Dmitri Wiederschain

Dmitri Wiederschain

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Dmitri Wiederschain

Dmitri Wiederschain

Publications by authors named "Dmitri Wiederschain"

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25Publications

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Single-vector inducible lentiviral RNAi system for oncology target validation.

Cell Cycle 2009 Feb 25;8(3):498-504. Epub 2009 Feb 25.

Oncology Research, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.4161/cc.8.3.7701DOI Listing
February 2009

PTEN-deficient cancers depend on PIK3CB.

Proc Natl Acad Sci U S A 2008 Sep 28;105(35):13057-62. Epub 2008 Aug 28.

Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.0802655105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2529105PMC
September 2008

Class IA phosphoinositide 3-kinase isoforms and human tumorigenesis: implications for cancer drug discovery and development.

Curr Opin Oncol 2008 Jan;20(1):77-82

Novartis Institute for Biomedical Research, Cambridge, Massachusetts 02319, USA.

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http://dx.doi.org/10.1097/CCO.0b013e3282f3111eDOI Listing
January 2008

RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity.

Cancer Res 2007 Jul;67(13):6026-30

Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1313DOI Listing
July 2007

Functional inactivation of P53 as a potential mechanism of MLL leukemogenesis.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2006 Oct;31(5):617-20

Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

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October 2006

Multiple mixed lineage leukemia (MLL) fusion proteins suppress p53-mediated response to DNA damage.

J Biol Chem 2005 Jul 25;280(26):24315-21. Epub 2005 Apr 25.

Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M412237200DOI Listing
July 2005

DNA damage-induced MDMX degradation is mediated by MDM2.

J Biol Chem 2003 Nov 8;278(46):45946-53. Epub 2003 Sep 8.

Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M308295200DOI Listing
November 2003

Critical contribution of the MDM2 acidic domain to p53 ubiquitination.

Mol Cell Biol 2003 Jul;23(14):4939-47

Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC162226PMC
http://dx.doi.org/10.1128/mcb.23.14.4939-4947.2003DOI Listing
July 2003

Molecular basis of p53 functional inactivation by the leukemic protein MLL-ELL.

Mol Cell Biol 2003 Jun;23(12):4230-46

Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC156137PMC
http://dx.doi.org/10.1128/mcb.23.12.4230-4246.2003DOI Listing
June 2003

Mutual dependence of MDM2 and MDMX in their functional inactivation of p53.

J Biol Chem 2002 May 12;277(22):19251-4. Epub 2002 Apr 12.

Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.C200150200
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http://dx.doi.org/10.1074/jbc.C200150200DOI Listing
May 2002