Publications by authors named "Dirk P Dittmer"

100Publications

Extracellular vesicles in virus infection and pathogenesis.

Curr Opin Virol 2020 Aug 23;44:129-138. Epub 2020 Aug 23.

Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, United States; Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, United States. Electronic address:

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http://dx.doi.org/10.1016/j.coviro.2020.07.014DOI Listing
August 2020

Purification Methods and the Presence of RNA in Virus Particles and Extracellular Vesicles.

Viruses 2020 08 21;12(9). Epub 2020 Aug 21.

Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.3390/v12090917DOI Listing
August 2020

DLX1008 (brolucizumab), a single-chain anti-VEGF-A antibody fragment with low picomolar affinity, leads to tumor involution in an in vivo model of Kaposi Sarcoma.

PLoS One 2020 14;15(5):e0233116. Epub 2020 May 14.

Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233116PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224538PMC
August 2020

Interleukin-1 Receptor-Associated Kinase (IRAK) Signaling in Kaposi Sarcoma-Associated Herpesvirus-Induced Primary Effusion Lymphoma.

J Virol 2020 May 4;94(10). Epub 2020 May 4.

Department of Microbiology and Immunology, Center for AIDS Research, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

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http://dx.doi.org/10.1128/JVI.02123-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199399PMC
May 2020

Burden of respiratory viral infection in persons with human immunodeficiency virus.

Influenza Other Respir Viruses 2020 Jul 9;14(4):465-469. Epub 2020 Mar 9.

Division of Pulmonary and Critical Care Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1111/irv.12734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298306PMC
July 2020

Kaposi Sarcoma-Associated Herpesvirus Infection and Endemic Burkitt Lymphoma.

J Infect Dis 2020 Jun;222(1):111-120

Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.1093/infdis/jiaa060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296861PMC
June 2020

Virus expression detection reveals RNA-sequencing contamination in TCGA.

BMC Genomics 2020 Jan 28;21(1):79. Epub 2020 Jan 28.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA.

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http://dx.doi.org/10.1186/s12864-020-6483-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986043PMC
January 2020

Runaway Kaposi Sarcoma-associated herpesvirus replication correlates with systemic IL-10 levels.

Virology 2020 01 2;539:18-25. Epub 2019 Oct 2.

UNC Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, School of Medicine, The University of North Carolina at Chapel Hill, 450 West Drive, Chapel Hill, NC, 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2019.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908428PMC
January 2020

Modern Techniques for the Isolation of Extracellular Vesicles and Viruses.

J Neuroimmune Pharmacol 2020 Sep 12;15(3):459-472. Epub 2019 Sep 12.

Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1007/s11481-019-09874-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065924PMC
September 2020

Kinome profiling of non-Hodgkin lymphoma identifies Tyro3 as a therapeutic target in primary effusion lymphoma.

Proc Natl Acad Sci U S A 2019 08 25;116(33):16541-16550. Epub 2019 Jul 25.

Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;

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http://dx.doi.org/10.1073/pnas.1903991116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697815PMC
August 2019

Prognostic value of B cells in cutaneous melanoma.

Genome Med 2019 05 28;11(1):36. Epub 2019 May 28.

Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1186/s13073-019-0647-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540526PMC
May 2019

Targeting mTOR with MLN0128 Overcomes Rapamycin and Chemoresistant Primary Effusion Lymphoma.

mBio 2019 02 19;10(1). Epub 2019 Feb 19.

UNC Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA

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http://dx.doi.org/10.1128/mBio.02871-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381283PMC
February 2019

Extracellular vesicles from Kaposi Sarcoma-associated herpesvirus lymphoma induce long-term endothelial cell reprogramming.

PLoS Pathog 2019 02 4;15(2):e1007536. Epub 2019 Feb 4.

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1371/journal.ppat.1007536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361468PMC
February 2019

Kaposi's Sarcoma-Associated Herpesvirus (KSHV)-Associated Disease in the AIDS Patient: An Update.

Cancer Treat Res 2019;177:63-80

Department of Microbiology & Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, CB #7295, NC, 27599, Chapel Hill, USA.

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http://dx.doi.org/10.1007/978-3-030-03502-0_3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201581PMC
June 2019

Large-scale, cross-flow based isolation of highly pure and endocytosis-competent extracellular vesicles.

J Extracell Vesicles 2018 30;7(1):1541396. Epub 2018 Nov 30.

Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, The University of North Carolina, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1080/20013078.2018.1541396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282418PMC
November 2018

Epstein-Barr virus enhances genome maintenance of Kaposi sarcoma-associated herpesvirus.

