Publications by authors named "Dirk Vanderschueren"

100Publications

Androgen action on renal calcium and phosphate handling: Effects of bisphosphonate treatment and low calcium diet.

Mol Cell Endocrinol 2020 08 10;514:110891. Epub 2020 Jun 10.

Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Aging, KU Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2020.110891DOI Listing
August 2020

Mechanical stress regulates bone regulatory gene expression independent of estrogen and vitamin D deficiency in rats.

J Orthop Res 2020 Jun 12. Epub 2020 Jun 12.

Department of Clinical Chemistry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/jor.24775DOI Listing
June 2020

Early effects of androgen deprivation on bone and mineral homeostasis in adult men: a prospective cohort study.

Eur J Endocrinol 2020 Aug;183(2):181-189

Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Aging, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1530/EJE-20-0348DOI Listing
August 2020

High serum FSH is not a risk factor for low bone mineral density in infertile men.

Bone 2020 Jul 15;136:115366. Epub 2020 Apr 15.

University Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark; International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2020.115366DOI Listing
July 2020

European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males: Endorsing organization: European Society of Endocrinology.

Andrology 2020 09 20;8(5):970-987. Epub 2020 Mar 20.

Division of Endocrinology, Diabetes and Gastroenterology, School of Medical Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1111/andr.12770DOI Listing
September 2020

Aromatase inhibitors and selective estrogen receptor modulators: Unconventional therapies for functional hypogonadism?

Andrology 2019 Nov 6. Epub 2019 Nov 6.

Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1111/andr.12725DOI Listing
November 2019

Androgen Receptor in Neurons Slows Age-Related Cortical Thinning in Male Mice.

J Bone Miner Res 2019 03 15;34(3):508-519. Epub 2019 Jan 15.

Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Aging (CHROMETA), KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/jbmr.3625DOI Listing
March 2019

Symptomatic androgen deficiency develops only when both total and free testosterone decline in obese men who may have incident biochemical secondary hypogonadism: Prospective results from the EMAS.

Clin Endocrinol (Oxf) 2018 10 23;89(4):459-469. Epub 2018 Jul 23.

Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Arthritis Research UK Centre for Epidemiology, Manchester Academic Health Science Centre, University of Manchester and NIHR Manchester Musculoskeletal Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, UK.

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http://dx.doi.org/10.1111/cen.13756DOI Listing
October 2018

Androgen and estrogen actions on male physical activity: a story beyond muscle.

J Endocrinol 2018 07 9;238(1):R31-R52. Epub 2018 May 9.

Molecular Endocrinology LaboratoryDepartment of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1530/JOE-18-0125DOI Listing
July 2018

Age-related changes in female mouse cortical bone microporosity.

Bone 2018 08 5;113:1-8. Epub 2018 May 5.

Biomechanics Section, Department of Mechanical Engineering, KU Leuven, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2018.05.003DOI Listing
August 2018

Reassessing Free-Testosterone Calculation by Liquid Chromatography-Tandem Mass Spectrometry Direct Equilibrium Dialysis.

J Clin Endocrinol Metab 2018 06;103(6):2167-2174

Clinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1210/jc.2017-02360DOI Listing
June 2018

Hypocalcemia after Denosumab in a Pulmonary Hypertension Patient Receiving Epoprostenol.

Respiration 2018;95(2):139-142. Epub 2017 Oct 30.

Department of Respiratory Diseases, KU Leuven - University of Leuven and University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1159/000481713DOI Listing
October 2018

Reproductive Hormone Levels Predict Changes in Frailty Status in Community-Dwelling Older Men: European Male Ageing Study Prospective Data.

J Clin Endocrinol Metab 2018 02;103(2):701-709

Andrology Research Unit, Division of Diabetes, Endocrinology, and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.

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http://dx.doi.org/10.1210/jc.2017-01172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800832PMC
February 2018

Elevated luteinizing hormone despite normal testosterone levels in older men-natural history, risk factors and clinical features.

Clin Endocrinol (Oxf) 2018 03 25;88(3):479-490. Epub 2017 Dec 25.

Manchester Academic Health Sciences Centre, Faculty of Medical and Human Sciences, Institute of Human Development, Centre for Endocrinology and Diabetes, Andrology Research Unit, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1111/cen.13524DOI Listing
March 2018

Estradiol and Age-Related Bone Loss in Men.

