Dirk Hose

Dirk Hose

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Dirk Hose

Dirk Hose

Publications by authors named "Dirk Hose"

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Copresentation of BMP-6 and RGD Ligands Enhances Cell Adhesion and BMP-Mediated Signaling.

Cells 2019 Dec 15;8(12). Epub 2019 Dec 15.

Department of Cellular Biophysics, Max Planck Institute for Medical Research, Jahnstr. 29, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.3390/cells8121646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953040PMC
December 2019

Cytogenetic subclone formation and evolution in progressive smoldering multiple myeloma.

Leukemia 2019 Nov 11. Epub 2019 Nov 11.

Medizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41375-019-0634-2DOI Listing
November 2019

Pacemaker cell characteristics of differentiated and HCN4-transduced human mesenchymal stem cells.

Life Sci 2019 Sep 7;232:116620. Epub 2019 Jul 7.

Department of Cardiology, Medical University Hospital Heidelberg, INF 410, D-69120 Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, University of Heidelberg, INF 410, D-69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2019.116620DOI Listing
September 2019

Hyaluronan hydrogels delivering BMP-6 for local targeting of malignant plasma cells and osteogenic differentiation of mesenchymal stromal cells.

Acta Biomater 2019 09 11;96:258-270. Epub 2019 Jul 11.

Institute of Physical Chemistry, Department of Biophysical Chemistry, Heidelberg University, Im Neuenheimer Feld 253, 69120 Heidelberg, Germany; Max Planck Institute for Medical Research, Department of Cellular Biophysics and Central Scientific Facility "Cellular Biotechnology", Jahnstr. 29, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2019.07.018DOI Listing
September 2019

RNA-Sequencing from Low-Input Material in Multiple Myeloma for Application in Clinical Routine.

Methods Mol Biol 2018 ;1792:97-115

Labor für Myelomforschung, Medizinische Klinik V, Universitätsklinikum Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/978-1-4939-7865-6_7DOI Listing
February 2019

Cytogenetic abnormalities in monoclonal gammopathy of undetermined significance.

Leukemia 2018 12 6;32(12):2717-2719. Epub 2018 Jul 6.

Department of Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41375-018-0202-1DOI Listing
December 2018

From Bench to Bedside: A View on Bioinformatics Pipelines.

Stud Health Technol Inform 2017 ;245:375-378

Institute of Medical Biometry and Informatics, Heidelberg University, Heidelberg, Germany.

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June 2018

Upregulation of FOXM1 in a subset of relapsed myeloma results in poor outcome.

Blood Cancer J 2018 02 15;8(2):22. Epub 2018 Feb 15.

Department of Pathology, The University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, 52242, Iowa, USA.

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http://dx.doi.org/10.1038/s41408-018-0060-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814454PMC
February 2018

Quantification of plasma cell dynamics using mathematical modelling.

R Soc Open Sci 2018 Jan 24;5(1):170759. Epub 2018 Jan 24.

Heidelberg University, Institute of Applied Mathematics, BIOQUANT and IWR, Heidelberg, Germany.

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http://dx.doi.org/10.1098/rsos.170759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792876PMC
January 2018

A tissue-based approach to selection of reference genes for quantitative real-time PCR in a sheep osteoporosis model.

BMC Genomics 2017 Dec 19;18(1):975. Epub 2017 Dec 19.

Department of Pediatrics, University Hospital Carl Gustav Carus, TU Dresden, Fetscherstraße 74, 01307, Dresden, Germany.

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http://dx.doi.org/10.1186/s12864-017-4356-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735898PMC
December 2017

Osteocyte Regulation of Receptor Activator of NF-κB Ligand/Osteoprotegerin in a Sheep Model of Osteoporosis.

Am J Pathol 2017 Aug 12;187(8):1686-1699. Epub 2017 Jun 12.

Experimental Trauma Surgery, Faculty of Medicine, Justus-Liebig University of Giessen, Giessen, Germany; Department of Trauma, Hand and Reconstructive Surgery, University Hospital of Giessen-Marburg, Giessen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.04.005DOI Listing
August 2017

Baseline characteristics, chromosomal alterations, and treatment affecting prognosis of deletion 17p in newly diagnosed myeloma.

Am J Hematol 2016 Nov 3;91(11):E473-E477. Epub 2016 Sep 3.

Medizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/ajh.24533DOI Listing
November 2016

Prognostic impact of cytogenetic aberrations in AL amyloidosis patients after high-dose melphalan: a long-term follow-up study.

Blood 2016 07 2;128(4):594-602. Epub 2016 Jun 2.

