Publications by authors named "Dolors Serra"

62Publications

Dietary Options for Rodents in the Study of Obesity.

Nutrients 2020 Oct 22;12(11). Epub 2020 Oct 22.

Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, E-08028 Barcelona, Spain.

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http://dx.doi.org/10.3390/nu12113234DOI Listing
October 2020

Moderate SIRT1 overexpression protects against brown adipose tissue inflammation.

Mol Metab 2020 Oct 10;42:101097. Epub 2020 Oct 10.

Instituto de Investigaciones Biomédicas Alberto Sols (Centro Mixto CSIC-UAM), 28029 Madrid, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), 28029 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2020.101097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600394PMC
October 2020

An overview of nanomedicines for neuron targeting.

Nanomedicine (Lond) 2020 07 3;15(16):1617-1636. Epub 2020 Jul 3.

Department of Basic Sciences, Faculty of Medicine & Health Sciences, Universitat Internacional de Catalunya, 08195, Sant Cugat del Vallès, Spain.

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http://dx.doi.org/10.2217/nnm-2020-0088DOI Listing
July 2020

The role of epigenetics in the development of obesity.

Biochem Pharmacol 2020 07 10;177:113973. Epub 2020 Apr 10.

Regulation of Lipid Metabolism Laboratory, Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, E-08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, E-28029 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2020.113973DOI Listing
July 2020

Low-density lipoprotein receptor-related protein 1 deficiency in cardiomyocytes reduces susceptibility to insulin resistance and obesity.

Metabolism 2020 05 26;106:154191. Epub 2020 Feb 26.

Institute of Biochemical Research of Barcelona (IIBB)-Spanish National Research Council (CSIC), Barcelona, Spain; Lipids and Cardiovascular Pathology Group, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain; Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2020.154191DOI Listing
May 2020

Impact of Adaptive Thermogenesis in Mice on the Treatment of Obesity.

Cells 2020 01 28;9(2). Epub 2020 Jan 28.

Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, E-08028 Barcelona, Spain.

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http://dx.doi.org/10.3390/cells9020316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072509PMC
January 2020

Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth.

Elife 2019 12 23;8. Epub 2019 Dec 23.

Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Sant Cugat del Vallès, Spain.

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http://dx.doi.org/10.7554/eLife.51063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927751PMC
December 2019

Hypothalamic endocannabinoids inversely correlate with the development of diet-induced obesity in male and female mice.

J Lipid Res 2019 07 28;60(7):1260-1269. Epub 2019 May 28.

Basic Sciences Department, Faculty of Medicine and Health Sciences Universitat Internacional de Catalunya, 08195 Sant Cugat del Vallès, Spain

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http://www.jlr.org/lookup/doi/10.1194/jlr.M092742
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http://dx.doi.org/10.1194/jlr.M092742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602126PMC
July 2019

Corrigendum to "The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling" [Metab Clin Exp 85 (2018) 59-75].

Metabolism 2019 Jul 18;96:101-102. Epub 2019 Apr 18.

Pharmacology Unit, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Spain; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Barcelona, Spain; Institut de Recerca Sant Joan de Déu (IR-SJD), Esplugues de Llobregat, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2019.04.009DOI Listing
July 2019

Mechanisms of Impaired Brown Adipose Tissue Recruitment in Obesity.

Front Physiol 2019 13;10:94. Epub 2019 Feb 13.

Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain.

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http://dx.doi.org/10.3389/fphys.2019.00094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381290PMC
February 2019

CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity.

Mol Metab 2019 01 2;19:75-85. Epub 2018 Nov 2.

Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, 08195, Sant Cugat del Vallès, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, E-28029, Madrid, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22128778183093
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http://dx.doi.org/10.1016/j.molmet.2018.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323189PMC
January 2019

New approaches targeting brown adipose tissue transplantation as a therapy in obesity.

Biochem Pharmacol 2018 09 19;155:346-355. Epub 2018 Jul 19.

Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, E-08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, E-28029 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2018.07.022DOI Listing
September 2018

Targeting AgRP neurons to maintain energy balance: Lessons from animal models.

Biochem Pharmacol 2018 09 18;155:224-232. Epub 2018 Jul 18.

Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, E-08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, E-28029 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2018.07.008DOI Listing
September 2018

CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy.

