Dmitry A Gordenin

Dmitry A Gordenin

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Dmitry A Gordenin

Publications by authors named "Dmitry A Gordenin"

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Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation.

PLoS Biol 2019 Sep 30;17(9):e3000464. Epub 2019 Sep 30.

Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.3000464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786661PMC
September 2019

Corrigendum to "APOBEC3B cytidine deaminase targets the non-transcribed strand of tRNA genes in yeast" [DNA Repair 53 (2017) 4-14].

DNA Repair (Amst) 2019 Aug 7;80:94-95. Epub 2019 Jun 7.

Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2019.05.006DOI Listing
August 2019

Mutational signatures of redox stress in yeast single-strand DNA and of aging in human mitochondrial DNA share a common feature.

PLoS Biol 2019 05 8;17(5):e3000263. Epub 2019 May 8.

Mutagenesis and DNA Repair Regulation Group, Laboratory of Genome Integrity and Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.3000263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527239PMC
May 2019

Michael Ter-Avanesyan (1949-2018) - Advent of the scientist.

Prion 2019 01 6;13(1):33-36. Epub 2019 Jan 6.

b Department of Genetics and Biotechnology , St. Petersburg State University , St. Petersburg , Russia.

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http://dx.doi.org/10.1080/19336896.2018.1563427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422388PMC
January 2019

Somatic mutation load and spectra: A record of DNA damage and repair in healthy human cells.

Environ Mol Mutagen 2018 10 27;59(8):672-686. Epub 2018 Aug 27.

Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Durham, North Carolina.

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http://dx.doi.org/10.1002/em.22215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188803PMC
October 2018

APOBEC3B cytidine deaminase targets the non-transcribed strand of tRNA genes in yeast.

DNA Repair (Amst) 2017 05 21;53:4-14. Epub 2017 Mar 21.

Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2017.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450012PMC
May 2017

The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts.

PLoS Genet 2016 10 27;12(10):e1006385. Epub 2016 Oct 27.

Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, United States Of America.

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http://dx.doi.org/10.1371/journal.pgen.1006385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082821PMC
October 2016

Clusters of Multiple Mutations: Incidence and Molecular Mechanisms.

Annu Rev Genet 2015 ;49:243-67

Mechanisms of Genome Dynamics Group, National Institute of Environmental Health Sciences, Department of Health and Human Services, National Institutes of Health, Durham, North Carolina 27709; email: ,

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http://dx.doi.org/10.1146/annurev-genet-112414-054714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710516PMC
September 2016

Suppression of allelic recombination and aneuploidy by cohesin is independent of Chk1 in Saccharomyces cerevisiae.

PLoS One 2014 31;9(12):e113435. Epub 2014 Dec 31.

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113435PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281242PMC
September 2015

An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers.

Nat Genet 2015 Sep 10;47(9):1067-72. Epub 2015 Aug 10.

Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1038/ng.3378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594173PMC
September 2015

Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition.

Genome Res 2014 Nov 12;24(11):1751-64. Epub 2014 Sep 12.

Laboratory of Molecular Genetics, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA; Laboratory of Structural Biology, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA;

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http://dx.doi.org/10.1101/gr.178335.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216917PMC
November 2014

Break-induced replication is a source of mutation clusters underlying kataegis.

Cell Rep 2014 Jun 29;7(5):1640-1648. Epub 2014 May 29.

Department of Biology, College of Liberal Arts and Sciences, University of Iowa, Iowa City, IA 52242-1324, USA; Department of Biology, School of Science, IUPUI, Indianapolis, IN 46202-5132, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.04.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274036PMC
June 2014

Clustered and genome-wide transient mutagenesis in human cancers: Hypermutation without permanent mutators or loss of fitness.

Bioessays 2014 04 26;36(4):382-393. Epub 2014 Feb 26.

Chromosome Stability Group, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Durham, NC, USA.

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http://dx.doi.org/10.1002/bies.201300140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145046PMC
April 2014

The sister chromatid cohesion pathway suppresses multiple chromosome gain and chromosome amplification.

Genetics 2014 Feb 2;196(2):373-84. Epub 2013 Dec 2.

National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.

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http://dx.doi.org/10.1534/genetics.113.159202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914611PMC
February 2014

The choice of nucleotide inserted opposite abasic sites formed within chromosomal DNA reveals the polymerase activities participating in translesion DNA synthesis.

DNA Repair (Amst) 2013 Nov 26;12(11):878-89. Epub 2013 Aug 26.

Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2013.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825800PMC
November 2013

Oxidative stress-induced mutagenesis in single-strand DNA occurs primarily at cytosines and is DNA polymerase zeta-dependent only for adenines and guanines.

Nucleic Acids Res 2013 Oct 7;41(19):8995-9005. Epub 2013 Aug 7.

Department of Biochemistry, Winship Cancer Institute, Emory University School of Medicine, 4013 Rollins Research Center, Atlanta, GA 30322, USA, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIH, DHHS), Research Triangle Park, NC 27709, USA and Department of Radiation Oncology, Emory University School of Medicine, 4013 Rollins Research Center, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1093/nar/gkt671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799438PMC
October 2013

Base damage within single-strand DNA underlies in vivo hypermutability induced by a ubiquitous environmental agent.

PLoS Genet 2012 13;8(12):e1003149. Epub 2012 Dec 13.

Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521656PMC
May 2013

Understanding the origins of UV-induced recombination through manipulation of sister chromatid cohesion.

