Publications by authors named "Do Ik Kwon"

6 Publications

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Dermoscopic findings of genital keratotic lesions: Bowenoid papulosis, seborrheic keratosis, and condyloma acuminatum.

Photodiagnosis Photodyn Ther 2021 Jul 19;36:102448. Epub 2021 Jul 19.

Department of Dermatology, Kosin University College of Medicine, Busan, South Korea. Electronic address:

Dermatologists often encounter keratotic or warty lesions in the genital area. Establishing a clear diagnosis may seem challenging, particularly when the differential diagnosis includes bowenoid papulosis, seborrheic keratosis, and condyloma acuminatum. This study aimed to compare the dermoscopic features of bowenoid papulosis (BP), seborrheic keratosis, and condyloma acuminatum in the genital area. All lesions histopathologically confirmed underwent clinical assessment and dermoscopic observation. Dermoscopically, glomerular vessels were predominant in bowenoid papulosis, whereas seborrheic keratosis was the least vascular-patterned disease. Most cases of bowenoid papulosis presented mucosal pigmentation and classified as "flat". Seborrheic keratosis had a pigmented, cerebriform appearance. Condyloma acuminatum was characterised by a finger-like appearance, highly vascular-patterned features surrounded by whitish halos. Dermoscopic findings can be useful for differentiating the entity of genital keratotic lesions ahead of an invasive method. When dermoscopic features favor BP, different from genital warts, it should be removed completely but conservatively.
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http://dx.doi.org/10.1016/j.pdpdt.2021.102448DOI Listing
July 2021

Clinical characteristics and long-term outcome of 223 patients with mycosis fungoides at a single tertiary center in Korea: A 29-year review.

J Am Acad Dermatol 2021 Jun 29. Epub 2021 Jun 29.

Department of Dermatology, Kosin University College of Medicine, Busan, Korea. Electronic address:

Background: Data regarding Asian patients with mycosis fungoides (MF) are limited.

Objective: We aimed to investigate the clinical profile and long-term outcomes of patients with MF in Korea.

Methods: A retrospective review of 223 patients with MF who were followed up for more than 6 months or died of MF within 6 months of diagnosis was performed.

Results: Approximately 96.4% and 3.6% of the patients had an early stage and advanced stage, respectively. The mean age at diagnosis was 44.8 years. The mean duration of symptoms before diagnosis was 47.0 months. Various subtypes were noted, including mycosis fungoides palmaris et plantaris (21.5%), folliculotropic (8.5%), pityriasis lichenoides-like (6.7%), ichthyosiform (4.0%), lichenoid purpura-like (2.7%), and hypopigmented (2.2%) MF. Juvenile patients accounted for 16.6%. The higher the skin T stage, the poorer the response to treatment. The 10-year overall survival was 96.8% in early-stage patients and 25.0% in advanced-stage patients. General prognosis was favorable, while recurrence and subtype switching were seen in 29.4% and 2.7% of patients, respectively.

Limitations: Our patients may not represent all Korean patients with MF.

Conclusion: MF in Korea has a high proportion of variants, a younger age at onset, and favorable prognosis. A high index of suspicion and skin biopsy are needed for early diagnosis.
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http://dx.doi.org/10.1016/j.jaad.2021.06.860DOI Listing
June 2021

Usefulness of dermoscopy in identifying amyloid purpura.

J Dermatol 2021 Jun 20;48(6):e260-e262. Epub 2021 Apr 20.

Department of Dermatology, Kosin University College of Medicine, Busan, South Korea.

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http://dx.doi.org/10.1111/1346-8138.15854DOI Listing
June 2021

Mycobacterium marinum Infection Spreading in a "Birds in Flocks" Pattern: All Caseating Granuloma is Not Tuberculosis.

Acta Derm Venereol 2020 Jul 2;100(14):adv00200. Epub 2020 Jul 2.

Department of Dermatology, Kosin University College of Medicine, 262 Gamcheon-ro, Seo-gu, Busan, 602-702, Korea.

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http://dx.doi.org/10.2340/00015555-3538DOI Listing
July 2020

The effectiveness of high-dose ultraviolet A-1 phototherapy for acute exacerbation of atopic dermatitis in Asians.

Photodermatol Photoimmunol Photomed 2020 Jul 18;36(4):263-270. Epub 2020 Mar 18.

Department of Dermatology, Kosin University College of Medicine, Busan, South Korea.

Background/purpose: Atopic dermatitis (AD) is an inflammatory skin disease characterized by a chronic course of exacerbations and remissions. High-dose ultraviolet A-1 (UVA-1) phototherapy has been effective in the treatment of acute exacerbations of AD. However, there have been no case studies in Asian patients to date. We investigated the effectiveness of high-dose UVA-1 phototherapy for treating acute exacerbation of AD in Asian patients.

Method: This study included 16 patients with acute exacerbation of AD. High-dose (100 J/cm ) regimens of UVA-1 therapy were employed. Therapeutic effectiveness was assessed based on the findings of clinical examinations and scoring of AD (SCORAD) index before treatment and after the 5th and 10th sessions of treatment. Additionally, side effects and recurrence during follow-up were retrospectively evaluated.

Results: The patients were between 7 and 50 years of age, with a mean age of 25.8 years. The SCORAD index was between 41 and 89.5, with a mean score of 64.9. Among the 16 patients, two patients discontinued treatment due to the aggravation of erythema and pruritus. Of the 14 patients who completed the 10 sessions of high-dose UVA-1 phototherapy, nine patients (64.3%) showed complete remission and five patients (35.7%) showed partial remission. The mean SCORAD index reduced from 64.9 (before treatment) to 23.3 (after the 10th session of treatment).

Conclusion: This is the first case study of high-dose UVA-1 phototherapy for acute exacerbation of AD in Asian patients, suggesting that high-dose UVA-1 phototherapy can be a well-tolerated and effective treatment for acute exacerbated AD. Future large-scale prospective studies are needed.
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http://dx.doi.org/10.1111/phpp.12546DOI Listing
July 2020

Low-dose Methotrexate Treatment for Solitary or Localized Primary Cutaneous Anaplastic Large Cell Lymphoma: A Long-term Follow-up Study.

Acta Derm Venereol 2020 02 29;100(4):adv00069. Epub 2020 Feb 29.

Department of Dermatology, Kosin University College of Medicine, 49267 Busan, Korea.

Although low-dose methotrexate (MTX) has been used widely in treatment of a variety of dermatological diseases, including multifocal primary cutaneous anaplastic large cell lymphoma (PCALCL), it has not been established for use in the treatment guidelines for solitary or localized PCALCL. Furthermore, there has been no report of long-term follow-up data in Asian patients with PCALCL treated with low-dose MTX. To investigate the effectiveness and clinical outcome of treatment with low-dose MTX, clinical and long-term follow-up data of 7 patients with solitary or localized PCALCL were analysed retrospectively. Of the 7 patients, 6 (85.7%) showed a complete response and 1 (14.3%) showed partial remission. During follow-up, mean duration of 92.1 months, 5 patients developed one or more cutaneous relapses. At the last follow-up, all of the patients with PCALCL were alive without disease. These results indicate that low-dose MTX is a highly effective and safe treatment for solitary or localized PCALCL as well as multiple relapsed lesions.
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http://dx.doi.org/10.2340/00015555-3413DOI Listing
February 2020
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