Proc Natl Acad Sci U S A 2018 11 14;115(48):E11379-E11387. Epub 2018 Nov 14.

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, The University of North Carolina, Chapel Hill, NC 27599

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http://dx.doi.org/10.1073/pnas.1810128115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275488PMC
November 2018

Epstein-Barr Virus-Positive Cancers Show Altered B-Cell Clonality.

mSystems 2018 Sep-Oct;3(5). Epub 2018 Sep 25.

Lineberger Comprehensive Cancer Center, School of Medicine at the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1128/mSystems.00081-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156273PMC
September 2018

Chromatin remodeling controls Kaposi's sarcoma-associated herpesvirus reactivation from latency.

PLoS Pathog 2018 09 13;14(9):e1007267. Epub 2018 Sep 13.

Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1007267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136816PMC
September 2018

Kaposi's Sarcoma-Associated Herpesvirus Latency Locus Renders B Cells Hyperresponsive to Secondary Infections.

J Virol 2018 10 12;92(19). Epub 2018 Sep 12.

Department of Microbiology and Immunology, Programs in Global Oncology and Virology, Lineberger Comprehensive Cancer Center and Center for AIDS Research, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1128/JVI.01138-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146794PMC
October 2018

RIG-I Detects Kaposi's Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner.

mBio 2018 07 3;9(4). Epub 2018 Jul 3.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

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http://dx.doi.org/10.1128/mBio.00823-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030556PMC
July 2018

Translational Model of Zika Virus Disease in Baboons.

J Virol 2018 08 31;92(16). Epub 2018 Jul 31.

Division of Comparative Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

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http://dx.doi.org/10.1128/JVI.00186-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069201PMC
August 2018

Nef Secretion into Extracellular Vesicles or Exosomes Is Conserved across Human and Simian Immunodeficiency Viruses.

mBio 2018 02 6;9(1). Epub 2018 Feb 6.

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

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http://dx.doi.org/10.1128/mBio.02344-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801467PMC
February 2018

Proposal of a Risk-Stratification Platform to Address Distinct Clinical Features of Pediatric Kaposi Sarcoma in Lilongwe, Malawi.

J Glob Oncol 2018 09 22;4:1-7. Epub 2017 Dec 22.

Nader Kim El-Mallawany, Jeremy S. Slone, Michael E. Scheurer, Saeed Ahmed, Gordon E. Schutze, and Parth S. Mehta, Baylor College of Medicine; Nader Kim El-Mallawany, Jeremy S. Slone, Michael E. Scheurer, and Parth S. Mehta, Texas Children's Cancer and Hematology Centers, Houston, TX; William Kamiyango, Jimmy Villiera, Saeed Ahmed, and Peter N. Kazembe, Baylor College of Medicine Children's Foundation Malawi; William Kamiyango, Jimmy Villiera, and Peter N. Kazembe, Kamuzu Central Hospital, Lilongwe, Malawi; Carrie L. Kovarik, University of Pennsylvania, Philadelphia, PA; Liane R. Campbell, Baylor College of Medicine Children's Foundation Tanzania, Baylor International Pediatric AIDS Initiative at Texas Children's Hospital, Mbeya, Tanzania; Anurag K. Agrawal, Children's Hospital and Research Center Oakland, Oakland, CA; and Dirk P. Dittmer and Anthony B. Eason, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC.

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http://dx.doi.org/10.1200/JGO.17.00054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180767PMC
September 2018

Kaposi's Sarcoma-Associated Herpesvirus Increases PD-L1 and Proinflammatory Cytokine Expression in Human Monocytes.

mBio 2017 10 10;8(5). Epub 2017 Oct 10.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

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http://dx.doi.org/10.1128/mBio.00917-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635685PMC
October 2017

Oral shedding of herpesviruses in HIV-infected patients with varying degrees of immune status.

AIDS 2017 09;31(15):2077-2084

aDepartment of Microbiology and Immunology bUNC Lineberger Comprehensive Cancer Center, Center for AIDS Research, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina cCenter for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, Massachusetts dUNC School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina eCenter for Medical Mycology, Case Western Reserve University, University Hospitals Cleveland Medical Center, Cleveland, Ohio fDepartment of Orofacial Sciences, UCSF School of Dentistry, University of California San Francisco, San Francisco, California gDivision of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.

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http://dx.doi.org/10.1097/QAD.0000000000001589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599345PMC
September 2017

Exclusion of Kaposi Sarcoma From Analysis of Cancer Burden.

