Domenico Accili

Domenico Accili

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Domenico Accili

Publications by authors named "Domenico Accili"

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Identification of as a human diabetes susceptibility gene with a role in β cell insulin secretion.

Proc Natl Acad Sci U S A 2019 Oct 16;116(40):20033-20042. Epub 2019 Sep 16.

Department of Medicine, Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, NY 10032;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1904311116
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http://dx.doi.org/10.1073/pnas.1904311116DOI Listing
October 2019

Altered Central Nutrient Sensing in Male Mice Lacking Insulin Receptors in Glut4-Expressing Neurons.

Endocrinology 2019 Sep;160(9):2038-2048

Department of Medicine and Berrie Diabetes Center, Columbia University College of Physicians & Surgeons, New York, New York.

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https://academic.oup.com/endo/advance-article/doi/10.1210/en
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http://dx.doi.org/10.1210/en.2019-00341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691683PMC
September 2019

A fluorescent reporter assay of differential gene expression response to insulin in hepatocytes.

Am J Physiol Cell Physiol 2019 Jul 15;317(1):C143-C151. Epub 2019 May 15.

Department of Medicine (Endocrinology), Columbia University , New York, New York.

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https://www.physiology.org/doi/10.1152/ajpcell.00504.2018
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http://dx.doi.org/10.1152/ajpcell.00504.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689749PMC
July 2019

Identification of Insulin-Responsive Transcription Factors That Regulate Glucose Production by Hepatocytes.

Diabetes 2019 Jun 1;68(6):1156-1167. Epub 2019 Apr 1.

Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db18
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http://dx.doi.org/10.2337/db18-1236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610019PMC
June 2019

Reprogramming Cells to Make Insulin.

J Endocr Soc 2019 Jun 24;3(6):1214-1226. Epub 2019 Apr 24.

Department of Medicine (Endocrinology), Columbia University, New York, New York.

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http://dx.doi.org/10.1210/js.2019-00040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546342PMC
June 2019

Induction of α cell-restricted Gc in dedifferentiating β cells contributes to stress-induced β-cell dysfunction.

JCI Insight 2019 May 23;5. Epub 2019 May 23.

Department of Medicine and Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York, USA.

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http://dx.doi.org/10.1172/jci.insight.128351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629129PMC
May 2019

microRNA-205-5p is a modulator of insulin sensitivity that inhibits FOXO function.

Mol Metab 2018 11 11;17:49-60. Epub 2018 Aug 11.

Naomi Berrie Diabetes Center and Departments of Medicine, Columbia University, New York, 10032, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22128778183075
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http://dx.doi.org/10.1016/j.molmet.2018.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197154PMC
November 2018

Insulin Action Research and the Future of Diabetes Treatment: The 2017 Banting Medal for Scientific Achievement Lecture.

Authors:
Domenico Accili

Diabetes 2018 09;67(9):1701-1709

Naomi Berrie Diabetes Center and Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY

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http://dx.doi.org/10.2337/dbi18-0025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110318PMC
September 2018

Distinct roles of systemic and local actions of insulin on pancreatic β-cells.

Metabolism 2018 05 7;82:100-110. Epub 2018 Jan 7.

Department of Medical Physiology, Chiba University, Graduate School of Medicine, Chiba 260-8670, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2017.12.017DOI Listing
May 2018

Biochemical and cellular properties of insulin receptor signalling.

Nat Rev Mol Cell Biol 2018 Jan 4;19(1):31-44. Epub 2017 Oct 4.

Columbia University College of Physicians & Surgeons, Department of Medicine, New York, New York 10032, USA.

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http://dx.doi.org/10.1038/nrm.2017.89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894887PMC
January 2018

Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling.

Cell 2017 Nov 19;171(4):824-835.e18. Epub 2017 Oct 19.

Naomi Berrie Diabetes Center, Columbia University, New York, NY 10032, USA; Department of Medicine, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.09.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687849PMC
November 2017

Alain Ktorza, PhD.

Diabetes Obes Metab 2017 09;19 Suppl 1

Department of Medicine, Endocrinology & Metabolism Service, Hadassah Medical Centre, Hebrew University of Jerusalem, Jerusalem, Israel.

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http://dx.doi.org/10.1111/dom.13036DOI Listing
September 2017

Pair Feeding, but Not Insulin, Phloridzin, or Rosiglitazone Treatment, Curtails Markers of β-Cell Dedifferentiation in Mice.

Diabetes 2017 08 15;66(8):2092-2101. Epub 2017 May 15.