Sci Rep 2018 05 3;8(1):6997. Epub 2018 May 3.

Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya (UIC), 08195, Sant Cugat del Vallès, Spain.

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http://dx.doi.org/10.1038/s41598-018-25485-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934389PMC
May 2018

The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling.

Metabolism 2018 08 9;85:59-75. Epub 2018 Mar 9.

Pharmacology Unit, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Spain; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Barcelona, Spain; Institut de Recerca Sant Joan de Déu (IR-SJD), Esplugues de Llobregat, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2018.03.005DOI Listing
August 2018

Ghrelin Causes a Decline in GABA Release by Reducing Fatty Acid Oxidation in Cortex.

Mol Neurobiol 2018 Sep 2;55(9):7216-7228. Epub 2018 Feb 2.

Department of Biochemistry and Physiology, Facultat de Farmàcia i Ciències de l'Alimentació and Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-30, E-08028, Barcelona, Spain.

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http://dx.doi.org/10.1007/s12035-018-0921-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096967PMC
September 2018

HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism.

Nat Commun 2017 11 24;8(1):1769. Epub 2017 Nov 24.

Department of Radiation Oncology, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.

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http://www.nature.com/articles/s41467-017-01965-8
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http://dx.doi.org/10.1038/s41467-017-01965-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701259PMC
November 2017

Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice.

Sci Rep 2017 11 22;7(1):16082. Epub 2017 Nov 22.

Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, E-08028, Barcelona, Spain.

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http://dx.doi.org/10.1038/s41598-017-16463-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700117PMC
November 2017

Hypothalamic Regulation of Liver and Muscle Nutrient Partitioning by Brain-Specific Carnitine Palmitoyltransferase 1C in Male Mice.

Endocrinology 2017 07;158(7):2226-2238

Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, 08195 Sant Cugat del Vallès, Barcelona, Spain.

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http://dx.doi.org/10.1210/en.2017-00151DOI Listing
July 2017

Brown Adipose Tissue Bioenergetics: A New Methodological Approach.

Adv Sci (Weinh) 2017 04 13;4(4):1600274. Epub 2017 Mar 13.

Department of Biochemistry and Physiology Institut de Biomedicina de la Universitat de Barcelona (IBUB) Universitat de Barcelona E-08028 Barcelona Spain.

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http://dx.doi.org/10.1002/advs.201600274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396156PMC
April 2017

(-)-UB006: A new fatty acid synthase inhibitor and cytotoxic agent without anorexic side effects.

Eur J Med Chem 2017 May 12;131:207-221. Epub 2017 Mar 12.

Department of Biochemistry and Physiology, Facultat de Farmàcia i Ciències de l'A limentació and Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, E-08028 Barcelona, Spain; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, E-28029 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.03.012DOI Listing
May 2017

Ceramides and mitochondrial fatty acid oxidation in obesity.

FASEB J 2017 04 21;31(4):1263-1272. Epub 2016 Dec 21.

Department of Biochemistry and Physiology, School of Pharmacy, Institut de Biomedicina, Universitat de Barcelona, Barcelona, Spain;

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http://dx.doi.org/10.1096/fj.201601156RDOI Listing
April 2017

Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes.

Biochim Biophys Acta 2016 12 26;1861(12 Pt A):1929-1941. Epub 2016 Sep 26.

Institute of Biomedicine Alberto Sols (CSIC/UAM), E-28029 Madrid, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2016.09.016DOI Listing
December 2016

Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+ breast cancer.

Histol Histopathol 2017 Jul 7;32(7):687-698. Epub 2016 Oct 7.

ProCURE (Program Against Cancer Therapeutic Resistance), Metabolism and Cancer Group, Catalan Institute of Oncology, Girona, Spain.

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http://dx.doi.org/10.14670/HH-11-830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784426PMC
July 2017

Fatty acid metabolism and the basis of brown adipose tissue function.

Adipocyte 2016 Apr-Jun;5(2):98-118. Epub 2015 Dec 10.

Department of Biochemistry and Molecular Biology, School of Pharmacy, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain; CIBER Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.

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http://dx.doi.org/10.1080/21623945.2015.1122857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916887PMC
July 2016

Carnitine palmitoyltransferase 1C: From cognition to cancer.

Prog Lipid Res 2016 Jan 18;61:134-48. Epub 2015 Dec 18.

