Publications by authors named "Dirk Reinhardt"

100Publications

Insights into the limitations of transient expression systems for the functional study of p53 acetylation site and oncogenic mutants.

Biochem Biophys Res Commun 2020 Apr 12;524(4):990-995. Epub 2020 Feb 12.

Department of Pediatric Hematology/Oncology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2020.02.002DOI Listing
April 2020

Early deaths from childhood cancer in Germany 1980-2016.

Cancer Epidemiol 2020 04 16;65:101669. Epub 2020 Jan 16.

German Childhood Cancer Registry, Institute for Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Centre of the Johannes Gutenberg University Mainz, 55101, Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.canep.2020.101669DOI Listing
April 2020

Evaluation of dsDNA from extracellular vesicles (EVs) in pediatric AML diagnostics.

Ann Hematol 2020 Mar 13;99(3):459-475. Epub 2020 Jan 13.

Department of Pediatric Hematology and Oncology, University Children's Hospital, University Hospital of Essen, Hufelandstrasse 55, 45147, Essen, Germany.

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http://dx.doi.org/10.1007/s00277-019-03866-wDOI Listing
March 2020

Cardio-toxicity in childhood cancer survivors "Cure is not enough".

J Thorac Dis 2018 Dec;10(Suppl 35):S4344-S4350

Clinic of Pediatrics III, University Hospital Essen, D-45122 Essen, Germany.

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http://dx.doi.org/10.21037/jtd.2018.11.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328387PMC
December 2018

Detection of AML-specific mutations in pediatric patient plasma using extracellular vesicle-derived RNA.

Ann Hematol 2019 03 23;98(3):595-603. Epub 2019 Jan 23.

Department of Pediatric Hematology and Oncology, University Hospital Essen, Hufelandstraße 55, D-45147, Essen, Germany.

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http://link.springer.com/10.1007/s00277-019-03608-y
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http://dx.doi.org/10.1007/s00277-019-03608-yDOI Listing
March 2019

[Acute Promyelocytic Leukemia: New treatment strategies with ATRA and ATO - AML-BFM-Recommendations].

Klin Padiatr 2018 Oct 6;230(6):299-304. Epub 2018 Nov 6.

Department of Pediatric Hematology-Oncology, Pediatrics III, University Hospital of Essen, Essen.

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http://dx.doi.org/10.1055/a-0750-5963DOI Listing
October 2018

Spontaneous reversion of a lineage switch following an initial blinatumomab-induced ALL-to-AML switch in -rearranged infant ALL.

Blood Adv 2018 06;2(12):1382-1385

Pediatric Hematology, Oncology and Stem Cell Transplantation, Children's Hospital, University of Würzburg, Würzburg, Germany; and.

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http://dx.doi.org/10.1182/bloodadvances.2018018093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020817PMC
June 2018

Endogenous Tumor Suppressor microRNA-193b: Therapeutic and Prognostic Value in Acute Myeloid Leukemia.

J Clin Oncol 2018 04 12;36(10):1007-1016. Epub 2018 Feb 12.

Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1200/JCO.2017.75.2204DOI Listing
April 2018

Panton-Valentine Leukocidin associated with S. aureus osteomyelitis activates platelets via neutrophil secretion products.

Sci Rep 2018 02 1;8(1):2185. Epub 2018 Feb 1.

Department of Anaesthesiology, Intensive Care and Pain Medicine, Experimental and Clinical Haemostasis, University of Muenster, Muenster, Germany.

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http://dx.doi.org/10.1038/s41598-018-20582-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794969PMC
February 2018

Single-cell whole exome and targeted sequencing in NPM1/FLT3 positive pediatric acute myeloid leukemia.

Pediatr Blood Cancer 2018 Feb 1;65(2). Epub 2017 Nov 1.

Department of Pediatrics III, University Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1002/pbc.26848DOI Listing
February 2018

A specific dietary intervention to restore brain structure and function after ischemic stroke.

Theranostics 2017 6;7(2):493-512. Epub 2017 Jan 6.

Department of Anatomy, Radboud university medical center, Donders Institute for Brain, Cognition & Behaviour, Nijmegen, The Netherlands.

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http://dx.doi.org/10.7150/thno.17559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327363PMC
October 2017

Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology.

Am J Med Genet A 2017 Apr 7;173(4):1017-1037. Epub 2017 Feb 7.

Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/ajmg.a.38142DOI Listing
April 2017

A common ancestral DNMT3A-mutated preleukemic clone giving rise to AML and MDS in an adolescent girl.

Leuk Lymphoma 2017 03 28;58(3):718-721. Epub 2016 Nov 28.

e Division of Pediatric Hematology and Oncology, Department of Pediatrics , University Medical Center Freiburg , Freiburg , Germany.