JAMA Oncol 2017 10;3(10):1429

AIDS Malignancy Consortium, New York, New York.

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http://dx.doi.org/10.1001/jamaoncol.2016.7092DOI Listing
October 2017

Incomplete viral suppression and mortality in HIV patients after antiretroviral therapy initiation.

AIDS 2017 09;31(14):1989-1997

aDepartment of Epidemiology bCenter for AIDS Research cDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina dDivision of Epidemiology, Ohio State University, Columbus, Ohio eJohns Hopkins University, Baltimore, Maryland fUniversity of Washington, Seattle, Washington gUniversity of California, San Diego, California hHarvard University, Cambridge, Massachusetts iUniversity of California, San Francisco, California jDivision of Infectious Diseases, Department of Medicine, Center for Global Health, Feinberg School of Medicine, Northwestern University, Chicago, Illinois kDepartment of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1097/QAD.0000000000001573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695564PMC
September 2017

Viral effects on the content and function of extracellular vesicles.

Nat Rev Microbiol 2017 Sep 26;15(9):559-572. Epub 2017 Jun 26.

UNC Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, CB# 7295, Chapel Hill, North Carolina 27599-7295, USA.

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http://dx.doi.org/10.1038/nrmicro.2017.60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555775PMC
September 2017

Chlamydia trachomatis Seroprevalence and Ultrasound-Diagnosed Uterine Fibroids in a Large Population of Young African-American Women.

Am J Epidemiol 2018 02;187(2):278-286

Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.

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http://dx.doi.org/10.1093/aje/kwx231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860578PMC
February 2018

NLRX1 negatively modulates type I IFN to facilitate KSHV reactivation from latency.

PLoS Pathog 2017 May 1;13(5):e1006350. Epub 2017 May 1.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1006350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426799PMC
May 2017

Diagnosis and Treatment of Kaposi Sarcoma.

Am J Clin Dermatol 2017 Aug;18(4):529-539

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, CB#7295, 450 West Dr., Chapel Hill, NC, 27517, USA.

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http://dx.doi.org/10.1007/s40257-017-0270-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509489PMC
August 2017

Genome Sequences of Diverse Human Cytomegalovirus Strains with Utility in Drug Screening and Vaccine Evaluation.

Genome Announc 2017 Jan 19;5(3). Epub 2017 Jan 19.

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center Program in Global Oncology, Center for AIDS Research (CfAR), School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

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http://dx.doi.org/10.1128/genomeA.01433-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5255926PMC
January 2017

Kaposi's sarcoma in Malawi: a continued problem for HIV-positive and HIV-negative individuals.

AIDS 2017 01;31(2):318-319

aLineberger Comprehensive Cancer Center bDepartment of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA cUNC Project-Malawi dLighthouse Trust Clinic, Kamuzu Central Hospital, Lilongwe eUniversity of Malawi College of Medicine, Blantyre, Malawi fDepartment of Medicine, Institute for Global Health and Infectious Diseases gGillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1097/QAD.0000000000001341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5180456PMC
January 2017

Expression of the Antisense-to-Latency Transcript Long Noncoding RNA in Kaposi's Sarcoma-Associated Herpesvirus.

J Virol 2017 02 31;91(4). Epub 2017 Jan 31.

Department of Microbiology and Immunology, Program in Global Oncology, Lineberger Comprehensive Cancer Center, and Center for AIDS Research, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

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http://dx.doi.org/10.1128/JVI.01698-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286886PMC
February 2017

Zika vaccine: Clinical trial and error?

Authors:
Dirk P Dittmer

Science 2016 Sep;353(6306):1375

Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.

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http://dx.doi.org/10.1126/science.aai8117DOI Listing
September 2016

Differential IgM expression distinguishes two types of pediatric Burkitt lymphoma in mouse and human.

Oncotarget 2016 09;7(39):63504-63513

Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC.

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http://dx.doi.org/10.18632/oncotarget.11531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325380PMC
September 2016

The K1 Protein of Kaposi's Sarcoma-Associated Herpesvirus Augments Viral Lytic Replication.

J Virol 2016 09 12;90(17):7657-66. Epub 2016 Aug 12.

Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

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http://dx.doi.org/10.1128/JVI.03102-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988170PMC
September 2016

Brief Report: A Phase 1b/Pharmacokinetic Trial of PTC299, a Novel PostTranscriptional VEGF Inhibitor, for AIDS-Related Kaposi's Sarcoma: AIDS Malignancy Consortium Trial 059.