Physiol Rev 2018 01;98(1)

Department of Clinical and Experimental Medicine, Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1152/physrev.00051.2017DOI Listing
January 2018

Sex steroids and the kidney: role in renal calcium and phosphate handling.

Mol Cell Endocrinol 2018 04 16;465:61-72. Epub 2017 Nov 16.

Clinical and Experimental Endocrinology, KU Leuven, Herestraat 49 Box 902, Belgium.

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http://dx.doi.org/10.1016/j.mce.2017.11.011DOI Listing
April 2018

Nonandrogenic Anabolic Hormones Predict Risk of Frailty: European Male Ageing Study Prospective Data.

J Clin Endocrinol Metab 2017 08;102(8):2798-2806

Andrology Research Unit, Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9WL, United Kingdom.

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http://dx.doi.org/10.1210/jc.2017-00090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546856PMC
August 2017

A shortened tamoxifen induction scheme to induce CreER recombinase without side effects on the male mouse skeleton.

Mol Cell Endocrinol 2017 09 11;452:57-63. Epub 2017 May 11.

Clinical and Experimental Endocrinology, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49 PO Box 902, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2017.05.012DOI Listing
September 2017

1β,25-Dihydroxyvitamin D: A new vitamin D metabolite in human serum.

J Steroid Biochem Mol Biol 2017 10 11;173:341-348. Epub 2017 Feb 11.

Department of Laboratory Medicine, University Hospitals Leuven, 3000 Leuven, Belgium; Department of Cardiovascular Sciences, KU Leuven, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.jsbmb.2017.02.004DOI Listing
October 2017

Hypervitaminosis D Associated With Tanning Bed Use: A Case Report.

Ann Intern Med 2017 Jan;166(2):155-156

From University Hospitals Leuven and KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.7326/L16-0138DOI Listing
January 2017

Frailty and bone health in European men.

Age Ageing 2017 07;46(4):635-641

Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal & Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1093/ageing/afw205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859977PMC
July 2017

Estrogens and Androgens in Skeletal Physiology and Pathophysiology.

Physiol Rev 2017 01;97(1):135-187

Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, Arkansas; Departments of Cellular and Molecular Medicine and Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium; Center for Metabolic Bone Diseases, University Hospitals Leuven, Leuven, Belgium; and Institut National de la Santé et de la Recherche Médicale UMR1011, University of Lille and Institut Pasteur de Lille, Lille, France.

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http://dx.doi.org/10.1152/physrev.00033.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539371PMC
January 2017

Androgens have antiresorptive effects on trabecular disuse osteopenia independent from muscle atrophy.

Bone 2016 12 10;93:33-42. Epub 2016 Sep 10.

Clinical and Experimental Endocrinology, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, PO box 902, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2016.09.011DOI Listing
December 2016

Changes in prevalence of obesity and high waist circumference over four years across European regions: the European male ageing study (EMAS).

Endocrine 2017 Feb 13;55(2):456-469. Epub 2016 Oct 13.

Department of Medicine, CIBER de Fisiopatologia Obesidad y Nutricion (CB06/03), Instituto Salud Carlos III, Complejo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela University, Santiago de Compostela, Spain.

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http://dx.doi.org/10.1007/s12020-016-1135-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5272876PMC
February 2017

Effects of sex hormone-binding globulin (SHBG) on androgen bioactivity in vitro.

Mol Cell Endocrinol 2016 12 26;437:280-291. Epub 2016 Aug 26.

Laboratory of Molecular Endocrinology, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49 PO Box 901, 3000, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2016.08.041DOI Listing
December 2016

Testosterone Treatment in Older Men.

N Engl J Med 2016 07;375(1):89-90

KU Leuven, Leuven, Belgium

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http://dx.doi.org/10.1056/NEJMc1603665DOI Listing
July 2016

Bone disorders: Mechanisms and targets.

Mol Cell Endocrinol 2016 09;432:1-2

Clinical and Experimental Endocrinology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.mce.2016.06.001DOI Listing
September 2016

Free 25-Hydroxyvitamin D: Impact of Vitamin D Binding Protein Assays on Racial-Genotypic Associations.

J Clin Endocrinol Metab 2016 05 23;101(5):2226-34. Epub 2016 Mar 23.

