Dinshaw J Patel

Dinshaw J Patel

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Dinshaw J Patel

Publications by authors named "Dinshaw J Patel"

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Crucial Roles of Two Hydrated Mg Ions in Reaction Catalysis of the Pistol Ribozyme.

Angew Chem Int Ed Engl 2020 Feb 9;59(7):2837-2843. Epub 2020 Jan 9.

Institute of Organic Chemistry and Center for Molecular Biosciences, Leopold-Franzens University, Innrain 80-82, 6020, Innsbruck, Austria.

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http://dx.doi.org/10.1002/anie.201912522DOI Listing
February 2020

Structure-function insights into the initial step of DNA integration by a CRISPR-Cas-Transposon complex.

Cell Res 2020 Feb 10;30(2):182-184. Epub 2020 Jan 10.

Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

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http://dx.doi.org/10.1038/s41422-019-0272-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015049PMC
February 2020

Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection.

Proc Natl Acad Sci U S A 2019 Dec 18;116(49):24507-24516. Epub 2019 Nov 18.

Molecular Biology Program, Sloan Kettering Institute, New York, NY 10065;

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http://dx.doi.org/10.1073/pnas.1913546116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900545PMC
December 2019

Second Messenger cA Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path.

Mol Cell 2019 09 17;75(5):933-943.e6. Epub 2019 Jul 17.

Structural Biology Program Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765193044
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http://dx.doi.org/10.1016/j.molcel.2019.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731140PMC
September 2019

CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA Cleavage with ApA>p Formation Terminating RNase Activity.

Mol Cell 2019 09 17;75(5):944-956.e6. Epub 2019 Jul 17.

Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731128PMC
September 2019

The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation.

Nat Struct Mol Biol 2019 08 5;26(8):720-731. Epub 2019 Aug 5.

Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter, Vienna, Austria.

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http://dx.doi.org/10.1038/s41594-019-0270-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828549PMC
August 2019

REC114 Partner ANKRD31 Controls Number, Timing, and Location of Meiotic DNA Breaks.

Mol Cell 2019 06 16;74(5):1053-1068.e8. Epub 2019 Apr 16.

Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765193022
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http://dx.doi.org/10.1016/j.molcel.2019.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555648PMC
June 2019

Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation.

Proc Natl Acad Sci U S A 2019 Jun 29;116(24):11946-11955. Epub 2019 May 29.

Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065;

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http://dx.doi.org/10.1073/pnas.1905013116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6575157PMC
June 2019

CasX: a new and small CRISPR gene-editing protein.

Cell Res 2019 May;29(5):345-346

Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA.

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http://www.nature.com/articles/s41422-019-0165-4
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http://dx.doi.org/10.1038/s41422-019-0165-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796933PMC
May 2019

Hatchet ribozyme structure and implications for cleavage mechanism.

Proc Natl Acad Sci U S A 2019 May 14;116(22):10783-10791. Epub 2019 May 14.

Life Science Institute, Zhejiang University, 310058 Hangzhou, China;

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http://dx.doi.org/10.1073/pnas.1902413116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561176PMC
May 2019

Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.

Mol Cell 2019 01 29;73(2):264-277.e5. Epub 2018 Nov 29.

Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Southern University of Science and Technology, Shenzhen, Guangdong 518055, China. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355164PMC
January 2019

Transcriptional elongation factor Paf1 core complex adopts a spirally wrapped solenoidal topology.

Proc Natl Acad Sci U S A 2018 10 17;115(40):9998-10003. Epub 2018 Sep 17.

Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, 100875 Beijing, China;

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http://dx.doi.org/10.1073/pnas.1812256115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176576PMC
October 2018

Functional evaluation of tryptophans in glycolipid binding and membrane interaction by HET-C2, a fungal glycolipid transfer protein.

Biochim Biophys Acta Biomembr 2018 May 3;1860(5):1069-1076. Epub 2018 Jan 3.

Dept. of Chemistry School of Advanced Sciences, VIT, Vellore, Tamil Nadu 632014, India. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2018.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963984PMC
May 2018

Atom-Specific Mutagenesis Reveals Structural and Catalytic Roles for an Active-Site Adenosine and Hydrated Mg in Pistol Ribozymes.