Amyloidosis Center, and Division of Hematology/Oncology/Rheumatology, Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany;

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http://dx.doi.org/10.1182/blood-2015-10-676361DOI Listing
July 2016

Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma.

Br J Cancer 2016 Mar 11;114(5):519-23. Epub 2016 Feb 11.

Institute of Human Genetics, CNRS-UPR1142, Montpellier F-34396, France.

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http://dx.doi.org/10.1038/bjc.2016.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782210PMC
March 2016

(18)F-FDG dynamic PET/CT in patients with multiple myeloma: patterns of tracer uptake and correlation with bone marrow plasma cell infiltration rate.

Clin Nucl Med 2015 Jun;40(6):e300-7

From the *Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center; †Medical Clinic V, University Hospital Heidelberg; ‡National Center for Tumor Diseases Heidelberg; §Department of Radiology, German Cancer Research Center; and ║Division of Nuclear Medicine, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1097/RLU.0000000000000773DOI Listing
June 2015

Massive parallel IGHV gene sequencing reveals a germinal center pathway in origins of human multiple myeloma.

Oncotarget 2015 May;6(15):13229-40

Tumour Immunogenetics Group, Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, UK.

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http://www.oncotarget.com/fulltext/3644
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537010PMC
http://dx.doi.org/10.18632/oncotarget.3644DOI Listing
May 2015

T cell-based targeted immunotherapies for patients with multiple myeloma.

Int J Cancer 2015 Apr 19;136(8):1751-68. Epub 2014 Sep 19.

Department of Internal Medicine V, University Clinic Heidelberg, University of Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.29190DOI Listing
April 2015

Translocation t(11;14) is associated with adverse outcome in patients with newly diagnosed AL amyloidosis when treated with bortezomib-based regimens.

J Clin Oncol 2015 Apr 16;33(12):1371-8. Epub 2015 Mar 16.

Tilmann Bochtler, Ute Hegenbart, Anja Seckinger, Christoph Kimmich, Hartmut Goldschmidt, Anthony D. Ho, Dirk Hose, and Stefan O. Schönland, Amyloidosis Center, University Hospital Heidelberg; Christina Kunz and Axel Benner, German Cancer Research Center; Martin Granzow and Anna Jauch, Institute of Human Genetics, University Heidelberg; and Hartmut Goldschmidt and Dirk Hose, National Center for Tumor Diseases, Heidelberg, Germany.

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http://dx.doi.org/10.1200/JCO.2014.57.4947DOI Listing
April 2015

Cellular uptake kinetics of bortezomib in relation to efficacy in myeloma cells and the influence of drug transporters.

Cancer Chemother Pharmacol 2015 Feb 5;75(2):281-91. Epub 2014 Dec 5.

Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00280-014-2643-1DOI Listing
February 2015

Insulin like growth factor binding protein 7 (IGFBP7) expression is linked to poor prognosis but may protect from bone disease in multiple myeloma.

J Hematol Oncol 2015 Feb 8;8:10. Epub 2015 Feb 8.

Wilhelminen Cancer Research Institute, Department of Internal Medicine I, Wilhelminenspital, Montleartstraße 37, 1160, Vienna, Austria.

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http://dx.doi.org/10.1186/s13045-014-0105-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333268PMC
February 2015

Dynamic contrast-enhanced magnetic resonance imaging for assessment of antiangiogenic treatment effects in multiple myeloma.

Clin Cancer Res 2015 Jan 28;21(1):106-12. Epub 2014 Oct 28.

Department of Hematology and Oncology, University Hospital of Heidelberg, Heidelberg, Germany. Department of Radiology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1029DOI Listing
January 2015

GenomicScape: an easy-to-use web tool for gene expression data analysis. Application to investigate the molecular events in the differentiation of B cells into plasma cells.

PLoS Comput Biol 2015 Jan 29;11(1):e1004077. Epub 2015 Jan 29.

U1040, INSERM, Montpellier, France; Department of Biological Hematology, CHU Montpellier, Montpellier, France; UFR Médecine, Université MONTPELLIER 1, Montpellier, France.

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http://dx.doi.org/10.1371/journal.pcbi.1004077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310610PMC
January 2015

Preclinical efficacy of sepantronium bromide (YM155) in multiple myeloma is conferred by down regulation of Mcl-1.

Oncotarget 2014 Nov;5(21):10237-50

Max-Eder Group Experimental Therapies for Hematologic Malignancies, German Cancer Research Center (DKFZ) and Dept. of Internal Medicine V, University of Heidelberg, Heidelberg, Germany. Dept. of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279369PMC
http://dx.doi.org/10.18632/oncotarget.2529DOI Listing
November 2014

PET/CT studies of multiple myeloma using (18) F-FDG and (18) F-NaF: comparison of distribution patterns and tracers' pharmacokinetics.