Bone & Mineral Unit (C.M.N., Y.W., C.M.S., E.S.O.), Oregon Health & Science University, Portland, Oregon 97239; School of Public Health (C.M.N., J.L.), Oregon Health & Science University, Portland, Oregon 97239; Medical Research Council Human Nutrition Research (K.S.J., A.P., I.S.), Cambridge, UK CB1 9NL; Department of Orthopedics (R.F.C.), University of California, Los Angeles, California 90095; Pacific Northwest National Laboratory (J.M.J., R.D.S., T.S., Y.G., A.A.S.), Richland, Washington 99354; Institute of Metabolism and Systems Research (M.H.), University of Birmingham, Birmingham, UK B15 2TT; University of California (J.S.A.), Los Angeles, California 90095; School of Medicine (C.M.S., C.G.L., E.S.O.), Oregon Health & Science University, Portland, Oregon 97239; Portland Veterans Affairs Medical Center (C.G.L.), Oregon 97239; Laboratory of Diagnostic Medicine (D.V.), KU Leuven, 3000 Belgium; Laboratory of Clinical and Experimental Endocrinology (D.V., R.B.), KU Leuven, 3000 Belgium; Department of Cardiovascular Sciences (S.P.), KU Leuven, Belgium 3000; Department of Laboratory Medicine (S.P.), University Hospitals Leuven, 3000 Belgium; MRC Keneba (A.P.), Keneba, The Gambia; and Department of Epidemiology (J.M.Z., J.A.C.), University of Pittsburgh, Pennsylvania 15261.

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http://dx.doi.org/10.1210/jc.2016-1104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870848PMC
May 2016

Low Free Testosterone Is Associated with Hypogonadal Signs and Symptoms in Men with Normal Total Testosterone.

J Clin Endocrinol Metab 2016 07 24;101(7):2647-57. Epub 2016 Feb 24.

Department of Clinical and Experimental Medicine (L.A., B.D., D.V.), KU Leuven, Laboratory of Clinical and Experimental Endocrinology, Leuven, Belgium; Department of Cellular and Molecular Medicine (L.A., M.R.L., F.C.), KU Leuven, Laboratory of Molecular Endocrinology, Leuven, Belgium; Department of Endocrinology (L.A., B.D., D.V.), University Hospitals Leuven, Leuven, Belgium; Andrology Research Unit (F.C.W.W., T.B.A.), Endocrinology and Diabetes Research Group, Institute of Human Development, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, UK; Manchester Royal Infirmary (F.C.W.W.), Central Manchester University Hospitals National Health Services (NHS) Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK; Arthritis Research UK Centre of Epidemiology (T.W.O.N., S.R.P.), The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; National Institute for Health Research Manchester Musculoskeletal Biomedical Research Unit (T.W.O.N.), Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK; Department of Clinical and Experimental Medicine (M.R.L.), KU Leuven, Laboratory of Gerontology and Geriatrics, Leuven, Belgium; Department of Surgery and Cancer, Imperial College London (I.T.H.), Hammersmith Campus, London, UK; Department of Physiology (I.T.H.), Institute of Biomedicine, University of Turku, Turku, Finland; Department of Human Nutrition (M.E.J.L.), University of Glasgow, Glasgow, UK; Department of Clinical Biochemistry (B.G.K.), University Hospital of South Manchester, Manchester, UK; Sexual Medicine and Andrology Unit (G.R.), Department of Experimental Clinical and Biochemical Sciences, University of Florence, Florence, Italy; Endocrinology Unit (G.F.), Department of Experimental Clinical and Biochemical Sciences, University of Florence, Florence, Italy; Department of Obstetrics, Gynaecology and Andrology (G.B.), Albert Szent-György Medica

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http://dx.doi.org/10.1210/jc.2015-4106DOI Listing
July 2016

Phosphorus metabolism in peritoneal dialysis- and haemodialysis-treated patients.

Nephrol Dial Transplant 2016 09 31;31(9):1508-14. Epub 2016 Jan 31.

Department of Nephrology and Renal Transplantation, University Hospitals Leuven, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1093/ndt/gfv414DOI Listing
September 2016

Low vitamin D and the risk of developing chronic widespread pain: results from the European male ageing study.

BMC Musculoskelet Disord 2016 Jan 16;17:32. Epub 2016 Jan 16.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, Stopford Building, Oxford Road, M13 9PT, Manchester, UK.