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http://dx.doi.org/10.1080/10428194.2016.1207765DOI Listing
March 2017

PHF6 mutations in paediatric acute myeloid leukaemia.

Br J Haematol 2016 12 21;175(5):967-971. Epub 2015 Dec 21.

Paediatric Oncology/Haematology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1111/bjh.13891DOI Listing
December 2016

Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study.

Eur J Cancer 2016 09 29;65:91-101. Epub 2016 Jul 29.

Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg, 69120, Germany; German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.06.009DOI Listing
September 2016

Lack of Effectiveness of Neutropenic Diet and Social Restrictions as Anti-Infective Measures in Children With Acute Myeloid Leukemia: An Analysis of the AML-BFM 2004 Trial.

J Clin Oncol 2016 08 6;34(23):2776-83. Epub 2016 Jun 6.

Lars Tramsen, Emilia Salzmann-Manrique, Konrad Bochennek, Thomas Klingebiel, and Thomas Lehrnbecher, Hospital for Children and Adolescents, Johann Wolfgang Goethe-University, Frankfurt; Dirk Reinhardt, Medical Center, University of Essen, Essen; Ursula Creutzig, Children's Hospital, Hannover Medical School, Hannover, Germany; and Lillian Sung, The Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1200/JCO.2016.66.7881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019758PMC
August 2016

Hematologic Response to Vorinostat Treatment in Relapsed Myeloid Leukemia of Down Syndrome.

Pediatr Blood Cancer 2016 09 18;63(9):1677-9. Epub 2016 May 18.

Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/pbc.26062DOI Listing
September 2016

Infectious Complications in Children With Acute Myeloid Leukemia and Down Syndrome: Analysis of the Prospective Multicenter Trial AML-BFM 2004.

Pediatr Blood Cancer 2016 Jun 27;63(6):1070-4. Epub 2016 Jan 27.

Division of Pediatric Hematology and Oncology, Hospital for Children and Adolescents, Johann Wolfgang Goethe-University, Frankfurt, Germany.

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http://dx.doi.org/10.1002/pbc.25917DOI Listing
June 2016

Exchange Transfusion and Leukapheresis in Pediatric Patients with AML With High Risk of Early Death by Bleeding and Leukostasis.

Pediatr Blood Cancer 2016 Apr 16;63(4):640-5. Epub 2015 Dec 16.

Department of Pediatric Hematology-Oncology, University of Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1002/pbc.25855DOI Listing
April 2016

Clinical Impact of Additional Cytogenetic Aberrations, cKIT and RAS Mutations, and Treatment Elements in Pediatric t(8;21)-AML: Results From an International Retrospective Study by the International Berlin-Frankfurt-Münster Study Group.

J Clin Oncol 2015 Dec 16;33(36):4247-58. Epub 2015 Nov 16.

Kim Klein, Gertjan Kaspers, Jacqueline Cloos, and Mathilda Bongers, Vrije Universiteit University Medical Center Amsterdam; Gertjan Kaspers and Ardine Reedijk, Dutch Childhood Oncology Group, The Hague; H. Berna Beverloo, Erasmus Medical Center, Rotterdam, the Netherlands; Christine J. Harrison, Newcastle University, Newcastle upon Tyne; Brenda Gibson, Royal Hospital for Sick Children, Glasgow, United Kingdom; Andrea Pession, Italian Association of Pediatric Hematology Oncology, Bologna, Italy; Dirk Reinhardt, Berlin-Frankfurt-Münster (BFM) -Germany, Essen; Martin Zimmerman and Ursula Creutzig, BFM-Germany, Hannover, Germany; Michael Dworzak, BFM-Austria, Vienna, Austria; Todd Alonzo, Donna Johnston, and Betsy Hirsch, Children's Oncology Group (COG) including Children's Cancer Group and Pediatric Oncology Group, Philadelphia (COG chair's office), PA; Michal Zapotocky, Czech Paediatric Hematology Working Group, Prague, Czech Republic; Barbara De Moerloose, European Organisation for Research and Treatment of Cancer-Children's Leukemia Group, Brussels, Belgium; Alcira Flynn, Grupo Argentino de Tratamiento de la Leucemia Aguda, Buenos Aires, Argentina; Vincent Lee, Hong Kong Paediatric Haematology and Oncology Study Group, Hong Kong, Special Administrative Region, People's Republic of China; Takashi Taga, Japanese Pediatric Leukemia/Lymphoma Study Group, Otsu; Akio Tawa, Japanese Pediatric Leukemia/Lymphoma Study Group, Osaka, Japan; Anne Auvrignon, French Leucémie Aiguë Myéloblastique Enfant Cooperative Group, Paris, France; Bernward Zeller, Nordic Society of Paediatric Haematology and Oncology, Oslo, Norway; Erik Forestier, Nordic Society of Paediatric Haematology and Oncology, Umeå, Sweden; Carmen Salgado, The National Program for Antineoplastic Drugs for Children, Santiago, Chile; Walentyna Balwierz, Polish Pediatric Leukemia Lymphoma Study Group, Krakow, Poland; Alexander Popa, Russian Acute Myeloid Leukemia Study Group, Moscow, Russia; and Jeffrey Rubnitz and