Department of Medicine and Naomi Berrie Diabetes Center, Columbia University, New York, New York

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db16
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http://dx.doi.org/10.2337/db16-1213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521857PMC
August 2017

Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice.

Nat Commun 2016 08 30;7:12631. Epub 2016 Aug 30.

Naomi Berrie Diabetes Center and Department of Medicine, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1038/ncomms12631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013715PMC
August 2016

Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in Mice.

Arterioscler Thromb Vasc Biol 2016 07 19;36(7):1328-37. Epub 2016 May 19.

From the Division of Molecular Medicine, Department of Medicine (M.W., P.F., A.E.B., M.M.M., V.N., S.A., C.L.W., A.R.T.), Naomi Berrie Diabetes Center (K.T., D.A.), and Department of Pathology, Obstetrics, and Gynaecology (I.W.T., J.K.), Columbia University, New York, NY; Section on Molecular Genetics, Department of Pediatrics, University Medical Center Groningen, Groningen, The Netherlands (M.W.); Department of Diabetes, Endocrinology, and Metabolism, Medical Hospital of Tokyo Medical and Dental University, Tokyo, Japan (K.T.); and Section on Molecular Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC (J.S.P.).

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http://dx.doi.org/10.1161/ATVBAHA.115.306670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919153PMC
July 2016

FoxO1 Deacetylation Decreases Fatty Acid Oxidation in β-Cells and Sustains Insulin Secretion in Diabetes.

J Biol Chem 2016 May 16;291(19):10162-72. Epub 2016 Mar 16.

From the Naomi Berrie Diabetes Center, Department of Medicine, Columbia University, New York, New York 10032,

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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.705608
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http://dx.doi.org/10.1074/jbc.M115.705608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858967PMC
May 2016

Altered Plasma Profile of Antioxidant Proteins as an Early Correlate of Pancreatic β Cell Dysfunction.

J Biol Chem 2016 Apr 25;291(18):9648-56. Epub 2016 Feb 25.

From the Department of Medicine and Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York 10032 and

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http://dx.doi.org/10.1074/jbc.M115.702183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850302PMC
April 2016

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes.

J Clin Endocrinol Metab 2016 Mar 29;101(3):1044-54. Epub 2015 Dec 29.

Departments of Medicine (F.C., R.B., J.Y.K.-M., D.A.) and Surgery (Y.O., P.R.S., L.E.R.), Columbia University College of Physicians and Surgeons, New York, New York 10032; Department of Clinical and Experimental Medicine (F.C.), Università Politecnica delle Marche, Ancona, Italy; and Department of Clinical and Experimental Medicine (M.M., L.M., M.S., P.M.), Islet Cell Laboratory, University of Pisa, 56100 Pisa, Italy.

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http://dx.doi.org/10.1210/jc.2015-2860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803182PMC
March 2016

Hypoglycemia Secondary to Sulfonylurea Ingestion in a Patient with End Stage Renal Disease: Results from a 72-Hour Fast.

Case Rep Endocrinol 2015 17;2015:742781. Epub 2015 Nov 17.

Division of Endocrinology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

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http://dx.doi.org/10.1155/2015/742781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664785PMC
December 2015

Gpr17 in AgRP Neurons Regulates Feeding and Sensitivity to Insulin and Leptin.

Diabetes 2015 Nov 15;64(11):3670-9. Epub 2015 Jul 15.

Naomi Berrie Diabetes Center and Department of Medicine, Columbia University Medical Center, New York, NY

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http://dx.doi.org/10.2337/db15-0390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613971PMC
November 2015

The new biology of diabetes.

Diabetologia 2015 Nov 7;58(11):2459-68. Epub 2015 Aug 7.

Department of Medicine and Naomi Berrie Diabetes Center, Columbia University Medical Center, 1150 St Nicholas Av., New York, NY, 10032, USA.

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http://dx.doi.org/10.1007/s00125-015-3722-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591190PMC
November 2015

Erratum to: The new biology of diabetes.

Diabetologia 2015 Nov;58(11):2683

Department of Medicine and Naomi Berrie Diabetes Center, Columbia University Medical Center, 1150 St Nicholas Av., New York, NY, 10032, USA.

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http://dx.doi.org/10.1007/s00125-015-3758-6DOI Listing
November 2015

Legacy Effect of Foxo1 in Pancreatic Endocrine Progenitors on Adult β-Cell Mass and Function.

Diabetes 2015 Aug 17;64(8):2868-79. Epub 2015 Mar 17.

Department of Medicine and Naomi Berrie Diabetes Center, Columbia University, New York, NY

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http://dx.doi.org/10.2337/db14-1696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512230PMC
August 2015

Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions.