Angew Chem Int Ed Engl 2017 12 15;56(50):15954-15958. Epub 2017 Nov 15.

Institute of Organic Chemistry and Center for Molecular Biosciences (CMBI), Leopold-Franzens University, Innrain 80-82, 6020, Innsbruck, Austria.

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http://dx.doi.org/10.1002/anie.201708679DOI Listing
December 2017

Structure-based mechanistic insights into catalysis by small self-cleaving ribozymes.

Curr Opin Chem Biol 2017 Dec 3;41:71-83. Epub 2017 Nov 3.

Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cbpa.2017.09.017DOI Listing
December 2017

Cryo-EM Structures Reveal Mechanism and Inhibition of DNA Targeting by a CRISPR-Cas Surveillance Complex.

Cell 2017 Oct;171(2):414-426.e12

Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA; Center for Molecular Microscopy, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683424PMC
October 2017

Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX.

Nat Commun 2017 10 30;8(1):1193. Epub 2017 Oct 30.

Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI, 53706, USA.

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http://dx.doi.org/10.1038/s41467-017-01206-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662737PMC
October 2017

TRF2 binds branched DNA to safeguard telomere integrity.

Nat Struct Mol Biol 2017 Sep 14;24(9):734-742. Epub 2017 Aug 14.

Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York, USA.

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http://dx.doi.org/10.1038/nsmb.3451DOI Listing
September 2017

Polycomb-like proteins link the PRC2 complex to CpG islands.

Nature 2017 09 6;549(7671):287-291. Epub 2017 Sep 6.

Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, 19 Xinjiekouwai Avenue, Beijing 100875, China.

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http://dx.doi.org/10.1038/nature23881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937281PMC
September 2017

Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes.

Nucleic Acids Res 2017 Sep;45(15):9149-9163

Key Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

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http://dx.doi.org/10.1093/nar/gkx547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587774PMC
September 2017

Inhibition Mechanism of an Anti-CRISPR Suppressor AcrIIA4 Targeting SpyCas9.

Mol Cell 2017 Jul 9;67(1):117-127.e5. Epub 2017 Jun 9.

Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595222PMC
July 2017

How α-Helical Motifs Form Functionally Diverse Lipid-Binding Compartments.

Annu Rev Biochem 2017 06 30;86:609-636. Epub 2017 Mar 30.

The Hormel Institute, University of Minnesota, Austin, Minnesota 55912; email: ,

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http://dx.doi.org/10.1146/annurev-biochem-061516-044445DOI Listing
June 2017

Histone chaperone networks shaping chromatin function.

Nat Rev Mol Cell Biol 2017 03 5;18(3):141-158. Epub 2017 Jan 5.

Biotech Research and Innovation Centre (BRIC) and Centre for Epigenetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.

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http://dx.doi.org/10.1038/nrm.2016.159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319910PMC
March 2017

New CRISPR-Cas systems discovered.

Cell Res 2017 03 21;27(3):313-314. Epub 2017 Feb 21.

Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA.

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http://dx.doi.org/10.1038/cr.2017.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339838PMC
March 2017

Histone chaperone networks shaping chromatin function.

Nat Rev Mol Cell Biol 2017 03 5;18(3):141-158. Epub 2017 Jan 5.

Biotech Research and Innovation Centre (BRIC) and Centre for Epigenetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.

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http://dx.doi.org/10.1038/nrm.2016.159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319910PMC
March 2017

PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease.

Cell 2016 Dec;167(7):1814-1828.e12

Structurel Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.11.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278635PMC
December 2016

Pistol ribozyme adopts a pseudoknot fold facilitating site-specific in-line cleavage.

Nat Chem Biol 2016 09 11;12(9):702-8. Epub 2016 Jul 11.

Structural Biology Program, Memorial Sloan-Kettering Cancer, New York, New York, USA.

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http://dx.doi.org/10.1038/nchembio.2125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990474PMC
September 2016

Structure and function of the bacterial decapping enzyme NudC.

Nat Chem Biol 2016 09 18;12(9):730-4. Epub 2016 Jul 18.

Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany.

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http://dx.doi.org/10.1038/nchembio.2132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003112PMC
September 2016

Structural basis underlying viral hijacking of a histone chaperone complex.

