Publications by authors named "Dirk Hubmacher"

36Publications

Acromelic dysplasias: how rare musculoskeletal disorders reveal biological functions of extracellular matrix proteins.

Ann N Y Acad Sci 2020 Sep 2. Epub 2020 Sep 2.

Leni & Peter W. May Department of Orthopedics, Icahn School of Medicine at Mount Sinai, New York, New York.

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http://dx.doi.org/10.1111/nyas.14465DOI Listing
September 2020

The quest for substrates and binding partners: A critical barrier for understanding the role of ADAMTS proteases in musculoskeletal development and disease.

Dev Dyn 2020 Sep 1. Epub 2020 Sep 1.

Orthopedic Research Laboratories, Leni & Peter W. May Department of Orthopedics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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http://dx.doi.org/10.1002/dvdy.248DOI Listing
September 2020

Tgfβ signaling is required for tenocyte recruitment and functional neonatal tendon regeneration.

Elife 2020 06 5;9. Epub 2020 Jun 5.

Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, United States.

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http://dx.doi.org/10.7554/eLife.51779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324157PMC
June 2020

The ADAMTS/Fibrillin Connection: Insights into the Biological Functions of ADAMTS10 and ADAMTS17 and Their Respective Sister Proteases.

Biomolecules 2020 04 12;10(4). Epub 2020 Apr 12.

Orthopaedic Research Laboratories, Leni & Peter W. May Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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http://dx.doi.org/10.3390/biom10040596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226509PMC
April 2020

Stable Knockdown of Genes Encoding Extracellular Matrix Proteins in the C2C12 Myoblast Cell Line Using Small-Hairpin (sh)RNA.

J Vis Exp 2020 02 12(156). Epub 2020 Feb 12.

Orthopaedic Research Laboratories, Leni & Peter W. May Department of Orthopaedics, Icahn School of Medicine at Mount Sinai;

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http://dx.doi.org/10.3791/60824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553128PMC
February 2020

A novel ADAMTS17 variant that causes Weill-Marchesani syndrome 4 alters fibrillin-1 and collagen type I deposition in the extracellular matrix.

Matrix Biol 2020 06 11;88:1-18. Epub 2019 Nov 11.

Orthopaedic Research Laboratories, Leni & Peter W. May Department of Orthopaedics, Icahn School of Medicine at Mt. Sinai, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2019.11.001DOI Listing
June 2020

Cell-Based Interaction Analysis of ADAMTS Proteases and ADAMTS-Like Proteins with Fibrillin Microfibrils.

Authors:
Dirk Hubmacher

Methods Mol Biol 2020 ;2043:195-206

Orthopaedic Research Laboratories, Leni & Peter W. May Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1007/978-1-4939-9698-8_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910243PMC
April 2020

The "other" 15-40%: The Role of Non-Collagenous Extracellular Matrix Proteins and Minor Collagens in Tendon.

J Orthop Res 2020 01 26;38(1):23-35. Epub 2019 Aug 26.

Leni & Peter W. May Department of Orthopaedics, Orthopaedic Research Laboratories, Icahn School of Medicine at Mt. Sinai, New York, New York, 10029.

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http://dx.doi.org/10.1002/jor.24440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917864PMC
January 2020

Limb- and tendon-specific Adamtsl2 deletion identifies a role for ADAMTSL2 in tendon growth in a mouse model for geleophysic dysplasia.

Matrix Biol 2019 09 7;82:38-53. Epub 2019 Feb 7.

Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44120, USA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685762PMC
September 2019

Interactions between lysyl oxidases and ADAMTS proteins suggest a novel crosstalk between two extracellular matrix families.

Matrix Biol 2019 01 17;75-76:114-125. Epub 2018 May 17.

The Rappaport Faculty of Medicine and Research Institute, Technion - Israel Institute of Technology, Haifa 31096, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2018.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240406PMC
January 2019

Unusual life cycle and impact on microfibril assembly of ADAMTS17, a secreted metalloprotease mutated in genetic eye disease.

Sci Rep 2017 02 8;7:41871. Epub 2017 Feb 8.

Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA.

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http://www.nature.com/articles/srep41871
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http://dx.doi.org/10.1038/srep41871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296908PMC
February 2017

ADAMTS proteins as modulators of microfibril formation and function.

Matrix Biol 2015 Sep 7;47:34-43. Epub 2015 May 7.

Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2015.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731137PMC
September 2015

Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia.

Dis Model Mech 2015 May 11;8(5):487-99. Epub 2015 Mar 11.

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA

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http://dx.doi.org/10.1242/dmm.017046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415891PMC
May 2015

Human eye development is characterized by coordinated expression of fibrillin isoforms.

Invest Ophthalmol Vis Sci 2014 Nov 18;55(12):7934-44. Epub 2014 Nov 18.

Department of Biomedical Engineering, Cleveland Clinic, Lerner Research Institute, Cleveland, Ohio, United States.

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http://dx.doi.org/10.1167/iovs.14-15453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263138PMC
November 2014

Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.

FEBS Lett 2014 Aug 14;588(17):2890-7. Epub 2014 Jul 14.

