Ding Ai

Ding Ai

UNVERIFIED PROFILE

Are you Ding Ai?   Register this Author

Register author
Ding Ai

Ding Ai

Publications by authors named "Ding Ai"

Are you Ding Ai?   Register this Author

43Publications

1021Reads

36Profile Views

Regulation of YAP by Mammalian Target of Rapamycin Complex 1 in Endothelial Cells Controls Blood Pressure Through COX-2/mPGES-1/PGE Cascade.

Hypertension 2019 Oct 5;74(4):936-946. Epub 2019 Aug 5.

From the Tianjin Key Laboratory of Metabolic Diseases, Key Laboratory of Immune Microenvironment and Disease-Ministry of Education, Department of Physiology and Pathophysiology, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin, Medical University, China (L.Y., J.H., B.L., M.Y., H.W., M.L., X.L., H.L., X.Z., Y.Z., D.A.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.12834DOI Listing
October 2019

Inhibition of polycomb repressor complex 2 ameliorates neointimal hyperplasia by suppressing trimethylation of H3K27 in vascular smooth muscle cells.

Br J Pharmacol 2019 Sep 19;176(17):3206-3219. Epub 2019 Jul 19.

Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Medical Epigenetics, and Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bph.14754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692584PMC
September 2019

Scalable Polymer Nanocomposites with Record High-Temperature Capacitive Performance Enabled by Rationally Designed Nanostructured Inorganic Fillers.

Adv Mater 2019 Jun 12;31(23):e1900875. Epub 2019 Apr 12.

Department of Materials Science and Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.2019008
Publisher Site
http://dx.doi.org/10.1002/adma.201900875DOI Listing
June 2019

Macrophage Raptor Deficiency-Induced Lysosome Dysfunction Exacerbates Nonalcoholic Steatohepatitis.

Cell Mol Gastroenterol Hepatol 2019 19;7(1):211-231. Epub 2018 Sep 19.

Tianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcmgh.2018.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282883PMC
April 2019

Inhibition of soluble epoxide hydrolase ameliorates hyperhomocysteinemia-induced hepatic steatosis by enhancing β-oxidation of fatty acid in mice.

Am J Physiol Gastrointest Liver Physiol 2019 Apr 21;316(4):G527-G538. Epub 2019 Feb 21.

Tianjin Key Laboratory of Metabolic Diseases; Key Laboratory of Immune Microenvironment and Disease (Ministry of Education); Collaborative Innovation Center of Tianjin for Medical Epigenetics and Department of Physiology and Pathophysiology, Tianjin Medical University , Tianjin , China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpgi.00148.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483021PMC
April 2019

Combinatorial Peptide Ligand Library-Based Photoaffinity Probe for the Identification of Phosphotyrosine-Binding Domain Proteins.

Anal Chem 2019 Mar 18;91(5):3221-3226. Epub 2019 Feb 18.

2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Biochemistry and Molecular Biology, Key Laboratory of Breast Cancer Prevention and Treatment (Ministry of Education), Cancer Institute and Hospital , Tianjin Medical University , Tianjin 300070 , China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.analchem.8b04781DOI Listing
March 2019

Elevating ATP-binding cassette transporter G1 improves re-endothelialization function of endothelial progenitor cells via Lyn/Akt/eNOS in diabetic mice.

FASEB J 2018 12;32(12):6525-6536

Tianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.201800248RRDOI Listing
December 2018

Omega-3 PUFA attenuate mice myocardial infarction injury by emerging a protective eicosanoid pattern.

Prostaglandins Other Lipid Mediat 2018 11 14;139:1-9. Epub 2018 Sep 14.

Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China; Tianjin Key Laboratory of Metabolic Diseases and Department of Physiology, Tianjin Medical University, Tianjin, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.prostaglandins.2018.09.002DOI Listing
November 2018

Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2 Mice.

