Dirk Brehmer

Dirk Brehmer

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Dirk Brehmer

Dirk Brehmer

Publications by authors named "Dirk Brehmer"

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21Publications

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MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells.

Biosci Rep 2015 Oct 2;35(6). Epub 2015 Oct 2.

Laboratory of Biosignaling & Therapeutics, KULeuven Department of Cellular and Molecular Medicine, University of Leuven, Campus Gasthuisberg, O&N1/ Box 901, Herestraat 49, 3000 Leuven, Belgium

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http://dx.doi.org/10.1042/BSR20150194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643329PMC
October 2015

PepShell: visualization of conformational proteomics data.

J Proteome Res 2015 Apr 12;14(4):1987-90. Epub 2015 Mar 12.

†Department of Medical Protein Research, VIB, Albert Baertsoenkaai 3, B-9000 Ghent, Belgium.

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http://dx.doi.org/10.1021/pr5012125DOI Listing
April 2015

Structural investigation of B-Raf paradox breaker and inducer inhibitors.

J Med Chem 2015 Feb 10;58(4):1818-31. Epub 2015 Feb 10.

Institut de Chimie Organique et Analytique, UMR CNRS-Université d'Orléans 7311 , Université d'Orléans BP 6759, Orléans 45067 Cedex 2, France.

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http://pubs.acs.org/doi/10.1021/jm501667n
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http://dx.doi.org/10.1021/jm501667nDOI Listing
February 2015

CD74-NRG1 fusions in lung adenocarcinoma.

Cancer Discov 2014 Apr 27;4(4):415-22. Epub 2014 Jan 27.

1Department of Translational Genomics; 2Department I of Internal Medicine; 3Laboratory of Translational Cancer Genomics; 4Network Genomic Medicine, University Hospital Cologne, Center of Integrated Oncology Cologne-Bonn; 5Center for Molecular Medicine Cologne (CMMC); 6Cologne Center for Genomics (CCG); 7Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD); 8Department of Pathology, University Hospital Medical Center, University of Cologne; 9Blackfield AG; 10Max Planck Institute for Neurological Research; 11Thoracic Surgery, Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH; 12Institute of Human Genetics, Cologne; 13Computational Molecular Biology Department, Max Planck Institute for Molecular Genetics, Berlin; 14Department of Prostate Cancer Research, Institute of Pathology; 15Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn; 16Institute of Pathology; 17Department of Internal Medicine II, Jena University Hospital, Friedrich-Schiller-University, Jena; 18Institute for Pathology Bad Berka, Bad Berka, Germany;19Division of Molecular Oncology, Aichi Cancer Center Research Institute; 20Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan; Departments of 21Surgery and22Pathology, St. Vincent's Hospital; 23Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;24Department of Pathology, 25CHU Grenoble Institut National de la Santé et de la Recherche Medicale (INSERM) U823, Institute Albert Bonniot, Grenoble-Alpes University, Grenoble, France; 26Laboratory of Oncology IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo; 27Laboratory for Molecular Medicine and Biotechnology, University Campus Bio-Medico, Rome, Italy; 28Center for the Biology of Disease, VIB, Leuven; and 29Oncology Discovery, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0633DOI Listing
April 2014

Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cells.

J Biol Chem 2013 Aug 8;288(33):24200-12. Epub 2013 Jul 8.

Laboratory of Biosignaling and Therapeutics, Department of Cellular and Molecular Medicine, University of Leuven, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1074/jbc.M113.471433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745365PMC
August 2013

Cellular targets of gefitinib.

Cancer Res 2005 Jan;65(2):379-82

Axxima Pharmaceuticals AG, Munich, Germany.

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January 2005

Influence of GrpE on DnaK-substrate interactions.

J Biol Chem 2004 Jul 21;279(27):27957-64. Epub 2004 Apr 21.

Zentrum für Molekulare Biologie Heidelberg, Universität Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1074/jbc.M403558200DOI Listing
July 2004

Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors.

Mol Cell Proteomics 2004 May 9;3(5):490-500. Epub 2004 Feb 9.

Axxima Pharmaceuticals AG, Max-Lebsche-Platz 32, 81377 Munich, Germany.

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http://dx.doi.org/10.1074/mcp.M300139-MCP200DOI Listing
May 2004

Evaluation of kinase inhibitor selectivity by chemical proteomics.

Assay Drug Dev Technol 2004 Apr;2(2):215-24

Axxima Pharmaceuticals AG, München, Germany.

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http://dx.doi.org/10.1089/154065804323056558DOI Listing
April 2004

Structure-function analysis of HscC, the Escherichia coli member of a novel subfamily of specialized Hsp70 chaperones.

J Biol Chem 2002 Oct 14;277(43):41060-9. Epub 2002 Aug 14.

Zentrum für Molekulare Biologie, Universität Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1074/jbc.M206520200DOI Listing
October 2002

The conserved helix C region in the superfamily of interferon-gamma /interleukin-10-related cytokines corresponds to a high-affinity binding site for the HSP70 chaperone DnaK.

J Biol Chem 2002 Jul 22;277(28):25668-76. Epub 2002 Apr 22.

Biomolecular Sciences Research Group, McClay Research Centre for Pharmaceutical Sciences, Queen's University of Belfast, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M202984200DOI Listing
July 2002