Publications by authors named "Dirk M Elston"

448 Publications

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Authors:
Dirk M Elston

J Am Acad Dermatol 2022 Aug 2. Epub 2022 Aug 2.

Professor and Chairman, Department of Dermatology and Dermatologic Surgery Medical University of SC; MSC 578 135 Rutledge Avenue, 11th Floor Charleston, SC. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2022.07.034DOI Listing
August 2022

Histologic Screening of Malignant Melanoma, Spitz, Dermal and Junctional Melanocytic Nevi Using a Deep Learning Model.

Am J Dermatopathol 2022 Jul 19. Epub 2022 Jul 19.

Department of Pathology and Laboratory Medicine, Medical University of South Carolina.

Objective: The integration of an artificial intelligence tool into pathologists' workflow may lead to a more accurate and timely diagnosis of melanocytic lesions, directly patient care. The objective of this study was to create and evaluate the performance of such a model in achieving clinical-grade diagnoses of Spitz nevi, dermal and junctional melanocytic nevi, and melanomas.

Methods: We created a beginner-level training environment by teaching our algorithm to perform cytologic inferences on 136,216 manually annotated tiles of hematoxylin and eosin-stained slides consisting of unequivocal melanocytic nevi, Spitz nevi, and invasive melanoma cases. We sequentially trained and tested our network to provide a final diagnosis-classification on 39 cases in total. Positive predictive value (precision) and sensitivity (recall) were used to measure our performance.

Results: The tile-classification algorithm predicted the 136,216 irrelevant, melanoma, melanocytic nevi, and Spitz nevi tiles at sensitivities of 96%, 93%, 94% and 73%, respectively. The final trained model was able to correctly classify and predict the correct diagnosis in 85.7% of unseen cases (n = 28), reporting at or near screening-level performances for precision and recall of melanoma (76.2%, 100.0%), melanocytic nevi (100.0%, 75.0%), and Spitz nevi (100.0%, 75.0%).

Conclusions: Our pilot study proves that convolutional networks trained on cellular morphology to classify melanocytic proliferations can be used as a powerful tool to assist pathologists in screening for melanoma versus other benign lesions.
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http://dx.doi.org/10.1097/DAD.0000000000002232DOI Listing
July 2022

Facial milia-like eruption in a patient with alopecia.

JAAD Case Rep 2022 Jul 25;25:111-113. Epub 2022 Jun 25.

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, SC, USA.

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http://dx.doi.org/10.1016/j.jdcr.2022.02.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310345PMC
July 2022

This Month in JAAD: September 2022.

Authors:
Dirk M Elston

J Am Acad Dermatol 2022 Jul 20. Epub 2022 Jul 20.

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2022.07.025DOI Listing
July 2022

Letter from the Editor: Delays in melanoma diagnosis.

Authors:
Dirk M Elston

J Am Acad Dermatol 2022 Jun 16. Epub 2022 Jun 16.

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2022.06.020DOI Listing
June 2022

What's Eating You? Mosquitoes (Culicidae).

Cutis 2022 Mar;109(3):126-128

Medical University of South Carolina, Charleston. Ms. Andrews is from the College of Medicine, and Drs. Ellis and Elston are from the Department of Dermatology and Dermatologic Surgery.

Mosquito bites cause a variety of reactions ranging from pruritic papules to severe systemic hypersensitivity reactions. The salivary glands of mosquitoes have been found to contain more than 70 different allergens. Herein, we describe the pathophysiology and clinical appearance of mosquito bite reactions as well as proper management of this condition.
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http://dx.doi.org/10.12788/cutis.0472DOI Listing
March 2022

Letter from the Editor: Cost-effectiveness of tuberculosis screening in patients already on biologic therapy.

Authors:
Dirk M Elston

J Am Acad Dermatol 2022 May 26. Epub 2022 May 26.