Circ Res 2018 11;123(11):e35-e47

From the Division of Molecular Medicine, Department of Medicine (W.W., W.L., T.F., Y.W., Y.T., C.W., B.C., I.T., A.R.T., N.W.), Columbia University Medical Center, New York, NY.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.118.313283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309796PMC
November 2018

Elevating ATP-binding cassette transporter G1 improves re-endothelialization function of endothelial progenitor cells via Lyn/Akt/eNOS in diabetic mice.

FASEB J 2018 Jun 12:fj201800248. Epub 2018 Jun 12.

Tianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.201800248DOI Listing
June 2018

The role of Hippo/yes-associated protein signalling in vascular remodelling associated with cardiovascular disease.

Br J Pharmacol 2018 04 10;175(8):1354-1361. Epub 2017 May 10.

Tianjin Key Laboratory of Metabolic Diseases; Collaborative Innovation Center of Tianjin for Medical Epigenetics; Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, 300070, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bph.13806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866970PMC
April 2018

Metabolic profiling of murine plasma reveals eicosapentaenoic acid metabolites protecting against endothelial activation and atherosclerosis.

Br J Pharmacol 2018 04 5;175(8):1190-1204. Epub 2017 Sep 5.

Tianjin Key Laboratory of Metabolic Diseases and Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bph.13971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866973PMC
April 2018

CYP2J2-derived EETs attenuated ethanol-induced myocardial dysfunction through inducing autophagy and reducing apoptosis.

Free Radic Biol Med 2018 03 8;117:168-179. Epub 2018 Feb 8.

Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan 430030, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2018.02.009DOI Listing
March 2018

Yes-Associated Protein Promotes Angiogenesis via Signal Transducer and Activator of Transcription 3 in Endothelial Cells.

Circ Res 2018 02 3;122(4):591-605. Epub 2018 Jan 3.

From the Collaborative Innovation Center of Tianjin for Medical Epigenetics and Department of Physiology and Pathophysiology (J.H., Q.B., M.L., H.L., Y.L., L.Y., B.L., C.Z., G.Z., K.Z., Y.Z., D.A.) and College of Optometry and Ophthalmology, Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute (Y.Z.), Tianjin Medical University, China; Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine (S.H., Y.Z.); Key Laboratory of Network Genetics, Collaborative Innovation Center for Cardiovascular Disorders, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing (X.L., X.-J.W.); Center for Molecular and Translational Medicine, Georgia State University, Atlanta (M.-H.Z.); and Tianjin Key Laboratory of Metabolic Diseases, China (Y.Z., D.A.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.117.311950DOI Listing
February 2018

Plasma metabolic profile reveals PGF2α protecting against non-proliferative diabetic retinopathy in patients with type 2 diabetes.

Biochem Biophys Res Commun 2018 02 2;496(4):1276-1283. Epub 2018 Feb 2.

Tianjin Key Laboratory of Metabolic Diseases and Department of Physiology, Tianjin Medical University, Tianjin 300070, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2018.01.188DOI Listing
February 2018

Spectrum evaluation-assisted eicosanoid metabolomics for global eicosanoid profiling in human vascular endothelial cells.

Clin Exp Pharmacol Physiol 2018 Jan 18;45(1):98-108. Epub 2017 Sep 18.

Tianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1440-1681.12825DOI Listing
January 2018

Hydroxyeicosapentaenoic acids and epoxyeicosatetraenoic acids attenuate early occurrence of nonalcoholic fatty liver disease.

Br J Pharmacol 2017 Jul 9;174(14):2358-2372. Epub 2017 Jun 9.

Tianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bph.13844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481642PMC
July 2017

Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow.

Nature 2016 12 7;540(7634):579-582. Epub 2016 Dec 7.

Institute of Vascular Medicine, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nature20602
Publisher Site
http://dx.doi.org/10.1038/nature20602DOI Listing
December 2016

Inhibition of soluble epoxide hydrolase alleviated atherosclerosis by reducing monocyte infiltration in Ldlr(-/-) mice.

J Mol Cell Cardiol 2016 09 3;98:128-37. Epub 2016 Aug 3.

Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China; Collaborative Innovation Center of Tianjin for Medical Epigenetics and Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin 300070, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2016.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559083PMC
September 2016

Endothelial ATP-binding cassette G1 in mouse endothelium protects against hemodynamic-induced atherosclerosis.

Biochem Biophys Res Commun 2016 08 11;477(2):247-54. Epub 2016 Jun 11.

Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, 300070, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2016.06.050DOI Listing
August 2016

Hyperhomocysteinemia activates the aryl hydrocarbon receptor/CD36 pathway to promote hepatic steatosis in mice.

Hepatology 2016 07 5;64(1):92-105. Epub 2016 Apr 5.

Collaborative Innovation Center of Tianjin for Medical Epigenetics and Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.28518DOI Listing
July 2016

Soluble epoxide hydrolase: A potential target for metabolic diseases.

J Diabetes 2016 May 9;8(3):305-13. Epub 2016 Jan 9.

Collaborative Innovation Center of Tianjin for Medical Epigenetics, Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/1753-0407.12358
Publisher Site
http://dx.doi.org/10.1111/1753-0407.12358DOI Listing
May 2016

Soluble epoxide hydrolase is involved in the development of atherosclerosis and arterial neointima formation by regulating smooth muscle cell migration.

Am J Physiol Heart Circ Physiol 2015 Dec 9;309(11):H1894-903. Epub 2015 Oct 9.

Department of Physiology and Pathophysiology, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University, Tianjin, China;

View Article

Download full-text PDF

Source
http://www.physiology.org/doi/10.1152/ajpheart.00289.2015
Publisher Site
http://dx.doi.org/10.1152/ajpheart.00289.2015DOI Listing
December 2015

Metabolomic analysis revealed the role of DNA methylation in the balance of arachidonic acid metabolism and endothelial activation.

Biochim Biophys Acta 2015 Oct 11;1851(10):1317-26. Epub 2015 Jul 11.

Department of Physiology and Pathophysiology, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University, Tianjin 300070, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbalip.2015.07.001DOI Listing
October 2015

Opposite effects of gene deficiency and pharmacological inhibition of soluble epoxide hydrolase on cardiac fibrosis.

PLoS One 2014 9;9(4):e94092. Epub 2014 Apr 9.

Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China; Department of Physiology, Tianjin Medical University, Tianjin, China.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094092PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981766PMC
June 2015

20-Hydroxyeicosatetraenoic acid involved in endothelial activation and thrombosis.

Am J Physiol Heart Circ Physiol 2015 Jun 27;308(11):H1359-67. Epub 2015 Mar 27.

Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China; Collaborative Innovation Center of Tianjin for Medical Epigenetics and Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpheart.00802.2014DOI Listing
June 2015

Systematic metabolomic analysis of eicosanoids after omega-3 polyunsaturated fatty acid supplementation by a highly specific liquid chromatography-tandem mass spectrometry-based method.

J Proteome Res 2015 Apr 17;14(4):1843-53. Epub 2015 Mar 17.

§Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/pr501200uDOI Listing
April 2015

Macrophage mTORC1 disruption reduces inflammation and insulin resistance in obese mice.

Diabetologia 2014 Nov 14;57(11):2393-404. Epub 2014 Aug 14.

Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-014-3350-5DOI Listing
November 2014

Ambient levels and temporal variations of PM2.5 and PM10 at a residential site in the mega-city, Nanjing, in the western Yangtze River Delta, China.

J Environ Sci Health A Tox Hazard Subst Environ Eng 2014 ;49(2):171-8

a Institute for Climate and Global Change Research, School of Atmospheric Sciences, Nanjing University , Nanjing , China.

View Article

Download full-text PDF

Source
http://www.tandfonline.com/doi/abs/10.1080/10934529.2013.838
Publisher Site
http://dx.doi.org/10.1080/10934529.2013.838851DOI Listing
June 2014

Disruption of mammalian target of rapamycin complex 1 in macrophages decreases chemokine gene expression and atherosclerosis.

Circ Res 2014 May 31;114(10):1576-84. Epub 2014 Mar 31.

