Publications by authors named "Diva D De León"

68Publications

Meeting Report: Updates in Diagnosis and Management of Hyperinsulinism and Neonatal Hypoglycemia: Highlights from the Fourth International Hyperinsulinism Symposium.

Pediatr Endocrinol Rev 2020 Jun;17(3):268-277

The Children's Hospital of Philadelphia 3500 Civic Center Blvd, Philadelphia, PA 19104, USA, E-mail:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.17458/per.vol17.2020.mr.ll.hyperinsulinismneonatalhypoglycemiaDOI Listing
June 2020

Activation of Protein Kinase A (PKA) signaling mitigates congenital hyperinsulinism associated hypoglycemia in the Sur1-/- mouse model.

PLoS One 2020 31;15(7):e0236892. Epub 2020 Jul 31.

Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0236892PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394442PMC
September 2020

18-F-L 3,4-Dihydroxyphenylalanine PET/Computed Tomography in the Management of Congenital Hyperinsulinism.

PET Clin 2020 Jul;15(3):349-359

Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA; Division of Endocrinology and Diabetes, Congenital Hyperinsulinism Center, The Children's Hospital of Philadelphia, 3500 Civic Center Boulevard, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cpet.2020.03.004DOI Listing
July 2020

Treatment Threshold for Neonatal Hypoglycemia.

N Engl J Med 2020 06;382(23):2272

Children's Hospital of Pittsburgh, Pittsburgh, PA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc2004233DOI Listing
June 2020

Neonatal Hypoglycemia: GLOW at the End of the Tunnel?

J Pediatr 2020 08 13;223:10-12. Epub 2020 May 13.

Congenital Hyperinsulinism Center, Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2020.03.056DOI Listing
August 2020

Continuous Glucose Monitoring Systems: Are They Useful for Evaluating Glycemic Control in Children with Hyperinsulinism?

Horm Res Paediatr 2019 24;92(5):319-327. Epub 2020 Mar 24.

Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000506230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192768PMC
June 2020

Novel Preparations of Glucagon for the Prevention and Treatment of Hypoglycemia.

Curr Diab Rep 2019 09 6;19(10):97. Epub 2019 Sep 6.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11892-019-1216-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951434PMC
September 2019

Congenital hyperinsulinism disorders: Genetic and clinical characteristics.

Am J Med Genet C Semin Med Genet 2019 12 14;181(4):682-692. Epub 2019 Aug 14.

Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajmg.c.31737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229866PMC
December 2019

Dysregulated insulin in pancreatic insufficient cystic fibrosis with post-prandial hypoglycemia.

J Cyst Fibros 2020 03 8;19(2):310-315. Epub 2019 Aug 8.

Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcf.2019.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007375PMC
March 2020

Surgical treatment of congenital hyperinsulinism: Results from 500 pancreatectomies in neonates and children.

J Pediatr Surg 2019 Jan 5;54(1):27-32. Epub 2018 Oct 5.

Department of Pediatrics and the Congenital Hyperinsulinism Center, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpedsurg.2018.10.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339589PMC
January 2019

The Effect of Continuous Intravenous Glucagon on Glucose Requirements in Infants with Congenital Hyperinsulinism.

JIMD Rep 2019 12;45:45-50. Epub 2018 Oct 12.

Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/8904_2018_140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336552PMC
October 2018

Prevalence of Adverse Events in Children With Congenital Hyperinsulinism Treated With Diazoxide.

J Clin Endocrinol Metab 2018 12;103(12):4365-4372

Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2018-01613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207144PMC
December 2018

Incidence and risk of celiac disease after type 1 diabetes: A population-based cohort study using the health improvement network database.

Pediatr Diabetes 2018 12 9;19(8):1422-1428. Epub 2018 Oct 9.

The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/pedi.12770
Publisher Site
http://dx.doi.org/10.1111/pedi.12770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249123PMC
December 2018

Islet Hormone and Incretin Secretion in Cystic Fibrosis after Four Months of Ivacaftor Therapy.

Am J Respir Crit Care Med 2019 02;199(3):342-351

2 Division of Pulmonary Medicine and Cystic Fibrosis Center, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
https://www.atsjournals.org/doi/10.1164/rccm.201806-1018OC
Publisher Site
http://dx.doi.org/10.1164/rccm.201806-1018OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835076PMC
February 2019

Continuous Intragastric Dextrose: A Therapeutic Option for Refractory Hypoglycemia in Congenital Hyperinsulinism.