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http://dx.doi.org/10.1186/s12891-016-0881-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715359PMC
January 2016

Determination of human reference values for serum total 1,25-dihydroxyvitamin D using an extensively validated 2D ID-UPLC-MS/MS method.

J Steroid Biochem Mol Biol 2016 11 10;164:127-133. Epub 2015 Dec 10.

Department of Clinical Chemistry, Endocrine Laboratory, VU University Medical Center, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2015.12.003DOI Listing
November 2016

Chronic widespread pain is associated with worsening frailty in European men.

Age Ageing 2016 Mar 17;45(2):268-74. Epub 2015 Dec 17.

Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust-Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1093/ageing/afv170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776622PMC
March 2016

Androgen Deficiency Exacerbates High-Fat Diet-Induced Metabolic Alterations in Male Mice.

Endocrinology 2016 Feb 12;157(2):648-65. Epub 2015 Nov 12.

Molecular Endocrinology Laboratory (V.D., M.R.L., L.A., F.C.), Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium; Gerontology and Geriatrics (M.R.L.), KU Leuven, 3000 Leuven, Belgium; Clinical and Experimental Endocrinology (F.J., L.A., G.C., B.D., D.V.), Department of Clinical and Experimental Medicine, KU Leuven, 3000 Leuven, Belgium; Gene Expression Unit (K.L., L.G.), Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium; Exercise Physiology Research Group (L.D.), Department of Kinesiology, KU Leuven, 3000 Leuven, Belgium; and Institute of Neuroscience (L.D.), Université Catholique de Louvain, 1348 Louvain-la-Neuve, Belgium.

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http://dx.doi.org/10.1210/en.2015-1713DOI Listing
February 2016

Muscle-bone interactions: From experimental models to the clinic? A critical update.

Mol Cell Endocrinol 2016 09 23;432:14-36. Epub 2015 Oct 23.

Clinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine, KU Leuven, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.mce.2015.10.017DOI Listing
September 2016

Endocrine determinants of incident sarcopenia in middle-aged and elderly European men.

J Cachexia Sarcopenia Muscle 2015 Sep 27;6(3):242-52. Epub 2015 Apr 27.

Research Group for Musculoskeletal Rehabilitation, Department of Rehabilitation Sciences, KU Leuven Leuven, Belgium.

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http://dx.doi.org/10.1002/jcsm.12030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575556PMC
September 2015

Enobosarm (GTx-024) Modulates Adult Skeletal Muscle Mass Independently of the Androgen Receptor in the Satellite Cell Lineage.

Endocrinology 2015 Dec 22;156(12):4522-33. Epub 2015 Sep 22.

Molecular Endocrinology Laboratory (V.D., M.R.L., F.C.), Department of Cellular and Molecular Medicine, Department of Gerontology and Geriatrics (M.R.L.), and Clinical and Experimental Endocrinology (F.J., D.V.), Department of Clinical and Experimental Medicine, KU Leuven, 3000 Leuven, Belgium; and Medical Research Council Centre for Inflammation Research (I.S., P.T.K.S.), University of Edinburgh, Edinburgh EH16 4SB, United Kingdom.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2015-1479DOI Listing
December 2015

Semaphorin signaling in bone.

Mol Cell Endocrinol 2016 09 11;432:66-74. Epub 2015 Sep 11.

Clinical and Experimental Endocrinology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2015.09.009DOI Listing
September 2016

Letter to the Editor: 25-Hydroxyvitamin D Does Not Interfere With Liquid Chromatography Tandem Mass Spectrometry Assays for 1,25-Dihydroxyvitamin D.

J Clin Endocrinol Metab 2015 Sep;100(9):L82-3

Clinical Department of Laboratory Medicine (S.P., I.J., J.B., P.V., D.V.), University Hospitals Leuven, 3000 Leuven, Belgium; Department of Cardiovascular Sciences (S.P., P.V.) and Laboratory of Clinical and Experimental Endocrinology (D.V.), Department of Clinical and Experimental Medicine, KU Leuven, 3000 Leuven, Belgium Email:

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http://dx.doi.org/10.1210/jc.2015-2863DOI Listing
September 2015

Possibilities and limitations of signal summing for an immunosuppressant LC-MS/MS method.