J Acquir Immune Defic Syndr 2016 May;72(1):52-7

*Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA;†Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA;‡Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR;§The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD;‖Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC;¶Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC; and#Division of Medical Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1097/QAI.0000000000000918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838493PMC
May 2016

Kaposi's Sarcoma-Associated Herpesvirus Latency Locus Compensates for Interleukin-6 in Initial B Cell Activation.

J Virol 2016 02 9;90(4):2150-4. Epub 2015 Dec 9.

Department of Microbiology and Immunology, Program in Global Oncology, Lineberger Comprehensive Cancer Center, and Center for AIDS Research, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1128/JVI.02456-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734016PMC
February 2016

Animal models of tumorigenic herpesviruses--an update.

Curr Opin Virol 2015 Oct;14:145-50

Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, Center for AIDS Research (CfAR), School of Medicine, University of North Carolina, Chapel Hill, USA.

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http://dx.doi.org/10.1016/j.coviro.2015.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628858PMC
October 2015

KSHV Latency Locus Cooperates with Myc to Drive Lymphoma in Mice.

PLoS Pathog 2015 Sep 1;11(9):e1005135. Epub 2015 Sep 1.

Department of Microbiology and Immunology, Program in Global Oncology, Lineberger Comprehensive Cancer Center, and Center for AIDS Research, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556645PMC
September 2015

Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1β Secretion: A Primary Human Monocyte Model.

PLoS One 2015 24;10(8):e0136708. Epub 2015 Aug 24.

Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America; The Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America; Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136708PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547738PMC
May 2016

Complete Genome Sequences of Mandrillus leucophaeus and Papio ursinus Cytomegaloviruses.

Genome Announc 2015 Aug 6;3(4). Epub 2015 Aug 6.

Department of Microbiology and Immunology, University of North Carolina School of Medicine, Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, USA

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http://dx.doi.org/10.1128/genomeA.00781-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541262PMC
August 2015

Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses.

Proc Natl Acad Sci U S A 2015 Aug 21;112(31):E4306-15. Epub 2015 Jul 21.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; University of North Carolina Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

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http://dx.doi.org/10.1073/pnas.1503831112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534226PMC
August 2015

High Accuracy of Common HIV-Related Oral Disease Diagnoses by Non-Oral Health Specialists in the AIDS Clinical Trial Group.

PLoS One 2015 6;10(7):e0131001. Epub 2015 Jul 6.

Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; Department of Medicine, New York University School of Medicine, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131001PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492974PMC
April 2016

Self-Reported Reproductive Tract Infections and Ultrasound Diagnosed Uterine Fibroids in African-American Women.

J Womens Health (Larchmt) 2015 Jun 22;24(6):489-95. Epub 2015 Apr 22.

2 Epidemiology Branch, National Institute of Environmental Health Sciences , National Institutes of Health, Research Triangle Park, North Carolina.

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http://dx.doi.org/10.1089/jwh.2014.5051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490779PMC
June 2015

Interleukin 1 receptor-associated kinase 1 (IRAK1) mutation is a common, essential driver for Kaposi sarcoma herpesvirus lymphoma.

Proc Natl Acad Sci U S A 2014 Nov 23;111(44):E4762-8. Epub 2014 Oct 23.

Department of Microbiology and Immunology and Program in Global Oncology of the Lineberger Comprehensive Cancer Center, School of Medicine, and

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http://dx.doi.org/10.1073/pnas.1405423111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226132PMC
November 2014

Complete genome sequence of cell culture-attenuated Guinea pig cytomegalovirus cloned as an infectious bacterial artificial chromosome.

Genome Announc 2014 Oct 16;2(5). Epub 2014 Oct 16.

University of North Carolina School of Medicine, Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1128/genomeA.00928-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200145PMC
October 2014

Toll-like receptor-3 is dispensable for the innate microRNA response to West Nile virus (WNV).

PLoS One 2014 15;9(8):e104770. Epub 2014 Aug 15.

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104770PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134228PMC
February 2016

What lies within: coinfections and immunity.

Cell Host Microbe 2014 Aug;16(2):145-147

Department of Microbiology and Immunology, Program in Global Oncology at the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2014.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135381PMC
August 2014

Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation.

Nat Med 2014 Aug 27;20(8):927-35. Epub 2014 Jul 27.

1] Department of Medicine, Division of Infectious Diseases, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. [2] Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. [3] Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1038/nm.3610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126843PMC
August 2014

Relationship of immunologic response to antiretroviral therapy with non-AIDS defining cancer incidence.