Nat Commun 2016 09 1;7:12707. Epub 2016 Sep 1.

Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/ncomms12707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025803PMC
September 2016

Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition.

Cell Res 2016 08 22;26(8):901-13. Epub 2016 Jul 22.

Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1038/cr.2016.88DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973337PMC
August 2016

Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin.

Proc Natl Acad Sci U S A 2016 08 15;113(35):E5108-16. Epub 2016 Aug 15.

Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA 90095; Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095

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http://dx.doi.org/10.1073/pnas.1609709113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024608PMC
August 2016

The CENP-T/-W complex is a binding partner of the histone chaperone FACT.

Genes Dev 2016 06 9;30(11):1313-26. Epub 2016 Jun 9.

UMR3664, Centre National de la Recherche Scientifique, Institut Curie, PSL (Paris Sciences et Lettres) Research University, F-75005 Paris, France; UMR3664, Centre National de la Recherche Scientifique, University Pierre and Marie Curie Paris 06, Sorbonne Universités, F-75005 Paris, France;

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http://dx.doi.org/10.1101/gad.275073.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911930PMC
June 2016

Drosha and Dicer: Slicers cut from the same cloth.

Cell Res 2016 05 29;26(5):511-2. Epub 2016 Apr 29.

Department of Biology, South University of Science and Technology of China, Shenzhen, Guangdong 518055, China.

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http://dx.doi.org/10.1038/cr.2016.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856758PMC
May 2016

Structural Basis for the Unique Multivalent Readout of Unmodified H3 Tail by Arabidopsis ORC1b BAH-PHD Cassette.

Structure 2016 Mar 11;24(3):486-94. Epub 2016 Feb 11.

Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201602, China. Electronic address:

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http://dx.doi.org/10.1016/j.str.2016.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775424PMC
March 2016

A Structural Perspective on Readout of Epigenetic Histone and DNA Methylation Marks.

Authors:
Dinshaw J Patel

Cold Spring Harb Perspect Biol 2016 Mar 1;8(3):a018754. Epub 2016 Mar 1.

Structural Biology Department, Memorial Sloan-Kettering Cancer Center, New York, New York 10065.

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http://dx.doi.org/10.1101/cshperspect.a018754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772102PMC
March 2016

Structural basis underlying CAC RNA recognition by the RRM domain of dimeric RNA-binding protein RBPMS.

Q Rev Biophys 2016 Jan 8;49:e1. Epub 2015 Sep 8.

Structural Biology Program,Memorial Sloan-Kettering Cancer Center,New York,NY 10065,USA.

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http://www.journals.cambridge.org/abstract_S0033583515000207
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http://dx.doi.org/10.1017/S0033583515000207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783296PMC
January 2016

Recognition of distinct RNA motifs by the clustered CCCH zinc fingers of neuronal protein Unkempt.

Nat Struct Mol Biol 2016 Jan 7;23(1):16-23. Epub 2015 Dec 7.

Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1038/nsmb.3140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703518PMC
January 2016

A Mini-Twister Variant and Impact of Residues/Cations on the Phosphodiester Cleavage of this Ribozyme Class.

Angew Chem Int Ed Engl 2015 Dec 16;54(50):15128-15133. Epub 2015 Oct 16.

Institute of Organic Chemistry and Center for Molecular Biosciences CMBI, Leopold-Franzens University, Innrain 80-82, 6020 Innsbruck (Austria).

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http://dx.doi.org/10.1002/anie.201506601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715771PMC
December 2015

Structural and Dynamic Basis for Low-Affinity, High-Selectivity Binding of L-Glutamine by the Glutamine Riboswitch.

Cell Rep 2015 Dec 19;13(9):1800-13. Epub 2015 Nov 19.

Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.10.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690532PMC
December 2015

DNA methylation pathways and their crosstalk with histone methylation.

Nat Rev Mol Cell Biol 2015 Sep;16(9):519-32

Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nrm4043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672940PMC
September 2015

Crystal structure reveals specific recognition of a G-quadruplex RNA by a β-turn in the RGG motif of FMRP.

Proc Natl Acad Sci U S A 2015 Sep 15;112(39):E5391-400. Epub 2015 Sep 15.

Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016;

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http://dx.doi.org/10.1073/pnas.1515737112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593078PMC
September 2015

Global RNA Fold and Molecular Recognition for a pfl Riboswitch Bound to ZMP, a Master Regulator of One-Carbon Metabolism.

Structure 2015 Aug 25;23(8):1375-1381. Epub 2015 Jun 25.

Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2015.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685959PMC
August 2015

A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks.

Nat Struct Mol Biol 2015 Aug 13;22(8):618-26. Epub 2015 Jul 13.

Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1038/nsmb.3055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685956PMC
August 2015

Profile of Dinshaw J. Patel.

Proc Natl Acad Sci U S A 2015 Aug 27;112(34):10570-2. Epub 2015 Jul 27.

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http://dx.doi.org/10.1073/pnas.1512793112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553825PMC
August 2015

Aub and Ago3 Are Recruited to Nuage through Two Mechanisms to Form a Ping-Pong Complex Assembled by Krimper.

Mol Cell 2015 Aug;59(4):564-75

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545750PMC
August 2015

TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms.

EMBO J 2015 Jul 15;34(13):1801-15. Epub 2015 May 15.

Center for RNA Research, Institute for Basic Science, Seoul, Korea School of Biological Sciences, Seoul National University, Seoul, Korea

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http://dx.doi.org/10.15252/embj.201590931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516432PMC
July 2015

V-cGAPs: attenuators of 3'3'-cGAMP signaling.

Cell Res 2015 May 24;25(5):529-30. Epub 2015 Apr 24.

Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1038/cr.2015.48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423086PMC
May 2015

Structural basis for molecular discrimination by a 3',3'-cGAMP sensing riboswitch.

Cell Rep 2015 Apr 26;11(1):1-12. Epub 2015 Mar 26.

Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732562PMC
April 2015

Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.

Genes Dev 2015 Mar;29(5):501-12

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA; Division of Newborn Medicine, Boston Children's Hospital, Boston, Massachusetts 02115, USA;

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http://dx.doi.org/10.1101/gad.258483.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358403PMC
March 2015

Adenylation of maternally inherited microRNAs by Wispy.

Mol Cell 2014 Dec 13;56(5):696-707. Epub 2014 Nov 13.

Center for RNA Research, Institute for Basic Science, Seoul 151-742, Korea; School of Biological Sciences, Seoul National University, Seoul 151-742, Korea. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378961PMC
December 2014

Uridylation by TUT4 and TUT7 marks mRNA for degradation.

Cell 2014 Dec;159(6):1365-76

Center for RNA Research, Institute for Basic Science, Seoul 151-742, Korea; School of Biological Sciences, Seoul National University, Seoul 151-742, Korea. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.10.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720960PMC
December 2014

In-line alignment and Mg²⁺ coordination at the cleavage site of the env22 twister ribozyme.

Nat Commun 2014 Nov 20;5:5534. Epub 2014 Nov 20.

Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://www.nature.com/articles/ncomms6534
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http://dx.doi.org/10.1038/ncomms6534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373348PMC
November 2014

RNA. Complete pairing not needed.

Authors:
Dinshaw J Patel

Science 2014 Oct;346(6209):542-3

Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/science.1262123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981181PMC
October 2014

c-di-AMP binds the ydaO riboswitch in two pseudo-symmetry-related pockets.

Nat Chem Biol 2014 Sep 3;10(9):780-6. Epub 2014 Aug 3.

Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1038/nchembio.1606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217635PMC
September 2014

The evolutionary journey of Argonaute proteins.

Nat Struct Mol Biol 2014 Sep;21(9):743-53

Laboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University, Wageningen, the Netherlands.

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http://dx.doi.org/10.1038/nsmb.2879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691850PMC
September 2014

Structural biology-based insights into combinatorial readout and crosstalk among epigenetic marks.

Biochim Biophys Acta 2014 Aug 18;1839(8):719-27. Epub 2014 Apr 18.

Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2014.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689310PMC
August 2014

Mechanism of DNA methylation-directed histone methylation by KRYPTONITE.

Mol Cell 2014 Aug 10;55(3):495-504. Epub 2014 Jul 10.

Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/j.molcel.2014.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127122PMC
August 2014

A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36.