Cell Cycle 2012 Nov 17;11(21):3937-44. Epub 2012 Sep 17.

Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, NC, USA.

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http://dx.doi.org/10.4161/cc.21945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507489PMC
November 2012

RAD53 is limiting in double-strand break repair and in protection against toxicity associated with ribonucleotide reductase inhibition.

DNA Repair (Amst) 2012 Mar 23;11(3):317-23. Epub 2012 Jan 23.

Chromosome Stability Group, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.dnarep.2011.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631316PMC
March 2012

Damage-induced localized hypermutability.

Cell Cycle 2011 Apr 1;10(7):1073-85. Epub 2011 Apr 1.

National Institute of Environmental Health Sciences, Research Triangle Park, NC USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100884PMC
http://dx.doi.org/10.4161/cc.10.7.15319DOI Listing
April 2011

Alkylation base damage is converted into repairable double-strand breaks and complex intermediates in G2 cells lacking AP endonuclease.

PLoS Genet 2011 Apr 28;7(4):e1002059. Epub 2011 Apr 28.

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1002059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084215PMC
April 2011

Genome-wide model for the normal eukaryotic DNA replication fork.

Proc Natl Acad Sci U S A 2010 Oct 27;107(41):17674-9. Epub 2010 Sep 27.

Laboratory of Molecular Genetics and Laboratory of Structural Biology, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1073/pnas.1010178107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955150PMC
October 2010

A single-strand specific lesion drives MMS-induced hyper-mutability at a double-strand break in yeast.

DNA Repair (Amst) 2010 Aug 21;9(8):914-21. Epub 2010 Jul 21.

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States.

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http://dx.doi.org/10.1016/j.dnarep.2010.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945237PMC
August 2010

Cohesin Is limiting for the suppression of DNA damage-induced recombination between homologous chromosomes.

PLoS Genet 2010 Jul 1;6(7):e1001006. Epub 2010 Jul 1.

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1001006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895640PMC
July 2010

The transition of closely opposed lesions to double-strand breaks during long-patch base excision repair is prevented by the coordinated action of DNA polymerase delta and Rad27/Fen1.

Mol Cell Biol 2009 Mar 15;29(5):1212-21. Epub 2008 Dec 15.

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1128/MCB.01499-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643827PMC
March 2009

Flexibility of eukaryotic Okazaki fragment maturation through regulated strand displacement synthesis.

J Biol Chem 2008 Dec 16;283(49):34129-40. Epub 2008 Oct 16.

Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://www.jbc.org/content/283/49/34129.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M806668200
Publisher Site
http://dx.doi.org/10.1074/jbc.M806668200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2590699PMC
December 2008

Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae.

PLoS Genet 2008 Nov 21;4(11):e1000264. Epub 2008 Nov 21.

Department of Health and Human Services, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577886PMC
November 2008

Apn1 and Apn2 endonucleases prevent accumulation of repair-associated DNA breaks in budding yeast as revealed by direct chromosomal analysis.

Nucleic Acids Res 2008 Apr 11;36(6):1836-46. Epub 2008 Feb 11.

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIH, DHHS), Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1093/nar/gkm1148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2346603PMC
April 2008

Division of labor at the eukaryotic replication fork.

Mol Cell 2008 Apr;30(2):137-44

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.molcel.2008.02.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654179PMC
April 2008

RNA-templated DNA repair.

Nature 2007 May 11;447(7142):338-41. Epub 2007 Apr 11.

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIH, DHHS), Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1038/nature05720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2121219PMC
May 2007

Conservative repair of a chromosomal double-strand break by single-strand DNA through two steps of annealing.

Mol Cell Biol 2006 Oct 14;26(20):7645-57. Epub 2006 Aug 14.

Head Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.00672-06
Publisher Site
http://dx.doi.org/10.1128/MCB.00672-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636868PMC
October 2006

Chromosomal site-specific double-strand breaks are efficiently targeted for repair by oligonucleotides in yeast.

Proc Natl Acad Sci U S A 2003 Dec 20;100(25):14994-9. Epub 2003 Nov 20.

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.2036296100
Publisher Site
http://dx.doi.org/10.1073/pnas.2036296100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC299876PMC
December 2003

Cadmium is a mutagen that acts by inhibiting mismatch repair.

Nat Genet 2003 Jul;34(3):326-9

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1038/ng1172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662193PMC
July 2003

Okazaki fragment maturation in yeast. II. Cooperation between the polymerase and 3'-5'-exonuclease activities of Pol delta in the creation of a ligatable nick.

J Biol Chem 2003 Jan 6;278(3):1626-33. Epub 2002 Nov 6.

Laboratory of Molecular Genetics, National Institute for Environmental and Health Sciences, National Institutes of Health, North Carolina 27709, USA.

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http://dx.doi.org/10.1074/jbc.M209803200DOI Listing
January 2003

Okazaki fragment maturation in yeast. I. Distribution of functions between FEN1 AND DNA2.

J Biol Chem 2003 Jan 6;278(3):1618-25. Epub 2002 Nov 6.

Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M209801200DOI Listing
January 2003

The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair.

EMBO J 2002 Nov;21(21):5930-42

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC131084PMC
http://dx.doi.org/10.1093/emboj/cdf587DOI Listing
November 2002

The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements.

Cell 2002 Jan;108(2):183-93

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/s0092-8674(02)00614-1DOI Listing
January 2002