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http://dx.doi.org/10.1200/JCO.2015.61.1947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321085PMC
December 2015

Subtype prediction in pediatric acute myeloid leukemia: classification using differential network rank conservation revisited.

BMC Bioinformatics 2015 Sep 23;16:305. Epub 2015 Sep 23.

Department of Pediatric Oncology/Hematology, Erasmus-MC Sophia Childrens Hospital, Rotterdam, The Netherlands.

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http://bmcbioinformatics.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12859-015-0737-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580220PMC
September 2015

Collaborative Efforts Driving Progress in Pediatric Acute Myeloid Leukemia.

J Clin Oncol 2015 Sep 24;33(27):2949-62. Epub 2015 Aug 24.

C. Michel Zwaan, Marry M. van den Heuvel-Eibrink, Sophia Children's Hospital/Erasmus MC, Rotterdam; C. Michel Zwaan, International Berlin-Frankfurt-Münster Study Group (I-BFM-SG) New Agents Committee; C. Michel Zwaan, Innovative Therapies for Children With Cancer Consortium; C. Michel Zwaan, Eveline S.J.M. De Bont, Marry M. van den Heuvel-Eibrink, Gertjan J.L. Kaspers, Dutch Childhood Oncology Group, Den Haag; Eveline S.J.M. De Bont, University of Groningen, University Medical Center Groningen, Groningen; Marry M. van den Heuvel-Eibrink, Gertjan J.L. Kaspers, Princess Máxima Center for Pediatric Oncology, Utrecht; Gertjan J.L. Kaspers, Vrije Universiteit Medical Center, Amsterdam, the Netherlands; Edward A. Kolb, Nemours/Alfred I. du Pont Hospital for Children, Wilmington, DE; Edward A. Kolb, Richard Aplenc, Lilian Sung, Children's Oncology Group, Monrovia, CA; Dirk Reinhardt, Universitäts-Klinikum, Essen; Ursula Creutzig, Hannover Medical School, Hannover; Dirk Reinhardt, Michael Dworzak, Henrik Hasle, Ursula Creutzig, Gertjan J.L. Kaspers, I-BFM Acute Myeloid Leukemia (AML) Study Group, Kiel, Germany; Jonas Abrahamsson, Sahlgrenska University Hospital, Goteborg; Jonas Abrahamsson and Henrik Hasle, Nordic Society for Pediatric Hematology and Oncology, Stockholm, Sweden; Souichi Adachi, Kyoto University, Kyoto; Souichi Adachi, Daisuke Tomizawa, The Japanese Pediatric Leukemia/Lymphoma Study Group, Nagoya; Daisuke Tomizawa, National Center for Child Health and Development, Tokyo, Japan; Richard Aplenc, Children's Hospital of Philadelphia, Philadelphia, PA; Barbara De Moerloose, Ghent University Hospital and Belgian Society of Paediatric Haematology Oncology, Ghent, Belgium; Michael Dworzak, St Anna Children's Hospital and Children's Cancer Research Institute, Medical University of Vienna, Vienna, Austria; Brenda E.S. Gibson, Royal Hospital for Sick Children, Glasgow; Brenda E.S. Gibson and Owen Smith, Children's Cancer and Leukemia Study Group, London, United King

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http://dx.doi.org/10.1200/JCO.2015.62.8289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567700PMC
September 2015

Family History and Relapse in Pediatric Acute Myeloid Leukemia.

Pediatr Blood Cancer 2015 Dec 16;62(12):2235-7. Epub 2015 Jul 16.

Mahak's Pediatric Cancer Treatment and Research Center, Tehran, Iran.

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http://dx.doi.org/10.1002/pbc.25649DOI Listing
December 2015

Improved outcome of pediatric patients with acute megakaryoblastic leukemia in the AML-BFM 04 trial.

Ann Hematol 2015 Aug 28;94(8):1327-36. Epub 2015 Apr 28.

Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1007/s00277-015-2383-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488462PMC
August 2015

Gene expression profiles associated with pediatric relapsed AML.