Genes Dev 2014 Aug;28(16):1758-71

Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA;

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http://dx.doi.org/10.1101/gad.246561.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197961PMC
August 2014

Molecular mechanism of action of plant DRM de novo DNA methyltransferases.

Cell 2014 May;157(5):1050-60

Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Howard Hughes Medical Institute and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.03.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123750PMC
May 2014

SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation.

Nature 2014 03 22;507(7490):124-128. Epub 2014 Jan 22.

Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1038/nature12931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963826PMC
March 2014

DNA-guided DNA interference by a prokaryotic Argonaute.

Nature 2014 Mar 16;507(7491):258-261. Epub 2014 Feb 16.

Laboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, the Netherlands.

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http://dx.doi.org/10.1038/nature12971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697943PMC
March 2014

A phosphate-binding pocket within the platform-PAZ-connector helix cassette of human Dicer.

Mol Cell 2014 Feb 30;53(4):606-16. Epub 2014 Jan 30.

Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217634PMC
February 2014

Non-CG methylation patterns shape the epigenetic landscape in Arabidopsis.

Nat Struct Mol Biol 2014 Jan 15;21(1):64-72. Epub 2013 Dec 15.

1] Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, California, USA. [2] Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, California, USA. [3] Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.1038/nsmb.2735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103798PMC
January 2014

Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.

Proc Natl Acad Sci U S A 2014 Jan 27;111(2):652-7. Epub 2013 Dec 27.

Laboratory of Non-Coding RNA, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

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http://dx.doi.org/10.1073/pnas.1321032111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896195PMC
January 2014

SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation.

Nature 2014 03 22;507(7490):124-128. Epub 2014 Jan 22.

Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1038/nature12931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963826PMC
March 2014

Readout of epigenetic modifications.

Annu Rev Biochem 2013 ;82:81-118

Structural Biology Department, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1146/annurev-biochem-072711-165700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696766PMC
November 2013

Small molecule epigenetic inhibitors targeted to histone lysine methyltransferases and demethylases.

Q Rev Biophys 2013 Nov 2;46(4):349-73. Epub 2013 Sep 2.

Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, 19 Xinjiekouwai Avenue, Beijing 100875, People's Republic of China.

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http://dx.doi.org/10.1017/S0033583513000085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696758PMC
November 2013

Structural basis of mRNA recognition and cleavage by toxin MazF and its regulation by antitoxin MazE in Bacillus subtilis.

Mol Cell 2013 Nov 10;52(3):447-58. Epub 2013 Oct 10.

Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.molcel.2013.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691852PMC
November 2013

Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1.

Nature 2013 Jun 1;498(7454):385-9. Epub 2013 May 1.

Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1038/nature12178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119789PMC
June 2013

EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2.

Nature 2013 May 1;497(7449):383-7. Epub 2013 May 1.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/nature12080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717558PMC
May 2013

Structural insights into lipid-dependent reversible dimerization of human GLTP.

Acta Crystallogr D Biol Crystallogr 2013 Apr 14;69(Pt 4):603-16. Epub 2013 Mar 14.

Structural Biology Unit, CIC bioGUNE, Technology Park of Bizkaia, 48160 Derio, Spain.

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http://dx.doi.org/10.1107/S0907444913000024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606038PMC
April 2013

Structure-function studies of STAR family Quaking proteins bound to their in vivo RNA target sites.

Genes Dev 2013 Apr;27(8):928-40

Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1101/gad.216531.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650229PMC
April 2013

The BEN domain is a novel sequence-specific DNA-binding domain conserved in neural transcriptional repressors.

Genes Dev 2013 Mar 6;27(6):602-14. Epub 2013 Mar 6.

Department of Developmental Biology, Sloan-Kettering Institute, New York, New York 10065, USA.

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http://dx.doi.org/10.1101/gad.213314.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613608PMC
March 2013

Thermodynamic profiles and nuclear magnetic resonance studies of oligonucleotide duplexes containing single diastereomeric spiroiminodihydantoin lesions.

Biochemistry 2013 Feb 13;52(8):1354-63. Epub 2013 Feb 13.

Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198-4628, United States.

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http://dx.doi.org/10.1021/bi301566vDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588586PMC
February 2013