Horm Res Paediatr 2019 7;91(1):62-68. Epub 2018 Aug 7.

Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000491105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661174PMC
November 2019

β-Cell secretory defects are present in pancreatic insufficient cystic fibrosis with 1-hour oral glucose tolerance test glucose ≥155 mg/dL.

Pediatr Diabetes 2018 11 21;19(7):1173-1182. Epub 2018 Jun 21.

Division of Endocrinology and Diabetes, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364976PMC
November 2018

Genetic characteristics of patients with congenital hyperinsulinism.

Curr Opin Pediatr 2018 08;30(4):568-575

Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOP.0000000000000645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084463PMC
August 2018

A unique allosteric insulin receptor monoclonal antibody that prevents hypoglycemia in the SUR-1 mouse model of KATP hyperinsulinism.

MAbs 2018 07 1;10(5):796-802. Epub 2018 Jun 1.

a Division of Endocrinology, Department of Pediatrics , The Children's Hospital of Philadelphia , Philadelphia , Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/19420862.2018.1457599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150619PMC
July 2018

Clinical heterogeneity of hyperinsulinism due to HNF1A and HNF4A mutations.

Pediatr Diabetes 2018 08 1;19(5):910-916. Epub 2018 Mar 1.

Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030428PMC
August 2018

Hyperinsulinism in the Neonate.

Clin Perinatol 2018 03 6;45(1):61-74. Epub 2017 Dec 6.

The Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA; Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clp.2017.10.007DOI Listing
March 2018

Congenital Hyperinsulinism and Hypopituitarism Attributable to a Mutation in FOXA2.

J Clin Endocrinol Metab 2018 03;103(3):1042-1047

Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2017-02157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276717PMC
March 2018

Population pharmacokinetics of exendin-(9-39) and clinical dose selection in patients with congenital hyperinsulinism.

Br J Clin Pharmacol 2018 03 6;84(3):520-532. Epub 2017 Dec 6.

The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bcp.13463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809353PMC
March 2018

Functional and Metabolomic Consequences of K Channel Inactivation in Human Islets.

Diabetes 2017 07 25;66(7):1901-1913. Epub 2017 Apr 25.

Division of Endocrinology and Diabetes, Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db17-0029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482088PMC
July 2017

GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells.

Stem Cell Reports 2017 03 9;8(3):589-604. Epub 2017 Feb 9.

Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, CTRB 5012, 3501 Civic Center Boulevard, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stemcr.2016.12.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355564PMC
March 2017

A severe case of hyperinsulinism due to hemizygous activating mutation of glutamate dehydrogenase.

Pediatr Diabetes 2017 Dec 6;18(8):911-916. Epub 2017 Feb 6.

Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545170PMC
December 2017

Octreotide use and safety in infants with hyperinsulinism.

Pharmacoepidemiol Drug Saf 2017 01 2;26(1):26-31. Epub 2016 Dec 2.

Children's Hospital of Philadelphia, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pds.4144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286465PMC
January 2017

Congenital Hypoglycemia Disorders: New Aspects of Etiology, Diagnosis, Treatment and Outcomes: Highlights of the Proceedings of the Congenital Hypoglycemia Disorders Symposium, Philadelphia April 2016.

Pediatr Diabetes 2017 02 18;18(1):3-9. Epub 2016 Oct 18.

The Children's Hospital of Philadelphia Congenital Hyperinsulinism Center and the Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473026PMC
February 2017

Use of Propranolol for Treating Hemangiomas in Infants with Previously Diagnosed Hypoglycemic Conditions.

Pediatr Dermatol 2016 Nov 30;33(6):e381-e384. Epub 2016 Aug 30.

Division of Pediatric Dermatology, Children's Hospital of Philadelphia, Philadelphia, PA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/pde.12975
Publisher Site
http://dx.doi.org/10.1111/pde.12975DOI Listing
November 2016

Adding Glucagon-Stimulated GH Testing to the Diagnostic Fast Increases the Detection of GH-Sufficient Children.

Horm Res Paediatr 2016 17;85(4):265-72. Epub 2016 Mar 17.

Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, Pa., USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000444678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865421PMC
April 2017

Late Presentation of Fulminant Necrotizing Enterocolitis in a Child with Hyperinsulinism on Octreotide Therapy.