Anal Bioanal Chem 2015 Aug 14;407(20):6191-9. Epub 2015 Jun 14.

Clinical Department of Laboratory Medicine, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium,

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http://dx.doi.org/10.1007/s00216-015-8799-7DOI Listing
August 2015

Development of and Recovery from Secondary Hypogonadism in Aging Men: Prospective Results from the EMAS.

J Clin Endocrinol Metab 2015 Aug 22;100(8):3172-82. Epub 2015 May 22.

Sexual Medicine and Andrology Unit (G.R., G.F., M.M.), Department of Experimental Clinical and Biomedical Sciences, University of Florence, 50139 Florence, Italy; Andrology Research Unit (E.L.C., T.A., J.D.F., F.C.W.W.), Centre for Endocrinology and Diabetes, Institute of Human Development, The University of Manchester, Manchester M13 9WL, United Kingdom; Department of Andrology and Endocrinology (L.A., D.V.), Katholieke Universiteit Leuven, B 3000 Leuven, Belgium; Arthritis Research UK Centre for Epidemiology (T.W.O.), Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, Manchester Academic Health Science Centre, University of Manchester and National Institute for Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester National Health Service Foundation Trust, Manchester M13 9WL, United Kingdom; Department of Obstetrics, Gynaecology, and Andrology (G.B.), Albert Szent-György Medical University, H6725 Szeged, Hungary; Department of Medicine (F.F.C.), Santiago de Compostela University, Complejo Hospitalario Universitario de Santiago, Centro de Investigación Biomedical en Red de Fisiopatología Obesidad y Nutricion (CB06/03), Instituto Salud Carlos III, 15076 Santiago de Compostela, Spain; Department of Clinical Biochemistry (B.K.), Istituto Nazionale Biostrutture e Biosistemi (M.M.), Consorzio Interuniversitario, 00136 Rome, Italy; University Hospital of South Manchester, Manchester M13 9WL, United Kingdom; Reproductive Medicine Centre (A.G.), Malmö University Hospital, University of Lund, SE-205 02 Malmö, Sweden; Department of Endocrinology (T.S.H.), Ashford and St Peter's National Health Service Trust, Surrey KT16 0PZ, United Kingdom; Department of Surgery and Cancer (I.T.H.), Institute of Reproductive and Developmental Biology, Imperial College London, London W12 0NN, United Kingdom; Department of Andrology and Reproductive Endocrinology (K.K.), Medical University of Łódź, 90-419 Łódź, Poland; Depar

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http://dx.doi.org/10.1210/jc.2015-1571DOI Listing
August 2015

The androgen receptor has no direct antiresorptive actions in mouse osteoclasts.

Mol Cell Endocrinol 2015 Aug 6;411:198-206. Epub 2015 May 6.

Clinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2015.04.030DOI Listing
August 2015

Androgens inhibit the osteogenic response to mechanical loading in adult male mice.

Endocrinology 2015 Apr 5;156(4):1343-53. Epub 2015 Feb 5.

Division of Clinical and Experimental Endocrinology (M.S., F.J., L.D., G.C., D.V.), Department of Clinical and Experimental Medicine, Molecular Endocrinology Laboratory (M.R.L., V.D., F.C.), Department of Cellular and Molecular Medicine, and Division of Gerontology and Geriatrics (M.R.L.), Department of Clinical and Experimental Medicine, KU Leuven, 3000 Leuven, Belgium; School of Veterinary Science (P.D.), University of Bristol, Bristol BS13NY, United Kingdom; and Laboratory of Pathophysiology (G.J.B., P.C.D.), University of Antwerp, B-2610 Antwerp, Belgium.

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http://dx.doi.org/10.1210/en.2014-1673DOI Listing
April 2015

Associations between sex steroids and the development of metabolic syndrome: a longitudinal study in European men.

J Clin Endocrinol Metab 2015 Apr 30;100(4):1396-404. Epub 2015 Jan 30.