PLoS One 2015 7;10(4):e0121730. Epub 2015 Apr 7.

Department of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands; Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121730PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388534PMC
March 2016

LincRNAs MONC and MIR100HG act as oncogenes in acute megakaryoblastic leukemia.

Mol Cancer 2014 Jul 15;13:171. Epub 2014 Jul 15.

Pediatric Hematology and Oncology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.

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http://molecular-cancer.biomedcentral.com/articles/10.1186/1
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http://dx.doi.org/10.1186/1476-4598-13-171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118279PMC
July 2014

Clinical relevance of molecular aberrations in paediatric acute myeloid leukaemia at first relapse.

Br J Haematol 2014 Sep 25;166(6):902-10. Epub 2014 Jun 25.

Department of Haematology, VU University Medical Centre, Amsterdam, The Netherlands; Department of Paediatric Oncology/Haematology, VU University Medical Centre, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/bjh.12989DOI Listing
September 2014

Response monitoring of infant acute myeloid leukemia treatment by quantification of the tumor specific MLL-FNBP1 fusion gene.

Leuk Lymphoma 2015 Mar 17;56(3):793-6. Epub 2014 Jul 17.

Department of Pediatrics, University Hospital Erlangen , Erlangen , Germany.

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http://dx.doi.org/10.3109/10428194.2014.928933DOI Listing
March 2015

[Quality management in implementing specialist pediatric palliative home care in Lower Saxony, Germany].

Z Evid Fortbild Qual Gesundhwes 2012 12;106(8):584-94. Epub 2012 May 12.

Netzwerk für die Versorgung schwerkranker Kinder und Jugendlicher e.V., Medizinische Hochschule Hannover.

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http://dx.doi.org/10.1016/j.zefq.2012.04.002DOI Listing
May 2013

CBL mutations do not frequently occur in paediatric acute myeloid leukaemia.

Br J Haematol 2012 Dec 1;159(5):577-84. Epub 2012 Oct 1.

Department of Paediatric Oncology/Haematology, Erasmus MC/Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1111/bjh.12068DOI Listing
December 2012

Paediatric palliative home care in areas of Germany with low population density and long distances: a questionnaire survey with general paediatricians.

BMC Res Notes 2012 Sep 11;5:498. Epub 2012 Sep 11.

Netzwerk für die Versorgung schwerkranker Kinder und Jugendlicher e,V, Carl-Neuberg-Straße 1, 30625 Hannover, 30625, Germany.

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http://dx.doi.org/10.1186/1756-0500-5-498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532334PMC
September 2012

Prospects and challenges of reprogrammed cells in hematology and oncology.

Pediatr Hematol Oncol 2012 Sep 2;29(6):507-28. Epub 2012 Aug 2.

Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.3109/08880018.2012.708707DOI Listing
September 2012

Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells.

Int J Cancer 2013 Feb 12;132(4):766-74. Epub 2012 Aug 12.

Department of Pediatric Hematology and Oncology, Hannover Medical School, Carl Neuberg Str-1, 30625 Hannover, Germany.

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http://dx.doi.org/10.1002/ijc.27726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562481PMC
February 2013

High GATA2 expression is a poor prognostic marker in pediatric acute myeloid leukemia.

Blood 2012 Sep 11;120(10):2064-75. Epub 2012 Jul 11.

Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1182/blood-2011-12-397083DOI Listing
September 2012

miRNAs can increase the efficiency of ex vivo platelet generation.

Ann Hematol 2012 Nov 5;91(11):1673-84. Epub 2012 Jul 5.

Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1007/s00277-012-1517-zDOI Listing
November 2012

Inhibition of NAMPT pathway by FK866 activates the function of p53 in HEK293T cells.

Biochem Biophys Res Commun 2012 Aug 21;424(3):371-7. Epub 2012 Jun 21.

Department of Pediatrics, Hematology and Oncology, Hannover Medical School, Carl Neuberg Str-1, 30625 Hannover, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2012.06.075DOI Listing
August 2012

Next-generation sequencing for minimal residual disease monitoring in acute myeloid leukemia patients with FLT3-ITD or NPM1 mutations.

Genes Chromosomes Cancer 2012 Jul 27;51(7):689-95. Epub 2012 Mar 27.

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/gcc.21955DOI Listing
July 2012

Differentially expressed miRNAs in cytogenetic and molecular subtypes of pediatric acute myeloid leukemia.

Pediatr Blood Cancer 2012 May 4;58(5):715-21. Epub 2011 Aug 4.

Department of Pediatric Oncology/Hematology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://doi.wiley.com/10.1002/pbc.23279
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http://dx.doi.org/10.1002/pbc.23279DOI Listing
May 2012