AIDS 2014 Apr;28(7):979-87

aUniversity of North Carolina, Chapel Hill, North Carolina bNorthwestern University, Chicago, Illinois cUniversity of Washington, Seattle, Washington dUniversity of Alabama, Birmingham, Alabama eJohns Hopkins University, Baltimore, Maryland fUniversity of California, San Diego gUniversity of California, San Francisco, California, USA.

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http://dx.doi.org/10.1097/QAD.0000000000000167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040952PMC
April 2014

An important role for mitochondrial antiviral signaling protein in the Kaposi's sarcoma-associated herpesvirus life cycle.

J Virol 2014 May 12;88(10):5778-87. Epub 2014 Mar 12.

Lineberger Comprehensive Cancer Center, Program in Global Oncology, and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1128/JVI.03226-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019080PMC
May 2014

Moving forward in HIV-associated cancer.

J Clin Oncol 2014 Mar 18;32(9):876-80. Epub 2014 Feb 18.

University of North Carolina, Chapel Hill, NC.

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http://ascopubs.org/doi/10.1200/JCO.2013.53.1376
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http://dx.doi.org/10.1200/JCO.2013.53.1376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948093PMC
March 2014

Not like a wrecking ball: EBV fine-tunes MYC lymphomagenesis.

Authors:
Dirk P Dittmer

Blood 2014 Jan;123(4):460-1

UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL.

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http://dx.doi.org/10.1182/blood-2013-11-537076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901062PMC
January 2014

Expression profile of microRNAs in Epstein-Barr virus-infected AGS gastric carcinoma cells.

J Virol 2014 Jan 13;88(2):1389-93. Epub 2013 Nov 13.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1128/JVI.02662-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911632PMC
January 2014

The open chromatin landscape of Kaposi's sarcoma-associated herpesvirus.

J Virol 2013 Nov 28;87(21):11831-42. Epub 2013 Aug 28.

Lineberger Comprehensive Cancer Center.

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http://dx.doi.org/10.1128/JVI.01685-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807352PMC
November 2013

Latency locus complements MicroRNA 155 deficiency in vivo.

J Virol 2013 Nov 21;87(21):11908-11. Epub 2013 Aug 21.

Department of Microbiology and Immunology, Program in Global Oncology, Lineberger Comprehensive Cancer Center, and Center for AIDS Research, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1128/JVI.01620-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807310PMC
November 2013

Systemically circulating viral and tumor-derived microRNAs in KSHV-associated malignancies.

PLoS Pathog 2013 18;9(7):e1003484. Epub 2013 Jul 18.

Lineberger Comprehensive Cancer Center, Program in Global Oncology, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715412PMC
February 2014

Kaposi sarcoma associated herpesvirus pathogenesis (KSHV)--an update.

Curr Opin Virol 2013 Jun 13;3(3):238-44. Epub 2013 Jun 13.

Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, Program in Global Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.

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http://dx.doi.org/10.1016/j.coviro.2013.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716290PMC
June 2013

Recent cancer incidence trends in an observational clinical cohort of HIV-infected patients in the US, 2000 to 2011.

Infect Agent Cancer 2013 May 24;8(1):18. Epub 2013 May 24.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, 715 Mary Ellen Jones Building, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1186/1750-9378-8-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671969PMC
May 2013

Maribavir inhibits Epstein-Barr virus transcription through the EBV protein kinase.

J Virol 2013 May 28;87(9):5311-5. Epub 2013 Feb 28.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1128/JVI.03505-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624302PMC
May 2013

Poisson factor models with applications to non-normalized microRNA profiling.

Bioinformatics 2013 May 21;29(9):1105-11. Epub 2013 Feb 21.

Center for Neuroscience and Regenerative Medicine, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1093/bioinformatics/btt091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634185PMC
May 2013

Tousled-like kinases modulate reactivation of gammaherpesviruses from latency.

Cell Host Microbe 2013 Feb;13(2):204-14

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S19313128130003
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http://dx.doi.org/10.1016/j.chom.2012.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602413PMC
February 2013

Viral latency locus augments B-cell response in vivo to induce chronic marginal zone enlargement, plasma cell hyperplasia, and lymphoma.

Blood 2013 Apr 30;121(15):2952-63. Epub 2013 Jan 30.

Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, Center for AIDS Research, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1182/blood-2012-03-415620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624941PMC
April 2013

Hsp90 inhibitors are efficacious against Kaposi Sarcoma by enhancing the degradation of the essential viral gene LANA, of the viral co-receptor EphA2 as well as other client proteins.

PLoS Pathog 2012 29;8(11):e1003048. Epub 2012 Nov 29.

Department of Microbiology and Immunology, Program in Global Oncology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510261PMC
April 2013