Department of Clinical and Experimental Medicine (L.A., B.D., D.V.), KU Leuven, Laboratory of Clinical and Experimental Endocrinology, B-3000 Leuven, Belgium; Department of Cellular and Molecular Medicine (L.A., M.R.L., F.C.), KU Leuven, Laboratory of Molecular Endocrinology, B-3000 Leuven, Belgium; Department of Endocrinology (L.A., B.D., D.V.), University Hospitals Leuven, B-3000 Leuven, Belgium; Andrology Research Unit (F.C.W.W., E.L.C., J.D.F., M.K.R.), Endocrinology and Diabetes Research Group, Institute of Human Development, Faculty of Medical and Human Sciences, The University of Manchester, Manchester M13 9WL, United Kingdom; Manchester Royal Infirmary (F.C.W.W.), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9WL, United Kingdom; Arthritis Research UK Centre of Epidemiology (T.W.O., S.R.P.), The University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9WL, United Kingdom; NIHR Manchester Musculoskeletal Biomedical Research Unit (T.W.O.), Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9WL, United Kingdom; The Endocrinology and Diabetes Research Group (M.K.R.), Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9WL United Kingdom; Manchester Diabetes Centre (M.K.R.), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9WL, United Kingdom; Department of Clinical and Experimental Medicine (M.R.L.), KU Leuven, Laboratory of Gerontology and Geriatrics, B-3000 Leuven, Belgium; Department of Surgery and Cancer (I.T.H.), Imperial College London, Hammersmith Campus, London W12 ONN, United Kingdom; Department of Endocrinology (T.S.H.), Ashford and St. Peter's NHS Foundation Trust Hospital, Chertsey, Surrey, KT16 0PZ, United Kingdom; Department of Hum

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2014-4184DOI Listing
April 2015

Arthralgia induced by endocrine treatment for breast cancer: A prospective study of serum levels of insulin like growth factor-I, its binding protein and oestrogens.

Eur J Cancer 2014 Nov 7;50(17):2925-31. Epub 2014 Oct 7.

Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Gynecology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium; Multidisciplinary Breast Center, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2014.08.012DOI Listing
November 2014

Sex steroid actions in male bone.

Endocr Rev 2014 Dec 9;35(6):906-60. Epub 2014 Sep 9.

Clinical and Experimental Endocrinology (D.V.) and Gerontology and Geriatrics (M.R.L., E.G.), Department of Clinical and Experimental Medicine; Laboratory of Molecular Endocrinology, Department of Cellular and Molecular Medicine (M.R.L., F.C.); and Centre for Metabolic Bone Diseases (D.V., M.R.L., E.G.), KU Leuven, B-3000 Leuven, Belgium; and Center for Bone and Arthritis Research (M.K.L., L.V., A.E.B., C.O.), Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.

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https://academic.oup.com/edrv/article-lookup/doi/10.1210/er.
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http://dx.doi.org/10.1210/er.2014-1024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234776PMC
December 2014

Vitamin D receptor and vitamin D action in muscle.

Endocrinology 2014 Sep;155(9):3210-3

Clinical and Experimental Endocrinology (R.B., D.V.), KU Leuven and department of Endocrinology, University Hospitals Leuven, B 3000 Leuven, Belgium; and Gerontology and Geriatrics (E.G.), KU Leuven and Department of Geriatrics, University Hospitals Leuven, B 3000 Leuven, Belgium.

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http://dx.doi.org/10.1210/en.2014-1589DOI Listing
September 2014

Reproductive endocrinology: functional effects of sex hormone-binding globulin variants.

Nat Rev Endocrinol 2014 Sep 22;10(9):516-7. Epub 2014 Jul 22.

Clinical and Experimental Endocrinology, KU Leuven and University Hospitals Leuven, Herestraat 49 PO Box 902, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1038/nrendo.2014.120DOI Listing
September 2014

Higher 25(OH)D2 is associated with lower 25(OH)D3 and 1,25(OH)2D3.

J Clin Endocrinol Metab 2014 Aug 14;99(8):2736-44. Epub 2014 May 14.

Division of Endocrinology (C.M.S., C.G.L., E.S.O.), Bone and Mineral Unit (C.M.S., C.M.N., S.S., C.G.L., E.S.O.), and Department of Public Health and Preventive Medicine (C.M.N.), Oregon Health & Science University, Portland, Oregon 97239; Research Service (C.G.L.), Portland Veterans Affairs Medical Center, Portland, Oregon 97239; Division of Epidemiology (E.B.-C.), Department of Family & Preventive Medicine, University California San Diego, La Jolla, California 92093-0607; Laboratory of Diagnostic Medicine (I.J., D.V.), KU Leuven, University of Leuven, 3000 Leuven, Belgium; Department of Epidemiology (J.A.C.), Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261; and Division of Geriatric Medicine and Centre for Metabolic Bone Diseases (S.B.), and Laboratory of Clinical and Experimental Endocrinology (R.B., D.V.), KU Leuven, University of Leuven, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1210/jc.2014-1069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121037PMC
August 2014

Bone: Which model to predict fracture risk?