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2022.05.042DOI Listing
May 2022

Letter from the editor: Diversity and inclusion in clinical trials Link to JAAD-D-21-03191.

Authors:
Dirk M Elston

J Am Acad Dermatol 2022 May 25. Epub 2022 May 25.

Professor and Chairman, Department of Dermatology and Dermatologic Surgery Medical University of SC; MSC 578, 135 Rutledge Avenue; 11th Floor Charleston, SC 29425-5780. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2022.05.041DOI Listing
May 2022

Letter from the editor: New paradigms for the treatment of psoriasis.

Authors:
Dirk M Elston

J Am Acad Dermatol 2022 May 26. Epub 2022 May 26.

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2022.05.044DOI Listing
May 2022

Letter from the Editor: Management of cutaneous polyarteritis nodosa.

Authors:
Dirk M Elston

J Am Acad Dermatol 2022 May 26. Epub 2022 May 26.

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2022.05.043DOI Listing
May 2022

This Month in JAAD: August 2022.

Authors:
Dirk M Elston

J Am Acad Dermatol 2022 08 22;87(2):293. Epub 2022 May 22.

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2022.05.037DOI Listing
August 2022

This Month in JAAD: July 2022.

Authors:
Dirk M Elston

J Am Acad Dermatol 2022 07 27;87(1):43. Epub 2022 Apr 27.

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2022.04.035DOI Listing
July 2022

Letter from the Editor: Faulty generalization.

Authors:
Dirk M Elston

J Am Acad Dermatol 2022 Apr 16. Epub 2022 Apr 16.

Department of Dermatology, Medical University of South Carolina, Charleston, South Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2022.04.015DOI Listing
April 2022

This Month in JAAD: June 2022.

Authors:
Dirk M Elston

J Am Acad Dermatol 2022 06 28;86(6):1230. Epub 2022 Mar 28.

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2022.03.040DOI Listing
June 2022

Letter from the Editor: What's in a name?

Authors:
Dirk M Elston

J Am Acad Dermatol 2022 Mar 1. Epub 2022 Mar 1.

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2022.02.049DOI Listing
March 2022

This month in JAAD: May 2022.

Authors:
Dirk M Elston

J Am Acad Dermatol 2022 05 23;86(5):996. Epub 2022 Feb 23.

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2022.02.035DOI Listing
May 2022

Aquatic Antagonists: Jellyfish Stings.

Cutis 2022 Jan;109(1):20-22

Dr. Park is from Geisinger Commonwealth School of Medicine, Scranton, Pennsylvania. Dr. Elston is from the Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston.

Jellies, more commonly known as jellyfish, are a common cause of stings in oceans throughout the world. Most stings result in immediate painful skin reactions that can be treated with hot water immersion and careful removal of adherent tentacles. Rarely, certain jellyfish species can cause life-threatening systemic reactions that must be treated promptly and monitored in the acute care setting. Wearing a full-body stinger suit or applying a sting-inhibiting lotion are common strategies that may reduce the risk for jellyfish injuries. Avoidance of waters during jellyfish season is prudent in regions that harbor more dangerous species of jellyfish, particularly along the Australian and Indo-Pacific coastlines.
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http://dx.doi.org/10.12788/cutis.0433DOI Listing
January 2022

What's Eating You? Caterpillars.

Cutis 2021 Dec;108(6):346-351

Drs. Ellis and Elston are from the Department of Dermatology and Dermatopathology, The Medical University of South Carolina, Charleston. Dr. Hossler is from Geisinger Health, Danville, Pennsylvania. Dr. Cowper is from the Department of Dermatology, Yale School of Medicine, New Haven, Connecticut. Dr. Rapini is from the Department of Dermatology, University of Texas Health Science Center, Houston.

Caterpillar envenomation is a worldwide problem, with manifestations ranging from dermatitis to iridocyclitis and a fatal hemorrhagic diathesis. This article focuses on the diagnosis and management of dermatoses related to caterpillars.
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http://dx.doi.org/10.12788/cutis.0406DOI Listing
December 2021

Frequency and patterns of editorial rejections (rejections without peer review) across medical journals.

