Publications by authors named "Dmitry Fiev"

3 Publications

  • Page 1 of 1

A prospective study of novel mathematical analysis of the contrast-enhanced computed tomography vs renal scintigraphy in renal function evaluation.

Eur J Radiol 2020 Sep 8;130:109169. Epub 2020 Jul 8.

Institute for Urology and Reproductive Health, Sechenov University, Moscow, Russia.

Purpose: whilst renal scintigraphy (RS) can be associated with interobserver variability, it remains the standard method of evaluating split renal function.

Aim: to compare the efficacy of the novel technique of kidney function assessment and renal scintigraphy.

Method: for this prospective single-arm study we recruited patients who were recommended dynamic renal scintigraphy with mTc-DTPA (diethylenetriaminepentacetate). After scintigraphy, mathematical analysis of computed tomography (MACT) was done in all patients, by a single person (SK) blinded to RS results.

Results: the study included a total of 97 patients with mean age of 50.9 (range, 23-78) years. From this sample, 65 were females and 32 males. All patients underwent both RS and contrast-enhanced computed tomography for further MACT in 2016-2018. CT results were found to be similar to renal scintigraphy results with Pearson correlation coefficient of 0.945 (р < 0.001). Substantial similarities in renal plasma flow for both kidneys were also observed (0.815, р < 0.001).

Conclusion: MACT proved feasible, effective and safe in estimating renal function. Its results are closely correlated with RS findings and could be easily integrated into surgical practice.
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http://dx.doi.org/10.1016/j.ejrad.2020.109169DOI Listing
September 2020

Multiple application of three-dimensional soft kidney models with localized kidney cancer: A pilot study.

Urologia 2018 Aug 27;85(3):99-105. Epub 2018 Mar 27.

2 Department of Urology, Clinic of Urology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.

Aim: To evaluate the effectiveness of three-dimensional printing application in urology for localized renal cancer treatment using three-dimensional printed soft models.

Materials And Methods: The study included five patients with kidney tumors. The patients were treated in the Urology Clinic of I.M. Sechenov First Moscow State Medical University from February 2016 to June 2017. Personalized three-dimensional printed models based on computed tomographic images were created. Five surgeons took part in a survey in which the utility of computed tomographic images versus three-dimensional printed models for presurgical planning was compared. A laparoscopic partial nephrectomy training using the developed three-dimensional printed models was performed by the same surgeons in a surgical training box.

Results: The patients underwent endoscopic surgery using laparoscopic access. The average time of surgery was 187 min. All the operations were performed with complete renal artery clamping. The average warm ischemia time was 19.5 min and the average blood loss was 170 mL. No conversions to open surgery or radical nephrectomy, and no postoperative complications and deaths were observed. All the surgical margins were negative. The tumors were morphologically identified as renal cell carcinoma in four cases and as oncocytoma in one case.

Conclusion: The developed three-dimensional printed models allow one to evaluate the pathological anatomy of tumors more effectively. High similarity between three-dimensional models and native kidneys contribute to improvement of surgical skills necessary for partial nephrectomy. Training on the three-dimensional models also allows surgeons to facilitate selection of an optimal surgical tactics for each patient.
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http://dx.doi.org/10.1177/0391560317749405DOI Listing
August 2018

Association of Mycoplasma hominis infection with prostate cancer.

Oncotarget 2011 Apr;2(4):289-97

NF Gamaleya Research Institute for Epidemiology and Microbiology, Moscow, Russia.

The origin of chronic inflammation preceding the development of prostate cancer (PCa) remains unknown. We investigated possible involvement of mycoplasma infection in PCa by screening prostate biopsies from two groups of Russian men undergoing PCa diagnosis. M. hominis was detected by standard PCR in 15% of the 125 patients in the first group and by quantitative real-time PCR in 37.4% of the 123 men in the second group. In both groups, stratification of patients according to diagnosis showed that M. hominis was present at three times higher frequency in patients with PCa than in those with benign prostatic hyperplasia. No M. hominis was detected in the prostates of 27 men without detectable prostate disease. In addition, PCa-positive men had higher titers of antibodies against M. hominis and average PSA levels were higher in M. hominis-positive men. These data, together with previous observations linking mycoplasma infection with cell transformation, genomic instability and resistance to apoptosis, suggest that M. hominis infection may be involved in PCa development and may, therefore, be a potential PCa marker and/or target for improved prevention and treatment of this disease.
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http://dx.doi.org/10.18632/oncotarget.256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248169PMC
April 2011
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