Cell Rep 2015 Jun 11;11(11):1797-808. Epub 2015 Jun 11.

Naomi Berrie Diabetes Center and Department of Medicine, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.05.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481188PMC
June 2015

Pathogenesis of selective insulin resistance in isolated hepatocytes.

J Biol Chem 2015 May 14;290(22):13972-80. Epub 2015 Apr 14.

From the Department of Medicine, Columbia University, New York, New York 10032 and

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http://dx.doi.org/10.1074/jbc.M115.638197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447970PMC
May 2015

Ceci n'est pas science.

Authors:
Domenico Accili

Cell Metab 2015 Apr;21(4):503-4

Columbia University Medical Center and Berrie Diabetes Center, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.03.011DOI Listing
April 2015

Anorexia and impaired glucose metabolism in mice with hypothalamic ablation of Glut4 neurons.

Diabetes 2015 Feb 3;64(2):405-17. Epub 2014 Sep 3.

Department of Medicine and Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, NY

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http://dx.doi.org/10.2337/db14-0752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303970PMC
February 2015

Glut4 expression defines an insulin-sensitive hypothalamic neuronal population.

Mol Metab 2014 Jul 19;3(4):452-9. Epub 2014 Apr 19.

Department of Medicine and Berrie Diabetes Center, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.molmet.2014.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060214PMC
July 2014

FOXO1 inhibition yields functional insulin-producing cells in human gut organoid cultures.

Nat Commun 2014 Jun 30;5:4242. Epub 2014 Jun 30.

Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

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http://dx.doi.org/10.1038/ncomms5242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083475PMC
June 2014

Preserved energy balance in mice lacking FoxO1 in neurons of Nkx2.1 lineage reveals functional heterogeneity of FoxO1 signaling within the hypothalamus.

Diabetes 2014 May 31;63(5):1572-82. Epub 2014 Jan 31.

Berrie Diabetes Center, Department of Medicine, College of Physicians & Surgeons, Columbia University, New York, NY.

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http://dx.doi.org/10.2337/db13-0651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994959PMC
May 2014

A differential dielectric affinity glucose sensor.

Lab Chip 2014 Jan 13;14(2):294-301. Epub 2013 Nov 13.

Department of Mechanical Engineering, Columbia University, New York, NY 10027, USA.

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http://dx.doi.org/10.1039/c3lc51026cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893139PMC
January 2014

Human insulin resistance is associated with increased plasma levels of 12α-hydroxylated bile acids.

Diabetes 2013 Dec 24;62(12):4184-91. Epub 2013 Jul 24.

Department of Medicine, Columbia University, New York, New York.

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http://dx.doi.org/10.2337/db13-0639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837033PMC
December 2013

Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability.

Nat Med 2013 Aug 7;19(8):1054-60. Epub 2013 Jul 7.

Department of Medicine, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1038/nm.3259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737382PMC
August 2013

Liver sinusoidal endothelial cells link hyperinsulinemia to hepatic insulin resistance.

Diabetes 2013 May 24;62(5):1478-89. Epub 2013 Jan 24.

Naomi Berrie Diabetes Center and Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.2337/db12-1296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636600PMC
May 2013

Application of combined omics platforms to accelerate biomedical discovery in diabesity.

Ann N Y Acad Sci 2013 May 9;1287:1-16. Epub 2013 May 9.

Department of Medicine, Stable Isotope and Metabolomics Core Facility, Albert Einstein College of Medicine Diabetes Center, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1111/nyas.12116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709136PMC
May 2013

Continuous monitoring of glucose in subcutaneous tissue using microfabricated differential affinity sensors.

J Diabetes Sci Technol 2012 Nov 1;6(6):1436-44. Epub 2012 Nov 1.

Department of Mechanical Engineering, Columbia University, New York, NY 10027, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570886PMC
http://dx.doi.org/10.1177/193229681200600625DOI Listing
November 2012

InsR/FoxO1 signaling curtails hypothalamic POMC neuron number.

PLoS One 2012 2;7(2):e31487. Epub 2012 Feb 2.

Naomi Berrie Diabetes Center, Department of Medicine, Columbia University Medical Center, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031487PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271107PMC
September 2012

Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ.

Cell 2012 Aug;150(3):620-32

Naomi Berrie Diabetes Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00928674120078
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http://dx.doi.org/10.1016/j.cell.2012.06.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413172PMC
August 2012

Increased atherosclerosis and endothelial dysfunction in mice bearing constitutively deacetylated alleles of Foxo1 gene.

J Biol Chem 2012 Apr 2;287(17):13944-51. Epub 2012 Mar 2.