Horm Res Paediatr 2016 12;86(2):131-136. Epub 2016 Feb 12.

Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, Pa., USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000443959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982848PMC
April 2017

Postprandial Hypoglycemia in Children after Gastric Surgery: Clinical Characterization and Pathophysiology.

Horm Res Paediatr 2016 23;85(2):140-6. Epub 2015 Dec 23.

Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, Pa., USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000442155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732946PMC
November 2016

Iatrogenic Necrolytic Migratory Erythema in an Infant with Congenital Hyperinsulinism.

Pediatr Dermatol 2016 Mar-Apr;33(2):e43-7. Epub 2015 Dec 9.

Division of Pediatric General, Thoracic and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pde.12741DOI Listing
January 2017

Congenital hyperinsulinism in children with paternal 11p uniparental isodisomy and Beckwith-Wiedemann syndrome.

J Med Genet 2016 Jan 6;53(1):53-61. Epub 2015 Nov 6.

Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jmedgenet-2015-103394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740975PMC
January 2016

High Risk of Diabetes and Neurobehavioral Deficits in Individuals With Surgically Treated Hyperinsulinism.

J Clin Endocrinol Metab 2015 Nov 1;100(11):4133-9. Epub 2015 Sep 1.

Division of Endocrinology and Diabetes (K.L., C.A.S., D.D.D.L.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104; Department of Pediatrics (K.L., J.R., C.A.S., D.D.D.L.), The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104; Biostatistics Core (P.R.G.), The Clinical and Translational Research Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104; and Department of Surgery (N.S.A.), The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104.

View Article

Download full-text PDF

Source
https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
Publisher Site
http://dx.doi.org/10.1210/jc.2015-2539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702456PMC
November 2015

A liquid chromatography-mass spectrometry assay for quantification of Exendin[9-39] in human plasma.

J Chromatogr B Analyt Technol Biomed Life Sci 2014 Feb 16;947-948:186-91. Epub 2013 Dec 16.

Protein and Proteomics Core Facility, The Children's Hospital of Philadelphia Research Institute, 3615 Civic Center Boulevard, Abramson Research Center, 816a, Philadelphia, PA 19104, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchromb.2013.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518449PMC
February 2014

A novel mutation in GATA6 causes pancreatic agenesis.

Pediatr Diabetes 2015 Feb 17;16(1):67-70. Epub 2014 Jan 17.

Division of Endocrinology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102676PMC
February 2015

Determination of insulin for the diagnosis of hyperinsulinemic hypoglycemia.

Best Pract Res Clin Endocrinol Metab 2013 Dec 9;27(6):763-9. Epub 2013 Jul 9.

Division of Pediatric Endocrinology, Children's Hospital of Philadelphia, Philadelphia, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.beem.2013.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141553PMC
December 2013

Clinical presentation and management of children with diffuse and focal hyperinsulinism: a review of 223 cases.

J Clin Endocrinol Metab 2013 Nov 20;98(11):E1786-9. Epub 2013 Sep 20.

MD, Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, Abramson Research Center Room 802A, Philadelphia, Pennsylvania 19104.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2013-2094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816257PMC
November 2013

Mechanotransduction drives post ischemic revascularization through K(ATP) channel closure and production of reactive oxygen species.

Antioxid Redox Signal 2014 Feb 31;20(6):872-86. Epub 2013 Jul 31.

1 Institute for Environmental Medicine, University of Pennsylvania , Perelman School of Medicine, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/ars.2012.4971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924794PMC
February 2014

Monogenic hyperinsulinemic hypoglycemia: current insights into the pathogenesis and management.

Int J Pediatr Endocrinol 2013 Feb 6;2013(1). Epub 2013 Feb 6.

Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, Abramson Research Center Room 802A, Philadelphia, PA, 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1687-9856-2013-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573904PMC
February 2013

Novel presentations of congenital hyperinsulinism due to mutations in the MODY genes: HNF1A and HNF4A.

J Clin Endocrinol Metab 2012 Oct 16;97(10):E2026-30. Epub 2012 Jul 16.

Clinical and Translational Research Center, The Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, 3615 Civic Center Boulevard, Abramson Research Center Room 802A, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2012-1356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674296PMC
October 2012

Compound heterozygous mutations in the SUR1 (ABCC 8) subunit of pancreatic K(ATP) channels cause neonatal diabetes by perturbing the coupling between Kir6.2 and SUR1 subunits.