Nat Rev Endocrinol 2014 Apr 11;10(4):194-5. Epub 2014 Feb 11.

Clinical and Experimental Endocrinology, KU Leuven, Herestraat 49 ON1 Box 902, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1038/nrendo.2014.15DOI Listing
April 2014

Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium.

Authors:
Alireza Moayyeri Yi-Hsiang Hsu David Karasik Karol Estrada Su-Mei Xiao Carrie Nielson Priya Srikanth Sylvie Giroux Scott G Wilson Hou-Feng Zheng Albert V Smith Stephen R Pye Paul J Leo Alexander Teumer Joo-Yeon Hwang Claes Ohlsson Fiona McGuigan Ryan L Minster Caroline Hayward José M Olmos Leo-Pekka Lyytikäinen Joshua R Lewis Karin M A Swart Laura Masi Chris Oldmeadow Elizabeth G Holliday Sulin Cheng Natasja M van Schoor Nicholas C Harvey Marcin Kruk Fabiola del Greco M Wilmar Igl Olivia Trummer Efi Grigoriou Robert Luben Ching-Ti Liu Yanhua Zhou Ling Oei Carolina Medina-Gomez Joseph Zmuda Greg Tranah Suzanne J Brown Frances M Williams Nicole Soranzo Johanna Jakobsdottir Kristin Siggeirsdottir Kate L Holliday Anke Hannemann Min Jin Go Melissa Garcia Ozren Polasek Marika Laaksonen Kun Zhu Anke W Enneman Mark McEvoy Roseanne Peel Pak Chung Sham Maciej Jaworski Åsa Johansson Andrew A Hicks Pawel Pludowski Rodney Scott Rosalie A M Dhonukshe-Rutten Nathalie van der Velde Mika Kähönen Jorma S Viikari Harri Sievänen Olli T Raitakari Jesús González-Macías Jose L Hernández Dan Mellström Osten Ljunggren Yoon Shin Cho Uwe Völker Matthias Nauck Georg Homuth Henry Völzke Robin Haring Matthew A Brown Eugene McCloskey Geoffrey C Nicholson Richard Eastell John A Eisman Graeme Jones Ian R Reid Elaine M Dennison John Wark Steven Boonen Dirk Vanderschueren Frederick C W Wu Thor Aspelund J Brent Richards Doug Bauer Albert Hofman Kay-Tee Khaw George Dedoussis Barbara Obermayer-Pietsch Ulf Gyllensten Peter P Pramstaller Roman S Lorenc Cyrus Cooper Annie Wai Chee Kung Paul Lips Markku Alen John Attia Maria Luisa Brandi Lisette C P G M de Groot Terho Lehtimäki José A Riancho Harry Campbell Yongmei Liu Tamara B Harris Kristina Akesson Magnus Karlsson Jong-Young Lee Henri Wallaschofski Emma L Duncan Terence W O'Neill Vilmundur Gudnason Timothy D Spector François Rousseau Eric Orwoll Steven R Cummings Nick J Wareham Fernando Rivadeneira Andre G Uitterlinden Richard L Prince Douglas P Kiel Jonathan Reeve Stephen K Kaptoge

Hum Mol Genet 2014 Jun 14;23(11):3054-68. Epub 2014 Jan 14.

Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1093/hmg/ddt675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038791PMC
June 2014

Androgens and estrogens in skeletal sexual dimorphism.

Asian J Androl 2014 Mar-Apr;16(2):213-22

Laboratory of Molecular Endocrinology, Department of Cellular and Molecular Medicine; Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, KU Leuven; Geriatric Medicine, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.4103/1008-682X.122356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955330PMC
November 2014

Low prolactin is associated with sexual dysfunction and psychological or metabolic disturbances in middle-aged and elderly men: the European Male Aging Study (EMAS).

J Sex Med 2014 Jan 29;11(1):240-53. Epub 2013 Oct 29.