J Am Acad Dermatol 2022 Feb 4. Epub 2022 Feb 4.

Department of Dermatology, Northwestern University, Chicago, Illinois; Department of Otolaryngology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2022.01.047DOI Listing
February 2022

Letter from the editor: Meta-analysis, study heterogeneity, and clinical significance.

Authors:
Dirk M Elston

J Am Acad Dermatol 2022 05 29;86(5):e245-e246. Epub 2022 Jan 29.

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2022.01.035DOI Listing
May 2022

Letter from the editor: Meta-analysis, forest plots, and assessment of heterogeneity.

Authors:
Dirk M Elston

J Am Acad Dermatol 2022 Jan 29. Epub 2022 Jan 29.

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2022.01.038DOI Listing
January 2022

Letter from the Editor: The use and misuse of systematic reviews and meta-analysis.

Authors:
Dirk M Elston

J Am Acad Dermatol 2022 05 29;86(5):e247. Epub 2022 Jan 29.

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2022.01.037DOI Listing
May 2022

Letter from the editor: Meta-analysis models.

Authors:
Dirk M Elston

J Am Acad Dermatol 2022 08 29;87(2):291-292. Epub 2022 Jan 29.

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2022.01.036DOI Listing
August 2022

Letter from the editor: More on meta-analysis.

Authors:
Dirk M Elston

J Am Acad Dermatol 2022 07 29;87(1):41-42. Epub 2022 Jan 29.

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2022.01.034DOI Listing
July 2022

Letter from the editor: Meta-analysis, study heterogeneity, and clinical significance.

Authors:
Dirk M Elston

J Am Acad Dermatol 2022 Jan 29. Epub 2022 Jan 29.

Department of Dermatology, Medical University of South Carolina, Charleston, South Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2022.01.024DOI Listing
January 2022

Purpura Fulminans in an Asplenic Intravenous Drug User.

Cutis 2021 Nov;108(5):E9-E12

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston.

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http://dx.doi.org/10.12788/cutis.0396DOI Listing
November 2021

This month in JAAD: April 2022.

Authors:
Dirk M Elston

J Am Acad Dermatol 2022 04 24;86(4):743. Epub 2021 Dec 24.

Department and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2021.12.034DOI Listing
April 2022

This month in JAAD: March 2022.

Authors:
Dirk M Elston

J Am Acad Dermatol 2022 03 2;86(3):528-529. Epub 2021 Dec 2.

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2021.11.044DOI Listing
March 2022

Botanical Briefs: Bloodroot (Sanguinaria canadensis).

Cutis 2021 Oct;108(4):212-214

Dr. Schwartzberg is from the Department of Medicine, Lehigh Valley Health Network, Allentown, Pennsylvania. Dr. Osswald is from the Department of Dermatology and Cutaneous Surgery, UT Health San Antonio, Texas. Dr. Elston is from the Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston.

Bloodroot (Sanguinaria canadensis) is a plant that historically has been used in medicine for its antimicrobial, antihypertensive, anti-inflammatory, and antineoplastic properties. In dermatology, bloodroot has been utilized for its cytotoxic effects; it has been marketed as black salve as an anticancer treatment, but it does not come without notable toxicities. Unwanted cosmetic outcomes and even irreversible scarring and premalignant conditions have been reported. This article aims to bring awareness to both the therapeutic potential of S canadensis as well as the potential toxicities and risks associated with this North American plant.
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http://dx.doi.org/10.12788/cutis.0345DOI Listing
October 2021

This month in JAAD: February 2022.

Authors:
Dirk M Elston

J Am Acad Dermatol 2022 02 18;86(2):297-298. Epub 2021 Nov 18.

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2021.11.017DOI Listing
February 2022
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