CIBER Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Biochemistry and Molecular Biology, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, E-08028 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.plipres.2015.11.004DOI Listing
January 2016

Vitamin E reduces adipose tissue fibrosis, inflammation, and oxidative stress and improves metabolic profile in obesity.

Obesity (Silver Spring) 2015 Aug 6;23(8):1598-606. Epub 2015 Jul 6.

Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad CEU San Pablo, Madrid, Spain.

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http://dx.doi.org/10.1002/oby.21135DOI Listing
August 2015

Essential role of Nrf2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes.

Free Radic Biol Med 2015 Jul 1;84:263-278. Epub 2015 Apr 1.

Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), 28029 Madrid, Spain; Instituto de Investigación Sanitaria La Paz, 28029 Madrid, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, 28029 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2015.03.019DOI Listing
July 2015

Altered circadian rhythm and metabolic gene profile in rats subjected to advanced light phase shifts.

PLoS One 2015 2;10(4):e0122570. Epub 2015 Apr 2.

Department of Biochemistry and Molecular Biology, Facultat de Farmàcia, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122570PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383616PMC
April 2016

Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation.

Am J Physiol Endocrinol Metab 2015 May 24;308(9):E756-69. Epub 2015 Feb 24.

Department of Biochemistry and Molecular Biology, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, Barcelona, Spain; Institut de Biomedicina de la Universitat de Barcelona Fisiopatología de la Obesidad y la Nutrición, Instituto de Salud Carlos III, Madrid, Spain;

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http://ajpendo.physiology.org/content/ajpendo/308/9/E756.ful
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http://ajpendo.physiology.org/content/ajpendo/early/2015/02/
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http://ajpendo.physiology.org/lookup/doi/10.1152/ajpendo.003
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http://dx.doi.org/10.1152/ajpendo.00362.2014DOI Listing
May 2015

Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells.

Int J Cancer 2015 May 3;136(9):2078-90. Epub 2014 Nov 3.

Signaling Networks Program, Division of Oncology, Department of Medicine I, Medical University Vienna, Vienna, Austria; Comprehensive Cancer Center, Medical University Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/ijc.29261DOI Listing
May 2015

Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance.

Cell Rep 2014 Oct 2;9(1):366-377. Epub 2014 Oct 2.

Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, 15782 Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), 15706 Santiago de Compostela, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.08.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157160PMC
October 2014

Enhancing hepatic fatty acid oxidation as a strategy for reversing metabolic disorders programmed by maternal undernutrition during gestation.

Cell Physiol Biochem 2014 14;33(5):1498-515. Epub 2014 May 14.

Laboratory of Molecular Biology, Nutrition, and Biotechnology (Nutrigenomics), University of the Balearic Islands and CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Palma de Mallorca, Balearic Islands.

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http://dx.doi.org/10.1159/000358714DOI Listing
April 2015

Long-term increased carnitine palmitoyltransferase 1A expression in ventromedial hypotalamus causes hyperphagia and alters the hypothalamic lipidomic profile.

PLoS One 2014 12;9(5):e97195. Epub 2014 May 12.

Department of Biochemistry and Molecular Biology, Facultat de Farmàcia, Universitat de Barcelona and Institut de Biomedicina de la Universitat de Barcelona (IBUB) and CIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, Barcelona, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097195PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018328PMC
June 2015

Important role of ventromedial hypothalamic carnitine palmitoyltransferase-1a in the control of food intake.

Am J Physiol Endocrinol Metab 2013 Aug 4;305(3):E336-47. Epub 2013 Jun 4.

Department of Pediatrics, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1152/ajpendo.00168.2013DOI Listing
August 2013

Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity.

Chirality 2013 May;25(5):281-7

Department of Biochemistry and Molecular Biology, Facultat de Farmàcia, Universitat de Barcelona, E-08028 Barcelona, Spain.

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http://doi.wiley.com/10.1002/chir.22139
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http://dx.doi.org/10.1002/chir.22139DOI Listing
May 2013

Hypothalamic ceramide levels regulated by CPT1C mediate the orexigenic effect of ghrelin.

Diabetes 2013 Jul 14;62(7):2329-37. Epub 2013 Mar 14.

Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain.

