
April 2013

Hepatic progenitor cells activation, fibrosis, and adipokines production in pediatric nonalcoholic fatty liver disease.

Hepatology 2012 Dec;56(6):2142-53

Unit of Liver Research, Bambino Gesù Children's Hospital, Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.

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http://dx.doi.org/10.1002/hep.25742DOI Listing
December 2012

The prognosis of perihilar cholangiocarcinoma after radical treatments.

Hepatology 2012 Sep;56(3):800-2

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http://dx.doi.org/10.1002/hep.25808DOI Listing
September 2012

Multiple cells of origin in cholangiocarcinoma underlie biological, epidemiological and clinical heterogeneity.

World J Gastrointest Oncol 2012 May;4(5):94-102

Vincenzo Cardinale, Domenico Alvaro, Department of Medico-Surgical Sciences and Biotechnologies, Polo Pontino, Sapienza University of Rome, 00137 Rome, Italy.

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http://www.wjgnet.com/1948-5204/full/v4/i5/94.htm
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http://dx.doi.org/10.4251/wjgo.v4.i5.94DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360107PMC
May 2012

Progranulin and cholangiocarcinoma: another bad boy on the block!

Authors:
Domenico Alvaro

Gut 2012 Feb 7;61(2):170-1. Epub 2011 Nov 7.

University Sapienza of Rome, Division of Gastroenterology, Department of Medico-Surgical Sciences and Biotechnologies, Fondazione Eleonora Lorillard Spencer Cenci, Rome, Italy.

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http://dx.doi.org/10.1136/gutjnl-2011-301518DOI Listing
February 2012

The biliary tree--a reservoir of multipotent stem cells.

Nat Rev Gastroenterol Hepatol 2012 02 28;9(4):231-40. Epub 2012 Feb 28.

Division of Gastroenterology, Department of Medico-Surgical Sciences and Biotechnology, Fondazione Eleonora Lorillard Spencer Cenci, Polo Pontino, Corso della Repubblica 79, 04100 Latina, Italy.

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http://dx.doi.org/10.1038/nrgastro.2012.23DOI Listing
February 2012

Multipotent stem/progenitor cells in human biliary tree give rise to hepatocytes, cholangiocytes, and pancreatic islets.

Hepatology 2011 Dec;54(6):2159-72

Department of Cell and Molecular Physiology, Biomedical Engineering, Program in Molecular Biology and Biotechnology, UNC School of Medicine, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1002/hep.24590DOI Listing
December 2011

Human hepatic stem cell and maturational liver lineage biology.

Hepatology 2011 Mar;53(3):1035-45

Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

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http://doi.wiley.com/10.1002/hep.24157
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http://dx.doi.org/10.1002/hep.24157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066046PMC
March 2011

Multipotent stem cells in the biliary tree.

Ital J Anat Embryol 2010 ;115(1-2):85-90

Division of Gastroenterology, Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy.

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January 2011

Lineage restriction of human hepatic stem cells to mature fates is made efficient by tissue-specific biomatrix scaffolds.

Hepatology 2011 Jan 13;53(1):293-305. Epub 2010 Dec 13.

Department of Cell and Molecular Physiology and Program in Molecular Biology and Biotechnology, UNC School of Medicine, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1002/hep.24012DOI Listing
January 2011

Ascofuranone: a possible therapeutic tool for autosomal dominant polycystic kidney disease?

Mol Cancer Ther 2010 Nov 26;9(11):3100; author reply 3101. Epub 2010 Oct 26.

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http://dx.doi.org/10.1158/1535-7163.MCT-10-0741DOI Listing
November 2010

Intra-hepatic and extra-hepatic cholangiocarcinoma: New insight into epidemiology and risk factors.

World J Gastrointest Oncol 2010 Nov;2(11):407-16

Vincenzo Cardinale, Rossella Semeraro, Alessia Torrice, Manuela Gatto, Cristina Napoli, Maria Consiglia Bragazzi, Raffaele Gentile, Domenico Alvaro, Dipartimento di Scienze e Biotecnologie Medico-Chirurgiche, Sapienza University of Rome, 00185 Rome, Italy.

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http://dx.doi.org/10.4251/wjgo.v2.i11.407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000454PMC
November 2010

Atorvastatin-induced prolonged cholestasis with bile duct damage.

Clin Drug Investig 2010 ;30(3):205-9

Division of Gastroenterology, Department of Clinical Medicine, University of Rome 'Sapienza', Rome, Italy.

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http://dx.doi.org/10.2165/11531660-000000000-00000DOI Listing
May 2010

Cholangiocarcinoma: update and future perspectives.

Dig Liver Dis 2010 Apr 22;42(4):253-60. Epub 2010 Jan 22.

Department of Clinical Medicine, Division of Gastroenterology, University of Rome Sapienza, Polo Pontino, R. Rosselini 51, Rome, Italy.

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http://dx.doi.org/10.1016/j.dld.2009.12.008DOI Listing
April 2010

Recent advances in the regulation of cholangiocyte proliferation and function during extrahepatic cholestasis.

Dig Liver Dis 2010 Apr 13;42(4):245-52. Epub 2010 Feb 13.

Digestive Disease Research Center, Scott & White, Texas A&M Health Science Center, 702 SW H.K. Dodgen Loop, Temple, TX 76504, USA.

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http://dx.doi.org/10.1016/j.dld.2010.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836402PMC
April 2010

New insights on cholangiocarcinoma.

World J Gastrointest Oncol 2010 Mar;2(3):136-45

Manuela Gatto, Domenico Alvaro, Division of Gastroenterology, Department of Clinical Medicine, University of Rome, "Sapienza", Polo Pontino, via R. Rossellini 51, 00137 Rome, Italy.

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http://www.wjgnet.com/1948-5204/full/v2/i3/136.htm
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http://dx.doi.org/10.4251/wjgo.v2.i3.136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999173PMC
March 2010