Eur J Nucl Med Mol Imaging 2014 Jul 22;41(7):1343-53. Epub 2014 Feb 22.

Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany,

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http://dx.doi.org/10.1007/s00259-014-2721-yDOI Listing
July 2014

Immunomodulatory drugs thalidomide and lenalidomide affect osteoblast differentiation of human bone marrow stromal cells in vitro.

Exp Hematol 2014 Jul 2;42(7):516-25. Epub 2014 Apr 2.

Wilhelminen Cancer Research Institute, First Department of Medicine, Center for Oncology and Hematology, Wilhelminenhospital, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2014.03.005DOI Listing
July 2014

Stability of the proteasome inhibitor bortezomib in cell based assays determined by ultra-high performance liquid chromatography coupled to tandem mass spectrometry.

J Chromatogr A 2014 Jun 16;1345:128-38. Epub 2014 Apr 16.

Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2014.04.024DOI Listing
June 2014

DNA methylation score is predictive of myeloma cell sensitivity to 5-azacitidine.

Br J Haematol 2014 Feb 13;164(4):613-6. Epub 2013 Nov 13.

CHU Montpellier, Institute of Research in Biotherapy, Montpellier, France; INSERM, U1040, Montpellier, France.

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http://dx.doi.org/10.1111/bjh.12660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104837PMC
February 2014

Sorafenib in patients with refractory or recurrent multiple myeloma.

Hematol Oncol 2013 Dec 15;31(4):197-200. Epub 2013 Mar 15.

Department of Internal Medicine III, Center for Integrated Oncology (CIO), University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1002/hon.2043DOI Listing
December 2013

Progression in smoldering myeloma is independently determined by the chromosomal abnormalities del(17p), t(4;14), gain 1q, hyperdiploidy, and tumor load.

J Clin Oncol 2013 Dec 21;31(34):4325-32. Epub 2013 Oct 21.

Kai Neben, Anna Jauch, Jens Hillengass, Nicola Lehners, Martin Granzow, Marc S. Raab, and Anthony D. Ho, University of Heidelberg; Thomas Hielscher, German Cancer Research Center; and Anja Seckinger, Hartmut Goldschmidt, and Dirk Hose,University of Heidelberg and National Center for Tumor Diseases, Heidelberg, Germany.

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http://dx.doi.org/10.1200/JCO.2012.48.4923DOI Listing
December 2013

DNA repair pathways in human multiple myeloma: role in oncogenesis and potential targets for treatment.

Cell Cycle 2013 Sep 9;12(17):2760-73. Epub 2013 Aug 9.

CHU Montpellier; Institute of Research in Biotherapy; Montpellier, France; INSERM; U1040; Montpellier, France.

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http://dx.doi.org/10.4161/cc.25951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899190PMC
September 2013

Modeling risk stratification in human cancer.

Bioinformatics 2013 May 14;29(9):1149-57. Epub 2013 Mar 14.

INSERM-UM1, U1040, Institut de Recherche en Biothérapie, 34295 Montpellier, France.

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http://dx.doi.org/10.1093/bioinformatics/btt124DOI Listing
May 2013

Development of gene expression-based score to predict sensitivity of multiple myeloma cells to DNA methylation inhibitors.

Mol Cancer Ther 2012 Dec 18;11(12):2685-92. Epub 2012 Oct 18.

CHU Montpellier, Institute of Research in Biotherapy, France.

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http://dx.doi.org/10.1158/1535-7163.MCT-12-0721DOI Listing
December 2012

STEAP1 is overexpressed in cancers: a promising therapeutic target.

Biochem Biophys Res Commun 2012 Dec 6;429(3-4):148-55. Epub 2012 Nov 6.

CHU Montpellier, Institute of Research in Biotherapy, Montpellier, France.

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http://dx.doi.org/10.1016/j.bbrc.2012.10.123DOI Listing
December 2012

The role of fluorescence in situ hybridization and gene expression profiling in myeloma risk stratification.

Srp Arh Celok Lek 2011 Dec;139 Suppl 2:84-9

Medizinische Klinik V, Universitätsklinikum Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.2298/sarh11s2084hDOI Listing
December 2011

Timing of the high-dose therapy in the area of new drugs.

Srp Arh Celok Lek 2011 Dec;139 Suppl 2:90-4

Department of Medicine V, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.2298/sarh11s2090sDOI Listing
December 2011