Berrie Diabetes Center and Department of Medicine, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1074/jbc.M111.332767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340149PMC
April 2012

Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice.

J Clin Invest 2012 Apr 19;122(4):1262-70. Epub 2012 Mar 19.

Department of Medicine, Columbia University, New York, New York 10032, USA.

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http://www.jci.org/articles/view/61919
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http://dx.doi.org/10.1172/JCI61919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314476PMC
April 2012

Generation of functional insulin-producing cells in the gut by Foxo1 ablation.

Nat Genet 2012 Mar 11;44(4):406-12, S1. Epub 2012 Mar 11.

Naomi Berrie Diabetes Center, Columbia University Medical Center, New York, New York, USA.

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http://dx.doi.org/10.1038/ng.2215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315609PMC
March 2012

Inactivation of arf-bp1 induces p53 activation and diabetic phenotypes in mice.

J Biol Chem 2012 Feb 20;287(7):5102-11. Epub 2011 Dec 20.

Institute for Cancer Genetics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

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http://dx.doi.org/10.1074/jbc.M111.322867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281631PMC
February 2012

FGF21 and the second coming of PPARγ.

Cell 2012 Feb;148(3):397-8

Department of Medicine and Berrie Diabetes Center, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.cell.2012.01.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357185PMC
February 2012

Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia.

Cell Metab 2012 Jan 22;15(1):65-74. Epub 2011 Dec 22.

Department of Medicine, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.cmet.2011.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253887PMC
January 2012

Homozygosity for an allele encoding deacetylated FoxO1 protects macrophages from cholesterol-induced inflammation without increasing apoptosis.

Arterioscler Thromb Vasc Biol 2011 Dec 22;31(12):2920-8. Epub 2011 Sep 22.

Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1161/ATVBAHA.110.219477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220790PMC
December 2011

Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation.

Cell Metab 2011 Dec 10;14(6):758-67. Epub 2011 Nov 10.

Naomi Berrie Diabetes Center, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.cmet.2011.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237922PMC
December 2011

FoxO feedback control of basal IRS-2 expression in pancreatic β-cells is distinct from that in hepatocytes.

Diabetes 2011 Nov 20;60(11):2883-91. Epub 2011 Sep 20.

Kovler Diabetes Center, Department of Medicine, University of Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.2337/db11-0340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198101PMC
November 2011

An unSIRTain role in longevity.

Nat Med 2011 Nov 7;17(11):1350-1. Epub 2011 Nov 7.

Berrie Diabetes Center & Department of Medicine, Columbia University College of Physicians & Surgeons, New York, NY, USA.

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http://dx.doi.org/10.1038/nm1111-1350DOI Listing
November 2011

Hormonal regulation of hepatic glucose production in health and disease.

Cell Metab 2011 Jul;14(1):9-19

Merck Research Laboratories, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1016/j.cmet.2011.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131084PMC
July 2011

Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor.

Proc Natl Acad Sci U S A 2011 Jun 6;108(25):10162-7. Epub 2011 Jun 6.

Biochemistry Department, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1019268108
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http://dx.doi.org/10.1073/pnas.1019268108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121842PMC
June 2011

Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor.

Proc Natl Acad Sci U S A 2011 Jun 6;108(25):10162-7. Epub 2011 Jun 6.

Biochemistry Department, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1019268108
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http://dx.doi.org/10.1073/pnas.1019268108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121842PMC
June 2011

Respective contributions of maternal insulin resistance and diet to metabolic and hypothalamic phenotypes of progeny.

Obesity (Silver Spring) 2011 Mar 14;19(3):492-9. Epub 2010 Oct 14.

Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1038/oby.2010.245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234171PMC
March 2011

Reconstitution of insulin action in muscle, white adipose tissue, and brain of insulin receptor knock-out mice fails to rescue diabetes.

J Biol Chem 2011 Mar 14;286(11):9797-804. Epub 2011 Jan 14.

Department of Medicine, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1074/jbc.M110.210807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059034PMC
March 2011

Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues.

Diabetes 2011 Mar 24;60(3):700-9. Epub 2011 Jan 24.

Department of Medicine, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.2337/db10-1056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046830PMC
March 2011

Cell biology. Selective insulin sensitizers.

Science 2011 Mar;331(6024):1529-31

Department of Medicine and Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

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http://dx.doi.org/10.1126/science.1204504DOI Listing
March 2011

n-3 Fatty acids decrease arterial low-density lipoprotein cholesterol delivery and lipoprotein lipase levels in insulin-resistant mice.

Arterioscler Thromb Vasc Biol 2010 Dec 7;30(12):2510-7. Epub 2010 Oct 7.

Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1161/ATVBAHA.110.215848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107680PMC
December 2010

Genetic analysis of type-1 insulin-like growth factor receptor signaling through insulin receptor substrate-1 and -2 in pancreatic beta cells.

J Biol Chem 2010 Dec 14;285(52):41044-50. Epub 2010 Oct 14.

Department of Genetics and Development, College of Physicians & Surgeons of Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1074/jbc.M110.144790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003403PMC
December 2010

FoxOs function synergistically to promote glucose production.

J Biol Chem 2010 Nov 29;285(46):35245-8. Epub 2010 Sep 29.

Department of Medicine, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1074/jbc.C110.175851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975147PMC
November 2010

Uncoupling of acetylation from phosphorylation regulates FoxO1 function independent of its subcellular localization.

J Biol Chem 2010 Aug 2;285(35):27396-401. Epub 2010 Jun 2.

Department of Medicine, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1074/jbc.M110.140228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930737PMC
August 2010

Hepatic FoxO1 ablation exacerbates lipid abnormalities during hyperglycemia.

J Biol Chem 2010 Aug 23;285(35):26861-8. Epub 2010 Jun 23.

Department of Medicine, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1074/jbc.M110.134023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930685PMC
August 2010

The effect of insulin signaling on female reproductive function independent of adiposity and hyperglycemia.

Endocrinology 2010 Apr 22;151(4):1863-71. Epub 2010 Feb 22.

Columbia University Medical Center, Russ Berrie Medical Pavilion, Room 608, 1150 St. Nicholas Avenue, New York, New York 10032, USA.

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http://dx.doi.org/10.1210/en.2009-0788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851187PMC
April 2010

Leptin therapy for type 1 diabetes gains traction.

Nat Med 2010 Apr;16(4):380

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http://dx.doi.org/10.1038/nm0410-380DOI Listing
April 2010

Hypoxia converts the myogenic action of insulin-like growth factors into mitogenic action by differentially regulating multiple signaling pathways.

Proc Natl Acad Sci U S A 2010 Mar 15;107(13):5857-62. Epub 2010 Mar 15.

Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1073/pnas.0909570107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851893PMC
March 2010

The impact of macrophage insulin resistance on advanced atherosclerotic plaque progression.

Circ Res 2010 Jan;106(1):58-67

Department of Medicine, Columbia University, 630 West 168th St, New York, NY 10032, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.109.208488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805467PMC
January 2010

Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells.

Diabetes 2009 Oct 7;58(10):2344-54. Epub 2009 Jul 7.

Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA.

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http://dx.doi.org/10.2337/db09-0167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750207PMC
October 2009

Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1.

Mol Cell Biol 2009 Aug 8;29(16):4417-30. Epub 2009 Jun 8.

Department of Medicine, College of Physicians & Surgeons of Columbia University, New York, New York 100321, USA.

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http://dx.doi.org/10.1128/MCB.01622-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725741PMC
August 2009

Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice.

J Clin Invest 2009 Apr 9;119(4):1029-41. Epub 2009 Mar 9.

Division of Molecular Medicine, Department of Medicine, Columbia University, 630 West 168th St., New York, New York 10032, USA.

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http://dx.doi.org/10.1172/JCI36523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662550PMC
April 2009

SirT1 gain of function increases energy efficiency and prevents diabetes in mice.

Cell Metab 2008 Oct;8(4):333-41

Naomi Berrie Diabetes Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.cmet.2008.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222897PMC
October 2008

The double life of Irs.

Cell Metab 2008 Jul;8(1):7-9

Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10027, USA.

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http://dx.doi.org/10.1016/j.cmet.2008.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712626PMC
July 2008

The impact of insulin resistance on macrophage death pathways in advanced atherosclerosis.

Novartis Found Symp 2007 ;286:99-109; discussion 109-12, 162-3, 196-203

Department of Medicine, 630 West 168th Street, Columbia University, New York, NY 10032, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613853PMC
April 2008

Mechanisms of disease: using genetically altered mice to study concepts of type 2 diabetes.

Nat Clin Pract Endocrinol Metab 2008 Mar 22;4(3):164-72. Epub 2008 Jan 22.

Department of Medicine, Mount Sinai School of Medicine, 1 Gustave L Levy Place, Atran AB4-36, Box 1055, New York, NY 10029-6574, USA.

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http://dx.doi.org/10.1038/ncpendmet0729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714226PMC
March 2008

Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver.

Cell Metab 2007 Sep;6(3):208-16

Naomi Berrie Diabetes Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.cmet.2007.08.006DOI Listing
September 2007