Faculty of Medicine, Department of Anatomy and Cell Biology, McGill University, Montreal, QC H3A 0C7, Canada; Faculty of Dentistry, McGill University, Montreal, QC H3A 0C7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2014.06.061DOI Listing
August 2014

Early fibrillin-1 assembly monitored through a modifiable recombinant cell approach.

Biomacromolecules 2014 Apr 7;15(4):1456-68. Epub 2014 Mar 7.

Department of Anatomy and Cell Biology, Faculty of Medicine, McGill University , Montreal, Quebec H3A 0C7, Canada.

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http://dx.doi.org/10.1021/bm5000696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961472PMC
April 2014

Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.

Invest Ophthalmol Vis Sci 2013 Dec 23;54(13):8337-44. Epub 2013 Dec 23.

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio.

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http://dx.doi.org/10.1167/iovs.13-13121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875392PMC
December 2013

The biology of the extracellular matrix: novel insights.

Curr Opin Rheumatol 2013 Jan;25(1):65-70

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1097/BOR.0b013e32835b137bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560377PMC
January 2013

Genetic and functional linkage between ADAMTS superfamily proteins and fibrillin-1: a novel mechanism influencing microfibril assembly and function.

Cell Mol Life Sci 2011 Oct 20;68(19):3137-48. Epub 2011 Aug 20.

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1007/s00018-011-0780-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729447PMC
October 2011

Classical and neonatal Marfan syndrome mutations in fibrillin-1 cause differential protease susceptibilities and protein function.

J Biol Chem 2011 Sep 22;286(37):32810-23. Epub 2011 Jul 22.

Faculty of Dentistry, Division of Biomedical Sciences, Faculty of Medicine, McGill University, Montreal H3A 2B2, Canada.

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http://dx.doi.org/10.1074/jbc.M111.221804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173189PMC
September 2011

Homocysteine modifies structural and functional properties of fibronectin and interferes with the fibronectin-fibrillin-1 interaction.

Biochemistry 2011 Jun 19;50(23):5322-32. Epub 2011 May 19.

Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1021/bi200183zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112360PMC
June 2011

Fibrillin-3 expression in human development.

Matrix Biol 2011 Jan 21;30(1):43-52. Epub 2010 Oct 21.

Faculty of Medicine, Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1016/j.matbio.2010.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961473PMC
January 2011

Functional consequences of homocysteinylation of the elastic fiber proteins fibrillin-1 and tropoelastin.

J Biol Chem 2010 Jan 4;285(2):1188-98. Epub 2009 Nov 4.

Faculty of Medicine, Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec H3A 2B2, Canada.

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http://dx.doi.org/10.1074/jbc.M109.021246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801247PMC
January 2010

One more piece in the fibrillin puzzle.

Structure 2009 May;17(5):635-6

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http://dx.doi.org/10.1016/j.str.2009.04.002DOI Listing
May 2009

Fibrillin assembly requires fibronectin.

Mol Biol Cell 2009 Feb 26;20(3):846-58. Epub 2008 Nov 26.

Faculty of Medicine, Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada H3A 2B2.

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http://dx.doi.org/10.1091/mbc.e08-08-0830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633374PMC
February 2009

Biogenesis of extracellular microfibrils: Multimerization of the fibrillin-1 C terminus into bead-like structures enables self-assembly.

Proc Natl Acad Sci U S A 2008 May 30;105(18):6548-53. Epub 2008 Apr 30.

Faculty of Medicine, Department of Anatomy and Cell Biology and Faculty of Dentistry, Division of Biomedical Sciences, McGill University, Montreal, QC, Canada.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0706335105
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http://dx.doi.org/10.1073/pnas.0706335105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373353PMC
May 2008

Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.

J Biol Chem 2007 Mar 25;282(12):8935-46. Epub 2007 Jan 25.

Faculty of Medicine, Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec H3A 2B2, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M608204200
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http://dx.doi.org/10.1074/jbc.M608204200DOI Listing
March 2007

Iron-uptake in the Euryarchaeon Halobacterium salinarum.

Biometals 2007 Jun 23;20(3-4):539-47. Epub 2007 Jan 23.

Department of Anatomy and Cell Biology, McGill University of Montreal, 3640 University Street, Montreal, QC, Canada H3A 2B2.

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http://dx.doi.org/10.1007/s10534-006-9064-5DOI Listing
June 2007

Fibrillins: from biogenesis of microfibrils to signaling functions.

Curr Top Dev Biol 2006 ;75:93-123

Department of Anatomy and Cell Biology, Faculty of Medicine, McGill University Montreal, Quebec, H3A 2B2, Canada.

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http://dx.doi.org/10.1016/S0070-2153(06)75004-9DOI Listing
October 2006

Modification of the structure and function of fibrillin-1 by homocysteine suggests a potential pathogenetic mechanism in homocystinuria.

J Biol Chem 2005 Oct 11;280(41):34946-55. Epub 2005 Aug 11.

Faculty of Medicine, Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec H3A2B2, Canada.

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http://dx.doi.org/10.1074/jbc.M504748200DOI Listing
October 2005

Effects of iron limitation on the respiratory chain and the membrane cytochrome pattern of the Euryarchaeon Halobacterium salinarum.

Biol Chem 2003 Dec;384(12):1565-73

Institut für Biochemie, Universität zu Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany.

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http://dx.doi.org/10.1515/BC.2003.173DOI Listing
December 2003