From the Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY (D.A., H.J., M. Westerterp, A.J.M., M. Wang, A.G., S.A., C.W., A.R.T.); Department of Physiology, Tianjin Medical University, Tianjin, China (D.A., Y.Z.); Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (M. Westerterp); and Department of Medicine, University of California at San Diego, CA (F.A., Y.I.M.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.114.302313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058053PMC
May 2014

Upregulation of Scavenger Receptor BI by Hepatic Nuclear Factor 4α through a Peroxisome Proliferator-Activated Receptor γ-Dependent Mechanism in Liver.

PPAR Res 2011 14;2011:164925. Epub 2011 Nov 14.

Department of Physiology and Pathophysiology, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Beijing 100191, China.

View Article

Download full-text PDF

Source
http://www.hindawi.com/journals/ppar/2011/164925/
Publisher Site
http://dx.doi.org/10.1155/2011/164925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236442PMC
August 2012

Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism.

J Clin Invest 2012 Aug 2;122(8):2807-16. Epub 2012 Jul 2.

Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://www.jci.org/articles/view/63563
Publisher Site
http://dx.doi.org/10.1172/JCI63563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408750PMC
August 2012

Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice.

J Clin Invest 2012 Apr 19;122(4):1262-70. Epub 2012 Mar 19.

Department of Medicine, Columbia University, New York, New York 10032, USA.

View Article

Download full-text PDF

Source
http://www.jci.org/articles/view/61919
Publisher Site
http://dx.doi.org/10.1172/JCI61919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314476PMC
April 2012

Activation of peroxisome proliferator-activated receptor-γ downregulates soluble epoxide hydrolase in cardiomyocytes.

Clin Exp Pharmacol Physiol 2011 Jun;38(6):358-64

Department of Physiology and Pathophysiology, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Beijing, China.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1440-1681.2011.05492.x
Publisher Site
http://dx.doi.org/10.1111/j.1440-1681.2011.05492.xDOI Listing
June 2011

Sorting out sortilin.

Authors:
Alan R Tall Ding Ai

Circ Res 2011 Jan;108(2):158-60

Division of Molecular Medicine, Department of Medicine, Columbia University Medical Center.

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/RES.0b013e31820d7daa
Publisher Site
http://dx.doi.org/10.1161/RES.0b013e31820d7daaDOI Listing
January 2011

Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events.

Proc Natl Acad Sci U S A 2010 Sep 13;107(39):17017-22. Epub 2010 Sep 13.

Department of Entomology and University of California-Davis Cancer Center, University of California, Davis, CA 95616, USA.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.1011278107
Publisher Site
http://dx.doi.org/10.1073/pnas.1011278107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947894PMC
September 2010

DNA methylation of the promoter of soluble epoxide hydrolase silences its expression by an SP-1-dependent mechanism.

Biochim Biophys Acta 2010 Sep 1;1799(9):659-67. Epub 2010 Oct 1.

Cardiovascular Research Center, Shantou University Medical College, Shantou, Guangdong 515041, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbagrm.2010.09.006DOI Listing
September 2010

Linking an insect enzyme to hypertension: angiotensin II-epoxide hydrolase interactions.

Kidney Int 2010 Jan 21;77(2):88-92. Epub 2009 Oct 21.

Cardiovascular Research Center, Shantou University Medical College, Shantou, Guangdong, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ki.2009.349DOI Listing
January 2010

Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy.

Proc Natl Acad Sci U S A 2009 Jan 6;106(2):564-9. Epub 2009 Jan 6.

Department of Physiology and Pathophysiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Sciences, Health Science Center, Ministry of Education, Peking University, Beijing 100083, China.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.0811022106
Publisher Site
http://dx.doi.org/10.1073/pnas.0811022106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626743PMC
January 2009

Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo.

Proc Natl Acad Sci U S A 2007 May 10;104(21):9018-23. Epub 2007 May 10.

Department of Physiology and Pathophysiology, Health Science Center, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Peking University, Beijing 100083, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0703229104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885620PMC
May 2007