Channels (Austin) 2012 Mar-Apr;6(2):133-8. Epub 2012 Mar 1.

Department of Cell Biology and Physiology and Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, St Louis, MO, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/chan.19980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396690PMC
October 2012

Postoperative surveillance and detection of postprandial hypoglycemia after fundoplasty in children.

J Pediatr 2011 Oct 17;159(4):597-601.e1. Epub 2011 May 17.

Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2011.03.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489543PMC
October 2011

Neonatal diabetes and congenital malabsorptive diarrhea attributable to a novel mutation in the human neurogenin-3 gene coding sequence.

J Clin Endocrinol Metab 2011 Jul 13;96(7):1960-5. Epub 2011 Apr 13.

Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
Publisher Site
http://dx.doi.org/10.1210/jc.2011-0029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135203PMC
July 2011

Calcineurin signaling regulates human islet {beta}-cell survival.

J Biol Chem 2010 Dec 13;285(51):40050-9. Epub 2010 Oct 13.

Division of Endocrinology, Department of Medicine and the Institute for Diabetes, Obesity, and Metabolism, the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M110.154955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000987PMC
December 2010

Use of metformin to control clozapine-associated weight gain in an adolescent with schizoaffective disorder.

J Child Adolesc Psychopharmacol 2010 Apr;20(2):153-7

Department of Child and Adolescent Psychiatry, University of Pennsylvania School of Medicine and Children's Hospital of Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/cap.2010.2022DOI Listing
April 2010

Increased glucagon-like peptide-1 secretion and postprandial hypoglycemia in children after Nissen fundoplication.

J Clin Endocrinol Metab 2009 Jan 28;94(1):39-44. Epub 2008 Oct 28.

The Children's Hospital of Philadelphia, Abramson Research Center, Room 802A, 3615 Civic Center Boulevard, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2008-1263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630870PMC
January 2009

Exendin-(9-39) corrects fasting hypoglycemia in SUR-1-/- mice by lowering cAMP in pancreatic beta-cells and inhibiting insulin secretion.

J Biol Chem 2008 Sep 17;283(38):25786-93. Epub 2008 Jul 17.

Division of Endocrinology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M804372200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258866PMC
September 2008

Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration.

J Clin Invest 2007 Apr;117(4):971-7

Division of Endocrinology, Diabetes, and Metabolism and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI29988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838936PMC
April 2007

A mutation in the TMD0-L0 region of sulfonylurea receptor-1 (L225P) causes permanent neonatal diabetes mellitus (PNDM).

Diabetes 2007 May 22;56(5):1357-62. Epub 2007 Feb 22.

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db06-17
Publisher Site
http://dx.doi.org/10.2337/db06-1746DOI Listing
May 2007

Mechanisms of Disease: advances in diagnosis and treatment of hyperinsulinism in neonates.

Nat Clin Pract Endocrinol Metab 2007 Jan;3(1):57-68

University of Pennsylvania, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/ncpendmet0368
Publisher Site
http://dx.doi.org/10.1038/ncpendmet0368DOI Listing
January 2007

Identification of transcriptional targets during pancreatic growth after partial pancreatectomy and exendin-4 treatment.

Physiol Genomics 2006 Jan;24(2):133-43

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/physiolgenomics.00156.2005DOI Listing
January 2006

Regeneration of pancreatic islets after partial pancreatectomy in mice does not involve the reactivation of neurogenin-3.

Diabetes 2006 Feb 16;55(2):269-72. Epub 2005 Dec 16.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Clinical Research Building 611 B, Philadelphia, 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/55.02.06.db05-1300DOI Listing
February 2006

Role of glucagon-like peptide-1 in the pathogenesis and treatment of diabetes mellitus.

Int J Biochem Cell Biol 2006 15;38(5-6):845-59. Epub 2005 Sep 15.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biocel.2005.07.011DOI Listing
May 2006

Role of endogenous glucagon-like peptide-1 in islet regeneration after partial pancreatectomy.

Diabetes 2003 Feb;52(2):365-71

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/diabetes.52.2.365DOI Listing
February 2003

Long-term (15 years) outcome in an infant with metastatic adrenocortical carcinoma.

J Clin Endocrinol Metab 2002 Oct;87(10):4452-6

Division of Endocrinology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2001-011978DOI Listing
October 2002