Sexual Medicine and Andrology Unit Department of Experimental, Clinical, and Biomedical Sciences, University of Florence, Florence, Italy; Endocrinology Unit, Medical Department, Azienda Usl Bologna Maggiore-Bellaria Hospital, Bologna, Italy.

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http://dx.doi.org/10.1111/jsm.12327DOI Listing
January 2014

Minimal interference from paricalcitol (Zemplar®) in underivatized 1,25-dihydroxyvitamin D LC-MS/MS assays.

Clin Chim Acta 2014 Feb 8;429:104-5. Epub 2013 Dec 8.

Clinical Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.cca.2013.12.002DOI Listing
February 2014

Osteoporosis in older men: recent advances in pathophysiology and treatment.

Best Pract Res Clin Endocrinol Metab 2013 Aug 23;27(4):527-39. Epub 2013 May 23.

Geriatric Medicine, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium; Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Molecular Endocrinology, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.beem.2013.04.010DOI Listing
August 2013

Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine.

J Clin Endocrinol Metab 2013 Aug;98(8):E1283-304

Clinical and Experimental Endocrinology, KU Leuven, Department of Endocrinology, Herestraat 49 ON1, Box 902, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1210/jc.2013-1195DOI Listing
August 2013

Sensitive routine liquid chromatography-tandem mass spectrometry method for serum estradiol and estrone without derivatization.

Anal Bioanal Chem 2013 Oct 28;405(26):8569-77. Epub 2013 Jul 28.

Clinical Department of Laboratory Medicine, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium,

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http://dx.doi.org/10.1007/s00216-013-7259-5DOI Listing
October 2013

The genomic landscape of prostate cancer.

Int J Mol Sci 2013 May 24;14(6):10822-51. Epub 2013 May 24.

Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, University of Leuven, Campus Gasthuisberg, Herestraat 49, P.O. Box 901, 3000 Leuven, Belgium.

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http://dx.doi.org/10.3390/ijms140610822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709705PMC
May 2013

Novel insights in the regulation and mechanism of androgen action on bone.

Curr Opin Endocrinol Diabetes Obes 2013 Jun;20(3):240-4

Clinical and Experimental Endocrinology, Department of Experimental Medicine, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1097/MED.0b013e32835f7d04DOI Listing
June 2013

Uremia suppresses immune signal-induced CYP27B1 expression in human monocytes.

Am J Nephrol 2012 16;36(6):497-508. Epub 2012 Nov 16.

Department of Nephrology, KU Leuven, UZ Gasthuisberg, Leuven, Belgium.

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http://dx.doi.org/10.1159/000345146DOI Listing
June 2013

Androgen receptor (AR) in osteocytes is important for the maintenance of male skeletal integrity: evidence from targeted AR disruption in mouse osteocytes.

J Bone Miner Res 2012 Dec;27(12):2535-43

Clinical and Experimental Endocrinology, Department of Experimental Medicine, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/jbmr.1713DOI Listing
December 2012

A role for selective androgen response elements in the development of the epididymis and the androgen control of the 5α reductase II gene.

FASEB J 2012 Oct 13;26(10):4360-72. Epub 2012 Jul 13.

Department of Cellular and Molecular Medicine, Katholieke Univesiteit Leuven, Campus Gasthuisberg O&N1 P.O. Box 901, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1096/fj.11-202283DOI Listing
October 2012

Oncogenic osteomalacia illustrating the effect of fibroblast growth factor 23 on phosphate homeostasis.

Clin Kidney J 2012 Jun 29;5(3):240-3. Epub 2012 Mar 29.

Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1093/ckj/sfs031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400509PMC
June 2012

The hinge region in androgen receptor control.

Mol Cell Endocrinol 2012 Jul 2;358(1):1-8. Epub 2012 Mar 2.

Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Campus Gasthuisberg O&N1, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.mce.2012.02.019DOI Listing
July 2012

Inhibition of cathepsin K for treatment of osteoporosis.

Curr Osteoporos Rep 2012 Mar;10(1):73-9

Leuven University Division of Geriatric Medicine and Centre for Metabolic Bone Diseases, UZ Leuven campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium.

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http://link.springer.com/10.1007/s11914-011-0085-9
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http://dx.doi.org/10.1007/s11914-011-0085-9DOI Listing
March 2012