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http://dx.doi.org/10.2337/db12-1451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712075PMC
July 2013

Mitochondrial fatty acid oxidation in obesity.

Antioxid Redox Signal 2013 Jul 5;19(3):269-84. Epub 2012 Oct 5.

Department of Biochemistry and Molecular Biology, Facultat de Farmàcia, Universitat de Barcelona, Institut de Biomedicina de la Universitat de Barcelona IBUB, Barcelona, Spain.

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http://dx.doi.org/10.1089/ars.2012.4875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691913PMC
July 2013

Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition.

J Biol Chem 2012 Jun 26;287(25):21224-32. Epub 2012 Apr 26.

From the Department of Basic Sciences, Facultat de Medicina i Ciències de la Salut, Universitat Internacional de Catalunya, E-08195 Sant Cugat del Vallès, Spain.

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http://dx.doi.org/10.1074/jbc.M111.337493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375544PMC
June 2012

Malonyl-CoA mediates leptin hypothalamic control of feeding independent of inhibition of CPT-1a.

Am J Physiol Regul Integr Comp Physiol 2011 Jul 20;301(1):R209-17. Epub 2011 Apr 20.

Department of Pediatrics, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1152/ajpregu.00092.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747894PMC
July 2011

Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation.

Hepatology 2011 Mar 11;53(3):821-32. Epub 2011 Feb 11.

Department of Biochemistry and Molecular Biology, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain.

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http://dx.doi.org/10.1002/hep.24140DOI Listing
March 2011

Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells.

J Lipid Res 2009 Sep 9;50(9):1789-99. Epub 2009 May 9.

Departments of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1194/jlr.M800535-JLR200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724792PMC
September 2009

CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity.

J Biol Chem 2008 Mar 11;283(11):6878-85. Epub 2008 Jan 11.

Molecular and Cellular Unit, School of Health Sciences, Universitat Internacional de Catalunya, Josep Trueta s/n, Sant Cugat del Vallés, Barcelona 08195, Spain.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M707965200
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http://dx.doi.org/10.1074/jbc.M707965200DOI Listing
March 2008

Definition by functional and structural analysis of two malonyl-CoA sites in carnitine palmitoyltransferase 1A.

J Biol Chem 2007 Jun 23;282(25):18212-24. Epub 2007 Apr 23.

Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), Cantoblanco, E-28049 Madrid, Spain.

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http://dx.doi.org/10.1074/jbc.M700885200DOI Listing
June 2007

CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistance.

Am J Physiol Endocrinol Metab 2007 Mar 24;292(3):E677-86. Epub 2006 Oct 24.

Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, Diagonal 643, E-08028, Spain.

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http://dx.doi.org/10.1152/ajpendo.00360.2006DOI Listing
March 2007

Mutagenesis of specific amino acids converts carnitine acetyltransferase into carnitine palmitoyltransferase.

Biochemistry 2006 May;45(19):6133-41

Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, E-08028 Spain.

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http://dx.doi.org/10.1021/bi0602664DOI Listing
May 2006

Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation.

Biochemistry 2006 Apr;45(14):4339-50

Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, E-08028 Barcelona, Spain.

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http://dx.doi.org/10.1021/bi052186qDOI Listing
April 2006

Alteration of the malonyl-CoA/carnitine palmitoyltransferase I interaction in the beta-cell impairs glucose-induced insulin secretion.

Diabetes 2005 Feb;54(2):462-71

Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, Diagonal 643, E-08028 Barcelona, Spain.

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http://dx.doi.org/10.2337/diabetes.54.2.462DOI Listing
February 2005

Redesign of carnitine acetyltransferase specificity by protein engineering.

J Biol Chem 2004 Aug 21;279(32):33899-908. Epub 2004 May 21.

Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, Diagonal 643, E-08028 Barcelona, Spain.

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http://dx.doi.org/10.1074/jbc.M402685200DOI Listing
August 2004

Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal.

Biochem J 2004 May;379(Pt 3):777-84

Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, E-08028 Barcelona, Spain.

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http://dx.doi.org/10.1042/BJ20031373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1224103PMC
May 2004

Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain.

J Biol Chem 2002 Mar 14;277(13):11473-80. Epub 2002 Jan 14.

Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, E-08028 Barcelona, Spain.

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http://dx.doi.org/10.1074/jbc.M111628200DOI Listing
March 2002